CN110151664A - A kind of Yak-skin Gelatin skin-protection product and preparation method thereof for dispelling red blood trace on face - Google Patents
A kind of Yak-skin Gelatin skin-protection product and preparation method thereof for dispelling red blood trace on face Download PDFInfo
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Abstract
The present invention relates to preparation for external application to skin technical fields, and in particular to one kind can dispel Yak-skin Gelatin skin-protection product of red blood trace on face and preparation method thereof.The skin-protection product includes following component: Yak-skin Gelatin, olive oil, Lavender, Bitter Orang P.E, Flos Sophorae extract, other auxiliary elements and deionized water.The present invention by Yak-skin Gelatin compound different plant components reach moisturizing, nourish, dispel red capillary, it is anti-oxidant, remove the purpose of free radical.Select Yak-skin Gelatin as principle active component, so that product is played, Yak-skin Gelatin is anti-oxidant, promotes the features such as vascular endothelial cell growth, moisturizing；Cooperate Bitter Orang P.E and Flos Sophorae extract, the permeability of facial vessels can be effectively reduced, while having hemostasia effect；Cooperate olive oil and Lavender, can effective pore refining, reduce the generation of the subtle scar of skin surface, while there is anti-inflammatory, analgesic activity, help skin repair, fundamentally alleviate or treat red capillary.
Description
Technical field
The present invention relates to preparation for external application to skin technical fields, and in particular to one kind can dispel the Yak-skin Gelatin of red blood trace on face
Skin-protection product and preparation method thereof.
Background technique
The skin of people is primarily present in the corium of skin by epidermis, corium, subcutaneous tissue up of three-layer, facial capillary
Layer.Facial telangiectasias is commonly called as red blood trace on face.Red blood trace on face mainly has heredity and secondary two types.
There are many induced factors for secondary red blood trace on face.Wherein, the generation of plateau red capillary has apparent regional.Qinghai-Tibet Platean
High aititude, hypoxemia, ultraviolet light irradiate a variety of natural conditions such as strong, climate change is obvious, the formation of Yi Yinqi red capillary.Plateau
Property weather caused by telangiectasis, be body since high altitude anoxia causes erythrocyte number to increase, aggregation enhancing, hardness increase
Greatly, deformability reduces, and platelet aggregation and pH value change so that blood viscosity increases and critical capillary radius increases.
Micro- resistance of blood flow is obviously increased, or even causes capilary blocking to further increase erythrocyte number, blood vessel underwent compensatory enlargement,
Over time, vessel retraction dysfunction causes permanent telangiectasis.The red capillary that facial telangiectasias causes
Patient's beauty is not only seriously affected, very big burden is also resulted in the psychology of patient.Not with social development living standards of the people
It is disconnected to improve, it is also higher and higher for the quality and performance requirement of cosmetics.The product for dispelling red capillary in the market is also very much, but
It is unobvious, big to skin irritation to there is selling at exorbitant prices, effect, or there is more or less side effect.
Summary of the invention
The problems such as based on telangiectasis caused by above-mentioned highlands resident red blood trace on face and high altitude weather, this
Being designed to provide for invention a kind of can dispel Yak-skin Gelatin skin-protection product of red blood trace on face and preparation method thereof.
A kind of Yak-skin Gelatin skin-protection product for dispelling red blood trace on face, the skin-protection product include following component: yak skin
Glue, olive oil, Lavender, Bitter Orang P.E, Flos Sophorae extract, other auxiliary elements and deionized water.
As a further improvement of the present invention, the Yak-skin Gelatin skin care that one kind of the invention can dispel red blood trace on face produces
Product, the following component including weight percent meter: Yak-skin Gelatin 15~35%；Olive oil 0.3~2.5%；Lavender
0.01~0.07%；Evening primrose oil 0.8~1.9%；Bitter Orang P.E 0.5~1.2%；Flos Sophorae extract 1.0~2.2%；Its
His auxiliary element 5.15~13.06%；Balance deionized water.
Optimization, other described auxiliary elements include: glycerol, propylene glycol, allantoin, Glyceryl stearate citrate,
Methyl hydroxybenzoate, Nipasol, tocopherol, EDETATE SODIUM, lactic acid-sodium lactate and essence.
As a further improvement of the present invention, the Yak-skin Gelatin skin care that one kind of the invention can dispel red blood trace on face produces
Product, the following component including weight percent meter: Yak-skin Gelatin 15~35%；Olive oil 0.3~2.5%；Lavender
0.01~0.07%；Bitter Orang P.E 0.5~1.2%；Flos Sophorae extract 1.0~2.2%；Glycerol 1.5~4.5%；Propylene glycol
2.5~5.5%；Allantoin 0.15~0.25%；Glyceryl stearate citrate 0.3~1.0%；Methyl hydroxybenzoate 0.1~
0.2%；Nipasol 0.03~0.08%；Tocopherol 0.03~0.25%；EDETATE SODIUM 0.03~0.05%；Lactic acid-lactic acid
Sodium 0.5~1.2%；Essence 0.01~0.03%；Balance deionized water.
Optimization, one kind of the invention can dispel the Yak-skin Gelatin skin-protection product of red blood trace on face, including weight percent
The following component of meter: Yak-skin Gelatin 25%；Olive oil 1.5%；Lavender 0.04%；Bitter Orang P.E 1.2%；Sophora flower mentions
Take object 1.0%；Glycerol 1.5%；Propylene glycol 3.5%；Allantoin 0.25%；Glyceryl stearate citrate 0.8%；Oxybenzene first
Ester 0.15%；Nipasol 0.05%；Tocopherol 0.15%；EDETATE SODIUM 0.05%；Lactic acid-sodium lactate 0.9%；Essence
0.01%；Balance deionized water.
Wherein, it is powdered gelatin object obtained by material, enzyme method extracts that the Yak-skin Gelatin, which is the skin of yak in Qinghai-tibet,
Matter, since yak living environment is severe, severe cold region, thus yak have extremely strong anti-adversity ability, disease resistance, tolerance and
Adaptability adapts to the harsh high and cold severe ecological environment such as the immalleable High aititude of general domestic animal, high anoxic；In addition yak
Living environment (including soil, herbage, water source etc.) contaminated situation it is less；It is obvious that early-stage study shows that Yak-skin Gelatin has
It is anti-oxidant, promote vascular endothelial cell growth, moisturizing isoreactivity.
The olive oil is rich in essential fatty acid from olive fruit squeezing, absorbs rapidly, is able to maintain skin elasticity
With it is moist, containing antioxidant, facial wrinkles can be eliminated, prevent skin aging, there is skin-care effect.
The Lavender is refined by lavender plant and is obtained, and is had and is repaired damaged cell, is promoted cytothesis, is accelerated
Wound healing can inhibit bacterium, reduce scar.
The Bitter Orang P.E is extracted by the young fruit powder of rue kind plant structure tangerine, bitter orange or citrus medic L. through methanol eddy, point
From the mainly extract containing synephrine and aurantiamarin is prepared, wherein synephrine and 80% or more content of hesperidin, have and receive
Contracting blood vessel reduces the permeability and anti-inflammatory effect of capillary.
When the Flos Sophorae extract is formed by the opening of leguminous plant Chinese scholartree (Sophorajaponica L.) summer flower or bud
The flower and alabastrum of harvesting is extracted through water and is obtained, and is had and is kept the normal resistance of capillary, prevents because of capillary fragility mistake
Greatly, bleeding caused by permeability is excessively high, cooling blood and hemostasis improve capillary microcirculation, keep the normal resistance of capillary
Function.
The allantoin has anti-inflammatory analgetic, promotes hyperplasia, repairs epithelial tissue, can increase and promote cuticlar water
Conjunction ability, guarantee product combination water ability increase, reduce moisture loss, make skin become it is smooth, wetting and it is flexible, alleviate with
Xerodermia is treated, is moisturized the skin.
The tocopherol is vitamin E, has and enters Skin Cell, and the protein active structure of energy stabilizing cell membrane is protected
The elasticity of skin is held, infringement etc. of the skin to free radical resisting, ultraviolet light and pollutant is helped.
The present invention also provides the preparation methods that one kind can dispel the Yak-skin Gelatin skin-protection product of red blood trace on face, including such as
Lower step:
Step 1: by the deionized water of special ratios, glycerol, propylene glycol, allantoin, EDTA disodium, methyl hydroxybenzoate it is mixed
Conjunction object is placed on emulsion pot and is heated to 80~95 DEG C, heat preservation；Yak-skin Gelatin is separately configured at room temperature, ultimate density 15~35%,
In configuration process, temperature is no more than 40 DEG C, fully stirs at room temperature, is uniformly dissolved Yak-skin Gelatin, is finally bright
Viscous liquid；
Step 2: Glyceryl stearate citrate, tocopherol, Nipasol being placed in oily phase pot and are heated to 80~95
DEG C, olive oil is added, is uniformly mixed；
Step 3: first the material in oily phase pot being pumped into emulsion pot, is kept for 80~95 DEG C of temperature, homogeneous 3~5 minutes；It can
Add lactic acid-sodium lactate to carry out pH value adjusting, it is made to show slightly subacidity；Then be cooled to 35~40 DEG C, be added Yak-skin Gelatin solution,
Essence, stirring 10 minutes or more；
Step 4: it is eventually adding Bitter Orang P.E, Flos Sophorae extract, Lavender active constituent, is stirred to uniform, cooling,
Storage, packing.
Further, the Yak-skin Gelatin skin-protection product for dispelling red blood trace on face, can be made into cream, lotion or moisturizing
Dew.
The practical approach of the Yak-skin Gelatin skin-protection product of red blood trace on face can be dispelled made from above-mentioned steps to need every angel
With, persistently use 30 days.
Compared to existing similar product, the invention has the following beneficial effects:
The present invention by Yak-skin Gelatin compound different plant components reach moisturizing, nourish, dispel red capillary, it is anti-oxidant,
Remove the purpose of free radical etc..Select Yak-skin Gelatin as principle active component, so that product is played, Yak-skin Gelatin is anti-oxidant, promotees
The features such as into vascular endothelial cell growth, moisturizing；Cooperate Bitter Orang P.E and Flos Sophorae extract, facial vessels can be effectively reduced
Permeability, while having hemostasia effect；Cooperate olive oil and Lavender, can effective pore refining, reduce skin surface
The generation of subtle scar, while there is anti-inflammatory, analgesic activity, help skin repair；Yak-skin Gelatin and the more function of active components of plants
Being mutually improved between effect ingredient, the effect of multi-faceted reparation is realized to facial capillary, is applied to skin of face, from basic
Upper alleviation or treatment red capillary.
The Yak-skin Gelatin skin-protection product that the present invention can dispel red blood trace on face complies fully with the " cosmetics health of country's promulgation
Specification " indices in (2015 editions), any potential hazard is free of, after continuous use product of the present invention 30 days, the red blood of face
Silk is substantially reduced, and skin brightness is promoted, and moisturizing degree improves, and sophistication increases.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
Embodiment 1
A kind of Yak-skin Gelatin skin-protection product 1 for dispelling red blood trace on face
Following component including weight percent meter: Yak-skin Gelatin 25%；Olive oil 1.5%；Lavender 0.04%；
Bitter Orang P.E 1.2%；Flos Sophorae extract 1.0%；Glycerol 1.5%；Propylene glycol 3.5%；Allantoin 0.25%；Glycerol stearate
Ester citrate 0.8%；Methyl hydroxybenzoate 0.15%；Nipasol 0.05%；Tocopherol 0.15%；EDETATE SODIUM 0.05%；Cream
Acid-sodium lactate 0.9%；Essence 0.01%；Balance deionized water.
The preparation method of the above-mentioned Yak-skin Gelatin skin-protection product 1 for dispelling red blood trace on face, includes the following steps:
Step 1: by the deionized water of special ratios, glycerol, propylene glycol, allantoin, EDTA disodium, methyl hydroxybenzoate it is mixed
Conjunction object is placed on emulsion pot and is heated to 95 DEG C, heat preservation；Yak-skin Gelatin is separately configured at room temperature, ultimate density 30%, configuration process
In, temperature is no more than 40 DEG C, fully stirs at room temperature, is uniformly dissolved Yak-skin Gelatin, is finally bright viscous liquid；
Step 2: Glyceryl stearate citrate, tocopherol, Nipasol are placed in oily phase pot and are heated to 95 DEG C, then
Olive oil is added, is uniformly mixed；
Step 3: first the material in oily phase pot being pumped into emulsion pot, is kept for 95 DEG C of temperature, homogeneous 5 minutes；Lactic acid-can be added
Sodium lactate carries out pH value adjusting, it is made to show slightly subacidity；35 DEG C are then cooled to, Yak-skin Gelatin solution, essence, stirring 15 is added
Minute；
Step 4: it is eventually adding Bitter Orang P.E, Flos Sophorae extract, Lavender active constituent, is stirred to uniform, cooling,
Storage, packing can be prepared by dispel the Yak-skin Gelatin skin-protection product 1 of red blood trace on face.
Embodiment 2
Embodiment 2-4 is matched according to the component proportion of table 1, and the product of preparation is respectively product 2-4, due to deionization
The size of water and other auxiliary element contents is little to the final potency due of this product, therefore, is not lifted specifically in this recipe
Example.
The component proportion of product 2-4 is made in table 1
The preparation method of the above-mentioned Yak-skin Gelatin skin-protection product 2 for dispelling red blood trace on face, includes the following steps:
Step 1: by the deionized water of special ratios, glycerol, propylene glycol, allantoin, EDTA disodium, methyl hydroxybenzoate it is mixed
Conjunction object is placed on emulsion pot and is heated to 80 DEG C, heat preservation；Yak-skin Gelatin is separately configured at room temperature, ultimate density 15%, configuration process
In, temperature is no more than 40 DEG C, fully stirs at room temperature, is uniformly dissolved Yak-skin Gelatin, is finally bright viscous liquid；
Step 2: Glyceryl stearate citrate, tocopherol, Nipasol are placed in oily phase pot and are heated to 80 DEG C, then
Olive oil is added, is uniformly mixed；
Step 3: first the material in oily phase pot being pumped into emulsion pot, is kept for 80 DEG C of temperature, homogeneous 3 minutes；Lactic acid-can be added
Sodium lactate carries out pH value adjusting, it is made to show slightly subacidity；37 DEG C are then cooled to, Yak-skin Gelatin solution, essence, stirring 12 is added
Minute；
Step 4: it is eventually adding Bitter Orang P.E, Flos Sophorae extract, Lavender active constituent, is stirred to uniform, cooling,
Storage, packing can be prepared by dispel the Yak-skin Gelatin skin-protection product 2 of red blood trace on face.
Embodiment 3
The preparation method of the above-mentioned Yak-skin Gelatin skin-protection product 3 for dispelling red blood trace on face, includes the following steps:
Step 1: by the deionized water of special ratios, glycerol, propylene glycol, allantoin, EDTA disodium, methyl hydroxybenzoate it is mixed
Conjunction object is placed on emulsion pot and is heated to 90 DEG C, heat preservation；Yak-skin Gelatin is separately configured at room temperature, ultimate density 35%, configuration process
In, temperature is no more than 40 DEG C, fully stirs at room temperature, is uniformly dissolved Yak-skin Gelatin, is finally bright viscous liquid；
Step 2: Glyceryl stearate citrate, tocopherol, Nipasol are placed in oily phase pot and are heated to 90 DEG C, then
Olive oil is added, is uniformly mixed；
Step 3: first the material in oily phase pot being pumped into emulsion pot, is kept for 90 DEG C of temperature, homogeneous 4 minutes；Lactic acid-can be added
Sodium lactate carries out pH value adjusting, it is made to show slightly subacidity；40 DEG C are then cooled to, Yak-skin Gelatin solution, essence, stirring 18 is added
Minute；
Step 4: it is eventually adding Bitter Orang P.E, Flos Sophorae extract, Lavender active constituent, is stirred to uniform, cooling,
Storage, packing can be prepared by dispel the Yak-skin Gelatin skin-protection product 3 of red blood trace on face.
Embodiment 4
The preparation method of the above-mentioned Yak-skin Gelatin skin-protection product 4 for dispelling red blood trace on face, includes the following steps:
Step 1: by the deionized water of special ratios, glycerol, propylene glycol, allantoin, EDTA disodium, methyl hydroxybenzoate it is mixed
Conjunction object is placed on emulsion pot and is heated to 93 DEG C, heat preservation；Yak-skin Gelatin is separately configured at room temperature, ultimate density 25%, configuration process
In, temperature is no more than 40 DEG C, fully stirs at room temperature, is uniformly dissolved Yak-skin Gelatin, is finally bright viscous liquid；
Step 2: Glyceryl stearate citrate, tocopherol, Nipasol are placed in oily phase pot and are heated to 93 DEG C, then
Olive oil is added, is uniformly mixed；
Step 3: first the material in oily phase pot being pumped into emulsion pot, is kept for 93 DEG C of temperature, homogeneous 3 minutes；Lactic acid-can be added
Sodium lactate carries out pH value adjusting, it is made to show slightly subacidity；36 DEG C are then cooled to, Yak-skin Gelatin solution, essence, stirring 16 is added
Minute；
Step 4: it is eventually adding Bitter Orang P.E, Flos Sophorae extract, Lavender active constituent, is stirred to uniform, cooling,
Storage, packing can be prepared by dispel the Yak-skin Gelatin skin-protection product 4 of red blood trace on face.
Embodiment 5
(1) product function is tested
Product 1-4 is subjected to the increased zoopery of capillary permeability caused by reduction histamine, is used 2 times daily, even
It is continuous to use 7 days.
Each group rat presses principal component dosage in each product (dosage in 5g product) smearing respectively and is administered, and blank control group is given etc.
The physiological saline of capacity, is administered three times, and is spaced 2 hours, and 30 minutes after medicine, 1 μ g/ml histamine is subcutaneously injected in rat back
0.1ml, 1% Evans blue physiological saline 4ml/kg of tail vein injection, puts to death rat immediately after 15 minutes, overturns skin of back,
And skin of back basket spot is laid into (blank control group selects normal rat skin) with 1.2cm punch, it is placed in acetone: physiology salt
It is impregnated in water (7:3) 6ml test tube, it is close to survey light with 72lw microcomputer type visible spectrophotometer at wavelength 610nm for next day centrifugation
Degree.Experimental result such as the following table 2:
2 product of the present invention functional test results of table
(2) main extract component efficacy test
Ingredient used in following experiments is main composition in product, including Yak-skin Gelatin, Bitter Orang P.E and Chinese scholartree
Flower extract is tested after mixing according to the proportions in product 1-4.
(1) free radical experiment is removed
DPPH1mg is taken to be dissolved in 20mL dehydrated alcohol, by the 99.5% of the sample of the 3mg/mL of 500 μ L volumes and 500 μ L
Ethyl alcohol and the 0.02%DPPH ethanol solution of 125 μ L are mixed.Mixture is shaken and in dark placement at room temperature
60min.Microplate reader detects the light absorption value of each sample under 517nm, is denoted as Ai；Dehydrated alcohol replaces sample solution as control, note
For A0.Operation repetitive 3 times.DPPH free radical scavenging activity calculation formula is as follows:
3 product of the present invention of table removes free radical result
| Test item | Product 1 | Product 2 | Product 3 | Product 4 |
| DPPH (%) | 69.83±0.00 | 51.45±0.01 | 63.18±0.01 | 59.34±0.00 |
(2) vascular endothelial cell appreciation rate detects
The proliferation of vascular endothelial cell is conducive to the reparation of damaged blood vessels.The VEC304 cell that conventional method recovery freezes,
The DMEM culture solution for containing 10% fetal calf serum is added, in 37 DEG C of 5%CO2Stationary culture in incubator.By well-grown VEC304
After 0.25% trypsin digestion 2-3min, gently cell suspension is made in piping and druming, secondary culture 2-3 times weekly.
The cell in exponential phase of growth is taken, appropriate 0.25% trypsin digestion 2min is added, with containing 10% tire ox blood
Clear DMEM culture solution is made into 1 × 105mL-196 orifice plates are added in cell suspension.The every hole of medication group adds cell suspension 160ul, medicine
Liquid 20ul, H2O220ul；Normal group adds cell suspension 160ul, physiological saline 40ul；Model group adds cell suspension 160ul,
Physiological saline 20ul, H2O220ul.In 37 DEG C of 5%CO220ul 5g/L MTT solution is added in every hole after being incubated in incubator for 24 hours,
Supernatant is sucked out in 37 DEG C of incubation 4h, and 150ul DMSO is added, microplate reader 490nm wavelength measurement OD value after mixing (see Table 4 for details).
4 product of the present invention vascular endothelial cell appreciation rate testing result of table
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (8)
1. the Yak-skin Gelatin skin-protection product that one kind can dispel red blood trace on face, which is characterized in that the skin-protection product includes such as the following group
Point: Yak-skin Gelatin, olive oil, Lavender, Bitter Orang P.E, Flos Sophorae extract, other auxiliary elements and deionized water.
2. the Yak-skin Gelatin skin-protection product that one kind according to claim 1 can dispel red blood trace on face, which is characterized in that should
Skin-protection product includes the following component of weight percent meter: Yak-skin Gelatin 15~35%；Olive oil 0.3~2.5%；Lavender essence
Oil 0.01~0.07%；Evening primrose oil 0.8~1.9%；Bitter Orang P.E 0.5~1.2%；Flos Sophorae extract 1.0~2.2%；
Other auxiliary elements 5.15~13.06%；Balance deionized water.
3. the Yak-skin Gelatin skin-protection product that one kind according to claim 2 can dispel red blood trace on face, which is characterized in that institute
State other auxiliary elements include: glycerol, propylene glycol, allantoin, Glyceryl stearate citrate, methyl hydroxybenzoate, Nipasol,
Tocopherol, EDETATE SODIUM, lactic acid-sodium lactate and essence.
4. one kind according to claim 1 or 3 can dispel the Yak-skin Gelatin skin-protection product of red blood trace on face, feature exists
In the skin-protection product includes the following component of weight percent meter: Yak-skin Gelatin 15~35%；Olive oil 0.3~2.5%；It smokes
Clothing grass essential oil 0.01~0.07%；Bitter Orang P.E 0.5~1.2%；Flos Sophorae extract 1.0~2.2%；Glycerol 1.5~
4.5%；Propylene glycol 2.5~5.5%；Allantoin 0.15~0.25%；Glyceryl stearate citrate 0.3~1.0%；Oxybenzene
Methyl esters 0.1~0.2%；Nipasol 0.03~0.08%；Tocopherol 0.03~0.25%；EDETATE SODIUM 0.03~0.05%；
Lactic acid-sodium lactate 0.5~1.2%；Essence 0.01~0.03%；Balance deionized water.
5. the Yak-skin Gelatin skin-protection product that one kind according to claim 4 can dispel red blood trace on face, which is characterized in that should
Skin-protection product includes the following component of weight percent meter: Yak-skin Gelatin 25%；Olive oil 1.5%；Lavender 0.04%；
Bitter Orang P.E 1.2%；Flos Sophorae extract 1.0%；Glycerol 1.5%；Propylene glycol 3.5%；Allantoin 0.25%；Glycerol stearate
Ester citrate 0.8%；Methyl hydroxybenzoate 0.15%；Nipasol 0.05%；Tocopherol 0.15%；EDETATE SODIUM 0.05%；Cream
Acid-sodium lactate 0.9%；Essence 0.01%；Balance deionized water.
6. the Yak-skin Gelatin skin-protection product that one kind according to claim 4 can dispel red blood trace on face, which is characterized in that institute
Stating the skin that Yak-skin Gelatin is yak in Qinghai-tibet is powdered gelatin mass obtained by material, enzyme method extracts；The olive oil is by olive
Olive fruit squeezes and obtains；The Lavender is refined by lavender plant and is obtained；The Bitter Orang P.E is by rue kind plant structure
The young fruit powder of tangerine, bitter orange or citrus medic L. is extracted through methanol eddy, and separation is prepared the mainly extraction containing synephrine and aurantiamarin
Object；The Flos Sophorae extract harvests when being formed by the opening of leguminous plant Chinese scholartree (Sophora japonica L.) summer flower or bud
Flower and alabastrum through water extract and obtain；The tocopherol is vitamin E.
7. the preparation method of the Yak-skin Gelatin skin-protection product as claimed in claim 4 for dispelling red blood trace on face, including walk as follows
It is rapid:
Step 1: the mixture of the deionized water of special ratios, glycerol, propylene glycol, allantoin, EDETATE SODIUM, methyl hydroxybenzoate is put
80~95 DEG C are heated in emulsion pot, heat preservation；Yak-skin Gelatin is separately configured at room temperature, and ultimate density 15~35% configured
Cheng Zhong, temperature are no more than 40 DEG C, fully stir at room temperature, be uniformly dissolved Yak-skin Gelatin, be finally bright sticky liquid
Body；
Step 2: Glyceryl stearate citrate, tocopherol, Nipasol are placed in oily phase pot and are heated to 80~95 DEG C, then
Olive oil is added, is uniformly mixed；
Step 3: first the material in oily phase pot being pumped into emulsion pot, is kept for 80~95 DEG C of temperature, homogeneous 3~5 minutes；Cream can be added
Acid-sodium lactate carries out pH value adjusting, it is made to show slightly subacidity；35~40 DEG C are then cooled to, Yak-skin Gelatin solution, perfume (or spice) is added
Essence, stirring 10 minutes or more；
Step 4: being eventually adding Bitter Orang P.E, Flos Sophorae extract, Lavender active constituent, stir to uniform, cooling, storage
It deposits, packing.
8. one kind according to claim 7 can dispel the preparation method of the Yak-skin Gelatin skin-protection product of red blood trace on face,
It is characterized in that, the Yak-skin Gelatin skin-protection product for dispelling red blood trace on face can be made into cream, lotion or skin cream.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112385842A (en) * | 2020-12-03 | 2021-02-23 | 中国科学院西北高原生物研究所 | Yak skin glue compound product with coagulation promoting and bleeding stopping effects and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1283508A (en) * | 2000-07-04 | 2001-02-14 | 张俊峰 | Beautifying cosmetics series for treating red blood trace on face |
| CN105662998A (en) * | 2016-01-29 | 2016-06-15 | 中国科学院西北高原生物研究所 | Yak hide collagen mask with ultraviolet ray resistance and preparation method |
| CN106726982A (en) * | 2016-12-28 | 2017-05-31 | 安徽紫檀科技有限公司 | Face cream for removing red blood streak and preparation method thereof |
| CN107353322A (en) * | 2017-03-17 | 2017-11-17 | 中国科学院西北高原生物研究所 | A kind of yak skin polypeptide products with anti-oxidation efficacy, preparation method and application |
| CN107653291A (en) * | 2017-11-15 | 2018-02-02 | 西藏央金生态农牧科技有限公司 | The standby method for hiding Yak-skin Gelatin original albumen and collagen polypeptide of multi-step enzyme method coordinate system |
-
2019
- 2019-06-05 CN CN201910484460.9A patent/CN110151664A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1283508A (en) * | 2000-07-04 | 2001-02-14 | 张俊峰 | Beautifying cosmetics series for treating red blood trace on face |
| CN105662998A (en) * | 2016-01-29 | 2016-06-15 | 中国科学院西北高原生物研究所 | Yak hide collagen mask with ultraviolet ray resistance and preparation method |
| CN106726982A (en) * | 2016-12-28 | 2017-05-31 | 安徽紫檀科技有限公司 | Face cream for removing red blood streak and preparation method thereof |
| CN107353322A (en) * | 2017-03-17 | 2017-11-17 | 中国科学院西北高原生物研究所 | A kind of yak skin polypeptide products with anti-oxidation efficacy, preparation method and application |
| CN107653291A (en) * | 2017-11-15 | 2018-02-02 | 西藏央金生态农牧科技有限公司 | The standby method for hiding Yak-skin Gelatin original albumen and collagen polypeptide of multi-step enzyme method coordinate system |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112385842A (en) * | 2020-12-03 | 2021-02-23 | 中国科学院西北高原生物研究所 | Yak skin glue compound product with coagulation promoting and bleeding stopping effects and preparation method thereof |
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