CN110167355A - 多药抗体药物偶联物 - Google Patents

多药抗体药物偶联物 Download PDF

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Publication number
CN110167355A
CN110167355A CN201780077877.2A CN201780077877A CN110167355A CN 110167355 A CN110167355 A CN 110167355A CN 201780077877 A CN201780077877 A CN 201780077877A CN 110167355 A CN110167355 A CN 110167355A
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China
Prior art keywords
antibody
group
drug
linking group
unit
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CN201780077877.2A
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Chinese (zh)
Inventor
M·R·列文古德
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Seagen Inc
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Seattle Genetics Inc
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Priority to CN202310259438.0A priority Critical patent/CN116271080A/zh
Publication of CN110167355A publication Critical patent/CN110167355A/zh
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily

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CN111892575A (zh) * 2020-08-20 2020-11-06 南京大学 一类紫草宁硫辛硫醚孪药分子及其合成方法和应用
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CN115737834A (zh) * 2022-11-11 2023-03-07 山东大学 一种抗体偶联药物cea-海兔毒素10衍生物及其在抗肿瘤中的应用
WO2025031307A1 (zh) * 2023-08-04 2025-02-13 上海华藕生物医药有限公司 多药连接体及抗体药物偶联物
WO2026138978A1 (zh) * 2024-12-27 2026-07-02 上海拓济医药有限责任公司 一种双毒素抗体药物偶联物及其医药用途

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KR20190095374A (ko) 2019-08-14
US20200129639A1 (en) 2020-04-30
EP3554266A1 (en) 2019-10-23
US20240033372A1 (en) 2024-02-01
KR20240119181A (ko) 2024-08-06
CA3043931A1 (en) 2018-06-21
EP3554266A4 (en) 2020-08-12
TWI828614B (zh) 2024-01-11
JP7244987B2 (ja) 2023-03-23
TW202435918A (zh) 2024-09-16
AU2017376926B2 (en) 2023-03-23
AU2017376926C1 (en) 2023-09-21
JP2018118953A (ja) 2018-08-02
NZ753550A (en) 2023-10-27
CN116271080A (zh) 2023-06-23
JP2023071996A (ja) 2023-05-23
WO2018112253A1 (en) 2018-06-21
MA50755A (fr) 2019-10-23
IL267003B2 (en) 2024-09-01

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