CN110115385A - 一种可增加骨密度的劲骨片及其生产方法 - Google Patents
一种可增加骨密度的劲骨片及其生产方法 Download PDFInfo
- Publication number
- CN110115385A CN110115385A CN201810148848.7A CN201810148848A CN110115385A CN 110115385 A CN110115385 A CN 110115385A CN 201810148848 A CN201810148848 A CN 201810148848A CN 110115385 A CN110115385 A CN 110115385A
- Authority
- CN
- China
- Prior art keywords
- strength
- osteocomma
- plum blossom
- powder
- bone density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000037182 bone density Effects 0.000 title claims abstract description 20
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 44
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 29
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 20
- 241000282994 Cervidae Species 0.000 claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 17
- MSWZFWKMSRAUBD-UHFFFAOYSA-N 2-Amino-2-Deoxy-Hexose Chemical compound NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims abstract description 12
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 11
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 11
- 241000208689 Eucommia ulmoides Species 0.000 claims abstract description 10
- 239000011728 vitamin K2 Substances 0.000 claims abstract description 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 8
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 7
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 18
- 239000011812 mixed powder Substances 0.000 claims description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 9
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 9
- 229920002472 Starch Polymers 0.000 claims description 9
- 235000019359 magnesium stearate Nutrition 0.000 claims description 9
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 9
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 9
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000011734 sodium Substances 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- 239000008107 starch Substances 0.000 claims description 9
- 235000019698 starch Nutrition 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 claims description 6
- 239000007888 film coating Substances 0.000 claims description 6
- 238000009501 film coating Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- -1 tabletting Substances 0.000 claims description 3
- 238000005550 wet granulation Methods 0.000 claims description 3
- 235000020985 whole grains Nutrition 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 229920002567 Chondroitin Polymers 0.000 claims 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 239000004615 ingredient Substances 0.000 abstract description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 3
- 239000011707 mineral Substances 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 150000001720 carbohydrates Chemical class 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 2
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 26
- 239000011575 calcium Substances 0.000 description 26
- 229910052791 calcium Inorganic materials 0.000 description 26
- 238000012360 testing method Methods 0.000 description 8
- 210000000689 upper leg Anatomy 0.000 description 8
- 238000011049 filling Methods 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 208000001132 Osteoporosis Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000003185 calcium uptake Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000003442 weekly effect Effects 0.000 description 3
- 241001148782 Davallia Species 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 235000012631 food intake Nutrition 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000003321 atomic absorption spectrophotometry Methods 0.000 description 1
- 238000001479 atomic absorption spectroscopy Methods 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000003913 calcium metabolism Effects 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000011990 functional testing Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/30—Physical treatment, e.g. electrical or magnetic means, wave energy or irradiation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明公开了一种劲骨片及其生产方法,所述劲骨片由碳酸钙、梅花鹿骨粉、硫酸软骨素、D‑氨基葡萄糖盐酸盐、骨碎补提取物、杜仲提取物、维生素K2以及赋形剂制备而成。本发明配方合理,通过优化各组分用量,最大程度保证了主要组分在增加骨密度方面的协同作用。本发明生产过程中对梅花鹿骨粉选择辐照灭菌(Co60),可有效防止其营养成分如蛋白质、糖类、微量元素及矿物质的流失,确保了本发明增加骨密度的保健效果。
Description
技术领域
本发明涉及保健食品技术领域,具体涉及一种可增加骨密度的劲骨片,本发明还涉及该劲骨片的生产方法。
背景技术
骨质疏松症是一种以骨量低下,骨微结构破坏,导致骨脆性增加,易发生骨折为特征的全身性骨病。骨质疏松受诸多因素影响,如年龄、身高、体重、BMI、绝经岁数、绝经年限、文化程度、职业、喝牛奶、晒太阳等诸多因素。
有研究表示,人群骨密度减低及骨质疏松症的患病率较高,与其对骨质疏松症的认知水平低、关注度不足密切相关。对于具有骨质疏松风险的患者,需要定期检测骨密度,除注意生活方式、提高含钙量高的食物摄取、适当运动外,也需要常规补充钙剂和维生素D等能增加骨密度的营养制剂。
目前,用于增加骨密度的保健食品较多,但大多存在效果不确定、副作用大等缺陷。为了进一步相应保健食品的保健效果和发挥各成分的协同作用,需要对各成分的用量、产品的质量控制以及生产方法等进行优化。
发明内容
本发明的目的在于克服现有技术的不足,提供一种配方合理、生产过程中有效成分流失少、效果确切的劲骨片。
为实现以上本发明的目的,本发明采用如下的技术方案:
本发明一种可增加骨密度的劲骨片,所述劲骨片由碳酸钙、梅花鹿骨粉、硫酸软骨素、D-氨基葡萄糖盐酸盐、骨碎补提取物、杜仲提取物、维生素K2以及赋形剂制备而成。
进一步地,上述劲骨片每900克由下述重量的原料制备而成:
碳酸钙262.5、梅花鹿骨粉120、硫酸软骨素72、D-氨基葡萄糖盐酸盐108、骨碎补提取物60、杜仲提取物90、0.2%维生素K27.5、余下为赋形剂。
每900克劲骨片中,上述赋形剂为:
微晶纤维素127、羧甲淀粉钠20、硬脂酸镁3、薄膜包衣预混剂30。
本发明一种可增加骨密度的劲骨片的生产方法,包括如下步骤:
(1)辐照灭菌:将梅花鹿骨粉以Co60辐照灭菌;
(2)过筛:将羧甲淀粉钠、D-氨基葡萄糖盐酸盐、梅花鹿骨粉、硫酸软骨素、杜仲提取物、骨碎补提取物、维生素K2、微晶纤维素、硬脂酸镁分别过60目筛,称量备用;
(3)混合:将上述备用的羧甲淀粉钠、D-氨基葡萄糖盐酸盐、梅花鹿骨粉、硫酸软骨素、杜仲提取物、骨碎补提取物置入混合机中混合20min,得混合粉1;将微晶纤维素和维生素K2按等量递加法混合均匀,得混合粉2;
(4)制粒、干燥、整粒
将混合粉1以70%乙醇湿法制粒,过18目得湿颗粒1;在65~70℃、干燥40~50分钟后,过16目筛整粒后备用;
(5)总混、压片、包衣
再将混合粉2与湿颗粒1以及硬脂酸镁一起共同混合20min,得总混颗粒;将上述所得总混颗粒压片,调节片重为0.9g/片;将薄膜包衣预混剂以纯化水配成8%的浓度,再进行包衣;
(6)包装、检验、入库。
与现有技术相比,本发明具有的有益效果如下:
本发明配方合理,通过优化各组分用量,最大程度保证了主要组分在增加骨密度方面的协同作用,确保了本发明的保健功效。本发明生产过程中对梅花鹿骨粉选择辐照灭菌(Co60),可有效防止其营养成分如蛋白质、糖类、微量元素及矿物质的流失,确保了本发明增加骨密度的保健效果,较好地解决了现有类似保健产品质量不稳定以及保健效果不确切的技术问题。
具体实施方式
为便于理解本发明,本发明列举实施例如下。如无具体说明,本发明的各种原料均可以通过市售得到;或根据本领域的常规方法制备得到。除非另有定义或说明,本文中所使用的所有专业与科学用语与本领域技术熟练入员所熟悉的意义相同。此外任何与所记载内容相似或均等的方法及材料皆可应用于本发明方法中。除非另外说明,本文中所使用的所有专业与科学用语与本领域技术熟练人员所熟悉的意义相同。
1000片(0.5g/片)劲骨片的配方如下:
碳酸钙262.5、梅花鹿骨粉120、硫酸软骨素72、D-氨基葡萄糖盐酸盐108、骨碎补提取物60、杜仲提取物90、0.2%维生素K27.5、余下为赋形剂、、微晶纤维素127、羧甲淀粉钠20、硬脂酸镁3、薄膜包衣预混剂30。
生产方法具体如下:
(1)辐照灭菌:将梅花鹿骨粉以Co60辐照灭菌;
(2)过筛:将羧甲淀粉钠、D-氨基葡萄糖盐酸盐、梅花鹿骨粉、硫酸软骨素、杜仲提取物、骨碎补提取物、维生素K2、微晶纤维素、硬脂酸镁分别过60目筛,称量备用;
(3)混合:将上述备用的羧甲淀粉钠、D-氨基葡萄糖盐酸盐、梅花鹿骨粉、硫酸软骨素、杜仲提取物、骨碎补提取物置入混合机中混合20min,得混合粉1;将微晶纤维素和维生素K2按等量递加法混合均匀,得混合粉2;
(4)制粒、干燥、整粒
将混合粉1以70%乙醇湿法制粒,过18目得湿颗粒1;在65℃、干燥45分钟后,过16目筛整粒后备用;
(5)总混、压片、包衣
再将混合粉2与湿颗粒1以及硬脂酸镁一起共同混合20min,得总混颗粒;将上述所得总混颗粒压片,调节片重为0.9g/片;将薄膜包衣预混剂以纯化水配成8%的浓度,再进行包衣;
(6)包装、检验、入库。
本制剂的服用方法为:每日2次,每次2片。
将本实施例制得的劲骨片,进行如下功能测试试验:
1、依据:《保健食品检验与评价技术规范》2003年版。
2、动物分组:大鼠用基础饲料适应性喂饲后,根据体重,随机分为下列五组:低钙对照组,高剂量碳酸钙对照组,劲骨片三个剂量组:250mg/kg.bw组、500mg/kg.bw组和1500mg/kg.bw组(分别相当于人体摄入量50mg/kg.bw的5、10、30倍),每组动物10-11只。五组动物均用低钙饲料饲喂低钙对照组以蒸馏水灌胃;三个剂量组以配制的样品液灌胃(灌胃液的配制:分别取劲骨片2.5g、5g、15g,加蒸馏水定容至100mL,配制成250mg/kg.bw、500mg/kg.bw、1500mg/kg.bw组的灌胃液);高剂量碳酸钙对照组经口灌入525mg/kg.bw的碳酸钙,该剂量相当于劲骨片高剂量组钙水平(劲骨片样品钙为175g碳酸钙/500g样品,高剂量组1500mg/kg.bw中,含钙为210mg/kg.bw,换算成碳酸钙:525mg/kg.bw灌胃液的配制:取碳酸钙525g加蒸馏水定容至100mL)。所有动物灌胃量均为10ml/kg.bw,每天一次,连续灌胃13周,每周称体重并按体重调整灌胃量。
3、检测指标
实验期间,第1-4周每周测量记录身长、体重一次。第5-13周每周称体重并按体重调整灌胃量。
钙吸收试验:试验3周后将动物进行3天钙代谢试验。记录3天进食量,收集72小时粪便,鼠粪样品在80度烘箱中烘干,置干燥器中冷却腊磨细。原子吸收法测定饲料、粪便中钙含量。
实验末CO2麻醉安乐处死物,取出双侧股骨:右侧股骨放置于105度烘箱中,烤至恒重、称量骨重;釆用原子吸收分光光度法测定右股骨钙含量。大鼠左股骨样品釆用小动物全自动高分辨率X光机测定骨密度。
4、结果
(1)劲骨片对大鼠钙吸收的影响
钙吸收实验开始时,劲骨片三个剂量组和碳酸钙对照组的体重和身长与低钙对照比较均无显著性差异(P>005);试验结束时,受试物三个剂量组及碳酸钙对照组组的身长与低钙对照组比较均无显著性差异(P>005),高剂量组体重与低钙对照组比较显著增加(P<0.05);受试物高剂量组和碳酸钙对照组的钙表观吸收率与低钙对照组比较均显著降低(P<0.01)。受试物低、中剂量组的钙表观吸收率与碳酸钙对照组比较均显著增加(P<0.01),故认为该样品钙吸收率较高。
(2)劲骨片对大鼠体重的影响
劲骨片三个剂量组和碳酸钙对照组的实验前体重与低钙对照组比较均无显著性差异((P>0.05),高剂量组的实验中、后期体重、碳酸钙对照组的实验后体重与低钙对照组比较均显著增加(P<005),低剂量组与碳酸钙对照组的体重与低钙对照组比较显著降低(P<0.05)。劲骨片实验中期和末期体重显著高于碳酸钙对照组(P<0.01)。故未见样品对动物体重的明显不良影响。
(3)劲骨片对大鼠骨重、骨密度及骨钙的影响
受试物中、高剂量组的右股骨骨重与低钙对照组比较均显著增加(P<0.01)。劲骨片三个剂量组以及碳酸钙对照组的左股骨骨密度、右股骨骨钙含量与低钙对照组比较均显著增加(P<0.05,P<0.01)受试物高剂量组的右股骨骨重与碳酸钙对照组比较显著增加(P<0.01),其余指标与碳酸钙对照组比较均无显著性差异(P>0.05)。
5、结论
本发明的劲骨片的钙吸收率较高,能显著增加骨密度和骨钙含量。
Claims (4)
1.一种可增加骨密度的劲骨片,其特征在于,所述劲骨片由碳酸钙、梅花鹿骨粉、硫酸软骨素、D-氨基葡萄糖盐酸盐、骨碎补提取物、杜仲提取物、维生素K2以及赋形剂制备而成。
2.如权利要求1所述的一种可增加骨密度的劲骨片,其特征在于,所述劲骨片每900克由下述重量的原料制备而成:
碳酸钙 262.5
梅花鹿骨粉 120
硫酸软骨素 72
D-氨基葡萄糖盐酸盐 108
骨碎补提取物 60
杜仲提取物 90
0.2%维生素K2 7.5
余下为赋形剂。
3.如权利要求1所述的一种可增加骨密度的劲骨片,其特征在于,每900克所述劲骨片中,赋形剂为:
微晶纤维素 127
羧甲淀粉钠 20
硬脂酸镁 3
薄膜包衣预混剂 30。
4.如权利要求1所述的一种可增加骨密度的劲骨片的生产方法,其特征在于,包括如下步骤:
(1)辐照灭菌:将梅花鹿骨粉以C060辐照灭菌;
(2)过筛:将羧甲淀粉钠、D-氨基葡萄糖盐酸盐、梅花鹿骨粉、硫酸软骨素、杜仲提取物、骨碎补提取物、维生素K2、微晶纤维素、硬脂酸镁分别过60目筛,称量备用;
(3)混合:将上述备用的羧甲淀粉钠、D-氨基葡萄糖盐酸盐、梅花鹿骨粉、硫酸软骨素、杜仲提取物、骨碎补提取物置入混合机中混合20min,得混合粉1;将微晶纤维素和维生素K2按等量递加法混合均匀,得混合粉2;
(4)制粒、干燥、整粒
将混合粉1以70%乙醇湿法制粒,过18目得湿颗粒1;在65~70℃、干燥40~50分钟后,过16目筛整粒后备用;
(5)总混、压片、包衣
再将混合粉2与湿颗粒1以及硬脂酸镁一起共同混合20min,得总混颗粒;将上述所得总混颗粒压片,调节片重为0.9g/片;将薄膜包衣预混剂以纯化水配成8%的浓度,再进行包衣;
(6)包装、检验、入库。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810148848.7A CN110115385A (zh) | 2018-02-05 | 2018-02-05 | 一种可增加骨密度的劲骨片及其生产方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810148848.7A CN110115385A (zh) | 2018-02-05 | 2018-02-05 | 一种可增加骨密度的劲骨片及其生产方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110115385A true CN110115385A (zh) | 2019-08-13 |
Family
ID=67519657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810148848.7A Pending CN110115385A (zh) | 2018-02-05 | 2018-02-05 | 一种可增加骨密度的劲骨片及其生产方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110115385A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114680329A (zh) * | 2020-12-25 | 2022-07-01 | 吉林省国大生物工程有限公司 | 一种增加骨密度的鹿骨氨糖软骨素钙片配方及其制备方法 |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101288686A (zh) * | 2008-05-15 | 2008-10-22 | 江西本草天工科技有限责任公司 | 一种增加骨密度的保健制剂及制备方法 |
CN101507734A (zh) * | 2009-03-31 | 2009-08-19 | 李希春 | 一种对鹿骨进行系列加工的方法 |
CN102552877A (zh) * | 2011-12-15 | 2012-07-11 | 广东汤臣倍健生物科技股份有限公司 | 一种改善骨质疏松、增加骨密度的保健制剂及其制备方法 |
CN102885304A (zh) * | 2012-10-12 | 2013-01-23 | 中科乐仁(北京)科技发展有限公司 | 一种增加骨密度的保健食品组合物及其制备方法 |
CN103251065A (zh) * | 2013-05-14 | 2013-08-21 | 吉林大学 | 家养梅花鹿鹿骨粉、其制备方法及由其制备的梅花鹿鹿骨咀嚼片 |
CN104664402A (zh) * | 2015-03-26 | 2015-06-03 | 江苏康缘药业股份有限公司 | 一种增加骨密度的组合物及其制备方法和应用 |
CN104705658A (zh) * | 2015-04-09 | 2015-06-17 | 四川健之源科技有限公司 | 一种具有增加骨密度功能的保健食品 |
CN105030879A (zh) * | 2015-05-15 | 2015-11-11 | 江西师范大学 | 壳寡糖健骨保健品及其制备方法 |
CN106235311A (zh) * | 2016-07-28 | 2016-12-21 | 广州赛莱拉干细胞科技股份有限公司 | 一种促进骨骼系统健康的组合物及其应用 |
CN106581130A (zh) * | 2016-12-02 | 2017-04-26 | 芜湖市诺康生物科技有限公司 | 一种增加骨密度片及其制备工艺 |
CN106880839A (zh) * | 2015-12-14 | 2017-06-23 | 吉林省东鳌鹿业集团有限公司 | 一种鹿骨片及其制备方法 |
-
2018
- 2018-02-05 CN CN201810148848.7A patent/CN110115385A/zh active Pending
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101288686A (zh) * | 2008-05-15 | 2008-10-22 | 江西本草天工科技有限责任公司 | 一种增加骨密度的保健制剂及制备方法 |
CN101507734A (zh) * | 2009-03-31 | 2009-08-19 | 李希春 | 一种对鹿骨进行系列加工的方法 |
CN102552877A (zh) * | 2011-12-15 | 2012-07-11 | 广东汤臣倍健生物科技股份有限公司 | 一种改善骨质疏松、增加骨密度的保健制剂及其制备方法 |
CN102885304A (zh) * | 2012-10-12 | 2013-01-23 | 中科乐仁(北京)科技发展有限公司 | 一种增加骨密度的保健食品组合物及其制备方法 |
CN103251065A (zh) * | 2013-05-14 | 2013-08-21 | 吉林大学 | 家养梅花鹿鹿骨粉、其制备方法及由其制备的梅花鹿鹿骨咀嚼片 |
CN104664402A (zh) * | 2015-03-26 | 2015-06-03 | 江苏康缘药业股份有限公司 | 一种增加骨密度的组合物及其制备方法和应用 |
CN104705658A (zh) * | 2015-04-09 | 2015-06-17 | 四川健之源科技有限公司 | 一种具有增加骨密度功能的保健食品 |
CN105030879A (zh) * | 2015-05-15 | 2015-11-11 | 江西师范大学 | 壳寡糖健骨保健品及其制备方法 |
CN106880839A (zh) * | 2015-12-14 | 2017-06-23 | 吉林省东鳌鹿业集团有限公司 | 一种鹿骨片及其制备方法 |
CN106235311A (zh) * | 2016-07-28 | 2016-12-21 | 广州赛莱拉干细胞科技股份有限公司 | 一种促进骨骼系统健康的组合物及其应用 |
CN106581130A (zh) * | 2016-12-02 | 2017-04-26 | 芜湖市诺康生物科技有限公司 | 一种增加骨密度片及其制备工艺 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114680329A (zh) * | 2020-12-25 | 2022-07-01 | 吉林省国大生物工程有限公司 | 一种增加骨密度的鹿骨氨糖软骨素钙片配方及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102133395B (zh) | 骨骼保健物或药物组合物及其应用 | |
CN104257887B (zh) | 一种促进排铅的组合物及其应用 | |
CN102552877A (zh) | 一种改善骨质疏松、增加骨密度的保健制剂及其制备方法 | |
CN102805858B (zh) | 一种高效补钙胶囊及制备方法 | |
CN106102484B (zh) | 用于减少膳食脂肪吸收的包含秋葵的组合物 | |
CN103083648B (zh) | 以乳矿物盐为原料的增加骨密度的片剂及其制备方法 | |
CN103039976A (zh) | 一种增加骨密度的保健食品及其制备方法 | |
JP2010222374A (ja) | マーカーを組み込んだ凍結乾燥食品 | |
CN110810855A (zh) | 一种具有润肠通便功能的膳食纤维组合物 | |
CN102085356B (zh) | 一种用于增加骨密度的组合物及其制备方法 | |
CN104146260B (zh) | 一种增加骨密度的保健食品及其制备方法 | |
CN109718308A (zh) | 一种葛根芹菜籽组合物制剂及其应用 | |
CN110115385A (zh) | 一种可增加骨密度的劲骨片及其生产方法 | |
WO2019235099A1 (ja) | 機能性食品 | |
Hu et al. | Effects of resistance training on biomarkers of bone formation and association with red blood cell variables | |
CN103946019B (zh) | 铁-纤维组合物、其制备和用途 | |
CN106727676A (zh) | 一种降低了高钙血风险的补钙组合物及其应用 | |
CN110115380A (zh) | 一种可增加骨密度的劲骨胶囊及其生产方法 | |
CN104224883A (zh) | 增加骨密度胶囊及其制备方法 | |
CN109601880B (zh) | 一种增加骨密度的保健食品 | |
JP5584206B2 (ja) | マーカーを含有する流動床食事及びその作製方法 | |
Herminiati et al. | The effectivity of Difructose Anhydride III to increase absorption of calcium in the femur bone of calcium deficient rats | |
CN105055355A (zh) | 羟基铝蒙脱石咀嚼片及其制备方法和应用 | |
CN113170883A (zh) | 一种增加骨密度的保健食品及其制备方法 | |
CN109906084A (zh) | 一种降低了高钙血风险的补钙组合物及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190813 |