CN110140816A - A kind of feed addictive preventing ewe endometritis and its application method - Google Patents

A kind of feed addictive preventing ewe endometritis and its application method Download PDF

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CN110140816A
CN110140816A CN201910595140.0A CN201910595140A CN110140816A CN 110140816 A CN110140816 A CN 110140816A CN 201910595140 A CN201910595140 A CN 201910595140A CN 110140816 A CN110140816 A CN 110140816A
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ewe
endometritis
feed addictive
preventing
sodium
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丛晓燕
位宾
张�杰
韩珍
韩福亮
张聪
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Shandong Asia Pacific Hahua Biotechnology Co Ltd
Shandong Heishi Biotechnology Co Ltd
Ji'nan Kuoda Biological Technology Co Ltd
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Shandong Asia Pacific Hahua Biotechnology Co Ltd
Shandong Heishi Biotechnology Co Ltd
Ji'nan Kuoda Biological Technology Co Ltd
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract

The invention discloses a kind of feed addictive for preventing ewe endometritis and its application methods.The feed addictive is by natural astaxanthin, fructooligosaccharide, γ-aminobutyric acid, sodium humate, Sodium Hyaluronate and Chinese herb feed additive (motherwort, cordate houttuynia, kuh-seng, Radix Astragali, the coptis, safflower and Radix Glycyrrhizae) it compounds, the endocrine function of adjustable postpartum ewe, promote postpartum milk secretion and restores normal breeding physiology activity, body's immunity is improved simultaneously, alleviate the stress damage being subject to when pregnancy ewes childbirth, maintain the structural integrity and physiological function of endometrium, it can replace the antibiotic in daily ration, resist invasion of the pathogen to endometrium, to accomplish to prevent the generation of ewe endometritis.

Description

A kind of feed addictive preventing ewe endometritis and its application method
Technical field
The present invention relates to a kind of feed addictive for preventing ewe endometritis and its application methods, belong to feed technology Field.
Background technique
Ewe endometritis is a kind of disease that the postpartum infection as caused by pathogen in turn results in breeding difficulty.Uterus Intimitis directly affects the heat and pregnancy of ewe, causes long-term infertility, and the output of milk reduces, the diseases such as inducing mammary inflammation, Seriously even result in the forfeiture of ewe reproductive performance.Currently, the disease incidence of countries in the world ewe endometritis all 20% with On, it is as caused by endometritis that wherein 80% or more ewe is infertile, this causes huge economic loss to sheep husbandry.
The pathogenic factor of endometritis is mainly include the following types: (1) cause pathogeny imcrobe infection.In all pathogenic factors In, the pathogenic factor highest of pathogenic microorganism.(2) operation of animal doctor and the personnel that practice midwifery is lack of standardization.Movement is thicker when midwifery Shandong, and midwifery tool causes infection also without having injured birth canal by disinfection.(3) it is lack of standardization to feed management.It feeds And mismanagement, the nutrition in diet is unevenly and milking can make the nutrition disequilibrium of ewe, resistance decline, uterine contraction Ability and frequency are reduced, and lead to the generation of endometritis.(4) ewe postpartum suffers from that mammitis, vaginitis, vagina are de-, uterus is de- Etc. diseases, cause immunity of organisms to reduce, also easily secondary endometritis.
Therefore, the present invention regulates and controls the physiological status of postpartum ewe by nutritional tools, improves the resisting stress of body and anti-inflammatory Disease ability, adjusts and enhances immune function, resists pathogen invasion, promotes the reparation and power of regeneration of endometrium, in maintenance The structural integrity and physiological function of film, prevent inflammation to the damaging action of endometrium.
Summary of the invention
The problem of for above-mentioned production, the present invention provides a kind of feed additions for preventing ewe endometritis Agent.Feed addictive of the invention by natural astaxanthin, fructooligosaccharide, γ-aminobutyric acid, sodium humate, Sodium Hyaluronate and in Chinese herbal medicine additive agent compounds, and the endocrine function of postpartum ewe is adjusted, and promotes postpartum milk secretion and restores normal breeding life Reason activity, while body's immunity is improved, alleviate the stress damage being subject to when pregnancy ewes childbirth, maintains the knot of endometrium Structure is complete and physiological function, can replace the antibiotic in daily ration, invasion of the pathogen to endometrium be resisted, to accomplish to prevent The generation of ewe endometritis.
The technical scheme is that a kind of feed addictive for preventing ewe endometritis, characterized in that by following The raw material of weight percent is made: natural astaxanthin 25-28%, fructooligosaccharide 23-27%, γ-aminobutyric acid 18-22%, rotten plant Sour sodium 7-9%, Sodium Hyaluronate 5-8% and Chinese herb feed additive 13-17%.Above-mentioned raw materials are that granularity is dry less than 0.5mm Powder.
The component and its parts by weight of said herbal medicine additive are as follows: motherwort 20-25, cordate houttuynia 15-20, kuh-seng 12-15, Radix Astragali 12-15, coptis 12-15, safflower 10-12, Radix Glycyrrhizae 10-12, are ground into the dry powder of 40-200 mesh after mixing.
Feed addictive optimum ratio (weight ratio): natural astaxanthin 26%, fructooligosaccharide 25%, γ-aminobutyric acid 20%, Sodium humate 8%, Sodium Hyaluronate 6% and Chinese herb feed additive 15%.
Application method: after each component is mixed, being added directly into mixed concentrate, and additive amount is 1.0-1.5% (with mixing Fine fodder meter)；Feeding period is to terminate the 1st day to the 90th day after pregnancy ewes childbirth.
Each raw material effect:
Natural astaxanthin: i.e. 3,3 '-dihydroxy -4,4 '-diketo-β, β '-carrotene belong to keto-acid carotenoids Element contains unsaturated ketone group and hydroxyl in molecular structure, and free radical can be attracted or provide electricity to free radical by constituting alpha-alcohol ketone Son is one of presently found most strong, most efficient natural.The antioxidant activity of Determination of Astaxanthin in Haematococcus Pluvialis is 10 times of beta carotene, 550 times of vitamin E, referred to as " supper vitamin ", can effectively clear oxygen in body cell from By base, the normal physiological status of body is maintained.Astaxanthin also has other various biological effects, including anti-inflammatory, anti-apoptotic, mentions High immunity of organism etc..
Fructooligosaccharide: also known as oligofructose can promote to grow, and improve efficiency of feed utilization, prevent disease, improve animal reproduction Power enhances body's immunity, also has immune induction activity, has the function of probiotic, can part substitute antibiotics.
γ-aminobutyric acid: be it is a kind of be distributed widely in the important inhibitory neurotransmitter of mammalian nervous maincenter, can promote Into feed intake, endocrine is adjusted, immune performance is improved and improves resisting stress capability.
Sodium humate: there is colloid property and adsorption capacity, form good ion exchange and catalytic action, make in feed Various nutritional ingredients sufficiently decompose and carry out good organic assembling, promote the assimilation of protein, improve gastrointestinal function, Improve the absorptivity of nutritional ingredient.
Sodium Hyaluronate: hyaluronic acid is a kind of acid mucopolysaccharide, is widely present in the skin corium of skin, improves skin Nutrition and Metabolism plays lubrication and nourishes；But also scavenging activated oxygen, there are regeneration, repair to damage skin.It is transparent For matter acid sodium as its sodium salt, property is more stable, and it is more permanent to play efficacy window.
Chinese herb feed additive: by motherwort, cordate houttuynia, kuh-seng, Radix Astragali, the coptis, safflower and Radix Glycyrrhizae prescription, wherein motherwort Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema are monarch drug in a prescription；Cordate houttuynia, kuh-seng, Radix Astragali and the coptis is clearing heat and detoxicating, anti-inflammatory diuresis is ministerial drug；Carthamus powder Stasis of blood analgesic is adjutant；Radix Glycyrrhizae coordinating the drug actions of a prescription is to make medicine.Above-mentioned raw materials collective effect have activating microcirculation and removing stasis medicinal, clearing heat and detoxicating, anti-inflammatory is sharp The effect of urine, removing blood stasis and acesodyne can comparatively fast restore the health status of postpartum ewe, enhance body's immunity and resisting stress energy Power also has antagonism and lethal effect to various bacteria and virus.
Beneficial effects of the present invention: above-mentioned several raw materials are carried out prescriptions by the present invention, wherein natural astaxanthin have it is anti-inflammatory, Anti-oxidant, anti-apoptotic improves the various biologicals effects such as immunity of organism, fructooligosaccharide, γ-aminobutyric acid, sodium humate and medium-height grass Medicine additive adjusts endocrine, improves the immune of body, resisting stress and antibacterial, antivirus action, moreover it is possible to improve efficiency of feed utilization； Sodium Hyaluronate, which has, adjusts endometrium Nutrition and Metabolism, has regeneration, repair to inner membrance.Each raw material collective effect, it is adjustable The endocrine function of postpartum ewe is saved, postpartum milk secretion is promoted and restores normal breeding physiology activity, improves body resisting stress energy Power and immune function maintain the structural intergrity and normal physiological function of endometrium, can replace the antibiotic in daily ration, resist Invasion of the pathogen to endometrium to accomplish the generation of prevention ewe endometritis, and improves the reproductive performance of ewe And the general level of the health.
Specific embodiment
In the present embodiment, natural astaxanthin active constituent content is 5%.Fructooligosaccharide content >=98%.γ-aminobutyric acid contains Amount >=98%.Sodium humate content >=98%.Hyaluronic acid sodium content >=98%, above-mentioned each ingredient requirement reach feed rank.
Embodiment 1:
Match (weight ratio): natural astaxanthin 26%, fructooligosaccharide 25%, γ-aminobutyric acid 20%, sodium humate 8%, thoroughly Bright matter acid sodium 6% and Chinese herb feed additive 15%.Above-mentioned raw materials granularity is the dry powder less than 0.5mm.
Chinese herb feed additive (parts by weight): motherwort 25, cordate houttuynia 18, kuh-seng 12, Radix Astragali 12, the coptis 12, safflower 11, sweet Grass 10, is ground into the dry powder of 100 mesh after mixing.
Experimental design:
According to ewe age, parity, physical condition and the expected date of childbirth close principle, the pregnant Small-fat-tail sheeps of 40 health are selected Ewe carries out feeding experiment in academy of agricultural sciences, Shandong Province animal and veterinary research institute zoopery base in the 7-10 month in 2018.It participates in The ewe of test is randomly divided into control group and test group, is respectively 20.Control group fed Ewe in suckling period mixed concentrate (Shandong Province The production of academy of agricultural sciences's herding centre of development feed factory), test group adds the feed addition that 1.2% present invention prepares in mixed concentrate Agent.Feeding period is to terminate the 1st day to the 90th day after ewe childbirth, experimental period 90 days.Every morning 7 during test: 00 and 18:00 in afternoon is respectively fed 1 time, first thick after essence, free water.Observe ewe puerperal endometritis incidence and 90 days Interior pregnancy rate, to evaluate the influence that feed addictive of the invention suffers from endometritis to ewe postpartum and reproductive performance restores； Vena cava anterior is taken a blood sample when off-test, inflammatory factor in serum, oxidative stress and the indexs such as immune is detected, to evaluate the present invention Feed addictive whether anti-inflammatory, resisting stress is played to ewe postpartum and the effect for the functions such as enhancing is immune.
Feeding effect is as shown in table 1-4.
The observation result of 1 ewe postpartum Major Clinical index of table
Note: same column shoulder mark lowercase difference person, significant difference (p < 0.05), similarly hereinafter.
The influence pg/mL that 2 compound additive of table secretes ewe postpartum inflammatory factor
Group TNF-α IL-6
Control group 311.4±4.3a 4.4±0.1a
Test group 265.4±12.3b 2.7±0.2b
Influence of 3 compound additive of table to ewe postpartum oxidative stress index
Group MDA(nMol/mL) SOD(IU/mL) CAT(IU/mL)
Control group 0.51±0.03a 13.2±1.01a 17.7±2.14a
Test group 0.39±0.05b 16.3±0.85b 23.9±1.32b
Influence g/L of 4 compound additive of table to ewe postpartum immune function
Group IgA IgG IgM Complement C_3 Complement C4
Control group 0.72±0.02a 1.37±0.02a 0.25±0.0a 0.07±0.01a 0.04±0.0a
Test group 0.98±0.01b 1.69±0.07b 0.38±0.0b 0.10±0.0b 0.05±0.0b
The result shows that ewe postpartum endometrium can not only effectively be prevented by adding 1.2% compound additive in mixed concentrate Scorching generation, and postpartum reproductive performance is promoted to restore.Seen from table 1,1.2% compound addition is added in test group mixed concentrate Agent suffers from endometritis without an example after ewe childbirth, improves 20.0% compared with the control group；Pregnancy rate is in 90 days postpartum 85.0%, 25.0% is improved compared with the control group.As can be seen from Table 2, adding 1.2% compound additive in mixed concentrate, ewe is produced Body inflammatory factor level significantly reduces afterwards, and compared with the control group, TNF-α and IL-6 level in blood reduce by 14.8% respectively With 38.6%.Seen from table 3,1.2% compound additive is added in mixed concentrate, the MDA level in ewe postpartum blood with it is right According to group compared to significant decrease 23.5%；Activities of antioxidant enzymes significantly increases, SOD and CAT level is respectively increased compared with control group 23.5% and 35.0%.By table 4 as it can be seen that adding 1.2% compound additive in mixed concentrate, ewe postpartum entirety immune level is bright It is aobvious to improve, compared with the control group, IgA, IgG, IgM, Complement C_3 in blood, Complement C4 level be respectively increased 36.1%, 23.4%, 52.0%, 42.9% and 25.0%.
It can be seen that natural astaxanthin, fructooligosaccharide, γ-aminobutyric acid, sodium humate, Sodium Hyaluronate and Chinese herbal medicine add Add agent to carry out compatibility, respective advantage can not only be given full play to, and there is synergistic effect, can effectively prevent ewe postpartum trouble Endometrium is scorching and is significantly improved to reproductive performance recovery, and can significantly improve anti-inflammatory ewe postpartum, resisting stress and The functions such as immune.
Embodiment 2
Match (weight ratio): natural astaxanthin 28%, fructooligosaccharide 24%, γ-aminobutyric acid 20%, sodium humate 7%, thoroughly Bright matter acid sodium 5% and Chinese herb feed additive 16%.Above-mentioned raw materials granularity is the dry powder less than 0.5mm.
The component and dosage of Chinese herb feed additive are the same as embodiment 1.
Application method: after each component is mixed, being added directly into mixed concentrate, and additive amount is 1.0-1.5% (with mixing Fine fodder meter)；Feeding period is to terminate the 1st day to the 90th day after pregnancy ewes childbirth.
Embodiment 3
Match (weight ratio): natural astaxanthin 25%, fructooligosaccharide 25%, γ-aminobutyric acid 20%, sodium humate 8%, thoroughly Bright matter acid sodium 5% and Chinese herb feed additive 17%.Above-mentioned raw materials granularity is the dry powder less than 0.5mm.
The component and dosage of Chinese herb feed additive are the same as embodiment 1.
Application method: after each component is mixed, being added directly into mixed concentrate, and additive amount is 1.0-1.5% (with mixing Fine fodder meter)；Feeding period is to terminate the 1st day to the 90th day after pregnancy ewes childbirth.

Claims (5)

1. a kind of feed addictive for preventing ewe endometritis, characterized in that be made of the raw material of following weight percentage: Natural astaxanthin 25-28%, fructooligosaccharide 23-27%, γ-aminobutyric acid 18-22%, sodium humate 7-9%, Sodium Hyaluronate 5- 8% and Chinese herb feed additive 13-17%.
2. a kind of feed addictive for preventing ewe endometritis as described in claim 1, characterized in that the Chinese herbal medicine The component and its parts by weight of additive are as follows: motherwort 20-25, cordate houttuynia 15-20, kuh-seng 12-15, Radix Astragali 12-15, coptis 12- 15, safflower 10-12, Radix Glycyrrhizae 10-12, are ground into the dry powder of 40-200 mesh after mixing.
3. a kind of feed addictive for preventing ewe endometritis as described in claim 1, characterized in that by following weight The raw material of percentage is made: natural astaxanthin 26%, fructooligosaccharide 25%, γ-aminobutyric acid 20%, sodium humate 8%, hyalomitome Sour sodium 6% and Chinese herb feed additive 15%.
4. a kind of feed addictive for preventing ewe endometritis as described in any one of claim 1-3, feature Be, the natural astaxanthin, fructooligosaccharide, γ-aminobutyric acid, sodium humate, Sodium Hyaluronate granularity be respectively less than 0.5mm.
5. a kind of user of feed addictive for preventing ewe endometritis as described in any one of claim 1-3 Method, characterized in that after mixing, be added directly into mixed concentrate, additive amount 1.0-1.5%；Feeding period is from pregnant female Start to terminate to the 90th day within the 1st day after sheep childbirth.
CN201910595140.0A 2019-07-03 2019-07-03 A kind of feed addictive preventing ewe endometritis and its application method Pending CN110140816A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114052123A (en) * 2021-11-24 2022-02-18 湖南农业大学 Feed additive, feed containing feed additive and application of feed additive

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102743503A (en) * 2012-07-13 2012-10-24 宁夏大学 Method for preparing Chinese medicinal compound effervescent tablets for treating endometritis of cows
CN106173294A (en) * 2016-07-13 2016-12-07 四川贡牛生物饲料有限公司 Ruminant stomach animal is fattened growth-promoting feedstuff additive
CN106578465A (en) * 2016-12-05 2017-04-26 刁海波 Special feed for captive sheep
CN109329617A (en) * 2018-11-16 2019-02-15 山东省农业科学院畜牧兽医研究所 A kind of feed addictive and its application method preventing cow postpartum retention of afterbirth

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102743503A (en) * 2012-07-13 2012-10-24 宁夏大学 Method for preparing Chinese medicinal compound effervescent tablets for treating endometritis of cows
CN106173294A (en) * 2016-07-13 2016-12-07 四川贡牛生物饲料有限公司 Ruminant stomach animal is fattened growth-promoting feedstuff additive
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Application publication date: 20190820