CN110090316A - 一种防黏连驻极体敷料及其制备方法 - Google Patents

一种防黏连驻极体敷料及其制备方法 Download PDF

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CN110090316A
CN110090316A CN201910340689.5A CN201910340689A CN110090316A CN 110090316 A CN110090316 A CN 110090316A CN 201910340689 A CN201910340689 A CN 201910340689A CN 110090316 A CN110090316 A CN 110090316A
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electret
adhered
dressing
polytetrafluoroethylene
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何立彬
吴帅
李毅
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Guangdong Taibao Medical Science Technology Co Ltd
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Abstract

本发明公开了一种防黏连驻极体敷料及其制备方法，包括驻极体层和亲水层，驻极体层由经过配料、搅拌、挤条、压延以及烘干等工序制备成的聚四氟乙烯膜组成，其中聚四氟乙烯膜表面分布着大小均匀的微孔，所述的驻极体为正极性，表面电荷为+1000V~+2000V。所述亲水层由经静电纺丝技术制备成的藻酸盐医用膜组成。本发明的防黏连驻极体敷料在接触人体皮肤创面时，渗液通过聚四氟乙烯膜表面的微孔进入藻酸盐医用膜从而被吸收，但聚四氟乙烯膜为疏水材料不会黏连伤口从而有效防止创面黏连，并且可以通过驻极体层所带微电流直接刺激创面部位以及亲水层吸收渗液维持创面湿性环境从而促进创面愈合。

Description

一种防黏连驻极体敷料及其制备方法
技术领域
本发明涉及医疗器械技术领域，具体为一种防黏连驻极体敷料及其制备方法。
背景技术
皮肤是人体最大的器官，具有保持人体内水分、防止过度散热、透气和防止细菌侵袭的功能。如果仅是皮肤的浅层或是小面积受损，新皮肤会自体得以再生，但如果受到严重的创伤，皮肤就不能靠自己修复，通常须附以医用敷料来促进创面愈合。优异的医用敷料基本上具有吸收渗液保持创面湿润环境的功能，但存在因亲水性差而黏连伤口的缺点。
发明内容
本发明的内容在于提供一种防黏连驻极体敷料及其制备方法，在现有医用敷料的基础上，结合聚四氟乙烯驻极体的特性，更好的促进创面愈合，更好的发挥医用敷料在促进伤口愈合方面的作用。
本发明的技术方案如下：一种防黏连驻极体敷料，包括驻极体层和亲水层，所述驻极体层由经过配料、搅拌、挤条、压延以及烘干等工序制备成的聚四氟乙烯膜组成，该聚四氟乙烯膜表面分布着大小均匀的微孔，所述亲水层由经静电纺丝技术制备成的藻酸盐医用膜组成。
优选的，所述聚四氟乙烯驻极体膜是由聚四氟乙烯，发泡剂和矿物油组成，其中聚四氟乙烯，发泡剂和矿物油的质量比为(3~5):(2~1):1。
优选的，所述聚四氟乙烯驻极体膜表面的微孔孔径为0.2μm~0.8μm。
优选的，所述藻酸盐医用膜由海藻酸钠与聚乙烯醇按照质量比1:1~2:1组成。
本发明的防黏连驻极体敷料的制备方法，包括如下步骤：
S1：制备聚四氟乙烯膜：将聚四氟乙烯粉末分散均匀后，与发泡剂、矿物油按质量比(3~5):(2~1):1进行混合搅拌，混合均匀后倒入挤出机，设定工艺参数，温度45℃，压力100kg/cm，将挤出的聚四氟乙烯条放入压延机进行压薄成膜，膜的厚度为20μm~50μm，最后经过烘干机烘干成型，烘干机温度设定为160℃~320℃，得到聚四氟乙烯膜；
S2：制备藻酸盐纺丝液：将海藻酸钠粉末与聚乙烯醇按质量比1:1~2:1溶解于蒸馏水中，搅拌制备得到2.0wt%~4.0wt%藻酸盐纺丝液；
S3：制备防黏连驻极体敷料：将S1制得聚四氟乙烯膜放置于静电纺丝设备的接收平台上，并将S2制得藻酸盐纺丝液加入静电纺丝设备的储液器中，开启静电纺丝设备，调节工艺参数，工作电压为18.0Kv~23.0Kv，工作距离为8cm~12cm，喷射速度为0.5ml/h~1.0ml/h，纺丝2h~3h，即得到防黏连驻极体敷料；
S4：防黏连驻极体敷料极化：将S3制得的防黏连驻极体敷料放入栅控恒压电晕充电系统中对防黏连驻极体敷料进行充电，聚四氟乙烯膜正面朝上，电晕电压为+15kV，栅压为+1000V~+1500V，充电时间5min，制得正极性+1000V~+1500V的防黏连驻极体敷料。
本发明的有益效果为：
（1）方法简单，制备时间短，所需的原料来源丰富，价格低廉，生产成本低，防黏连驻极体敷料由驻极体层和亲水层组成，兼具亲水和疏水结构；
（2）防黏连驻极体敷料不仅具有医用敷料基本吸收渗液功能而且具有防止创面黏连的作用；
（3）防黏连驻极体敷料所用原料藻酸盐具有良好的生物相容性，对伤口有促进伤口愈合作用；
（4）防黏连驻极体敷料的驻极体层为生物驻极体，可以通过本身带有的微电流直接刺激与之接触的创面残存上皮细胞，电刺激可改善局部的血液供应从而改善上皮细胞的生长环境以及电刺激可使细胞周围环境发生生物及化学改变，使氧张力降低，刺激细胞分化从而促进创面愈合。
具体实施方式
实施例一：
一种防黏连驻极体敷料的制备方法，包括以下步骤：
S1：制备聚四氟乙烯膜：将聚四氟乙烯粉末分散均匀后，与发泡剂、矿物油按质量比4:0:1进行混合搅拌，混合均匀后倒入挤出机，设定工艺参数，温度45℃，压力100kg/cm，将挤出的聚四氟乙烯条放入压延机进行压薄成膜，膜的厚度为30μm，最后经过烘干机烘干成型，烘干机温度设定为230℃，得到聚四氟乙烯膜；
S2：制备藻酸盐纺丝液：将海藻酸钠粉末与聚乙烯醇按质量比2:1溶解于蒸馏水中，搅拌制备得到4.0wt%藻酸盐纺丝液；
S3：制备防黏连驻极体敷料：将S1制得聚四氟乙烯膜放置于静电纺丝设备的接收平台上，并将S2制得藻酸盐纺丝液加入静电纺丝设备的储液器中，开启静电纺丝设备，调节工艺参数，工作电压为20.0Kv，工作距离为10cm，喷射速度为0.8ml/h，纺丝3h，即得到防黏连驻极体敷料；
S4：防黏连驻极体敷料极化：将S3制得的防黏连驻极体敷料放入栅控恒压电晕充电系统中对防黏连驻极体敷料进行充电，聚四氟乙烯膜正面朝上，电晕电压为+15kV，栅压为+1000V，充电时间5min，制得正极性+1000V的防黏连驻极体敷料。
实施例二
一种防黏连驻极体敷料的制备方法，包括以下步骤：
S1：制备聚四氟乙烯膜：将聚四氟乙烯粉末分散均匀后，与发泡剂、矿物油按质量比4:1:1进行混合搅拌，混合均匀后倒入挤出机，设定工艺参数，温度45℃，压力100kg/cm，将挤出的聚四氟乙烯条放入压延机进行压薄成膜，膜的厚度为30μm，最后经过烘干机烘干成型，烘干机温度设定为230℃，得到聚四氟乙烯膜；
S2：制备藻酸盐纺丝液：将海藻酸钠粉末与聚乙烯醇按质量比2:1溶解于蒸馏水中，搅拌制备得到4.0wt%藻酸盐纺丝液；
S3：制备防黏连驻极体敷料：将S1制得聚四氟乙烯膜放置于静电纺丝设备的接收平台上，并将S2制得藻酸盐纺丝液加入静电纺丝设备的储液器中，开启静电纺丝设备，调节工艺参数，工作电压为20.0Kv，工作距离为10cm，喷射速度为0.8ml/h，纺丝3h，即得到防黏连驻极体敷料；
S4：防黏连驻极体敷料极化：将S3制得的防黏连驻极体敷料放入栅控恒压电晕充电系统中对防黏连驻极体敷料进行充电，聚四氟乙烯膜正面朝上，电晕电压为+15kV，栅压为+1000V，充电时间5min，制得正极性+1000V的防黏连驻极体敷料。
实施例三
一种防黏连驻极体敷料的制备方法，包括以下步骤：
S1：制备聚四氟乙烯膜：将聚四氟乙烯粉末分散均匀后，与发泡剂、矿物油按质量比4:2:1进行混合搅拌，混合均匀后倒入挤出机，设定工艺参数，温度45℃，压力100kg/cm，将挤出的聚四氟乙烯条放入压延机进行压薄成膜，膜的厚度为30μm，最后经过烘干机烘干成型，烘干机温度设定为230℃，得到聚四氟乙烯膜；
S2：制备藻酸盐纺丝液：将海藻酸钠粉末与聚乙烯醇按质量比2:1溶解于蒸馏水中，搅拌制备得到4.0wt%藻酸盐纺丝液；
S3：制备防黏连驻极体敷料：将S1制得聚四氟乙烯膜放置于静电纺丝设备的接收平台上，并将S2制得藻酸盐纺丝液加入静电纺丝设备的储液器中，开启静电纺丝设备，调节工艺参数，工作电压为20.0Kv，工作距离为10cm，喷射速度为0.8ml/h，纺丝3h，即得到防黏连驻极体敷料；
S4：防黏连驻极体敷料极化：将S3制得的防黏连驻极体敷料放入栅控恒压电晕充电系统中对防黏连驻极体敷料进行充电，聚四氟乙烯膜正面朝上，电晕电压为+15kV，栅压为+1000V，充电时间5min，制得正极性+1000V的防黏连驻极体敷料。
实施例四
一种防黏连驻极体敷料的制备方法，包括以下步骤：
S1：制备聚四氟乙烯膜：将聚四氟乙烯粉末分散均匀后，与发泡剂、矿物油按质量比4:1:1进行混合搅拌，混合均匀后倒入挤出机，设定工艺参数，温度45℃，压力100kg/cm，将挤出的聚四氟乙烯条放入压延机进行压薄成膜，膜的厚度为30μm，最后经过烘干机烘干成型，烘干机温度设定为230℃，得到聚四氟乙烯膜；
S2：制备藻酸盐纺丝液：将海藻酸钠粉末与聚乙烯醇按质量比2:1溶解于蒸馏水中，搅拌制备得到4.0wt%藻酸盐纺丝液；
S3：制备防黏连驻极体敷料：将S1制得聚四氟乙烯膜放置于静电纺丝设备的接收平台上，并将S2制得藻酸盐纺丝液加入静电纺丝设备的储液器中，开启静电纺丝设备，调节工艺参数，工作电压为20.0Kv，工作距离为10cm，喷射速度为0.8ml/h，纺丝3h，即得到防黏连驻极体敷料；
S4：防黏连驻极体敷料极化：将S3制得的防黏连驻极体敷料放入栅控恒压电晕充电系统中对防黏连驻极体敷料进行充电，聚四氟乙烯膜正面朝上，电晕电压为+15kV，栅压为+1200V，充电时间5min，制得正极性+1200V的防黏连驻极体敷料。
实施例五
一种防黏连驻极体敷料的制备方法，包括以下步骤：
S1：制备聚四氟乙烯膜：将聚四氟乙烯粉末分散均匀后，与发泡剂、矿物油按质量比4:1:1进行混合搅拌，混合均匀后倒入挤出机，设定工艺参数，温度45℃，压力100kg/cm，将挤出的聚四氟乙烯条放入压延机进行压薄成膜，膜的厚度为30μm，最后经过烘干机烘干成型，烘干机温度设定为230℃，得到聚四氟乙烯膜；
S2：制备藻酸盐纺丝液：将海藻酸钠粉末与聚乙烯醇按质量比2:1溶解于蒸馏水中，搅拌制备得到4.0wt%藻酸盐纺丝液；
S3：制备防黏连驻极体敷料：将S1制得聚四氟乙烯膜放置于静电纺丝设备的接收平台上，并将S2制得藻酸盐纺丝液加入静电纺丝设备的储液器中，开启静电纺丝设备，调节工艺参数，工作电压为20.0Kv，工作距离为10cm，喷射速度为0.8ml/h，纺丝3h，即得到防黏连驻极体敷料；
S4：防黏连驻极体敷料极化：将S3制得的防黏连驻极体敷料放入栅控恒压电晕充电系统中对防黏连驻极体敷料进行充电，聚四氟乙烯膜正面朝上，电晕电压为+15kV，栅压为+1500V，充电时间5min，制得正极性+1200V的防黏连驻极体敷料。
实施例六（对比例）
一种防黏连驻极体敷料的制备方法，包括以下步骤：
S1：制备藻酸盐纺丝液：将海藻酸钠粉末与聚乙烯醇按质量比2:1溶解于蒸馏水中，搅拌制备得到4.0wt%藻酸盐纺丝液；
S2：制备驻极体敷料：将S1制得藻酸盐纺丝液加入静电纺丝设备的储液器中，开启静电纺丝设备，调节工艺参数，工作电压为20.0Kv，工作距离为10cm，喷射速度为0.8ml/h，纺丝3h，即得到驻极体敷料。
S3：驻极体敷料极化：将S2制得的防黏连驻极体敷料放入栅控恒压电晕充电系统中对防黏连驻极体敷料进行充电，聚四氟乙烯膜正面朝上，电晕电压为+15kV，栅压为+1200V，充电时间5min，制得正极性+1200V的防黏连驻极体敷料。
实施例七
以上仅仅列出了本发明的部分实施例并进行了说明，将上述实施例一与实施例六所制备的驻极体敷料进行伤口修复实验和伤口防黏连实验。实验结果如表1所示：
表1 伤口修复实验结果
实施例一 实施例二 实施例三 实施例四 实施例五 实施例六
伤口愈合时间（d） 13 9 7 6 8 18
愈合情况 伤口愈合完整 伤口愈合完整 伤口愈合完整 伤口愈合完整 伤口愈合完整 黏连伤口
由上表可知，本发明能对伤口创面完整修复，不黏连伤口，促进伤口愈合，在经过多次的研究探索，实施例四为本发明的最优方案，即在步骤1中聚四氟乙烯、发泡剂和矿物油按照质量比4:1:1进行混合，在步骤4中用栅压为+1200V制得正极性+1200V的防黏连驻极体敷料时，生产出的防黏连驻极体敷料具备有最佳的对创面的修复效果。
以上对本发明的特定实施例进行了说明，但本发明的保护内容不仅仅限定于以上实施例，在本发明的所属技术领域中，只要掌握通常知识，就可以在其技术要旨范围内进行多种多样的变更。

Claims (6)

1.一种防黏连驻极体敷料，包括驻极体层和亲水层，所述驻极体层由经过配料、搅拌、挤条、压延以及烘干等工序制备成的聚四氟乙烯膜组成，该聚四氟乙烯膜表面分布着大小均匀的微孔，所述亲水层由经静电纺丝技术制备成的藻酸盐医用膜组成。
2.根据权利要求1所述的一种防黏连驻极体敷料，其特征在于，所述聚四氟乙烯膜由由聚四氟乙烯，发泡剂和矿物油组成，其中聚四氟乙烯，发泡剂和矿物油的质量比为(3~5):(2~1):1。
3.根据权利要求1所述的一种防黏连驻极体敷料，其特征在于，所述聚四氟乙烯膜表面的微孔大小为0.2μm~0.8μm。
4.根据权利要求1所述的一种防黏连驻极体敷料，其特征在于，所述驻极体层的表面电荷为+1000V~+1500V。
5.根据权利要求1所述的一种防黏连驻极体敷料，其特征在于，所述藻酸盐医用膜由海藻酸钠与聚乙烯醇按照质量比1:1~2:1组成。
6.权利要求1~6任一所述的一种防黏连驻极体敷料的制备方法，其特征在于，包括如下步骤：
S1：制备聚四氟乙烯膜：将聚四氟乙烯粉末分散均匀后，与发泡剂、矿物油按质量比(3~5):(2~1):1进行混合搅拌，混合均匀后倒入挤出机，设定工艺参数，温度45℃，压力100kg/cm，将挤出的聚四氟乙烯条放入压延机进行压薄成膜，膜的厚度为20μm~50μm，最后经过烘干机烘干成型，烘干机温度设定为160℃~320℃，得到聚四氟乙烯膜；
S2：制备藻酸盐纺丝液：将海藻酸钠粉末与聚乙烯醇按质量比1:1~2:1溶解于蒸馏水中，搅拌制备得到2.0wt%~4.0wt%藻酸盐纺丝液；
S3：制备防黏连驻极体敷料：将S1制得聚四氟乙烯膜放置于静电纺丝设备的接收平台上，并将S2制得藻酸盐纺丝液加入静电纺丝设备的储液器中，开启静电纺丝设备，调节工艺参数，工作电压为18.0Kv~23.0Kv，工作距离为8cm~12cm，喷射速度为0.5ml/h~1.0ml/h，纺丝2h~3h，即得到防黏连驻极体敷料；
S4：防黏连驻极体敷料极化：将S3制得的防黏连驻极体敷料放入栅控恒压电晕充电系统中对防黏连驻极体敷料进行充电，聚四氟乙烯膜正面朝上，电晕电压为+15kV，栅压为+1000V~+1500V，充电时间5min，制得正极性+1000V~+1500V的防黏连驻极体敷料。
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