CN101337025A - Oral preparation capable of anti-aging, whitening, moistening skin and relieving restlessness and preparation method thereof - Google Patents
Oral preparation capable of anti-aging, whitening, moistening skin and relieving restlessness and preparation method thereof Download PDFInfo
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- CN101337025A CN101337025A CNA2008100458349A CN200810045834A CN101337025A CN 101337025 A CN101337025 A CN 101337025A CN A2008100458349 A CNA2008100458349 A CN A2008100458349A CN 200810045834 A CN200810045834 A CN 200810045834A CN 101337025 A CN101337025 A CN 101337025A
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Abstract
The invention provides a preparation for oral administration, which has the effects of resisting aging, lightening skin, moistening skin and relieving restlessness, and the preparation method thereof, and belongs to the natural health-care food, in particular to the plant-based health-care food and the preparation method thereof. The raw materials mainly comprise potentilla anserina, Hippophae rhamnoides, flos rosae rugosae, red raspberry, rhizoma polygonati, Chinese wolfberry fruit, soybean extractive, angelica sinensis, mulberry fruit, jujube seed, etc. The preparation method comprises the following steps: extracting, filtering, drying, etc., and the raw material can be prepared into capsules, tablets, granules or oral solutions, etc. The product has the effects of moistening skin, relieving restlessness, stilling mind and calming nerves.
Description
(1) technical field:
A kind ofly anti-ageingly whiten, skin moistening relieving restlessness oral formulations and preparation method thereof, belong to natural health care, particularly be the health food of raw material, and its preparation method with the plant.
(2) background technology:
The women owing to the endocrine disturbance appears in the reason of physiology and psychology easily, phenomenons such as dim complexion, face skin sore, xerosis cutis, insomnia and dreamful sleep, irritated irritability very easily occurred after 35 years old, affect women's live and work.Most abroad women take the balance of hormone with endocrine regulation, but hormone all has side effect, and inapplicable to domestic women.
(3) summary of the invention:
The problem to be solved in the present invention is exactly that to provide a kind of at above deficiency be the health food of raw material with the plant, and its preparation method.This product has the effect of skin moistening relieving restlessness, the nerves calming.Its technical scheme is as follows:
It mainly comprises the raw material of following weight parts:
Radix potentillae anserinae 50--70, Fructus Hippophae 70--90, Flos Rosae Rugosae 9--15, Fructus Rubi 90--110, Rhizoma Polygonati 70--90, Fructus Lycii 100-120, soybean extract 20--30, Radix Angelicae Sinensis 70--90, Fructus Mori 70--90, Semen Ziziphi Spinosae 200--220.
In order to reach better effect, raw material of the present invention also comprises Radix Puerariae 130--150 part.
In order to reach further effect, raw material of the present invention also comprises Fructus Jujubae 70--90 part.
In order to also have better effect, raw material of the present invention also comprises Fructus Gardeniae 40--60 part, and Radix Paeoniae Alba 110--130 part.
Preparation method of the present invention may further comprise the steps:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract.
2) with the Radix potentillae anserinae drying, be ground into fine powder.
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
If also with the Radix Puerariae combination, its preparation method is:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, concentrate, get filtrate, perhaps dry, get extract.
2) with the Radix potentillae anserinae drying, be ground into fine powder.
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
If also with the Fructus Jujubae combination, its preparation method is:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract.
2) with the Radix potentillae anserinae drying, be ground into fine powder.
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
If also with the Fructus Gardeniae combination, its preparation method is:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract.
2) with the Radix potentillae anserinae drying, be ground into fine powder.
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
If also with Radix Paeoniae Alba combination, its preparation method is:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae, the Radix Paeoniae Alba are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract.
2) with the Radix potentillae anserinae drying, be ground into fine powder.
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
Being used for characteristic and function that raw material of the present invention has is:
Semen Ziziphi Spinosae: be the dry mature seed of Rhamnaceae plant Ziziphi Spinosae, sweet in the mouth, property is flat.Function mind tranquilizing and the heart calming, nourishing the liver arresting sweating.Modern pharmacological research shows that Semen Ziziphi Spinosae has tranquilizing soporific, anti-aging effects.
Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum, sweet in the mouth, property is flat.Function the kidney invigorating and essence nourishing, nourishing the liver lung moistening.Modern pharmacological research shows to have antioxidation.
Radix Puerariae: be the dry root of legume pueraria lobata or Radix Puerariae rattan, sweet in the mouth, suffering, property is flat.The function expelling pathogenic factors from muscles for reducing heat, deliver rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Modern pharmacological research shows to have antioxidation.
Rhizoma Polygonati: be the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati, Rhizoma Polygonati or Polygonatum cyrtonema Hua, sweet in the mouth, property is flat.The function nourishing YIN and moistening the lung, invigorating the spleen and replenishing QI, nourishing kidney replenishing essence.Modern pharmacological research shows to have anti-aging effects.
Fructus Hippophae: be the dry mature fruit of Elaeangnaceae plant Fructus Hippophae, sweet in the mouth, acid, property is flat.Function lung moistening nourishing the stomach, the antidiarrheal of promoting the production of body fluid, help digestion.Has anti-aging effects.
Fructus Mori: be the dry fruit ear of moraceae plants Mulberry, sweet in the mouth, acid, cold in nature.The function nourishing YIN and benefiting blood, promote the production of body fluid, intestine moistening.
Flos Rosae Rugosae: be the dry flower of rosaceous plant Flos Rosae Rugosae, sweet in the mouth, little hardship, warm in nature.Function promoting QI circulation for relieving depression and blood dissipating blood stasis, pain relieving.
Fructus Jujubae: be the dry mature fruit of Rhamnaceae plant Fructus Jujubae, sweet in the mouth, warm in nature.Function invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen.Modern pharmacological research shows to have sedative-hypnotic effect, anti-aging effects.
Radix potentillae anserinae: be the dried root of rosaceous plant potentilla anseriana, sweet in the mouth, hardship, property is flat.Function benefiting qi and nourishing blood, the dampness removing that promotes the production of body fluid, the Fructus Alpiniae Oxyphyllae of reposing, anti-aging effects.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica, sweet in the mouth, suffering, hardship, warm in nature.Function is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving.Modern pharmacological research shows to have antioxidation.
The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae, bitter in the mouth, acid, cold nature.Function nourishes blood and battalion, relieving spasm to stop pain, yin fluid astringing easing the affected liver.
Fructus Rubi: be the dry fruit of rosaceous plant rubus chingii Hu, sweet in the mouth, acid, property is flat.The function liver and kidney tonifying, controlling nocturnal emission with astringent drugs place urine.Has anti-aging effects.
Fructus Gardeniae: be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae, bitter in the mouth, cold in nature.Function pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Modern pharmacological research shows to have sedative-hypnotic effect.
Soybean extract: for legume soybean through the extract that extraction forms, have antioxidation, improve effects such as sleeping, improve looks, improve menopause syndrome.
Advantage compared with prior art of the present invention is: above each material combination, produce good synergism, the product of making has the effect of antioxidation (defying age), looks improving and the skin nourishing, whitening and speckle dispelling, skin moistening relieving restlessness, the nerves calming, is applicable to dim complexion, face skin sore, xerosis cutis, insomnia and dreamful sleep, irritated irritability and the women of senilism phenomenon is arranged.
For showing the effect of product of the present invention to looks improving and the skin nourishing, whitening and speckle dispelling, skin moistening relieving restlessness, the nerves calming, to 100 ages at 35-65 between year, the women of serious primary disease such as no cardiovascular, liver, kidney has done the observation of system, and experimenter group takes that oral formulations colour of the present invention is dark and gloomy, face has skin sore, xerosis cutis, insomnia and dreamful sleep, irritated irritability.
Instructions of taking: select for use capsule conduct of the present invention to be subjected to test preparation, each 3, once a day.Viewing duration, the experimenter need keep reasonable diet structure and work rest program.
Observing time: 30 days.
Return the feedback result: 100 women that tried later in 30 days have the skin sore of 98 women's face to disappear, skin smooth, moist, flexible, and no longer insomnia is happy.Effective percentage reaches 98%.
(4) description of drawings:
Accompanying drawing is technological process of production figure of the present invention.
(5) specific embodiment:
Embodiment one:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 50, Fructus Hippophae 90, Flos Rosae Rugosae 9, Fructus Rubi 110, Rhizoma Polygonati 70, Fructus Lycii 120, soybean extract 20, Radix Angelicae Sinensis 90, Fructus Mori 70, Semen Ziziphi Spinosae 220.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori extraction twice, added 6 times of amounts of crude drug, 35% ethanol extraction for the first time 1.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 1 hour of 6 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.1, uses the spray dryer spray drying, 175 ℃ of spray dryer inlet temperature, and 115 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 7%, be ground into fine powder and cross 100 mesh sieves at 70 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select 85% ethanol for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content content 4% with drying equipment at 65 ℃, and granule is crossed 40 mesh sieves, uses the mixer mixing, and is encapsulated, makes 1000 altogether, the 0.3g/ grain.
Embodiment two:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 60, Fructus Hippophae 80, Flos Rosae Rugosae 12, Fructus Rubi 100, Rhizoma Polygonati 80, Fructus Lycii 110, soybean extract 24, Radix Angelicae Sinensis 84, Fructus Mori 80, Semen Ziziphi Spinosae 210.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori extraction twice, added 8 times of amounts of crude drug, 40% ethanol extraction for the first time 2 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 2 hours of 8 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.15, uses the spray dryer spray drying, 180 ℃ of spray dryer inlet temperature, and 120 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 8%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select 70-85% ethanol for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content content 5% with drying equipment at 65 ℃, and compacting is made 1000, the 0.3g/ sheet in flakes altogether then.
Embodiment three:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 70, Fructus Hippophae 70, Flos Rosae Rugosae 15, Fructus Rubi 90, Rhizoma Polygonati 90, Fructus Lycii 100, soybean extract 30, Radix Angelicae Sinensis 70, Fructus Mori 90, Semen Ziziphi Spinosae 200.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori extraction twice, added 10 times of amounts of crude drug, 45% ethanol extraction for the first time 2.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 3 hours of 10 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.2, uses the spray dryer spray drying, 185 ℃ of spray dryer inlet temperature, and 125 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 9%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select starch slurry for use be binding agent to the mixture after will sterilizing and add dextrin and make granule in right amount with facility for granulating, is dried to water content 4% with drying equipment at 65 ℃, and granule is crossed 20 mesh sieves, use the mixer mixing, dissolved granule is made in pack, makes 1000 bags altogether, the 2g/ bag.
Embodiment four:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 50, Fructus Hippophae 90, Flos Rosae Rugosae 9, Fructus Rubi 110, Rhizoma Polygonati 70, Fructus Lycii 120, soybean extract 20, Radix Angelicae Sinensis 90, Fructus Mori 70, Semen Ziziphi Spinosae 220, Radix Puerariae 130.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae extraction twice, added 6 times of amounts of crude drug, 35% ethanol extraction for the first time 1.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 1 hour of 6 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and get filtrate.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 7%, be ground into fine powder and cross 100 mesh sieves at 70 ℃.
3) Radix potentillae anserinae fine powder and soybean extract being put into filtrate fully mixes, 180 orders filter, and add purified water and make oral liquid to 10000ml and bottling, be to sterilize 30 minutes under the 0.068mPa with autoclaving at 115 ℃, air pressure, make 1000 bottles altogether, the 10ml/ bottle.
Embodiment five:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 60, Fructus Hippophae 80, Flos Rosae Rugosae 12, Fructus Rubi 100, Rhizoma Polygonati 80, Fructus Lycii 110, soybean extract 24, Radix Angelicae Sinensis 84, Fructus Mori 80, Semen Ziziphi Spinosae 210, Radix Puerariae 140.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae extraction twice, added 8 times of amounts of crude drug, 40% ethanol extraction for the first time 2 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 2 hours of 8 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.15, uses the spray dryer spray drying, 180 ℃ of spray dryer inlet temperature, and 120 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 8%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select water for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content content 4% with drying equipment at 65 ℃, and granule is crossed 40 mesh sieves, uses the mixer mixing, and is encapsulated, makes 1000 altogether, the 0.3g/ grain.
Embodiment six:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 70, Fructus Hippophae 70, Flos Rosae Rugosae 15, Fructus Rubi 90, Rhizoma Polygonati 90, Fructus Lycii 100, soybean extract 30, Radix Angelicae Sinensis 70, Fructus Mori 90, Semen Ziziphi Spinosae 200, Radix Puerariae 150.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae extraction twice, added 10 times of amounts of crude drug, 45% ethanol extraction for the first time 2.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 3 hours of 10 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.2, uses the spray dryer spray drying, 185 ℃ of spray dryer inlet temperature, and 125 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 9%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select 85% ethanol for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content 6% with drying equipment at 75 ℃, and compacting is made 1000, the 0.3g/ sheet in flakes altogether then.
Embodiment seven:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 50, Fructus Hippophae 90, Flos Rosae Rugosae 9, Fructus Rubi 110, Rhizoma Polygonati 70, Fructus Lycii 120, soybean extract 20, Radix Angelicae Sinensis 90, Fructus Mori 70, Semen Ziziphi Spinosae 220, Radix Puerariae 130, Fructus Jujubae 90.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae extraction twice, added 6 times of amounts of crude drug, 35% ethanol extraction for the first time 1.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 1 hour of 6 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.1, uses the spray dryer spray drying, 175 ℃ of spray dryer inlet temperature, and 115 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 7%, be ground into fine powder and cross 100 mesh sieves at 70 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select water for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content content 4% with drying equipment at 65 ℃, and granule is crossed 40 mesh sieves, uses the mixer mixing, and dissolved granule is made in pack, makes 1000 bags altogether, the 2g/ bag.
Embodiment eight:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 60, Fructus Hippophae 80, Flos Rosae Rugosae 12, Fructus Rubi 100, Rhizoma Polygonati 80, Fructus Lycii 110, soybean extract 24, Radix Angelicae Sinensis 84, Fructus Mori 80, Semen Ziziphi Spinosae 210, Radix Puerariae 140, Fructus Jujubae 80.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae extraction twice, added 8 times of amounts of crude drug, 40% ethanol extraction for the first time 2 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 2 hours of 8 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and get filtrate.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 8%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3) Radix potentillae anserinae fine powder and soybean extract being put into filtrate fully mixes, 180 orders filter, and add purified water and make oral liquid to 10000ml and bottling, be to sterilize 30 minutes under the 0.068mPa with autoclaving at 115 ℃, air pressure, make 1000 bottles altogether, the 10ml/ bottle.
Embodiment nine:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 70, Fructus Hippophae 70, Flos Rosae Rugosae 15, Fructus Rubi 90, Rhizoma Polygonati 90, Fructus Lycii 100, soybean extract 30, Radix Angelicae Sinensis 70, Fructus Mori 90, Semen Ziziphi Spinosae 200, Radix Puerariae 150, Fructus Jujubae 70.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae extraction twice, added 10 times of amounts of crude drug, 45% ethanol extraction for the first time 2.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 3 hours of 10 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.2, uses the spray dryer spray drying, 185 ℃ of spray dryer inlet temperature, and 125 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 9%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select 85% ethanol for use with facility for granulating be that binding agent adds dextrin and makes granule in right amount to the mixture after will sterilizing, and is dried to water content content 6% with drying equipment at 75 ℃, and granule is crossed 40 mesh sieves, use the mixer mixing, dissolved granule is made in pack, makes 1000 bags altogether, the 2g/ bag.
Embodiment ten:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 50, Fructus Hippophae 90, Flos Rosae Rugosae 9, Fructus Rubi 110, Rhizoma Polygonati 70, Fructus Lycii 120, soybean extract 20, Radix Angelicae Sinensis 90, Fructus Mori 70, Semen Ziziphi Spinosae 220, Radix Puerariae 130, Fructus Jujubae 90, Fructus Gardeniae 40.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae extraction twice, added 6 times of amounts of crude drug, 35% ethanol extraction for the first time 1.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 1 hour of 6 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.1, uses the spray dryer spray drying, 175 ℃ of spray dryer inlet temperature, and 115 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 7%, be ground into fine powder and cross 100 mesh sieves at 70 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select water for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content content 4% with drying equipment at 65 ℃, and granule is crossed 40 mesh sieves, uses the mixer mixing, and is encapsulated, makes 1000 altogether, the 0.3g/ grain.
Embodiment 11:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 60, Fructus Hippophae 80, Flos Rosae Rugosae 12, Fructus Rubi 100, Rhizoma Polygonati 80, Fructus Lycii 110, soybean extract 24, Radix Angelicae Sinensis 84, Fructus Mori 80, Semen Ziziphi Spinosae 210, Radix Puerariae 140, Fructus Jujubae 80, Fructus Gardeniae 50.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae extraction twice, added 8 times of amounts of crude drug, 40% ethanol extraction for the first time 2 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 2 hours of 8 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.15, uses the spray dryer spray drying, 180 ℃ of spray dryer inlet temperature, and 120 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 8%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select 85% ethanol for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content content 6% with drying equipment at 75 ℃, and compacting is made 1000, the 0.3g/ sheet in flakes altogether then.
Embodiment 12:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 70, Fructus Hippophae 70, Flos Rosae Rugosae 15, Fructus Rubi 90, Rhizoma Polygonati 90, Fructus Lycii 100, soybean extract 30, Radix Angelicae Sinensis 70, Fructus Mori 90, Semen Ziziphi Spinosae 200, Radix Puerariae 150, Fructus Jujubae 70, Fructus Gardeniae 60.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae extraction twice, added 10 times of amounts of crude drug, 45% ethanol extraction for the first time 2.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 3 hours of 10 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.2, uses the spray dryer spray drying, 185 ℃ of spray dryer inlet temperature, and 125 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 9%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select water for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content content 6% with drying equipment at 75 ℃, and granule is crossed 40 mesh sieves, uses the mixer mixing, and is encapsulated, makes 1000 altogether, the 0.3g/ grain.
Embodiment 13:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 50, Fructus Hippophae 90, Flos Rosae Rugosae 9, Fructus Rubi 110, Rhizoma Polygonati 70, Fructus Lycii 120, soybean extract 20, Radix Angelicae Sinensis 90, Fructus Mori 70, Semen Ziziphi Spinosae 220, Radix Puerariae 130, Fructus Jujubae 90, Fructus Gardeniae 40, the Radix Paeoniae Alba 130.
Its preparation method may further comprise the steps:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae, the Radix Paeoniae Alba are extracted twice, added for the first time 6 times of amounts of crude drug, 35% ethanol extraction 1.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 1 hour of 6 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and get filtrate.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 7%, be ground into fine powder and cross 100 mesh sieves at 70 ℃.
3) Radix potentillae anserinae fine powder and soybean extract being put into filtrate fully mixes, 180 orders filter, and add purified water and make oral liquid to 10000ml and bottling, be to sterilize 30 minutes under the 0.068mPa with autoclaving at 115 ℃, air pressure, make 1000 bottles altogether, the 10ml/ bottle.
Embodiment 14:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 60, Fructus Hippophae 80, Flos Rosae Rugosae 12, Fructus Rubi 100, Rhizoma Polygonati 80, Fructus Lycii 110, soybean extract 24, Radix Angelicae Sinensis 84, Fructus Mori 80, Semen Ziziphi Spinosae 210, Radix Puerariae 140, Fructus Jujubae 80, Fructus Gardeniae 50, the Radix Paeoniae Alba 120.
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae, Radix Paeoniae Alba extraction twice, added 8 times of amounts of crude drug, 40% ethanol extraction for the first time 2 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 2 hours of 8 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.15, uses the spray dryer spray drying, 180 ℃ of spray dryer inlet temperature, and 120 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 8%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select 85% ethanol for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content content 6% with drying equipment at 75 ℃, and compacting is made 1000, the 0.3g/ sheet in flakes altogether then.
Embodiment 15:
Take by weighing each raw material by following weight proportion:
Radix potentillae anserinae 70, Fructus Hippophae 70, Flos Rosae Rugosae 15, Fructus Rubi 90, Rhizoma Polygonati 90, Fructus Lycii 100, soybean extract 30, Radix Angelicae Sinensis 70, Fructus Mori 90, Semen Ziziphi Spinosae 200, Radix Puerariae 150, Fructus Jujubae 70, Fructus Gardeniae 60, the Radix Paeoniae Alba 110.
Its preparation method may further comprise the steps:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae, the Radix Paeoniae Alba are extracted twice, added for the first time 10 times of amounts of crude drug, 45% ethanol extraction 2.5 hours, extracting solution reclaims ethanol, filters, and gets filtrate; Add for the second time the water extraction 3 hours of 10 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.2, uses the spray dryer spray drying, 185 ℃ of spray dryer inlet temperature, and 125 ℃ of leaving air temps get extract.
2) Radix potentillae anserinae is cleaned with drinking water, be dried to water content 9%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract, Radix potentillae anserinae fine powder and soybean extract mix homogeneously.
4) to select starch slurry for use be binding agent to the mixture after will sterilizing and add dextrin and make granule in right amount with facility for granulating, is dried to water content content 4% with drying equipment at 75 ℃, and granule is crossed 20 mesh sieves, use the mixer mixing, dissolved granule is made in pack, makes 1000 bags altogether, the 2g/ bag.
Claims (10)
1, a kind ofly anti-ageingly whiten, skin moistening relieving restlessness oral formulations, it is characterized in that preparing the raw material that its active component raw material comprises following weight portion:
Radix potentillae anserinae 50--70, Fructus Hippophae 70--90, Flos Rosae Rugosae 9--15, Fructus Rubi 90--110, Rhizoma Polygonati 70--90, Fructus Lycii 100-120, soybean extract 20--30, Radix Angelicae Sinensis 70--90, Fructus Mori 70--90, Semen Ziziphi Spinosae 200--220.
2, claim 1 describedly anti-ageingly whiten, the preparation method of skin moistening relieving restlessness oral formulations, it is characterized in that may further comprise the steps:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract;
2) with the Radix potentillae anserinae drying, be ground into fine powder;
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
3, according to claim 1 describedly anti-ageingly whiten, skin moistening relieving restlessness oral formulations, it is characterized in that wherein raw material also has Radix Puerariae 130--150 part.
4, according to claim 3 describedly anti-ageingly whiten, the preparation method of skin moistening relieving restlessness oral formulations, it is characterized in that may further comprise the steps:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract;
2) with the Radix potentillae anserinae drying, be ground into fine powder;
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
5, according to claim 3 describedly anti-ageingly whiten, skin moistening relieving restlessness oral formulations, it is characterized in that wherein raw material also has Fructus Jujubae 70--90 part.
6, according to claim 5 describedly anti-ageingly whiten, the preparation method of skin moistening relieving restlessness oral formulations, it is characterized in that may further comprise the steps:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract;
2) with the Radix potentillae anserinae drying, be ground into fine powder;
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
7, according to claim 5 describedly anti-ageingly whiten, skin moistening relieving restlessness oral formulations, it is characterized in that wherein raw material also has Fructus Gardeniae 40--60 part.
8, according to claim 7 describedly anti-ageingly whiten, the preparation method of skin moistening relieving restlessness oral formulations, it is characterized in that may further comprise the steps:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract;
2) with the Radix potentillae anserinae drying, be ground into fine powder;
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
9, according to claim 7 describedly anti-ageingly whiten, skin moistening relieving restlessness oral formulations, it is characterized in that wherein raw material also has Radix Paeoniae Alba 110--130 part.
10, according to claim 9 describedly anti-ageingly whiten, the preparation method of skin moistening relieving restlessness oral formulations, it is characterized in that may further comprise the steps:
1) Semen Ziziphi Spinosae, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Sinensis, Flos Rosae Rugosae, Fructus Rubi, Fructus Hippophae, Fructus Mori, Radix Puerariae, Fructus Jujubae, Fructus Gardeniae, the Radix Paeoniae Alba are extracted twice, add crude drug 6--10 for the first time and doubly measured the 35--45% ethanol extraction 1.5-2.5 hour, filter, get filtrate; Added water extraction 1--3 hour that crude drug 6--10 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract;
2) with the Radix potentillae anserinae drying, be ground into fine powder;
3) with extract or filtrate, Radix potentillae anserinae fine powder and soybean extract mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
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| CN2008100458349A CN101337025B (en) | 2008-08-18 | 2008-08-18 | Oral preparation capable of anti-aging, whitening, moistening skin and relieving restlessness and preparation method thereof |
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Cited By (6)
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| CN102836341A (en) * | 2012-09-27 | 2012-12-26 | 安徽燕之坊食品有限公司 | Medicinal granule with whitening effect and preparation method thereof |
| CN103446272A (en) * | 2013-08-19 | 2013-12-18 | 西藏本源德利生物药业有限公司 | Composition for improving sleep, and preparation method and use thereof |
| CN104274551A (en) * | 2014-09-23 | 2015-01-14 | 苏州市天灵中药饮片有限公司 | Potentilla anserine and herpetospermum seed chewable tablet and preparation method thereof |
| CN104274550A (en) * | 2014-09-23 | 2015-01-14 | 苏州市天灵中药饮片有限公司 | Potentilla anserine-herpetospermum seed liver protecting effervescent tablet and preparation method thereof |
| CN106036851A (en) * | 2016-06-13 | 2016-10-26 | 国药药材健康产业新疆有限公司 | Dietary therapy composition for improving endocrine disturbance and caring skin and application of dietary therapy composition in preparation of other food |
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| CN1218665C (en) * | 2002-12-25 | 2005-09-14 | 黑龙江大通生物技术有限公司 | Defatted rana amurensis ovary powder for women healthy food |
| CN1969975B (en) * | 2006-12-08 | 2010-12-08 | 四川央金藏药科技有限公司 | Formulation for replenishing qi, regenerating blood, tonigying kidney and nourishing face and method for preparing same |
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2008
- 2008-08-18 CN CN2008100458349A patent/CN101337025B/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102836341A (en) * | 2012-09-27 | 2012-12-26 | 安徽燕之坊食品有限公司 | Medicinal granule with whitening effect and preparation method thereof |
| CN103446272A (en) * | 2013-08-19 | 2013-12-18 | 西藏本源德利生物药业有限公司 | Composition for improving sleep, and preparation method and use thereof |
| CN103446272B (en) * | 2013-08-19 | 2016-01-06 | 西藏本源德利生物药业有限公司 | A kind of composition and method of making the same of improving water flood and purposes |
| CN104274551A (en) * | 2014-09-23 | 2015-01-14 | 苏州市天灵中药饮片有限公司 | Potentilla anserine and herpetospermum seed chewable tablet and preparation method thereof |
| CN104274550A (en) * | 2014-09-23 | 2015-01-14 | 苏州市天灵中药饮片有限公司 | Potentilla anserine-herpetospermum seed liver protecting effervescent tablet and preparation method thereof |
| CN106036851A (en) * | 2016-06-13 | 2016-10-26 | 国药药材健康产业新疆有限公司 | Dietary therapy composition for improving endocrine disturbance and caring skin and application of dietary therapy composition in preparation of other food |
| CN110150664A (en) * | 2019-06-26 | 2019-08-23 | 中国农业大学 | A kind of rose functional food improving acne |
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| CN101337025B (en) | 2011-01-26 |
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