CN108651993A - A kind of male health-care composition, preparation and the preparation method and application thereof - Google Patents
A kind of male health-care composition, preparation and the preparation method and application thereof Download PDFInfo
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- CN108651993A CN108651993A CN201810864650.9A CN201810864650A CN108651993A CN 108651993 A CN108651993 A CN 108651993A CN 201810864650 A CN201810864650 A CN 201810864650A CN 108651993 A CN108651993 A CN 108651993A
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- PWAOOJDMFUQOKB-WCZZMFLVSA-N ginsenoside Re Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@H]3[C@@]([C@@]4(CC[C@@H]([C@H]4[C@H](O)C3)[C@](C)(CCC=C(C)C)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C)(C)C2)O[C@H](CO)[C@@H](O)[C@@H]1O PWAOOJDMFUQOKB-WCZZMFLVSA-N 0.000 description 1
- AOGZLQUEBLOQCI-UHFFFAOYSA-N ginsenoside-Re Natural products CC1OC(OCC2OC(OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C2O)C(O)C(O)C1O AOGZLQUEBLOQCI-UHFFFAOYSA-N 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 239000008361 herbal raw material Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical group [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000010630 lipid peroxidation (MDA) assay Methods 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229940101270 nicotinamide adenine dinucleotide (nad) Drugs 0.000 description 1
- 235000020956 nicotinamide riboside Nutrition 0.000 description 1
- 239000011618 nicotinamide riboside Substances 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical class [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035806 respiratory chain Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of male health-care compositions, including raw material and auxiliary material, raw material in parts by weight, including 1 10 parts of nicotinamide adenine dinucleotide, 1 10 parts of protopanoxadiols, 28 parts of Herba Epimedii secondary glycosides I, 3 10 parts of precious leaves of pulse plants glycosides I, 29 parts of dehydrobenzenes and 1 10 parts of ursodesoxycholic acid.Above-mentioned composition prescription, proportioning are reasonable, compatibility is proper, wherein NADH, protopanoxadiol (PPD), Herba Epimedii secondary glycosides I, precious leaves of pulse plants glycosides I synergistic effects, fully adjustable gonad axis, kidney-replenishing, tonifying liver, long-term use can delay gonad axis aging periods, improve sexual function, the composition meets traditional Chinese medicine and modern medicine is theoretical, it is easy to use, good absorption effect has good palatability without bad and toxic side effect, it is taken especially suitable for male, alleviates or improve the various symptoms of male senility syndrome.Preparation and preparation process containing the composition are additionally provided, preparation method is simple, and mild condition is suitable for industrialized mass production.
Description
Technical field
The invention belongs to health product production technical fields, are related to a kind of male health-care product, relate in particular to one kind
Male health-care composition, preparation and the preparation method and application thereof.
Background technology
Generally, the function of male to male sex hormone after 50 years old can gradually fail, especially point of testis sterone
Secreting can gradually decrease, and due to the variation of this hormone in vivo secretion, produce certain somatopsychic disturbance, clinical manifestation is psychiatric
Symptom, such as neuroticism, emotional lability, emotional, irritable, temperish, burnout, often there is sense of depression, memory, thinking ability
And aprosexia, sleep is reduced, interest declines, feels depressed, reacting slow etc., and is often accompanied by uneasiness, fear, feeling of lonely, is lacked
Weary self-confidence easily tangles trival matters etc..
To solve the above problems, emerged a large amount of very different male health-care product on the market at present, but it is common
It is that drug is made in the Chinese medicine preparation that basic component is formed that health products, which are all with herbal raw material, and specific active ingredient therein is still not
Bright and clear, and each raw material does not all carry out the purification of bulk pharmaceutical chemicals, active constituent content is low in health products, poor effect, takes for a long time
These traditional Chinese medicine health care products are also easily to body toxic side effect, in addition, Chinese medicine composition is there is also cost height, taste flavor is bitter, makes
The problems such as Preparation Method is complicated, cost of material is high.
Nicotinamide adenine dinucleotide (NADH) is a kind of coenzyme of transmission proton (accurately saying it is hydrogen ion), it occurs
In many metabolic responses of cell, nicotinamide adenine dinucleotide includes the nicotinamide adenine dinucleotide of reduction form
(NADH), also referred to as reduced Coenzyme I, further includes the nicotinamide adenine dinucleotide (NAD) of oxidised form, also referred to as oxidized form is auxiliary
Enzyme I.NADH is a kind of basic redox coenzyme, whether all plays core pivot in respiration or photosynthesis
Knob acts on.In addition, NADH cannot be aoxidized directly by molecular oxygen, but dehydrogenation can be carried out by the effect of nadh dehydrogenase and become
NAD, in respiratory chain, by this effect, but flavine, quinone, cytochromes etc. are gradually reduced, and last oxygen is reduced into
Water.This using NAD is the substrate of medium by O2The approach aoxidized is the oxidative pathway of the main organic matter of aerobe.Mesh
Before, industrial quarters, the world of medicine or the nicotinamide adenine dinucleotide (NADH) that is used as biochemical reagents substantially pass through ferment
Prepared by female bacterium fermentation or external enzymatic, application field and specific pharmacokinetics are also at one in biomedicine field
Early period gropes the phase.There is no product that NADH is applied to male health-care field at present, with provide it is a kind of safe and free of toxic and side effects and
Efficient male health-care product.
Invention content
For this purpose, technical problem to be solved by the present invention lies in existing male health-care product, that there are drug effects is poor, toxic to body
Side effect, active constituent content is low, of high cost, taste is bad, preparation method is complicated, to propose a kind of effect it is good, to human body
It has no toxic side effect, active constituent content is high, of low cost, rich in taste, the simple male health-care composition of preparation process, preparation
And the preparation method and application thereof.
In order to solve the above technical problems, the technical scheme is that：
The present invention provides a kind of male health-care composition, and the male health-care composition includes raw material and auxiliary material, the original
Expect in parts by weight, including 1-10 parts of nicotinamide adenine dinucleotide, 1-10 parts of protopanoxadiols, 2-8 parts of Herba Epimedii are secondary
I, 3-10 parts of precious I, 2-9 parts of dehydrobenzenes of leaves of pulse plants glycosides of glycosides and 1-10 parts of ursodesoxycholic acid.
Preferably, the auxiliary material is in parts by weight, including 1-9 parts of chondroitin sulfates and 2-11 parts of s- gland methionine.
Preferably, the auxiliary material is in parts by weight, further include 1-5 parts of vitamin Es, 2-4 parts of zinc, 3-5 parts of vitamin Bs,
1-4 portions of Chinese yams, 2-5 portions of puncture vines, 2-4 portions of raspberries and 1-3 parts of leek seeds.
The present invention also provides a kind of male health-care preparations comprising the composition.
The present invention also provides a kind of methods preparing the male health-care preparation comprising following steps：
S1, raw material and auxiliary material are crossed into 30-80 mesh sieve respectively, keeps grain graininess uniform；
S2, proportionally raw material, auxiliary material and water stirred at 25-40 DEG C；
S3,1h is stirred to get male health-care aqua after the obtained mixtures of step S2 are warming up to 50 DEG C.
The present invention also provides a kind of methods preparing the male health-care preparation comprising following steps：
S1, dry major ingredient and auxiliary material each component are crossed to 60 mesh sieve, and mixing of weighing in proportion；
Whole grain and compressing tablet process are carried out after S2, the mixture drying for obtaining step S1, obtains male health-care tablet.
The present invention also provides a kind of methods preparing the male health-care preparation comprising following steps：
S1, major ingredient and auxiliary material each component are crossed to 60 mesh sieve, and mixing of weighing in proportion；
S2, the obtained mixtures of step S1 are filled in flexible glue utricule, and pass through pelleting, sizing drying, washes ball, dries in the air
Ball picks up the step of ball, obtains male health-care soft capsule.
The present invention also provides a kind of methods preparing the male health-care preparation, which is characterized in that includes the following steps：
S1, auxiliary material component is crushed as particle, addition ethyl alcohol and heating and refluxing extraction 2h, the additive amount of ethyl alcohol into particle
It it is 5 times of component particles quality, first time filtration treatment obtains the dregs of a decoction and liquid, and the ethyl alcohol that the dregs of a decoction are measured with 3 times is heated to reflux
1h is extracted, second of filtration treatment mixes the liquid being obtained by filtration for the first time, for the second time, and is concentrated under reduced pressure and is made relatively close
Degree is that the thick paste of 1.35-1.4 is spare；
S2, the water that the obtained thick pastes of step S1 are added to 7 times of amounts, heating and refluxing extraction 4h obtain volatile oil, the dregs of a decoction and liquid
Mixture, point take the volatile oil, and the dregs of a decoction and medical filtration are detached, obtain supernatant and the solid dregs of a decoction；
S3, major ingredient is mixed with the obtained volatile oil of step S2 and the dregs of a decoction, adds the water boiling and extraction 2h of 18 times of amounts, filters
To filtrate and filter residue, filtrate is centrifuged, obtains the first supernatant；By filter residue plus 12 times of water boiling and extraction 1h measured, filtering
Filtrate and filter residue are obtained, filtrate is centrifuged, obtains the second supernatant；By the first supernatant, the second supernatant and step S2
In supernatant mixing, be concentrated under reduced pressure be made relative density be 1.35-1.4 thick paste it is spare；
S4, it by dextrin, superfine silica gel powder mixing and is stirred together for uniformly with thick paste made from step S3, the mixture that will be obtained
After drying and crushing, dextrin is added, spray into sieving after the obtained volatile oil of step S2, mixing and is packed into capsule shells, obtains male
Health-caring capsule.
Preferably, the volumetric concentration of the ethyl alcohol is 70%.
The present invention also provides a kind of male health-care compositions to support kidney health products, the immune force health-care of raising in nourishing liver
Application in product, anti-aging health care product, improvement memory health products.
The above technical solution of the present invention has the following advantages over the prior art：
Male health-care composition of the present invention, including raw material and auxiliary material, raw material in parts by weight, including 1-10 parts of cigarettes
Amide adenine-dinucleotide, 1-10 part protopanoxadiol, precious I, 2-9 parts of the leaves of pulse plants glycosides of 2-8 parts of I, 3-10 parts of Herba Epimedii secondary glycosides are de-
Hydrogen meter androsterone and 1-10 parts of ursodesoxycholic acid.Above-mentioned composition prescription, proportioning are reasonable, and compatibility is proper, wherein NADH, protoplast's ginseng two
Alcohol (PPD), Herba Epimedii secondary glycosides I, precious leaves of pulse plants glycosides I synergistic effects, fully adjustable gonad axis, kidney-replenishing, tonifying liver, long-term use can
Delay gonad axis aging periods, improve sexual function, dehydrobenzene (DHEA) can live Maitong gas, have supplement qi and blood, reduce body
Interior calcium loss, improve sclerotin the effect of, ursodesoxycholic acid can coordinating the drug actions of a prescription, make composition phase and, altogether the replenishing essence of have reinforce the kidney, tonifying Qi lead to
The benefits of arteries and veins arrest sweating, soothing the liver are calmed the nerves, hence it is evident that improve sexual function, anti-aging, improve Abwehrkraft des Koepers, improve sleep, reduce night sweat etc.
The effect of kidney deficiency and bodily weakness.It is theoretical that the composition meets traditional Chinese medicine and modern medicine, easy to use, good absorption effect, without bad and
Toxic side effect has good palatability, is taken especially suitable for male, alleviate or improve the various diseases of male senility syndrome
Shape, the composition, which is put forward for the first time, produces the specific active ingredient such as NADH and Herba Epimedii secondary glycosides I and PPD for male health-care
Product, and by pharmacological evaluation, be aided with specific auxiliary material medicinal material, being capable of raw medicinal material is proliferated spermatid in the side of significantly improving rush
Into effect, synergistic function has occurred in former, auxiliary material.
(2) male health-care composition of the present invention, auxiliary material in parts by weight, including 1-9 parts of chondroitin sulfates and 2-
11 parts of s- gland methionine.Wherein chondroitin sulfate has the function of Maitong gas living, supplement qi and blood, beneficial to activating muscles and bones, s- adenosines
Methionine plays the role of dredging the channel so that the precise and tiny and sufficient qi and blood of chondroitin sulfate is able to be transported in kidney, to which nourshing kidney is hard
The moon further improves male senility syndrome.
Specific implementation mode
Embodiment 1
The present embodiment provides a kind of male health-care composition, the male health-care composition includes raw material and auxiliary material, wherein
The raw material in parts by weight, including 1 part of nicotinamide adenine dinucleotide (NADH), 10 parts of protopanoxadiols (PPD), 2 parts
Herba Epimedii secondary glycosides I, 10 parts of precious leaves of pulse plants glycosides I, 2 parts of dehydrobenzenes (DHEA) and 10 parts of ursodesoxycholic acid.In parts by weight, described
Auxiliary material includes 1 part of chondroitin sulfate and 11 parts of s- gland methionine.
Wherein, NADH is prepared using following technique：(1) crude extract of extraction nicotinamide-nucleotide adenylyltransferase or its is pure
Enzyme, by plasmid pRSET bmj of niacinamide-containing nucleosides adenylyl transferase gene, transformed competence colibacillus bacterial cell
E.coliHB101 is cultivated 24 hours on Luriabroth (LB) tablet (kanamycins containing 100mg/L) at 37 DEG C.Inoculation is single
A be cloned in 5 milliliters of LB liquid mediums (kanamycins containing 100mg/L) is cultivated 20-24 hours at 30 DEG C.It is collected by centrifugation
Thalline, and be suspended in 1 milliliter of 100mM Tris hydrochloride buffer (pH7.5).Then ultrasonic treatment bacterial cell is used.Centrifugation
(at 10 DEG C, with the pelleted by centrifugation 10 minutes of relative centrifugal force 17800g) and supernatant is collected, as thick leach protein is (or thick
Extract).The nicotinamide-nucleotide adenylyltransferase thick leach protein of recombination is heat-treated 10 minutes through 70 DEG C, centrifugation (at 10 DEG C, with
The pelleted by centrifugation of relative centrifugal force 17800g 10 minutes) and supernatant is collected, it obtains nicotinamide-nucleotide adenylyltransferase and slightly carries
Albumen.
(2) thick leach protein for taking step (1) to obtain, with wash enzyme buffer liquid (risHCl/0.001MEDTA of 0.02M,
PH7.0) it is diluted to protein content 5-0mg/ml.By obtained enzyme dilution and PB solution (2.0mol/L potassium dihydrogen phosphates,
PH7.5) isometric mixing, is added epoxy type fixed enzyme vector LX 3000 (10 milligrams of enzymes/gram carrier), in shaking table (rotating speed
It is reacted 20 hours at 25 DEG C in 100rpm), sock filtration is used after the completion of reaction, is cleaned 5-6 times with enzyme buffer liquid is washed, consolidate
Surely change nicotinamide-nucleotide adenylyltransferase.
(3) it uses immobilization nicotinamide-nucleotide adenylyltransferase to prepare nicotinamide adenine dinucleotide, it is molten to prepare substrate
Liquid：The trinosin (ATP) of nicotinamide nucleotide, 10mM containing 5mM, 100mMTris hydrochloride buffers and a concentration of
The MgCl of 10mM2, adjust pH to 7.5.1 milliliter of substrate solution is taken, 0.05 gram of immobilization nicotinamide riboside adenylyl is then added and turns
Enzyme is moved, is reacted 2-20 hours at 37 DEG C.Centrifugation (at 10 DEG C with the pelleted by centrifugation of relative centrifugal force 17800g 15 minutes) is simultaneously
Collect supernatant.The content of nicotinamide adenine dinucleotide in the supernatant as obtained by high pressure liquid chromatography (HPLC) measurement.
Test result shows that the conversion ratio that nicotinamide nucleotide is converted into nicotinamide adenine dinucleotide is more than 80%.
The treasured leaves of pulse plants glycosides I is extracted as follows：Using icariin as raw material, directly beta-glucosidase is used to digest
Icariin prepares baohuoside Ⅰ, cuts off β-D-Glucose of icariin C-7, prepares the baohuoside Ⅰ of high-purity.Study table
Bright, epimedium flavone glycosides is poor in the absorption of enteron aisle, due to hydrolase existing for human body intestinal canal (intestinal mucosa enzyme and enterobacteriaceae
Enzyme) can due to ethnic group, age, disease difference, therefore the hydrolysis of epimedium flavone glycosides can be influenced so influence its absorb and
The performance of curative effect.Hydrolysis is the initial step of epimedium flavone glycosides bioconversion, and deglycosylation makes glucosides be easy to expand in enteron aisle
It dissipates and absorbs.Therefore oral epimedium flavone, is mainly sent out in the form of gut metabolism product (secondary glycosides or aglycon) by absorption
Wave curative effect.The present invention abandoned it is traditional directly use way of the Herba Epimedii as bulk pharmaceutical chemicals, but it is precious to be extracted active ingredient
Leaves of pulse plants glycosides I and epimedium aglucone, this is done so that anti-osteoporosis, and it is stronger to increase the bioactivity such as Male vitality.External selection is high
Imitate safety epimedium flavone glycosides hydrolase, by its it is sweet to barren wort total chromocor be hydrolyzed into aglycon, it is always yellow Herba Epimedii can be enhanced
The bioavilability of ketone is to promote barren wort total chromocor oral absorption, improves drug effect.Traditional method for transformation is generally chemistry acid
Solution or alkaline hydrolysis prepare precious leaves of pulse plants glycosides from icariin, but technique controlling difficulty is big, and the product of degradation is not easy to control, and by-product is more, production
Product yield is low, prior Environmental Factors.Using zymotechnic bioconversion, reaction condition is mild, and specificity is strong, product yield
Height, deglycosylation increase bioavilability.
In above-mentioned composition, PPD derives from ginsenoside, and modern pharmacology research shows the type of the glycosyl of PPD institutes band
Closely related with quantity and its physiological activity, glycosyl is more, and activity is lower.After population takes ginsenoside, the saponin(e of polysaccharide-based
The collective effect by enteric microorganism, saliva enzyme system, enteron aisle enzyme, gastric juice is needed, another structure recurrence drug effect is converted into.This
The exactly difference of Chinese herbal medicine natural component and chemical drugs has directly absorbed drug effect after chemical drugs are oral；Chinese herbal medicine naturally at
It is mostly pro-drug to divide, itself is relatively low without drug effect or drug effect, competence exertion drug effect after only converting in vivo.Such as natural three
Polysaccharide-based ginsenoside Re, Rg1, Rf of alcohols are difficult to penetration cell film, and absorptivity is low, pharmacological activity is low, also cause to get angry
With the side effects such as nose is bleeding.If Re, Rg1, Rf etc., which are converted to F1, Rh1, Rg2 and aglycon, can not only greatly improve absorptivity,
Drug effect can also be increased substantially and reduce toxic side effect.
The present embodiment additionally provides a kind of male health-care aqua, and the male health-care aqua includes above-mentioned composition, described
Aqua is made by the steps：
S1, raw material and auxiliary material crossed to 30-80 mesh sieve respectively, in the present embodiment, is sieved using 50 mesh, keep grain graininess uniform；
S2, proportionally raw material, auxiliary material and water stirred at 25-40 DEG C, the addition of water and former, auxiliary material
The ratio of gross mass is 4：1；
S3,1h is stirred to get male health-care aqua after the obtained mixtures of step S2 are warming up to 50 DEG C.
The male health-care aqua can be used as nourishing liver support kidney health products, improve immunity health products, anti-aging health care product,
Improve memory health products application.
Embodiment 2
The present embodiment provides a kind of male health-care composition, the male health-care composition includes raw material and auxiliary material, wherein
The raw material in parts by weight include 10 parts of nicotinamide adenine dinucleotide (NADH), 1 part of protopanoxadiol (PPD), 8 parts it is excessive
Sheep leaves of pulse plants secondary glycosides I, 3 parts of precious leaves of pulse plants glycosides I, 9 parts of dehydrobenzenes (DHEA) and 1 part of ursodesoxycholic acid.The auxiliary material in parts by weight,
Further include 1 part of vitamin E, 4 parts of zinc, 3 parts of vitamin Bs, 4 parts of Chinese yams, 2 including 9 parts of chondroitin sulfates and 2 parts of s- gland methionine
Part puncture vine, 4 portions of raspberries and 1 part of leek seed.
The present embodiment also provides a kind of male health-care tablet, and the tablet is made by the steps：
S1, dry major ingredient and auxiliary material each component are crossed to 60 mesh sieve, and mixing of weighing in proportion；
S2, the mixture that step S1 is obtained is pelletized in granulator, whole grain is carried out by common process after drying,
And be put into tablet press machine and carry out compressing tablet process, male health-care tablet is obtained, the theoretical piece weight of the tablet is 500mg.
The male health-care tablet can be used as nourishing liver support kidney health products, improve immunity health products, anti-aging health care product,
Improve memory health products application.
Embodiment 3
The present embodiment provides a kind of male health-care composition, the male health-care composition includes raw material and auxiliary material, wherein
The raw material in parts by weight include 6 parts of nicotinamide adenine dinucleotide (NADH), 5 parts of protopanoxadiols (PPD), 5 parts it is excessive
Sheep leaves of pulse plants secondary glycosides I, 7 parts of precious leaves of pulse plants glycosides I, 4 parts of dehydrobenzenes (DHEA) and 6 parts of ursodesoxycholic acid.The auxiliary material in parts by weight,
Including 6 parts of chondroitin sulfates and 7 parts of s- glands methionine, 5 parts of vitamin Es, 2 parts of zinc, 5 parts of vitamin Bs, 1 portion of Chinese yam, 5 portions of puncture vines,
2 portions of raspberries and 3 parts of leek seeds.
The present embodiment also provides a kind of male health-care soft capsule, and the soft capsule is made by the steps：
S1, major ingredient and auxiliary material each component are crossed to 60 mesh sieve, and mixing of weighing in proportion；
S2, the obtained mixtures of step S1 are filled in flexible glue utricule, and pass through pelleting, sizing drying, washes ball, dries in the air
Ball picks up the step of ball, obtains male health-care soft capsule.The flexible glue utricule is prepared with common process：Glycerol and water are added molten
In glue tank, it is then separately added into gelatin and relevant auxiliary materials, flexible glue utricule is made in stirring, vacuum outgas.
The male health-care soft capsule can be used as nourishing liver and support kidney health products, improve immunity health products, anti-aging health care
Product improve memory health products application.
Embodiment 4
The present embodiment provides a kind of male health-care composition, the male health-care composition includes raw material and auxiliary material, wherein
The raw material in parts by weight include 4 parts of nicotinamide adenine dinucleotide (NADH), 7 parts of protopanoxadiols (PPD), 6 parts it is excessive
Sheep leaves of pulse plants secondary glycosides I, 5 parts of precious leaves of pulse plants glycosides I, 7 parts of dehydrobenzenes (DHEA) and 4 parts of ursodesoxycholic acid.The auxiliary material in parts by weight,
Including 4 parts of chondroitin sulfates and 3 parts of s- glands methionine, 3 parts of vitamin Es, 3 parts of zinc, 4 parts of vitamin Bs, 2.5 portions of Chinese yams, 4 parts of punctures
Lamb's-quarters, 3 portions of raspberries and 2 parts of leek seeds.
The present embodiment also provides a kind of male health-care capsule, and the male health-care capsule is made by the steps：
S1, to crush auxiliary material component be coarse granule, and the coarse grained grain size is 50 μm, into particle plus volumetric concentration
70% ethyl alcohol heating and refluxing extraction 2h, the additive amount of ethyl alcohol is 5 times of auxiliary material component particles quality, then at first time filtering
Reason, obtain the dregs of a decoction and liquid, by the dregs of a decoction with 3 times amount ethyl alcohol heating and refluxing extraction 1h, second of filtration treatment, will first time,
The liquid mixing being obtained by filtration for the second time, and it is spare that the thick paste that obtained relative density is 1.35-1.4 is concentrated under reduced pressure；
S2, the water that the obtained thick pastes of step S1 are added to 7 times of amounts, heating and refluxing extraction 4h obtain volatile oil, the dregs of a decoction and liquid
Mixture, point take the volatile oil, and the dregs of a decoction and medical filtration are detached, obtain supernatant and the solid dregs of a decoction；
S3, major ingredient is mixed with the obtained volatile oil of step S2 and the dregs of a decoction, adds the water boiling and extraction 2h of 18 times of amounts, filters
To filtrate and filter residue, filtrate is centrifuged, obtains the first supernatant；By filter residue plus 12 times of water boiling and extraction 1h measured, filtering
Filtrate and filter residue are obtained, filtrate is centrifuged, obtains the second supernatant；By the first supernatant, the second supernatant and step S2
In supernatant mixing, be concentrated under reduced pressure be made relative density be 1.35-1.4 thick paste it is spare；
S4, it by dextrin, superfine silica gel powder mixing and is stirred together for uniformly with thick paste made from step S3, the mixture that will be obtained
After drying and crushing, dextrin is added, spray into sieving after the obtained volatile oil of step S2, mixing and is packed into capsule shells, obtains male
Health-caring capsule.
The male health-care capsule can be used as nourishing liver support kidney health products, improve immunity health products, anti-aging health care product,
Improve memory health products application.
Experimental example
1, security verification
By described in embodiment 2 male health-care composition carry out security verification, using this field conventional authentication method into
Row verification, test result are as follows：
(1) acute toxicity testing shows：According to acute toxicity dose grading standard, true border nontoxicity grade；
(2) Micronucleus test, sperm malformation test, Salmonella reversion test result are feminine gender；
(3) 30 days feeding trials：Experimental animal growing state is good, hematological examination, biochemical analysis, main dirty body ratio
And histology sample material, animal and it is other come to an end fruit compared with the control group, be showed no exception, it was demonstrated that the composition described in embodiment
It is safe and non-toxic.
2, animal experiment
Male Wistar rat 42 is chosen, weight (200 ± 20) g is provided by Lanzhou University's medical experiment animal center,
Adaptability cultivates a couple of days, and rat presses the entrainment illumination in 12h daytime, keeps suitable temperature and relative humidity.Experimental animal
Be randomly divided into normal group, positive controls, the experimental group and 0.1g/ (kg d) (Chinese hollys used in per kilogram rat of 3 various doses
The amount of Qi polysaccharide) polysaccharides control group and 0.1g/ (kg d) (amount of deer blood used in per kilogram rat) deer blood control group, every group
6.3 dosage groups give 0.05,0.1 and 0.2g/ (kg d) (polysaccharides used in per kilogram rat, deer blood composition respectively
Polysaccharide and the sum of deer blood content) composition described in dose delivery example 2 fills with normal saline dilution according to 1mL/ (100g)
Stomach.2 isometric physiological saline of the daily gavage of control group, continuous 14d.In addition to Normal group, remaining each group uses
The methods of Michiharu Miura (Stroke, 2001,32 (5):1201-1207), tepidarium modeling.After modeling for 24 hours, claim
Animal is put to death in weight, femoral artery bloodletting.
(1) femoral artery bloodletting takes serum, serum measured by radioimmunoassay testosterone (T), hypophysis interstitial cell stimulating hormone (LH)
With hypophysis gametogenous hormone (FSH) content.
Experimental data does variance analysis and comparison among groups using SPSS softwares.The result shows that low dose group (0.05g/ (kg
D) rat blood serum T, LSH, FSH sex hormone level) can be significantly improved, has highly significant (P with positive controls comparing difference<
0.01)；Other experimental group Levels of Serum Sex Hormones in Rats improve.Polysaccharides and deer blood group are relative to positive right
According to group, Levels of Serum Sex Hormones in Rats improves, but not as good as each dosage group of composition.Illustrate polysaccharides and deer blood
In conjunction with can preferably protect rat reproductive system, promote the normal development of Testicular Germ Cell.
(2) testis tissue SOD vitality tests and MDA assays：It takes rat side testis to weigh, adds physiological saline, ice
The tissue that mass concentration is 10% is made under bath to be homogenized, takes supernatant quick freeze to preserve after centrifugation, measures SOD in testis tissue
Horizontal and MDA contents, the results are shown in Table 1.
Table 1
| Group | Size of animal (only) | SOD(NU mg/prot) | MDA(NU mg/prot) |
| Normal group | 6 | 315.25±35.14** | 0.72±0.23** |
| Positive controls | 6 | 227.22±15.12 | 2.45±1.33 |
| Low dosage 0.05g (kg d) | 6 | 364.13±41.54** | 1.17±0.67** |
| Middle dosage 0.1g (kg d) | 6 | 265.35±15.43** | 1.42±0.53** |
| High dose 0.2g (kg d) | 6 | 269.35±41.45** | 1.41±0.75** |
| Polysaccharides 0.1g (kg d) | 6 | 258.98±21.43 | 1.62±0.61 |
| Deer blood 0.1g (kg d) | 6 | 269.28±30.43 | 1.44±0.57 |
The above results show that composition, polysaccharides, deer blood described in the embodiment of the present invention can improve rat testicle group
Middle SOD activity is knitted, MDA contents is reduced, enhances Antioxidation Ability of Rats, and the composition described in the embodiment of the present invention compares matrimony vine
The activity of polysaccharide and deer blood group is stronger.Therefore, the present composition has the function of male health-care.
3, clinical trial example
A, case 1
Certain man, 36 years old；Main suit：Operating pressure is big, fatiguability, sexual disorder.
Physical examination：Red tongue body, few tongue, stringy,thready and rapid pulse, spirit is poor, belongs to kidney yang deficiency syndrome sex dysfunction.
Treatment：The preparation described in the embodiment of the present invention 1 is taken, one time a day, each 50ml.
Effect：It is effective to take a course for the treatment of, it is after taking two courses for the treatment of, full of vitality, sexual function is prosperous and powerful.
B, case 2
Certain man, 52 years old；Main suit：Prostatitis, sexual life be uncoordinated, premature ejaculation, defective ejaculation.
Physical examination：Pulse condition heavy thin, inability, pink tongue, tongue are white.Belong to：Sex dysfunction caused by the deficiency of the kidney yin, kidney-yang deficiency,.
Treatment：Preparation described in the embodiment of the present invention 2 is taken, one time a day, every 2.
Effect：Taking a course for the treatment of has that morning is vigorous, and sexual function significantly improves after two courses for the treatment of, follow-up investigation after 1 year, I
Hale and hearty, energy is full, and love life is harmonious.
C, case 3
Certain man, 45 years old；Main suit：Deficient in energy, fatiguability, weak, insomnia are felt, infertility in 5 years after marriage is seen a doctor, defective ejaculation,
Survival rate is low, cures without remarkable result.
Physical examination：Thready and soft pulse is powerless, and without god, category YIN-deficiency type anti-fatigue ability is low, malnutritive, makes smart energy for pale tongue, eye
Power is low.
Treatment：Preparation described in the embodiment of the present invention 3 is taken, one time a day, 2 tablets each time.
Effect：After taking a course for the treatment of, antifatigue significant effect, other symptoms are obviously improved, full of vitality.Take two
After the course for the treatment of, sperm increases, and survival rate improves 30%, adheres to taking three months 1 year, wife's pregnancy.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (10)
1. a kind of male health-care composition, which is characterized in that the male health-care composition includes raw material and auxiliary material, the raw material
In parts by weight, including 1-10 parts of nicotinamide adenine dinucleotide, 1-10 parts of protopanoxadiols, 2-8 parts of Herba Epimedii secondary glycosides
I, 3-10 parts of precious I, 2-9 parts of dehydrobenzenes of leaves of pulse plants glycosides and 1-10 parts of ursodesoxycholic acid.
2. male health-care composition according to claim 1, which is characterized in that the auxiliary material in parts by weight, including 1-9
Part chondroitin sulfate and 2-11 parts of s- gland methionine.
3. male health-care composition according to claim 2, which is characterized in that the auxiliary material in parts by weight, further includes
1-5 parts of vitamin Es, 2-4 parts of zinc, 3-5 parts of vitamin Bs, 1-4 portions of Chinese yams, 2-5 portions of puncture vines, 2-4 portions of raspberries and 1-3 portions of leek
Seed.
4. a kind of male health-care preparation, which is characterized in that including composition as described in any one of claims 1-3.
5. a kind of method preparing male health-care preparation as claimed in claim 4, which is characterized in that include the following steps：
S1, raw material and auxiliary material are crossed into 30-80 mesh sieve respectively, keeps grain graininess uniform；
S2, proportionally raw material, auxiliary material and water stirred at 25-40 DEG C；
S3,1h is stirred to get male health-care aqua after the obtained mixtures of step S2 are warming up to 50 DEG C.
6. a kind of method preparing male health-care preparation as claimed in claim 4, which is characterized in that include the following steps：
S1, dry major ingredient and auxiliary material each component are crossed to 60 mesh sieve, and mixing of weighing in proportion；
Whole grain and compressing tablet process are carried out after S2, the mixture drying for obtaining step S1, obtains male health-care tablet.
7. a kind of method preparing male health-care preparation as claimed in claim 4, which is characterized in that include the following steps：
S1, major ingredient and auxiliary material each component are crossed to 60 mesh sieve, and mixing of weighing in proportion；
S2, the obtained mixtures of step S1 are filled in flexible glue utricule, and pass through pelleting, sizing drying, washes ball, the ball that dries in the air, picks up
The step of ball, obtains male health-care soft capsule.
8. a kind of method preparing male health-care preparation as claimed in claim 4, which is characterized in that include the following steps：
S1, auxiliary material component is crushed as particle, the additive amount of addition ethyl alcohol and heating and refluxing extraction 2h into particle, ethyl alcohol are group
Divide granular mass 5 times, first time filtration treatment obtains the dregs of a decoction and liquid, by the dregs of a decoction and 3 times of ethyl alcohol heating and refluxing extractions measured
1h, second of filtration treatment mix the liquid being obtained by filtration for the first time, for the second time, and obtained relative density is concentrated under reduced pressure and is
The thick paste of 1.35-1.4 is spare；
S2, the water that the obtained thick pastes of step S1 are added to 7 times of amounts, heating and refluxing extraction 4h obtain the mixed of volatile oil, the dregs of a decoction and liquid
Object is closed, divides and takes the volatile oil, and the dregs of a decoction and medical filtration are detached, obtains supernatant and the solid dregs of a decoction；
S3, major ingredient is mixed with the obtained volatile oil of step S2 and the dregs of a decoction, adds the water boiling and extraction 2h of 18 times of amounts, filter is obtained by filtration
Liquid and filter residue, filtrate is centrifuged, and obtains the first supernatant；By filter residue plus 12 times of water boiling and extraction 1h measured, it is obtained by filtration
Filtrate and filter residue, filtrate is centrifuged, and obtains the second supernatant；It will be in the first supernatant, the second supernatant and step S2
Supernatant mixes, and it is spare that the thick paste that obtained relative density is 1.35-1.4 is concentrated under reduced pressure；
S4, by dextrin, superfine silica gel powder mixing and with thick paste made from step S3 be stirred together for uniformly, by obtained mixture dry
And after crushing, dextrin is added, spray into sieving after the obtained volatile oil of step S2, mixing and is packed into capsule shells, obtains male health-care
Capsule.
9. the method for male health-care preparation according to claim 8, which is characterized in that the volumetric concentration of the ethyl alcohol is
70%.
10. a kind of male health-care composition as described in any one of claims 1-3 supports kidney health products, raising immunity in nourishing liver
Application in health products, anti-aging health care product, improvement memory health products.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810864650.9A CN108651993A (en) | 2018-08-01 | 2018-08-01 | A kind of male health-care composition, preparation and the preparation method and application thereof |
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|---|---|---|---|
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ID=63788832
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110237089A (en) * | 2019-06-19 | 2019-09-17 | 泓博元生命科技（深圳）有限公司 | The application of NADH and/or NMN prevention and treatment male erectile dysfunction |
| WO2021202245A1 (en) * | 2020-04-02 | 2021-10-07 | Egaceutical Corporation | Viral treatment regimens |
-
2018
- 2018-08-01 CN CN201810864650.9A patent/CN108651993A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110237089A (en) * | 2019-06-19 | 2019-09-17 | 泓博元生命科技（深圳）有限公司 | The application of NADH and/or NMN prevention and treatment male erectile dysfunction |
| WO2020253493A1 (en) * | 2019-06-19 | 2020-12-24 | 泓博元生命科技（深圳）有限公司 | Use of nadh and/or nmn in prevention and treatment of male erectile dysfunction |
| WO2021202245A1 (en) * | 2020-04-02 | 2021-10-07 | Egaceutical Corporation | Viral treatment regimens |
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