CN110088099B - 作为ehmt2抑制剂的胺取代的杂环化合物及其使用方法 - Google Patents

作为ehmt2抑制剂的胺取代的杂环化合物及其使用方法 Download PDF

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CN110088099B
CN110088099B CN201780078660.3A CN201780078660A CN110088099B CN 110088099 B CN110088099 B CN 110088099B CN 201780078660 A CN201780078660 A CN 201780078660A CN 110088099 B CN110088099 B CN 110088099B
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compound
cancer
methyl
halogen
mmol
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CN110088099A (zh
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约翰·埃默森·坎贝尔
肯尼思·W·邓肯
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Epizyme Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN201780078660.3A 2016-12-19 2017-12-19 作为ehmt2抑制剂的胺取代的杂环化合物及其使用方法 Active CN110088099B (zh)

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US201662436139P 2016-12-19 2016-12-19
US62/436,139 2016-12-19
US201762517840P 2017-06-09 2017-06-09
US62/517,840 2017-06-09
PCT/US2017/067192 WO2018118842A1 (en) 2016-12-19 2017-12-19 Amine-substituted heterocyclic compounds as ehmt2 inhibitors and methods of use thereof

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AU2018353150B2 (en) * 2017-10-18 2024-06-06 Epizyme, Inc. Methods of using EHMT2 inhibitors in treating or preventing blood disorders
MA50418A (fr) * 2017-10-18 2021-04-07 Epizyme Inc Composés hétérocycliques substitués par une amine, utilisés comme inhibiteurs de l'ehmt2, sels de ceux-ci, et leurs méthodes de synthèse
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CN115160297B (zh) 2020-12-22 2023-03-31 益方生物科技(上海)股份有限公司 杂芳基化合物及其制备方法和用途
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TW202325289A (zh) 2021-11-09 2023-07-01 美商雅捷可斯治療公司 Ｊａｋ２抑制劑之形式及組合物
TW202334139A (zh) 2021-11-09 2023-09-01 美商雅捷可斯治療公司 作為ｊａｋ２抑制劑之６－雜芳氧基苯并咪唑及氮雜苯并咪唑
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