MX2019006983A - Conjugados de anticuerpo-farmaco de multiples farmacos. - Google Patents

Conjugados de anticuerpo-farmaco de multiples farmacos.

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Publication number
MX2019006983A
MX2019006983A MX2019006983A MX2019006983A MX2019006983A MX 2019006983 A MX2019006983 A MX 2019006983A MX 2019006983 A MX2019006983 A MX 2019006983A MX 2019006983 A MX2019006983 A MX 2019006983A MX 2019006983 A MX2019006983 A MX 2019006983A
Authority
MX
Mexico
Prior art keywords
drug
units
conjugates
adcs
deprotection
Prior art date
Application number
MX2019006983A
Other languages
English (en)
Inventor
R Levengood Matthew
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of MX2019006983A publication Critical patent/MX2019006983A/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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Abstract

La presente descripción proporciona, inter alia, Conjugados de Anticuerpo-fármaco de múltiples fármacos (MDADC) y Unidades de Montaje de Ligación (LA) que se construyen en una materia específica de sitio a través de desprotección "ortogonal" y carga de fármaco. También se proporcionan, Unidades de Montaje de Ligación protegidas, que permiten la desprotección "ortogonal" y construcción de MD-ADC y Unidades LA de la presente descripción.
MX2019006983A 2016-12-14 2017-12-14 Conjugados de anticuerpo-farmaco de multiples farmacos. MX2019006983A (es)

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