CN111298052A - Medicine for treating diabetes - Google Patents
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Abstract
The invention discloses a medicine for treating diabetes, which comprises the following raw materials in percentage by weight: 11.1 to 15.1 percent of ginseng fruit, 11.1 to 15.1 percent of polygonatum, 10.1 to 14.1 percent of kudzu root, 10.1 to 14.1 percent of medlar, 10.1 to 12.1 percent of mulberry leaf, 9.1 to 13.1 percent of malt, 8.5 to 12.5 percent of astragalus, 8.5 to 12.5 percent of rhizoma polygonati and 3.4 to 9.4 percent of coptis, and relates to the technical field of medicines. The medicine for treating diabetes mellitus can enhance the immunity and defense line of the organism, resist virus infection and protect the vitality of pancreas by combining the formula; the normal metabolism of islet cells is recovered, and the secretion function of islet B cells is improved; culturing damaged islet B cells to regenerate, strengthen insulin receptor and fully exert the regulation effect of insulin; replenishing trace elements closely related to diabetes mellitus energetically; rapidly reducing blood sugar and urine sugar, and actively preventing and treating complications; the health of the diabetes patient is comprehensively recovered; the Tangshu capsule is only suitable for type II diabetes, and toxicological experiments prove that the Tangshu capsule has no toxic or side effect, is safe, convenient and reliable, has small dosage, is easy to be accepted by patients and has quick and obvious curative effect.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a medicine for treating diabetes.
Background
Diabetes is a generally recognized persistent disease in the world at present, is caused by relative or absolute deficiency of insulin secretion in human bodies, and patients in China reach hundreds of millions of people in recent years. For a long time, Chinese and western medicine are dedicated to overcoming the persistent ailment and providing a plurality of medicines and methods, and the traditional Chinese medicine starts from treating the root cause, treats the symptoms and the symptoms in a dialectical way and deeply extracts related medicines, so that the blood sugar can be quickly and accurately reduced. Not only can control the blood sugar within an ideal range, but also can prevent and delay the occurrence and development of progressive blood vessel and nerve damage of diabetes.
The existing medicines for treating diabetes mellitus are mostly only capable of controlling blood sugar to a certain extent, treating symptoms and not treating the root causes, have poor treatment effect on diabetes mellitus, only play a role in health care in part of medicines for treating diabetes mellitus, and lack of ideal medicines capable of treating both symptoms and root causes quickly and effectively, so that the medicines for treating diabetes mellitus are provided.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a medicine for treating diabetes, which solves the problems that the existing medicine for treating diabetes has poor treatment effect on diabetes, lacks ideal medicines which can be used for treating both symptoms and root causes and can be fast and effectively.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: a medicine for treating diabetes comprises the following raw materials in percentage by weight: 11.1 to 15.1 percent of ginseng fruit, 11.1 to 15.1 percent of polygonatum, 10.1 to 14.1 percent of kudzu root, 10.1 to 14.1 percent of medlar, 10.1 to 12.1 percent of mulberry leaf, 9.1 to 13.1 percent of malt, 8.5 to 12.5 percent of astragalus, 8.5 to 12.5 percent of rhizoma polygonati and 3.4 to 9.4 percent of coptis.
Preferably, the raw materials comprise the following components in percentage by weight: 11.1 percent of ginseng fruit, 11.1 percent of polygonatum, 10.1 percent of kudzuvine root, 10.1 percent of medlar, 10.1 percent of mulberry leaf, 13.1 percent of malt, 12.5 percent of astragalus, 12.5 percent of rhizoma polygonati and 9.4 percent of coptis.
Preferably, the raw materials comprise the following components in percentage by weight: 13.1 percent of ginseng fruit, 13.1 percent of polygonatum, 12.1 percent of kudzuvine root, 12.1 percent of medlar, 11.1 percent of mulberry leaf, 11.1 percent of malt, 10.5 percent of astragalus, 10.5 percent of rhizoma polygonati and 6.4 percent of coptis.
Preferably, the raw materials comprise the following components in percentage by weight: 15.1 percent of ginseng fruit, 15.1 percent of polygonatum, 14.1 percent of kudzuvine root, 14.1 percent of medlar, 12.1 percent of mulberry leaf, 9.1 percent of malt, 8.5 percent of astragalus, 8.5 percent of rhizoma polygonati and 3.4 percent of coptis.
Preferably, the preparation method of the medicine for treating diabetes comprises the following steps:
s1, ultrasonic extraction and crushing: pulverizing commercially available folium Mori with a pulverizing device, sieving with 40 mesh sieve, adding 40 times volume of water into folium Mori powder, soaking for 45min at 80 deg.C, extracting with ultrasonic wave for 10min, concentrating the filtrate, precipitating with ethanol, drying at 70 deg.C, pulverizing into 80-100 mesh folium Mori extract fine powder, and making into material A;
s2: extracting raw materials, namely soaking five raw materials of polygonatum odoratum, medlar, kudzu root, astragalus and sealwort in 10 times of water for 60min, decocting for three times, filtering the three decocted liquids, clarifying by using chitosan and a high-speed tube type centrifuge to obtain a clarified liquid, concentrating the clarified liquid into a paste, drying at 70 ℃, and crushing into 80-100 meshes of fine powder to prepare a material B;
s3: crushing raw materials: after drying, respectively pulverizing commercially available ginseng fruit, malt and coptis root, and sieving with 80-100 mesh fine powder to obtain material C;
s4: stirring raw materials: mixing the material A, the material B and the material C, stirring uniformly by using a stirring device, and filling into a sterilized bag for later use;
s5: preparing capsule granules: at this time, the mixture in S4 is processed by a capsule filling machine, and then filled into capsules 0.6 g each.
Preferably, when the commercially available mulberry leaves in S1 are pulverized by the pulverizing device, the rotation speed of the pulverizing device is controlled at 120r/min and 100-.
Preferably, in the step S2, five raw materials including polygonatum odoratum, medlar, kudzuvine root, astragalus root and rhizoma polygonati are decocted for 2 hours for the first time, 1 hour for the second time and 1 hour for the third time.
Preferably, when the materials A, B and C are mixed and stirred by the stirring device in the step S4, the rotating speed of the stirring device is controlled to be 80-100 r/min.
(III) advantageous effects
The invention provides a medicine for treating diabetes. Compared with the prior art, the method has the following beneficial effects: the medicine for treating diabetes comprises the following raw materials in percentage by weight: 11.1-15.1% of ginseng fruit, 11.1-15.1% of polygonatum odoratum, 10.1-14.1% of kudzu root, 10.1-14.1% of medlar, 10.1-12.1% of mulberry leaf, 9.1-13.1% of malt, 8.5-12.5% of astragalus root, 8.5-12.5% of rhizoma polygonati and 3.4-9.4% of coptis root, S1, ultrasonic extraction and crushing: pulverizing commercially available folium Mori with a pulverizing device, sieving with 40 mesh sieve, adding 40 times volume of water into folium Mori powder, soaking for 45min at 80 deg.C, extracting with ultrasonic wave for 10min, concentrating the filtrate, precipitating with ethanol, drying at 70 deg.C, pulverizing into 80-100 mesh folium Mori extract fine powder, and making into material A; s2: extracting raw materials, namely soaking five raw materials of polygonatum odoratum, medlar, kudzu root, astragalus and sealwort in 10 times of water for 60min, decocting for three times, filtering the three decocted liquids, clarifying by using chitosan and a high-speed tube type centrifuge to obtain a clarified liquid, concentrating the clarified liquid into a paste, drying at 70 ℃, and crushing into 80-100 meshes of fine powder to prepare a material B; s3: crushing raw materials: after drying, respectively pulverizing commercially available ginseng fruit, malt and coptis root, and sieving with 80-100 mesh fine powder to obtain material C; s4: stirring raw materials: mixing the material A, the material B and the material C, stirring uniformly by using a stirring device, and filling into a sterilized bag for later use; s5: preparing capsule granules: processing the mixture in the S4 by a capsule filling machine, and then filling the mixture into No. 0 capsules, wherein each capsule is 0.6 g, and the composition of the formula can enhance the immunity and defense line of the organism, resist virus infection and protect the activity of pancreas; the normal metabolism of islet cells is recovered, and the secretion function of islet B cells is improved; culturing damaged islet B cells to regenerate, strengthen insulin receptor and fully exert the regulation effect of insulin; replenishing trace elements closely related to diabetes mellitus energetically; rapidly reducing blood sugar and urine sugar, and actively preventing and treating complications; the health of the diabetes patient is comprehensively recovered; the Tangshu capsule is only suitable for type II diabetes, toxicological experiments prove that the Tangshu capsule has no toxic or side effect, safety, convenience and reliability, small dosage, easy acceptance by patients and quick and obvious curative effect, and the total effective rate of 95 patients is 93.68 percent when the Tangshu capsule is applied and treated, wherein 56 patients with obvious effect account for 59 percent.
The kudzu root extract has the function of reducing blood sugar: the kudzu root has obvious blood sugar reducing effect on alloxan hyperglycemia, can improve sugar tolerance and also has blood sugar reducing effect on adrenergic hyperglycemia; the concentrated radix Puerariae extract can enter human body in the state of plant molecule, repair and protect islet cells, inhibit glucagon secretion, and promote insulin secretion, thereby reducing blood sugar. Meanwhile, the kudzu root extract can also improve an insulin resistance system, enhance the sensitivity of an insulin receptor, promote the binding affinity with the insulin receptor and improve the biological effect of insulin cells, thereby realizing stable and rapid blood glucose reduction; the kudzu root extract can effectively block the complicating diseases: the kudzu root extract can activate blood vessels of diabetics in a short time, soften blood vessel walls and increase the elasticity of smooth muscles, so that the vascular resistance is reduced, the blood flow speed is increased, the deposition of substances in the blood vessels is reduced, the blood circulation in a human body is improved, and the incidence rate of blood sugar, blood fat and cardiovascular and cerebrovascular diseases is reduced; nephropathy is one of the typical complications of diabetes, and is the main cause of death and disability of diabetics. The high-quality radix puerariae extract of our company has a good inhibition effect on non-enzymatic glycosylation of protein, and can also reduce pericyte damage caused by non-enzymatic glycosylation of protein, the radix puerariae alcohol extract has an obvious inhibition effect on non-enzymatic glycosylation of Human Serum Albumin (HSA), and the inhibition rate is 40%; has obvious inhibiting effect on non-enzymatic glycosylation of lens protein, and the inhibiting rate is 46 percent. Is the best choice for protecting and strengthening the kidney function and is the most direct reason for obviously improving the diabetic retinopathy; the antioxidation of the kudzu root extract: the highly concentrated active component of radix Puerariae extract can effectively scavenge free radicals, inhibit oxidation of pancreatic islet, and effectively scavenge free radicals in human body from different directions in cooperation with selenium polysaccharide. Thereby inhibiting the oxidative damage of tissues such as erythrocyte membranes, liver, spleen, brain and the like, and effectively preventing and controlling diabetes and complications thereof. Besides, it can also raise immunity and memory of human body.
The ginseng fruit saponin and the polygonatum saponin in the medicine have stronger immune function, and particularly have more remarkable effects on humoral immunity and cellular immunity; modern pharmacological research shows that both kudzuvine root and malt have the function of reducing blood sugar.
The traditional Chinese medicines in the formula have strong hypoglycemic effect on hyperglycemia caused by glucose, epinephrine, alloxan, streptozotocin, pancreatic hyperglycemia and the like; besides, the traditional Chinese medicine composition has better prevention and treatment effects on complications such as hypertension, hyperlipidemia, heart disease, cerebral obstruction, stomach and kidney, retinopathy and the like caused by diabetes.
Malt: the malt is rich in nutrition and is a natural substance for reducing blood sugar, and the malt can reduce the blood sugar of rabbits and people by 40% or more by oral administration, and the action can last for 7 hours; the malt contains rich maltose, and is a few nutrient substance which can reduce blood sugar and supplement sugar required by human body. The malt is the preferred health food for the middle-aged and the elderly, especially for women, because the malt belongs to high dietary fiber food, after entering the intestinal tract, the malt can help the intestinal peristalsis, accelerate the nutrient absorption and food emptying in the intestinal tract, take away the fat remained in the intestinal tract, and is beneficial to the metabolism of the human body, so the malt has the reputation of 'intestinal tract scavenger'; both Kudzuvine root and malt have the function of reducing blood sugar. Pure extracts of radix Puerariae, fructus Hordei Germinatus, and fructus Hordei Germinatus extract (selenium-rich powder) have effects of resisting insulin resistance, promoting B cell repair, and enhancing insulin activity. And can reduce blood sugar, improve insulin sensitivity and improve insulin resistance to different degrees.
Berberine has effects of promoting regeneration of injured islet B cells and insulin secretion of residual B cells until islet function is completely recovered, inhibiting hepatic gluconeogenesis, promoting glycolysis of peripheral tissues to glucose, and resisting glycemic hormone.
Medlar and the like contain rich microelements which are closely related to diabetes, particularly chromium elements play an important role in increasing the number and affinity of insulin receptors and reducing blood sugar.
The important components of the mulberry leaves are alkaloid compounds, wherein the most important is deoxynojirimycin, and modern medicine proves that DNJ can inhibit the decomposition of sucrase, maltase, α -glucosaccharase and α -amylase on starch and sugar in a human body after entering the human body, thereby blocking the absorption of the human body on the sugar and inhibiting the rise of blood sugar to achieve the effect of preventing and treating diabetes mellitus, and the 'source sugar control and negative insulin reduction' are the treatment directions of diabetes mellitus accepted by the medical community at present, namely the speed and the quantity of food converted into blood sugar are controlled, the blood sugar is prevented from rising, and the method belongs to the prior control, so that the deoxynojirimycin has the effect of reducing the blood sugar without increasing insulin.
Drawings
FIG. 1 is a flow chart of the manufacturing process of the present invention;
FIG. 2 is a chart comparing the present invention with the market-oriented medicine for treating diabetes;
FIG. 3 is a chart comparing the drugs for diabetes treatment according to the embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-3, an embodiment of the present invention provides a technical solution: the medicine for treating diabetes comprises the following specific embodiments:
example 1
The raw materials comprise the following components in percentage by weight: 11.1 percent of ginseng fruit, 11.1 percent of polygonatum, 10.1 percent of kudzuvine root, 10.1 percent of medlar, 10.1 percent of mulberry leaf, 13.1 percent of malt, 12.5 percent of astragalus, 12.5 percent of rhizoma polygonati and 9.4 percent of coptis.
In the invention, the preparation method of the medicine for treating diabetes comprises the following steps:
s1, ultrasonic extraction and crushing: pulverizing commercially available folium Mori with a pulverizing device, sieving with 40 mesh sieve, adding 40 times volume of water into folium Mori powder, soaking for 45min at 80 deg.C, extracting with ultrasonic wave for 10min, concentrating the filtrate, precipitating with ethanol, drying at 70 deg.C, and pulverizing into 80 mesh folium Mori extract fine powder to obtain material A;
s2: extracting raw materials, namely soaking five raw materials of polygonatum odoratum, medlar, kudzu root, astragalus and sealwort in 10 times of water for 60min, decocting for three times, filtering the three decocted liquids, clarifying by using chitosan and a high-speed tube type centrifuge to obtain a clarified liquid, concentrating the clarified liquid into a paste, drying at 70 ℃, and crushing into 80-mesh fine powder to prepare a material B;
s3: crushing raw materials: after drying, respectively crushing commercially available ginseng fruit, malt and coptis root, and sieving the crushed ginseng fruit, malt and coptis root into 80-mesh fine powder to prepare a material C;
s4: stirring raw materials: mixing the material A, the material B and the material C, stirring uniformly by using a stirring device, and filling into a sterilized bag for later use;
s5: preparing capsule granules: at this time, the mixture in S4 is processed by a capsule filling machine, and then filled into capsules 0.6 g each.
In the present invention, when the commercially available mulberry leaves at S1 are pulverized by the pulverizer, the rotation speed of the pulverizer is controlled to 100 r/min.
In the invention, in S2, five raw materials including polygonatum odoratum, medlar, kudzu vine root, astragalus root and sealwort are decocted for 2 hours for the first time, 1 hour for the second time and 1 hour for the third time.
In the invention, when the material A, the material B and the material C are mixed and stirred by the stirring device in the step S4, the rotating speed of the stirring device is controlled to be 80 r/min.
Example 2
The raw materials comprise the following components in percentage by weight: 13.1 percent of ginseng fruit, 13.1 percent of polygonatum, 12.1 percent of kudzuvine root, 12.1 percent of medlar, 11.1 percent of mulberry leaf, 11.1 percent of malt, 10.5 percent of astragalus, 10.5 percent of rhizoma polygonati and 6.4 percent of coptis.
In the invention, the preparation method of the medicine for treating diabetes comprises the following steps:
s1, ultrasonic extraction and crushing: pulverizing commercially available folium Mori with a pulverizing device, sieving with 40 mesh sieve, adding 40 times volume of water into folium Mori powder, soaking for 45min at 80 deg.C, extracting with ultrasonic wave for 10min, concentrating the filtrate, precipitating with ethanol, drying at 70 deg.C, and pulverizing into 90 mesh folium Mori extract fine powder to obtain material A;
s2: extracting raw materials, namely soaking five raw materials of polygonatum odoratum, medlar, kudzu root, astragalus and sealwort in 10 times of water for 60min, decocting for three times, filtering the three decocted liquids, clarifying by using chitosan and a high-speed tube type centrifuge to obtain a clarified liquid, concentrating the clarified liquid into a paste, drying at 70 ℃, and crushing into 90-mesh fine powder to prepare a material B;
s3: crushing raw materials: after drying, respectively crushing commercially available ginseng fruit, malt and coptis root, and sieving the crushed ginseng fruit, malt and coptis root into 90-mesh fine powder to prepare a material C;
s4: stirring raw materials: mixing the material A, the material B and the material C, stirring uniformly by using a stirring device, and filling into a sterilized bag for later use;
s5: preparing capsule granules: at this time, the mixture in S4 is processed by a capsule filling machine, and then filled into capsules 0.6 g each.
In the present invention, when the commercially available mulberry leaves at S1 are pulverized by the pulverizer, the rotation speed of the pulverizer is controlled to 110 r/min.
In the invention, in S2, five raw materials including polygonatum odoratum, medlar, kudzu vine root, astragalus root and sealwort are decocted for 2 hours for the first time, 1 hour for the second time and 1 hour for the third time.
In the invention, when the material A, the material B and the material C are mixed and stirred by the stirring device in the step S4, the rotating speed of the stirring device is controlled at 90 r/min.
Example 3
The raw materials comprise the following components in percentage by weight: 15.1 percent of ginseng fruit, 15.1 percent of polygonatum, 14.1 percent of kudzuvine root, 14.1 percent of medlar, 12.1 percent of mulberry leaf, 9.1 percent of malt, 8.5 percent of astragalus, 8.5 percent of rhizoma polygonati and 3.4 percent of coptis.
In the invention, the preparation method of the medicine for treating diabetes comprises the following steps:
s1, ultrasonic extraction and crushing: pulverizing commercially available folium Mori with a pulverizing device, sieving with 40 mesh sieve, adding 40 times volume of water into folium Mori powder, soaking for 45min at 80 deg.C, extracting with ultrasonic wave for 10min, concentrating the filtrate, precipitating with ethanol, drying at 70 deg.C, and pulverizing into 100 mesh folium Mori extract fine powder to obtain material A;
s2: extracting raw materials, namely soaking five raw materials of polygonatum odoratum, medlar, kudzu root, astragalus and sealwort in 10 times of water for 60min, decocting for three times, filtering the three decocted liquids, clarifying by using chitosan and a high-speed tube type centrifuge to obtain a clarified liquid, concentrating the clarified liquid into a paste, drying at 70 ℃, and crushing into 100-mesh fine powder to prepare a material B;
s3: crushing raw materials: after drying, respectively crushing commercially available ginseng fruit, malt and coptis root, and sieving the crushed ginseng fruit, malt and coptis root fine powder by 100 meshes to prepare a material C;
s4: stirring raw materials: mixing the material A, the material B and the material C, stirring uniformly by using a stirring device, and filling into a sterilized bag for later use;
s5: preparing capsule granules: at this time, the mixture in S4 is processed by a capsule filling machine, and then filled into capsules 0.6 g each.
In the present invention, when the commercially available mulberry leaves at S1 are pulverized by the pulverizer, the rotation speed of the pulverizer is controlled to 120 r/min.
In the invention, in S2, five raw materials including polygonatum odoratum, medlar, kudzu vine root, astragalus root and sealwort are decocted for 2 hours for the first time, 1 hour for the second time and 1 hour for the third time.
In the present invention, when the material A, the material B and the material C are mixed and stirred by the stirring device in the step S4, the rotation speed of the stirring device is controlled at 100 r/min.
Clinical experiments
Example 1 Shen De Zhi: male 71 year old famous painter, patient self-documented: the doctor lets take insulin for more than ten years, the insulin is taken for 3 times every day, 20 units are taken in the morning, 15 units are taken in the noon and 15 units are taken in the evening, and the blood sugar before meals can be controlled to be about 8.5 mmol/L. The people have suffered from cerebral embolism, cataract and serious eye strain, which greatly influences our career.
Tangshu tablets were taken three times a day, two tablets each time, at 1 month of 2012, with constant insulin dosage. After the Tangshu tablets are taken for one month, the blood sugar before meals is reduced to 6mmol/L, the whole body becomes vigorous, and eyes are bright; at the moment, I begin to reduce the dosage of insulin, beat 3 times a day with 15 units in the morning, 10 units in the noon and 15 units in the evening; then, the dosage of insulin is gradually reduced according to the condition of blood sugar, the insulin is completely stopped within four months, only the Tangshu tablet is taken, the blood sugar control is very stable, the body is vigorous, eyes are good, and fine lines are also clearly seen when the Tangshu tablet is drawn. Tangshu tablet not only cures our diabetes, but also cures many syndromes, and happy I uses a painting brush to express the mood for expelling the disease magic, and draws at the moment just like flowing of elegant air, and the pen is quiet and red, and the pen is led to the spirit.
Example 2: zhang Yuling: female 70 year old famous painter, patient self-written: after the patient suffers from the diabetes for more than 20 years, the highest fasting blood sugar reaches 20.5mmol/L, western medicines are taken at the beginning, and the blood sugar can not be adjusted later, so that the doctor can take insulin for ten years, the insulin is taken for 3 times every day, 15 units are taken in the morning, 10 electric potentials are taken at noon and 10 electric potentials are taken at night, and the blood sugar before meals can be controlled to be about 8.5 mmol/L. The eyes are spent as early as possible, the painter strokes the eyes, and the painter stops the strokes, so that the diabetes syndrome has great influence on the career.
The Tangshu tablet is taken in one month in 2012, two tablets are taken 3 times a day, and the dosage of the insulin is unchanged. After the Tangshu tablet is taken for one month, the blood sugar before meals is reduced to 6.5mmol/L, the whole body becomes vigorous, and the eyes are bright. At the moment, I start to reduce the insulin dosage to 10 units in the morning, 10 units in the noon and 10 units in the evening, then gradually reduce the insulin dosage according to the blood sugar condition, stop all insulin in four months, only take the Tangshu tablet, the Tangshu tablet is also gradually reduced according to the blood sugar condition, and stop the Tangshu tablet in three months.
At present, I insist on walking for at least one hour every night, eat light food mostly, eat low GI food mostly, and keep blood sugar diseases in a normal range.
Example 3: liu Jian Wei, famous director, five and sixteen years of age this year. Because of working fatigue for many years, diet irregularity often shows more than three and less symptoms, daily emaciation and some dizziness, the doctor visits the hospital for examination in 2019 and 1 month, the blood sugar before meal is 20mmol/L, the glycosylated hemoglobin is 11 percent, and the diabetes is diagnosed. Hospitalization with 40 units of insulin per day, as well as oral delivery of both damekang and baizaipin; after ten days, the blood sugar is reduced to 8.5mmol/L, the glycosylated hemoglobin is 10 percent, and insulin is continuously pumped and the Dameikang and the Baoxepin are taken after discharge. After three months, the inventor finds that the Tangshu tablets are taken three times a day, natto kinase is also taken for the fatty liver, western medicines are completely stopped, and insulin is stopped. After one week, reducing blood sugar to 5.5mmol/L, continuing to use Tangshu tablet and natto, and reducing insulin dosage by one third; one month later, insulin is reduced by one third, three months later, insulin is completely stopped, only two tablets of Tangshu tablets and natto are taken three times a day, blood sugar is kept about 5.5%, and glycosylated hemoglobin is reduced to below 8%. At present, the complexion is ruddy, the sleep is peaceful, the walking becomes forceful, and the director also becomes vigorous.
Comparative experiment
A certain diabetes treatment drug manufacturer respectively selects diabetes treatment drugs in consistent and consistent in the formula preparation process of the embodiments S1-S3 and diabetes treatment drugs in the market to carry out drug effect comparison experiments, as can be seen from figure 2, the diabetes treatment drugs in consistent and consistent in the formula preparation process of the embodiments S1-S3 have blood sugar of 5.7mmol/L after use and the diabetes treatment drugs in the market and the blood sugar of 8.5mmol/L after use, so that the drug efficiency of the diabetes treatment drugs prepared by the invention is far superior to that of the diabetes treatment drugs in consistent and consistent in the market, as can be seen from figure 3, the drug efficiency of the diabetes treatment drugs prepared by the embodiment 2 is the best, and is the optimal scheme; the other two are acceptable.
In conclusion, the combination of the formula can enhance the immunity and defense line of the organism, resist virus infection and protect the activity of pancreas; the normal metabolism of islet cells is recovered, and the secretion function of islet B cells is improved; culturing damaged islet B cells to regenerate, strengthen insulin receptor and fully exert the regulation effect of insulin; replenishing trace elements closely related to diabetes mellitus energetically; rapidly reducing blood sugar and urine sugar, and actively preventing and treating complications; the health of the diabetes patient is comprehensively recovered; the Tangshu capsule is only suitable for type II diabetes, toxicological experiments prove that the Tangshu capsule has no toxic or side effect, safety, convenience and reliability, small dosage, easy acceptance by patients and quick and obvious curative effect, and the total effective rate of 95 patients is 93.68 percent when the Tangshu capsule is applied and treated, wherein 56 patients with obvious effect account for 59 percent.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A medicine for treating diabetes is characterized in that: the raw materials comprise the following components in percentage by weight: 11.1 to 15.1 percent of ginseng fruit, 11.1 to 15.1 percent of polygonatum, 10.1 to 14.1 percent of kudzu root, 10.1 to 14.1 percent of medlar, 10.1 to 12.1 percent of mulberry leaf, 9.1 to 13.1 percent of malt, 8.5 to 12.5 percent of astragalus, 8.5 to 12.5 percent of rhizoma polygonati and 3.4 to 9.4 percent of coptis.
2. A diabetes treatment drug according to claim 1, characterized in that: the raw materials comprise the following components in percentage by weight: 11.1 percent of ginseng fruit, 11.1 percent of polygonatum, 10.1 percent of kudzuvine root, 10.1 percent of medlar, 10.1 percent of mulberry leaf, 13.1 percent of malt, 12.5 percent of astragalus, 12.5 percent of rhizoma polygonati and 9.4 percent of coptis.
3. A diabetes treatment drug according to claim 1, characterized in that: the raw materials comprise the following components in percentage by weight: 13.1 percent of ginseng fruit, 13.1 percent of polygonatum, 12.1 percent of kudzuvine root, 12.1 percent of medlar, 11.1 percent of mulberry leaf, 11.1 percent of malt, 10.5 percent of astragalus, 10.5 percent of rhizoma polygonati and 6.4 percent of coptis.
4. A diabetes treatment drug according to claim 1, characterized in that: the raw materials comprise the following components in percentage by weight: 15.1 percent of ginseng fruit, 15.1 percent of polygonatum, 14.1 percent of kudzuvine root, 14.1 percent of medlar, 12.1 percent of mulberry leaf, 9.1 percent of malt, 8.5 percent of astragalus, 8.5 percent of rhizoma polygonati and 3.4 percent of coptis.
5. A diabetes treatment drug according to any one of claims 1 to 4, characterized in that: the preparation method specifically comprises the following steps:
s1, ultrasonic extraction and crushing: pulverizing commercially available folium Mori with a pulverizing device, sieving with 40 mesh sieve, adding 40 times volume of water into folium Mori powder, soaking for 45min at 80 deg.C, extracting with ultrasonic wave for 10min, concentrating the filtrate, precipitating with ethanol, drying at 70 deg.C, pulverizing into 80-100 mesh folium Mori extract fine powder, and making into material A;
s2: extracting raw materials, namely soaking five raw materials of polygonatum odoratum, medlar, kudzu root, astragalus and sealwort in 10 times of water for 60min, decocting for three times, filtering the three decocted liquids, clarifying by using chitosan and a high-speed tube type centrifuge to obtain a clarified liquid, concentrating the clarified liquid into a paste, drying at 70 ℃, and crushing into 80-100 meshes of fine powder to prepare a material B;
s3: crushing raw materials: after drying, respectively pulverizing commercially available ginseng fruit, malt and coptis root, and sieving with 80-100 mesh fine powder to obtain material C;
s4: stirring raw materials: mixing the material A, the material B and the material C, stirring uniformly by using a stirring device, and filling into a sterilized bag for later use;
s5: preparing capsule granules: at this time, the mixture in S4 is processed by a capsule filling machine, and then filled into capsules 0.6 g each.
6. The method for preparing a medicine for treating diabetes according to claim 5, wherein the medicine comprises: when the commercially available mulberry leaves in the S1 are crushed by the crushing device, the rotating speed of the crushing device is controlled at 120r/min and 100-.
7. The method for preparing a medicine for treating diabetes according to claim 5, wherein the medicine comprises: in the step S2, five raw materials including polygonatum odoratum, Chinese wolfberry, kudzu vine root, astragalus root and sealwort are decocted for 2 hours for the first time, 1 hour for the second time and 1 hour for the third time.
8. The method for preparing a medicine for treating diabetes according to claim 5, wherein the medicine comprises: and in the step S4, when the material A, the material B and the material C are mixed and stirred by the stirring device, the rotating speed of the stirring device is controlled to be 80-100 r/min.
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| CN111643641A (en) * | 2020-07-08 | 2020-09-11 | 上海中医药大学 | Food therapy formula for clearing heat, invigorating spleen and tonifying kidney and preparation method and application thereof |
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| CN111643641A (en) * | 2020-07-08 | 2020-09-11 | 上海中医药大学 | Food therapy formula for clearing heat, invigorating spleen and tonifying kidney and preparation method and application thereof |
| CN111643641B (en) * | 2020-07-08 | 2022-02-11 | 上海中医药大学 | Food therapy formula for clearing heat, invigorating spleen and tonifying kidney and preparation method and application thereof |
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