CN110074995A - A kind of Dandruff-removal composition containing soapberry extract - Google Patents
A kind of Dandruff-removal composition containing soapberry extract Download PDFInfo
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- CN110074995A CN110074995A CN201910423970.5A CN201910423970A CN110074995A CN 110074995 A CN110074995 A CN 110074995A CN 201910423970 A CN201910423970 A CN 201910423970A CN 110074995 A CN110074995 A CN 110074995A
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- dandruff
- soapberry extract
- removal composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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Abstract
The invention discloses a kind of Dandruff-removal compositions containing soapberry extract, are formed using the cation guar gum of moderate charge densities, soapberry extract, ZPT solution and water as raw material.The present invention forms micella using the anionic surfactant package ZPT usually contained in the cationic polymer and shampoo in formula, to overcome the problems, such as that ZPT easy to knot groups, dispersion are non-uniform, it can uniformly be sprawled during hair washing, and reach good debris removing effect.
Description
Technical field
The invention belongs to daily chemical product technical fields, and in particular to a kind of Dandruff-removal composition containing soapberry extract.
Background technique
Zinc pyrithione (ZPT) is the common debris removing agent of shampoo.It is a kind of suspended matter, during making shampoo
Easy to knot groups, dispersion are uneven, cause local accumulation during hair washing that can not uniformly sprawl on scalp.This makes product exist
It has a greatly reduced quality in terms of dandruff-removing itching-relieve effect.Therefore, in the debris removing shampoo containing ZPT, ZPT uniform deposition on scalp how to be made to be
Realize the key factor of its effective debris removing.
Summary of the invention
The purpose of the present invention is to provide a kind of Dandruff-removal compositions containing soapberry extract, ZPT can be overcome in tradition
Easy to knot groups, the non-uniform problem of dispersion, realize good debris removing effect in hair washing product.
To achieve the above object, the present invention adopts the following technical scheme:
A kind of Dandruff-removal composition containing soapberry extract, raw material form percentage are as follows: moderate charge densities
Cation guar gum 0.5%-2.5%, 10wt% soapberry extract 15%-50.0%, 48wt% ZPT solution 2.5%-10.0%, surplus
For deionized water.
Preferably, the raw material of the Dandruff-removal composition containing soapberry extract forms percentage are as follows: medium
The cation guar gum 1.0% of charge density, 10wt% soapberry extract 20%, 48wt% ZPT solution 6%, deionized water 73%.
The charge density of the cation guar gum is 0.72-0.73meq/g.
The ZPT solution is suspension obtained in the polyacrylic acid aqueous solution for be dispersed in zinc pyrithione 1.5vol%.
The Dandruff-removal composition containing soapberry extract the preparation method comprises the following steps: room temperature, weak base (pH 7.0-8.5),
Under the conditions of stirring (80-120r/min), 48wt% ZPT solution is slowly added into 10wt% soapberry extract, and sufficiently mixed
Close 30min；Then the cation guar gum for the moderate charge densities being dissolved in deionized water is added, continues to stir 60min, makes each
Raw material is sufficiently mixed.
The anionic surfactant usually contained in the cationic polymer and shampoo in formula is utilized in the present invention
ZPT is wrapped to form micella, this makes hair washing product prepared therefrom in use, it can be diluted to form wadding glue by a large amount of water,
To make ZPT be brought in scalp surface with wadding glue, and it is made to play good debris removing effect.
Difference with the prior art of the present invention:
1, applicant it has been investigated that, wadding glue forming amount with cation guar gum charge density be incremented by and increase, ZPT sink
Accumulated amount is also incremented by successively；There is glue tendency of excessively wadding a quilt with cotton in the cation guar gum of high charge density, and a large amount of ZPT can be attached to hair
Rather than in scalp surface, hair burden is set to become weight, debris removing effect is deteriorated, therefore should select the cationic Guar of moderate charge densities
Glue.
2, applicant wraps up wadding the study found that when dilution forms wadding glue by carrying out to the debris removing hair washing product containing ZPT
If when partial size≤1 micron ZPT in glue, being easy high aggregation cluster；And when the partial size of ZPT is in 2 microns, wadding glue is just
Often, debris removing significant effect.The present invention utilizes its hydrogen bond action by the way that the soapberry extract containing a large amount of amino, carboxyl is added
Under, absorption and the simultaneous characteristic of repulsive force, so that ZPT uniform particle diameter in wadding glue, and 2 microns are maintained, to have
Being excessively formed for the glue that prevents from wadding a quilt with cotton in the debris removing hair washing product containing ZPT is imitated, ZPT during hair washing is made to be easy to uniformly sprawl, thus
Effectively promote product debris removing effect.It, can be effective when soapberry extract (substance content 10%) additive amount is 20% through testing
It maintains partial size of the ZPT in wadding glue in 2 microns, is obviously improved debris removing effect.
Detailed description of the invention
Fig. 1 by be added soapberry extract (A) be not added soapberry extract (B) institute is formationed wadding glue Electronic Speculum comparison
Figure.
Fig. 2 is to utilize hair washing product (A) made from Dandruff-removal composition of the present invention and commercially available hair washing product (B) after water dilutes
Form the microscopic comparison of wadding glue.
Fig. 3 is the lab diagram being measured in the test of debris removing efficacy assessments.
Specific embodiment
In order to make content of the present invention easily facilitate understanding, With reference to embodiment to of the present invention
Technical solution is described further, but the present invention is not limited only to this.
The preparation of soapberry extract: being crushed to 0.5-3mm for soapberry shell, sieving, by mass volume ratio 1g:6mL
It soaks in water 12 hours, carbohydrase (200,000 unit) then is added by 3g/kg, under conditions of pH value 3.0-6.5, temperature 50 C
Enzymatic hydrolysis 2 hours, later in 95 DEG C destroy the enzyme treatment 30 minutes, be cooled to room temperature and be put into ultracentrifuge to it, with 1.6 ten thousand turns/
Minute centrifugation, takes supernatant to be concentrated into 10%.
The preparation of ZPT solution: suspension is made in the polyacrylic acid aqueous solution that zinc pyrithione is dispersed in 1.5vol%.
The charge density of cation guar gum used is 0.72-0.73meq/g.
Embodiment 1
A kind of Dandruff-removal composition containing soapberry extract, raw material form percentage are as follows: moderate charge densities
Cation guar gum 1%, 10wt% soapberry extract 20.0%, 48wt% ZPT solution 6%, deionized water 73%.
Embodiment 2
A kind of Dandruff-removal composition containing soapberry extract, raw material form percentage are as follows: moderate charge densities
Cation guar gum 0.5%, 10wt% soapberry extract 50.0%, 48wt% ZPT solution 2.5%, deionized water 47%.
Embodiment 3
A kind of Dandruff-removal composition containing soapberry extract, raw material form percentage are as follows: moderate charge densities
Cation guar gum 2.5%, 10wt% soapberry extract 15.0%, 48wt% ZPT solution 10%, deionized water 74.5%.
Dandruff-removal composition containing soapberry extract the preparation method comprises the following steps: room temperature, weak base (pH 7.0-8.5), stirring
Under the conditions of (80-120r/min), 48wt% ZPT solution is slowly added into 10wt% soapberry extract, and is sufficiently mixed
30min；Then the cation guar gum for the moderate charge densities being dissolved in deionized water is added, continues to stir 60min, makes each original
Material is sufficiently mixed.
The preparation of Application Example shampoo
Formula table:
Preparation step:
1, a certain amount of water is weighed into suitable container, is then stirred under the low speed；
2, slowly by carbomer dispersion into water, 20min is stirred；
3, the sodium hydroxide dissolved with water is added in above-mentioned polymer solution, adjusts pH value to 7.0, polymer starts swollen
It is swollen；
4, laureth sodium sulfovinate, CAB, 6501, Dandruff-removal composition under agitation, is added, continues stirring to dissolution；
5, preservative, sodium chloride is added；
6, fragrance is added, stirs 30min；
7, pH value is adjusted in claimed range, continues to stir 20min to get the shampoo.
The evaluation experimental (external biological modelling) of debris removing effect
1. main agents and instrument
Chlosma (ATCC14521), Leeming-Notman medium base, cycloheximide solution；Pharmaceutical grade olive oil；
Pigskin；Anti-dandruff agent be zinc pyrithione (ZPT) (wt%0.1-0.2, it is not soluble in water, be 2.7 × 10 to the MIC of chlosma- 3G/L).Experimental group uses the prepared shampoo (number 1#) of Application Example, and control group uses and do not add anti-dandruff agent
The same money shampoo (number 2#) that ZPT is prepared.
BSC-1100IIA2 Biohazard Safety Equipment；LRH-250A biochemical cultivation case,；YX-280A autoclave sterilizer.
2. test method
2.1 support pretreatments: by pigskin hair and fat meat reject clean, the square piece of the cm of 4 cm × 4 is cut into, using Co60-
Gamma-ray irradiation sterilization treatment.
2.2 weigh 44.0 g of Leeming-Notman medium base in 1 L deionized water, boil to completely molten
Solution, every 80 mL are added 1.6 mL olive oil, are cooled to 50 DEG C or so after high pressure sterilization, and every 80 mL is added 40 under sterile working
Mg cycloheximide solution, preparation LN plate (mm of 90 mm × 15) are spare.100 μ L, 1 × 10 are added dropwise on LN plate5~3 ×
105The chlosma bacteria suspension of CFU/mL, coating are uniformly stand-by.
The test of 2.3 fungistatic effects: shampoo test method: using plate contact method, uniform with 0.5 g hair washing water sample
After wiping 1 min of pig skin surfaces, the shampoo on pigskin is rinsed with 100 mL sterile waters, rinsing time is 1 min, rinsing times
It is 2 times；Pigskin is placed in divulge information to dry in the air in Biohazard Safety Equipment after having rinsed and is attached to pig skin surfaces without obvious water droplet, then by pigskin
On microbiological contamination plate (as shown in Figure 3), the attaching time is 15 min, removes pigskin after the completion of attaching, plate is just being placed in (32 ± 2)
3~4 d are cultivated in DEG C insulating box, observe chlosma growing state.Each sample does parallel laboratory test in 2 groups, and solely by 2 times
The result of vertical experiment compare in parallel between group.
Using availability indexes P characterize antibacterial test as a result, calculation formula is as follows:
P=S1/S0,
In formula, S1 is the area of plate aseptic area, and S0 is the floor space of plate.S1 is calculated using Image J software；S0 is
The floor space of LN plate (mm of 90 mm × 15), with 63.585 cm2Meter；Pigskin area is with 16 cm2Meter.
2.4 debris removing efficacy assessments methods
2.5 result
Test proves that shampoo of the present invention containing ZPT has stronger debris removing effect.
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with
Modification, is all covered by the present invention.
Claims (8)
1. a kind of Dandruff-removal composition containing soapberry extract, it is characterised in that: its raw material forms percentage are as follows:
Cation guar gum 0.5%-2.5%, 10wt% soapberry extract 15%-50.0%, the 48wt% ZPT solution of moderate charge densities
2.5%-10.0%, surplus are deionized water.
2. the Dandruff-removal composition according to claim 1 containing soapberry extract, it is characterised in that: its raw material composition is pressed
Percent by weight are as follows: the cation guar gum 1.0% of moderate charge densities, 10wt% soapberry extract 20%, 48wt% ZPT
Solution 6%, deionized water 73%.
3. the Dandruff-removal composition according to claim 1 or 2 containing soapberry extract, it is characterised in that: the cation
The charge density of guar gum is 0.72-0.73meq/g.
4. the Dandruff-removal composition according to claim 1 or 2 containing soapberry extract, it is characterised in that: the ZPT solution
It is suspension obtained in the polyacrylic acid aqueous solution for be dispersed in zinc pyrithione 1.5vol%.
5. the Dandruff-removal composition according to claim 1 or 2 containing soapberry extract, it is characterised in that: the debris removing group
Close object the preparation method comprises the following steps: under room temperature, weak base, stirring condition, 48wt% ZPT solution is slowly added into 10wt% soapberry
In extracting solution, and it is sufficiently mixed 30min；Then the cation guar gum for the moderate charge densities being dissolved in deionized water is added,
Continue to stir 60min, is sufficiently mixed each raw material.
6. the Dandruff-removal composition according to claim 5 containing soapberry extract, it is characterised in that: the weak base condition
PH is 7.0-8.5.
7. the Dandruff-removal composition according to claim 5 containing soapberry extract, it is characterised in that: the revolving speed of the stirring
For 80-120r/min.
8. a kind of debris removing hair washing product of the Dandruff-removal composition preparation using described in claim 1 containing soapberry extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910423970.5A CN110074995B (en) | 2019-05-21 | 2019-05-21 | Dandruff removing composition containing soapberry extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910423970.5A CN110074995B (en) | 2019-05-21 | 2019-05-21 | Dandruff removing composition containing soapberry extract |
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| Publication Number | Publication Date |
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| CN110074995A true CN110074995A (en) | 2019-08-02 |
| CN110074995B CN110074995B (en) | 2022-04-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910423970.5A Active CN110074995B (en) | 2019-05-21 | 2019-05-21 | Dandruff removing composition containing soapberry extract |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112754983A (en) * | 2021-02-25 | 2021-05-07 | 李岳勿 | Dandruff-removing and itching-relieving shampoo and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999066886A1 (en) * | 1998-06-24 | 1999-12-29 | Unilever Plc | Antimicrobial hair treatment composition |
| CN106333882A (en) * | 2015-07-07 | 2017-01-18 | 上海蓝盎电子科技发展有限公司 | Natural plant shampoo |
| CN108158878A (en) * | 2017-12-25 | 2018-06-15 | 朱浩奇 | A kind of Hair-loss-preventingshampoo shampoo and preparation method thereof |
| CN109363957A (en) * | 2018-12-07 | 2019-02-22 | 胡小龙 | A kind of antidandruff and antipruritic shampoo |
-
2019
- 2019-05-21 CN CN201910423970.5A patent/CN110074995B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999066886A1 (en) * | 1998-06-24 | 1999-12-29 | Unilever Plc | Antimicrobial hair treatment composition |
| CN106333882A (en) * | 2015-07-07 | 2017-01-18 | 上海蓝盎电子科技发展有限公司 | Natural plant shampoo |
| CN108158878A (en) * | 2017-12-25 | 2018-06-15 | 朱浩奇 | A kind of Hair-loss-preventingshampoo shampoo and preparation method thereof |
| CN109363957A (en) * | 2018-12-07 | 2019-02-22 | 胡小龙 | A kind of antidandruff and antipruritic shampoo |
Non-Patent Citations (1)
| Title |
|---|
| 王劲 等: "香波的功效及其配方设计", 《日用化学品科学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112754983A (en) * | 2021-02-25 | 2021-05-07 | 李岳勿 | Dandruff-removing and itching-relieving shampoo and preparation method thereof |
| CN112754983B (en) * | 2021-02-25 | 2022-07-12 | 广州市柏亚化妆品有限公司 | Dandruff-removing and itching-relieving shampoo and preparation method thereof |
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| CN110074995B (en) | 2022-04-08 |
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