CN110090275A - A kind of Chinese medicine composition and preparation method thereof for conditioning blood sugar - Google Patents
A kind of Chinese medicine composition and preparation method thereof for conditioning blood sugar Download PDFInfo
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The Chinese medicine composition and preparation method thereof that the invention discloses a kind of for conditioning blood sugar; the Chinese medicine composition is oral tabletting form; it is made of the raw material of following components, in terms of mass fraction: 30 parts of Rice enriched-Se, 1 part of alpha-amylase, 20 parts of mulberry leaf, 9 parts of chrysanthemum, 7 parts of smilax, 18 parts of dioscorea japonica, 12 parts of pueraria lobata, 4 parts of xylitol, 3 parts of microcrystalline cellulose, 3 parts of Ultra Tex 2,4 parts of magnesium stearate.The beneficial effects of the present invention are: the main material of drug component used in the present invention is in herbaceous plant or food materials, toxic side effect is small, substantially with a kind of administration of food form, reduces the psychological burden of the medication of patient.It is effectively improved simultaneously through clinical test and conditioning blood sugar.
Description
Technical field
The present invention relates to a kind of health care Chinese medicines, in particular to a kind of for the Chinese medicine composition of conditioning blood sugar and its preparation side
Method.
Background technique
Diabetes are one group of metabolic diseases characterized by hyperglycemia.Hyperglycemia be then due to defect of insulin secretion or
Its biological effect is impaired, or both have concurrently and cause.Long-standing hyperglycemia when diabetes, cause various tissues, especially eye,
Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.Currently, China has become the most state of global diabetic
Family.
The treatment of diabetes B is typically all to pass through insulin injection or oral hypoglycemic drug.But take for a long time and
Injection is easy to appear adverse side effect.About the treatment and prevention of diabetes B, educational circles is not it is widely recognized that be to depend merely on to take medicine to control
Treat the disease that just can solve problem.Therefore, finding can be used for treating diabetes, the natural bioactivity substance of conditioning blood sugar balance
Or functional food is one of the important hot issue of the current research for the treatment of diabetes both at home and abroad.
Summary of the invention
The purpose of the invention is to overcome shortcoming and defect of the existing technology, and provide a kind of for conditioning blood sugar
Chinese medicine composition and preparation method thereof.
To achieve the above object, the technical scheme is that the Chinese medicine composition is oral tabletting form, by with the following group
The raw material divided is made, in terms of mass fraction:
30 parts of Rice enriched-Se, 20 parts of mulberry leaf, 9 parts of chrysanthemum, 7 parts of smilax, 18 parts of dioscorea japonica, 12 parts of pueraria lobata, 4 parts of xylitol,
3 parts of microcrystalline cellulose, 3 parts of Ultra Tex 2,4 parts of magnesium stearate.
The present invention also provides a kind of preparation methods of Chinese medicine composition for conditioning blood sugar as described in power 1, including with
Lower step:
1. Rice enriched-Se is crushed into powder in pulverizer, 200 meshes are then crossed, which is passed through into microwave heating
Mode, by every 100g mixed powder by 800 watts in a manner of 2 minutes it is heat aging, alpha-amylase is then added and is digested, when enzymatic hydrolysis
Between be 3 days, then enzymolysis liquid is boiled, is subsequently placed in centrifuge, 2000 revs/min son centrifugation 20 minutes, take upper layer newborn
The clear liquid, is then freeze-dried by the Rice enriched-Se clear liquid of white, obtains Rice enriched-Se enzymatic hydrolysis dry powder;
2. smilax, dioscorea japonica and pueraria lobata are crushed into powder in pulverizer together, 200 meshes are then crossed, are mixed
Powder, then by microwave heating, by every 100g mixed powder by 800 watts in a manner of 2 minutes it is heat aging, it is mixed to obtain curing
Close powder;
3. the then heating after 1h is soaked in water to mulberry leaf to be concentrated, then with 0 DEG C, 5000r/min high speed centrifugation 5min after,
Precipitating is discarded, ethyl alcohol is added in gained water extract, liquid is discarded supernatant after staying overnight, mulberry leaf alcohol hypostasis is obtained, by the mulberry leaf alcohol hypostasis
Crushed after being dried obtains mulberry leaf alcohol hypostasis powder;
It is added to the water 4. chrysanthemum is smashed, is heated at 85 DEG C 2 hours, then with 0 DEG C, 5000r/min high speed centrifugation
After 5min, precipitating is discarded, ethyl alcohol is added in gained water extract, liquid is discarded supernatant after staying overnight, chrysanthemum alcohol hypostasis is obtained, by the chrysanthemum
Alcohol hypostasis crushed after being dried obtains chrysanthemum alcohol hypostasis powder;
5. by step curing mixed powder 2., the mulberry leaf alcohol hypostasis powder and step of step 3. chrysanthemum alcohol hypostasis powder 4.,
And xylitol, microcrystalline cellulose, Ultra Tex 2, magnesium stearate are after mixing, and Rice enriched-Se enzyme is then added
Solution dry powder is sufficiently stirred, and described is placed in compression molding in the mold of tablet press machine, obtains the Chinese medicine group of oral tabletting form
Close object.
The beneficial effects of the present invention are: the main material of drug component used in the present invention is in herbaceous plant or food materials, poison
Small side effects reduce the psychological burden of the medication of patient, in addition, first right through the invention substantially with a kind of administration of food form
Rice enriched-Se enzymatic hydrolysis can greatly improve the Se content in oral solution by measuring and calculating, and reason is mainly due to α-amylasehydrolysis
Starch in rice flour makes Starch Conversion monosaccharide or disaccharides and is dissolved in water, and improves content of the protein in rice flour,
And selenium is with protein in rice flour in bonding state, and the selenium ingredient of conjugated protein has been directly facilitated in hydrolytic process from starch
Middle soluble precipitation, so that selenium relative amount be promoted to increase.And due to selenium be the indispensable microelement of human body, its have it is following
Effect: as antioxidant protection biology film integrality.The antioxidant effect of vitamin Wheat Protein, selenium is higher than vitamin
500 times;It participates in composition and removes free radical enzyme system;Natural antidote.Much heavy metals can be resisted and be reduced in vivo to selenium
Toxic effect, such as silver, cadmium, lead, mercury.
In addition, oral tabletting through the invention can preferably improve and conditioning blood sugar, is specifically shown in by clinical test
Embodiment data.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with embodiment to the present invention make into
One step it is described in detail.
[embodiment]
The Chinese medicine composition is oral tabletting form, is made of the raw material of following components, in terms of mass fraction:
30 parts of Rice enriched-Se, 20 parts of mulberry leaf, 9 parts of chrysanthemum, 7 parts of smilax, 18 parts of dioscorea japonica, 12 parts of pueraria lobata, 4 parts of xylitol,
3 parts of microcrystalline cellulose, 3 parts of Ultra Tex 2,4 parts of magnesium stearate.
Preparation method, comprising the following steps:
1. Rice enriched-Se is crushed into powder in pulverizer, 200 meshes are then crossed, which is passed through into microwave heating
Mode, by every 100g mixed powder by 800 watts in a manner of 2 minutes it is heat aging, alpha-amylase is then added and is digested, when enzymatic hydrolysis
Between be 3 days, then enzymolysis liquid is boiled, is subsequently placed in centrifuge, 2000 revs/min son centrifugation 20 minutes, take upper layer newborn
The clear liquid, is then freeze-dried by the Rice enriched-Se clear liquid of white, obtains Rice enriched-Se enzymatic hydrolysis dry powder;Richness of the present invention
Selenium rice preferably uses the Rice enriched-Se in Poyang Lake in Jiangxi province area.2. smilax, dioscorea japonica and pueraria lobata are crushed in pulverizer together
Then Cheng Fen crosses 200 meshes, obtains mixed powder, then by microwave heating, with every 100g mixed powder with 800 watt 2
Minute mode is heat aging, obtains curing mixed powder;
3. the then heating after 1h is soaked in water to mulberry leaf to be concentrated, then with 0 DEG C, 5000r/min high speed centrifugation 5min after,
Precipitating is discarded, ethyl alcohol is added in gained water extract, liquid is discarded supernatant after staying overnight, mulberry leaf alcohol hypostasis is obtained, by the mulberry leaf alcohol hypostasis
Crushed after being dried obtains mulberry leaf alcohol hypostasis powder;
It is added to the water 4. chrysanthemum is smashed, is heated at 85 DEG C 2 hours, then with 0 DEG C, 5000r/min high speed centrifugation
After 5min, precipitating is discarded, ethyl alcohol is added in gained water extract, liquid is discarded supernatant after staying overnight, chrysanthemum alcohol hypostasis is obtained, by the chrysanthemum
Alcohol hypostasis crushed after being dried obtains chrysanthemum alcohol hypostasis powder;
5. by step curing mixed powder 2., the mulberry leaf alcohol hypostasis powder and step of step 3. chrysanthemum alcohol hypostasis powder 4.,
And xylitol, microcrystalline cellulose, Ultra Tex 2, magnesium stearate are after mixing, and Rice enriched-Se enzyme is then added
Solution dry powder is sufficiently stirred, and described is placed in compression molding in the mold of tablet press machine, obtains the Chinese medicine group of oral tabletting form
Close object.Of the invention every kilogram of Se content reaches 800 micrograms or more.
By this setting, the mixed powder of curing can be adhesion-molded with the progress of Rice enriched-Se clear liquid, thus, it is possible to reduce ground
Using the dosage for molding microcrystalline cellulose, Ultra Tex 2, magnesium stearate, improve oral mouthfeel.And
It is extracted by active constituent of the above-mentioned special process to mulberry leaf and chrysanthemum, additional alkaloid can be removed, reduce side effect,
The alcohol hypostasis system's polysaccharide extracted combination, controls its sugar content so as to compare specific aim, is accurately used for blood glucose
Conditioning.
Clinical test:
Random selection is diagnosed as in type 2 diabetic patient 25, and using three times per day, it is aftermeals that one time 6g is oral
With one week as a treatment course.Control group 25 are treated using conventional melbine, and daily early two hours after meal are primary,
One week is 1 course for the treatment of;It is observed continuously 4 weeks.
Criterion of therapeutical effect is drafted referring to State Administration of Traditional Chinese Medicine's Standards for Diagnosis and Curative Effect of Chinese Medical Symptom:
A, cure: clinical symptoms disappear, without recidivist after follow-up half a year;
B, effective: clinical symptoms, sign are substantially reduced;
C, effectively: clinical symptoms, sign mitigate, and seizure frequency is reduced, and the breaking-out duration is shorter;
D, invalid: symptom, sign without improvement or add severe one.
Test group is compared with control group curative effect, and test group conditioning blood sugar 10, total effective rate is up to 80%, with control group 50
Total effective rate 60%, is compared, and is significantly better than control group.Illustrate that the present invention is significant in efficacy in terms of conditioning blood sugar, has good
Good promotional value.
During clinical drug trial of the invention, 20 patients are taken at random, through pretherapy and post-treatment blood, routine urinalysis, liver, kidney function
Energy, electrocardiogram are showed no exception.Illustrate that the medicine is harmless to the human body heart, Liver and kidney function.Clinically also without obvious adverse reaction.
The above disclosure is only the preferred embodiments of the present invention, cannot limit the right model of the present invention with this certainly
It encloses, therefore equivalent changes made in accordance with the claims of the present invention, is still within the scope of the present invention.
Claims (2)
1. a kind of Chinese medicine composition for conditioning blood sugar, it is characterised in that: the Chinese medicine composition is oral tabletting form, by with
The raw material of lower component is made, in terms of mass fraction:
30 parts of Rice enriched-Se, 1 part of alpha-amylase, 20 parts of mulberry leaf, 9 parts of chrysanthemum, 7 parts of smilax, 18 parts of dioscorea japonica, 12 parts of pueraria lobata, wood
4 parts of sugar alcohol, 3 parts of microcrystalline cellulose, 3 parts of Ultra Tex 2,4 parts of magnesium stearate.
2. a kind of preparation method of the Chinese medicine composition for conditioning blood sugar as described in power 1, it is characterised in that including following step
It is rapid:
1. Rice enriched-Se is crushed into powder in pulverizer, 200 meshes are then crossed, which is passed through into microwave heating side
Formula, by every 100g mixed powder by 800 watts in a manner of 2 minutes it is heat aging, alpha-amylase is then added and is digested, enzymolysis time
It is 3 days, then enzymolysis liquid is boiled, is subsequently placed in centrifuge, 2000 revs/min of sons is centrifuged 20 minutes, take upper layer milky white
The clear liquid, is then freeze-dried by the Rice enriched-Se clear liquid of color, obtains Rice enriched-Se enzymatic hydrolysis dry powder;
2. smilax, dioscorea japonica and pueraria lobata are crushed into powder in pulverizer together, 200 meshes are then crossed, mixed powder is obtained,
Then by microwave heating, by every 100g mixed powder by 800 watts in a manner of 2 minutes it is heat aging, obtain curing mixed powder
Body;
3. the then heating after 1h is soaked in water to mulberry leaf to be concentrated, then with 0 DEG C, 5000r/min high speed centrifugation 5min after, discard
Gained water extract is added ethyl alcohol, discards supernatant liquid after staying overnight, obtain mulberry leaf alcohol hypostasis by precipitating, and the mulberry leaf alcohol hypostasis is dry
After crush, obtain mulberry leaf alcohol hypostasis powder;
Be added to the water 4. chrysanthemum is smashed, be heated at 85 DEG C 2 hours, then with 0 DEG C, 5000r/min high speed centrifugation 5min after,
Precipitating is discarded, ethyl alcohol is added in gained water extract, liquid is discarded supernatant after staying overnight, chrysanthemum alcohol hypostasis is obtained, by the chrysanthemum alcohol hypostasis
Crushed after being dried obtains chrysanthemum alcohol hypostasis powder;
5. by step curing mixed powder 2., the mulberry leaf alcohol hypostasis powder and step of step 3. chrysanthemum alcohol hypostasis powder 4. and
After mixing, it is dry that Rice enriched-Se enzymatic hydrolysis is then added in xylitol, microcrystalline cellulose, Ultra Tex 2, magnesium stearate
Powder is sufficiently stirred, and described is placed in compression molding in the mold of tablet press machine, obtains the Chinese medicine composition of oral tabletting form.
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CN102861263A (en) * | 2012-09-24 | 2013-01-09 | 天津鑫瑞生物医药科技有限公司 | Blood glucose reducing preparation made of pure traditional Chinese medicines |
CN104397587A (en) * | 2014-12-18 | 2015-03-11 | 江西省科学院应用化学研究所 | Preparation method of natural selenium-rich rice flake containing high-content SDS (slowly digestible starch) |
CN104435535A (en) * | 2014-11-11 | 2015-03-25 | 郑玉柱 | Health medicament for treating type 2 diabetes mellitus |
CN105456622A (en) * | 2015-12-11 | 2016-04-06 | 苏州泽达兴邦医药科技有限公司 | Traditional Chinese medicinal composition for treating impaired glucose regulation, preparation, and preparation method thereof |
CN106853146A (en) * | 2015-12-08 | 2017-06-16 | 韩丰河 | A kind of Chinese medicine composition for treating diabetes |
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2019
- 2019-05-31 CN CN201910470837.5A patent/CN110090275A/en active Pending
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CN102861263A (en) * | 2012-09-24 | 2013-01-09 | 天津鑫瑞生物医药科技有限公司 | Blood glucose reducing preparation made of pure traditional Chinese medicines |
CN104435535A (en) * | 2014-11-11 | 2015-03-25 | 郑玉柱 | Health medicament for treating type 2 diabetes mellitus |
CN104397587A (en) * | 2014-12-18 | 2015-03-11 | 江西省科学院应用化学研究所 | Preparation method of natural selenium-rich rice flake containing high-content SDS (slowly digestible starch) |
CN106853146A (en) * | 2015-12-08 | 2017-06-16 | 韩丰河 | A kind of Chinese medicine composition for treating diabetes |
CN105456622A (en) * | 2015-12-11 | 2016-04-06 | 苏州泽达兴邦医药科技有限公司 | Traditional Chinese medicinal composition for treating impaired glucose regulation, preparation, and preparation method thereof |
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Title |
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Application publication date: 20190806 |