CN110088099B - 作为ehmt2抑制剂的胺取代的杂环化合物及其使用方法 - Google Patents

作为ehmt2抑制剂的胺取代的杂环化合物及其使用方法 Download PDF

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CN110088099B
CN110088099B CN201780078660.3A CN201780078660A CN110088099B CN 110088099 B CN110088099 B CN 110088099B CN 201780078660 A CN201780078660 A CN 201780078660A CN 110088099 B CN110088099 B CN 110088099B
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compound
cancer
methyl
halogen
mmol
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CN110088099A (zh
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约翰·埃默森·坎贝尔
肯尼思·W·邓肯
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Epizyme Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D491/04—Ortho-condensed systems
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CN201780078660.3A 2016-12-19 2017-12-19 作为ehmt2抑制剂的胺取代的杂环化合物及其使用方法 Active CN110088099B (zh)

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US201662436139P 2016-12-19 2016-12-19
US62/436,139 2016-12-19
US201762517840P 2017-06-09 2017-06-09
US62/517,840 2017-06-09
PCT/US2017/067192 WO2018118842A1 (en) 2016-12-19 2017-12-19 Amine-substituted heterocyclic compounds as ehmt2 inhibitors and methods of use thereof

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