CN110150664A - A kind of rose functional food improving acne - Google Patents
A kind of rose functional food improving acne Download PDFInfo
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- CN110150664A CN110150664A CN201910560839.3A CN201910560839A CN110150664A CN 110150664 A CN110150664 A CN 110150664A CN 201910560839 A CN201910560839 A CN 201910560839A CN 110150664 A CN110150664 A CN 110150664A
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- rose
- functional food
- flos rosae
- acne
- rosae rugosae
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- 206010000496 acne Diseases 0.000 title claims abstract description 29
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 28
- 241000220317 Rosa Species 0.000 title claims abstract description 23
- 235000013376 functional food Nutrition 0.000 title claims abstract description 16
- 239000000284 extract Substances 0.000 claims abstract description 33
- 241000628997 Flos Species 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 235000013305 food Nutrition 0.000 claims abstract description 5
- 235000013361 beverage Nutrition 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 238000002481 ethanol extraction Methods 0.000 claims abstract description 4
- 235000011888 snacks Nutrition 0.000 claims abstract description 4
- 238000005303 weighing Methods 0.000 claims abstract description 4
- 238000005469 granulation Methods 0.000 claims abstract description 3
- 230000003179 granulation Effects 0.000 claims abstract description 3
- 229940100688 oral solution Drugs 0.000 claims abstract description 3
- 238000004806 packaging method and process Methods 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000000605 extraction Methods 0.000 claims description 9
- 235000019441 ethanol Nutrition 0.000 claims description 6
- 238000000108 ultra-filtration Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
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- 206010039792 Seborrhoea Diseases 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
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- 229930003944 flavone Natural products 0.000 description 2
- 150000002213 flavones Chemical class 0.000 description 2
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- 150000004676 glycans Chemical class 0.000 description 2
- 239000003163 gonadal steroid hormone Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
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- 239000005017 polysaccharide Substances 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
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- 231100000241 scar Toxicity 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
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- 208000008742 seborrheic dermatitis Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
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- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 102000011727 Caspases Human genes 0.000 description 1
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- 241000186427 Cutibacterium acnes Species 0.000 description 1
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- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 241000698291 Rugosa Species 0.000 description 1
- 229930183118 Tanshinone Natural products 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 230000000049 anti-anxiety effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
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- 238000009395 breeding Methods 0.000 description 1
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- 230000004663 cell proliferation Effects 0.000 description 1
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- 230000000378 dietary effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
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- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of with the rose functional food for improving acne effect, and the functional food main functional component is Flos Rosae Rugosae extract, and extract mainly uses ultrasonic wave Assisted Ethanol extraction method.The functional food is made by the techniques such as allotment, sterilization, granulation, tabletting, packaging of extract with other raw materials after weighing proportionally.Tablet, oral solution, capsule, electuary, snack food or beverage is made in this functional food, has effects that significantly improve acne.
Description
Technical field
The invention belongs to technical field of functional food, and in particular to a kind of rose functional food for improving acne.
Background technique
Rose is oblate spheroid, and color multiplicity, aromatic flavour are widely used in the fields such as food, drug and cosmetics, are
A kind of ornamental value is very strong, eats medicine and excellent flowers.Rich in nutrition content in rose, have protein, fat, minerals and other
The element that needed by human body is wanted contains three kinds of unsaturated fatty acids necessary to human body: linolenic acid, linoleic plus oleic acid.Meanwhile rose
Rare flower also contains many active constituents, such as volatile oil, polysaccharide, carrotene and Polyphenols substance, has qi-regulating and blood, beauty
The pharmacology such as beauty treatment, anticancer, anti-oxidant, antianxiety and healthcare function.
Acne is a kind of hair follicle sebum gland disease, often the hair position intensive in sebaceous glands such as face, neck, backs, clinical
Symptom includes seborrhea, opening and closed comedones, papule and useless fellow and different degrees of scar.Pathogenesis of acne machine
System is complicated, mainly related with cryptorrhea, propionibacterium acnes field planting, hypersteatosis, inflammatory reaction etc., additionally with
The correlations such as environmental factor, inherent cause, dietary factor.Acne is apt to occur in adolescence, gradually subsides within 20-25 years old, but has big
About 20% women will appear Tardive ance, and 30% Women with Acne can continue to breeding time, and 70% women can be
It was generated before menstrual period or aggravates acne, acne serious person might have deep mixed scar more afterwards, will affect personal image, sternly
Severe one may will affect its mental health and daily life.Psychology of liking to be beautiful is generally existing in modern youth, therefore acne of dispelling
It is paid close attention to by people always, the drug that treatment acne is used for a long time can generate certain side effect, therefore the present invention is from natural products
Angle set out, study and excavate with improve acne effect functional mass, and develop have improvement acne effect rose
Flower functional product.
Summary of the invention
The present invention, as function raw material, provides a rose that can improve acne using Flos Rosae Rugosae extract for consumer
Rare colored functional food, such as tablet, oral solution, capsule, electuary, snack food or beverage, this product significant effect and safety, without pair
Effect.
Rose functional food of the present invention, main functional component are Flos Rosae Rugosae extract, are by Flos Rosae Rugosas pollen
It is broken, 40 meshes are crossed, use ultrasonic wave Assisted Ethanol extraction method to extract according to following condition: Extraction solvent is molten for 70% ethyl alcohol
Liquid (v:v), Extracting temperature are 70 DEG C, extraction time 50min, and solid-liquid ratio is 1:50 (m:v), and extraction time is twice, filter,
It collects, merging filtrate, carries out ultrafiltration with 3~50,000 kD polysulfone ultrafiltration membranes, be freeze-dried, obtained after rotary evaporation removal ethyl alcohol
To Flos Rosae Rugosae extract.
It is characterized in that the functional food is to use primary raw material for rose or Flos Rosae Rugosae extract, and with rose
Colored or Flos Rosae Rugosae extract is the formula of primary raw material, with other auxiliary materials after weighing proportionally by allotment, sterilization, granulation, pressure
Tablet, capsule, electuary, snack food or beverage is made in the techniques such as piece, packaging.
Inventive point and creation point of the invention is: extracting in the functional food comprising that can improve the rose of acne
Object contains flavones, polysaccharide isoreactivity ingredient in extract.Studies have shown that Flos Rosae Rugosae extract is adjusting sex hormone level, is inhibiting
Sebum secretion and reduce inflammatory reaction in terms of have good effect, in addition, it is raw materials used be all it is food-borne, safety and to machine
Body is without side-effects.
Detailed description of the invention
Fig. 1 is Flos Rosae Rugosae extract to Hamster serum testosterone (T) and estradiol (E2) content influence；
Fig. 2 is Flos Rosae Rugosae extract to Golden Hamster Flank organs tissue triglycerides (TG) and caspase
(Caspase-3) influence of content；
Fig. 3 is influence of the Flos Rosae Rugosae extract to Hamster serum tumor necrosis factor-alpha (TNF-α) content；
Fig. 4 is influence of the Flos Rosae Rugosae extract to Hamster serum MMP-2 (MMP-2) content.
Specific embodiment
Below by way of specific embodiment, the present invention is described in detail.The following example, representative only of the invention are lifted
Example should not be construed as the restriction range that the present invention is implemented.All letters to preparation method of the present invention and product development form
Single replacement or variation, all belong to the scope of protection of the present invention.
Embodiment 1
A kind of preparation method for the rose tablet improving acne, comprising the following steps:
Step 1: rose is crushed, and crosses 40 meshes, is carried out using ultrasonic wave Assisted Ethanol extraction method according to following condition
Extract: Extraction solvent is 70% ethanol solution (v:v), and Extracting temperature is 70 DEG C, extraction time 50min, solid-liquid ratio 1:50
(m:v), extraction time is that twice, filtering is collected, merging filtrate, carries out ultrafiltration, rotary evaporation with 3~50,000 kD polysulfone ultrafiltration membranes
It is freeze-dried after removal ethyl alcohol, obtains Flos Rosae Rugosae extract.
Step 2: crushing raw materials such as Flos Rosae Rugosae extract, microcrystalline cellulose, dextrin, magnesium stearates and sieve with 100 mesh sieve,
It is weighed, is uniformly mixed with the ratio of 25 parts of Flos Rosae Rugosae extract, 69 parts of microcrystalline cellulose, 4 parts of dextrin, 2 parts of magnesium stearate
After carry out tabletting.
Step 3: carrying out tabletting using rotary pelleting machine, after the completion of tabletting to tablet carry out ultraviolet sterilization 30min to get
Improve acne rose tablet.Gained tablet weight is 0.7g, and with a thickness of 3-4mm, tablet weight variation 1.59%, friability is
0.21%, disintegration time 300s, hardness 3.5kg.
The application of the present invention is not limited to the above for those of ordinary skills can be according to the above description
It is improved or converted, all these modifications and variations should all belong to the protection domain of appended claims of the present invention.
Functional evaluation test:
Given the test agent: the Flos Rosae Rugosae extract that the embodiment of the present invention 1 obtains.
Dose design: low, the high dose of Flos Rosae Rugosae extract stomach-filling are respectively 50mg/kg BW, 100mg/kg BW (with total
Flavones content meter).
Experimental animal: it is limited to be purchased from Beijing dimension tonneau China experimental animal technology by male golden yellow gopher, 100~120g of weight
Company, credit number SCXK (capital) 2016-0011.Raising temperature is 23 ± 2 DEG C, and relative humidity is 55 ± 5%, and day-night change is
12h (early 8 points to 8 points of evening are daytime), ventilation condition is good.
Experimental method: after Golden Hamster adaptive feeding 1 week, 32 Golden Hamsters are randomly divided into 4 groups by weight, respectively
For model group (M), positive control tanshinone group (Y), Flos Rosae Rugosae extract low dose group (FD), Flos Rosae Rugosae extract high dose group
(FG).Golden Hamster itself is the Acne Model of hyperleydigism, therefore directlys adopt Golden Hamster as this test
Model group, model group stomach-filling distilled water, positive control tanshinone group stomach-filling 0.375g/kg BW tanshinone, daily set time fill
Stomach given the test agent, 1 adjustment stomach-filling amount of weighing weekly, experimental period are 4 weeks.Experiment terminates the previous day will golden yellowly with shaver
Hair on the Flank organs of mouse two sides is cleaned out, at the end of Golden Hamster fasting 12h, free water, eye socket takes blood, and 4 DEG C are quiet
It sets overnight, 4000 × g is centrifuged 10min, separates serum, -80 DEG C of preservations, for measuring T, E2, TNF-α, MMP-2 content.With trip
Calliper to measure Golden Hamster abdomen two sides Flank organs maximum transverse diameter (cm) and vertical diameter (cm) are marked, Flank organs area is calculated
(cm2)=maximum transverse diameter × maximum indulges diameter × pi/4.Win Golden Hamster Flank organs, -80 DEG C of preservations, for measuring
) and Caspase-3 content TG.
Experimental result:
Influence of 1 Flos Rosae Rugosae extract of table to Golden Hamster Flank organs area
Note: there are significant difference, p < 0.05 between the different group of letter above each column result.
Golden Hamster Flank organs area is to intervene the most intuitive of object intervention effect to embody, as shown in Table 1, by 4 weeks by
Test agent intervention, Flos Rosae Rugosae extract low dose group and high dose group can significantly slow the increasing of Golden Hamster Flank organs area
It is long.
The shadow of the main reason for sex hormone level imbalance is acne hair, the development of sebaceous glands and sebum secretion by androgen
It rings, T is a kind of main androgen, E2It is a kind of very strong estrogen of bioactivity, E2Sebum secretion amount can be made to reduce, by Fig. 1
It is found that Flos Rosae Rugosae extract high dose group can significantly reduce the content of Hamster serum T, show by given the test agent intervention in 4 weeks
It writes and increases serum E2Content.
Main component in sebum is TG, and content is about 40~60%, when hypersteatosis, will lead to skin angle
Matter layer hyperkeratinization and inflammatory reaction, further result in seborrhea and inflammatory acne；Caspase-3 is a kind of important
Apoptotic proteins enzyme, can promote sebocyte cell apoptosis so that inhibit Flank organs growth, as shown in Figure 2, by 4 weeks by
Test agent intervention, Flos Rosae Rugosae extract low dose group and high dose group can significantly reduce the content of TG in Flank organs tissue,
Dramatically increase the content of Caspase-3 in Flank organs tissue.
Inflammatory factor can stimulate sebocyte cell proliferation and sebum generate, deteriorate acne, from the figure 3, it may be seen that by 4 weeks by
Test agent intervention, Flos Rosae Rugosae extract low dose group and high dose group can significantly reduce containing for inflammatory factor TNF-α in serum
Amount.
Matrix metalloproteinase is related to acne inflammatory reaction, as shown in Figure 4, by given the test agent intervention in 4 weeks, rose
Extract low dose group and high dose group can significantly reduce the content of MMP-2 in serum.
As can be seen from the above results product of the present invention raw materials used (Flos Rosae Rugosae extract) makees acne with good improvement
With.
The application of the present invention is not limited to the above for those of ordinary skills can be according to the above description
It is improved or converted, all these modifications and variations should all belong to the protection domain of appended claims of the present invention.
Claims (3)
1. it is a kind of improve acne rose functional food, which is characterized in that primary raw material be rose or Flos Rosae Rugosae extract,
And using rose or Flos Rosae Rugosae extract as the formula of primary raw material, with other auxiliary materials after weighing proportionally by deploying, killing
The techniques such as bacterium, granulation, tabletting, packaging are made.
2. improving the rose functional food of acne as claimed in claim 1, which is characterized in that the Flos Rosae Rugosae extract
Extracting method be rose is crushed, cross 40 meshes, mentioned using ultrasonic wave Assisted Ethanol extraction method according to following condition
Take: Extraction solvent be 70% ethanol solution (v:v), Extracting temperature be 70 DEG C, extraction time 50min, solid-liquid ratio be 1:50 (m:
V), extraction time is that twice, filtering is collected, merging filtrate, carries out ultrafiltration with 3~50,000 kD polysulfone ultrafiltration membranes, rotary evaporation is gone
Except being freeze-dried after ethyl alcohol, Flos Rosae Rugosae extract is obtained.
3. improving the rose functional food of acne as claimed in claim 1, it is characterised in that the functional food is made
Tablet, oral solution, capsule, electuary, snack food or beverage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910560839.3A CN110150664A (en) | 2019-06-26 | 2019-06-26 | A kind of rose functional food improving acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910560839.3A CN110150664A (en) | 2019-06-26 | 2019-06-26 | A kind of rose functional food improving acne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110150664A true CN110150664A (en) | 2019-08-23 |
Family
ID=67625580
Family Applications (1)
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| CN201910560839.3A Pending CN110150664A (en) | 2019-06-26 | 2019-06-26 | A kind of rose functional food improving acne |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111436607A (en) * | 2020-01-08 | 2020-07-24 | 云南农业大学 | Rose extract for inhibiting SW480 proliferation of human colorectal cancer cells and application thereof |
| CN114403448A (en) * | 2022-02-17 | 2022-04-29 | 北京鲜汽十族食品科技有限公司 | Rose tangerine peel water and preparation method thereof |
| CN114451546A (en) * | 2022-02-23 | 2022-05-10 | 广州正广生物科技有限公司 | Composition for improving coldness of hands and feet and preparation method thereof |
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