CN110074995B

CN110074995B - Dandruff removing composition containing soapberry extract

Info

Publication number: CN110074995B
Application number: CN201910423970.5A
Authority: CN
Inventors: 余水洪; 于�玲; 游丽丽; 欧霖拱
Original assignee: Fujian Research Institute Of Light Industry
Current assignee: Fujian Research Institute Of Light Industry
Priority date: 2019-05-21
Filing date: 2019-05-21
Publication date: 2022-04-08
Anticipated expiration: 2039-05-21
Also published as: CN110074995A

Abstract

The invention discloses a dandruff removing composition containing soapberry extract, which is prepared from cationic guar gum with medium charge density, soapberry extract, ZPT solution and water. The invention utilizes cationic polymer in the formula and anionic surfactant usually contained in shampoo to wrap ZPT to form micelle, so as to overcome the problems of easy agglomeration and uneven dispersion of ZPT, and ensure that the ZPT can be uniformly spread in the process of washing hair, thereby achieving good effect of removing dandruff.

Description

Dandruff removing composition containing soapberry extract

Technical Field

The invention belongs to the technical field of daily chemical articles, and particularly relates to a dandruff removing composition containing a soapberry extracting solution.

Background

Zinc Pyrithione (ZPT) is a commonly used antidandruff agent for shampoos. It is a suspended substance, and is easy to agglomerate and disperse unevenly in the process of preparing shampoo, so that the hair is locally accumulated on scalp and cannot be spread evenly in the process of washing hair. This makes the product far from effective in removing dandruff and relieving itching. Therefore, in the dandruff removing shampoo containing ZPT, how to ensure that ZPT is uniformly deposited on the scalp is a key factor for realizing effective dandruff removal.

Disclosure of Invention

The invention aims to provide a dandruff removing composition containing a soapberry extract, which can overcome the problems of easy agglomeration and uneven dispersion of ZPT in the traditional shampoo products and realize a good dandruff removing effect.

In order to achieve the purpose, the invention adopts the following technical scheme:

a dandruff removing composition containing soapberry extract comprises the following raw materials in percentage by weight: 0.5-2.5% of cationic guar gum with medium charge density, 15-50.0% of 10wt% of soapberry extract, 2.5-10.0% of 48wt% of ZPT solution and the balance of deionized water.

Preferably, the anti-dandruff composition containing the soapberry extract comprises the following raw materials in percentage by weight: 1.0% of cationic guar gum with medium charge density, 10wt% of soapberry extract liquid 20%, 48wt% of ZPT solution 6% and 73% of deionized water.

The charge density of the cationic guar gum is 0.72-0.73 meq/g.

The ZPT solution is a suspension prepared by dispersing zinc pyrithione in a 1.5vol% aqueous solution of polyacrylic acid.

The preparation method of the dandruff removing composition containing the soapberry extract comprises the following steps: slowly adding 48wt% ZPT solution into 10wt% fructus Sapindi Mukouossi extractive solution at room temperature under the conditions of weak base (pH of 7.0-8.5) and stirring (80-120 r/min), and mixing thoroughly for 30 min; then adding cationic guar gum with medium charge density dissolved in deionized water, and continuing stirring for 60min to fully mix the raw materials.

In the invention, the cationic polymer in the formula and the anionic surfactant usually contained in the shampoo are used for coating the ZPT to form micelles, so that the shampoo product prepared from the ZPT can be diluted by a large amount of water to form floccule, and the ZPT is brought to the surface of scalp along with the floccule to play a good anti-dandruff effect.

The difference between the invention and the prior art is as follows:

1. the applicant finds that the formation amount of the flocculation gum increases along with the increment of the charge density of the cationic guar gum, and the deposition amount of the ZPT sequentially increases; cationic guar with high charge density or excessive flocculation tendency is generated, a large amount of ZPT can be attached to the hair instead of the scalp surface, so that the hair is heavily burdened, and the dandruff removing effect is poor, therefore, cationic guar with medium charge density is selected.

2. The applicant researches on the dandruff removing shampoo product containing ZPT, and finds that when the ZPT is diluted to form floccule, the ZPT wrapped in the floccule is easy to highly aggregate into clusters if the particle size of the ZPT is less than or equal to 1 micron; when the particle size of the ZPT is about 2 micrometers, the flocculent gum is normal, and the dandruff removing effect is obvious. The invention adds soapberry extract containing a large amount of amino and carboxyl, and utilizes the characteristic that the adsorption force and the repulsion force exist simultaneously under the action of hydrogen bonds, so that the particle diameter of the ZPT in the flocculent gum is uniform and is maintained at about 2 microns, the excessive formation of the flocculent gum in the scurf-removing shampoo product containing the ZPT is effectively prevented, the ZPT is easy to spread uniformly in the shampoo process, and the scurf-removing effect of the product is effectively improved. Experiments prove that when the addition amount of the soapberry extract (the content of active substances is 10%) is 20%, the particle size of ZPT in the flocculent gum can be effectively maintained to be about 2 micrometers, and the dandruff removing effect is remarkably improved.

Drawings

FIG. 1 is the contrast image of the catkin formed by adding the soapberry extract (A) and not adding the soapberry extract (B) under an electron microscope.

FIG. 2 is an electron microscope contrast image of the floc formed by diluting a shampoo (A) prepared by using the anti-dandruff composition of the invention and a commercially available shampoo (B) with water.

Fig. 3 is an experimental diagram of the measurement performed in the evaluation test of the dandruff removing efficacy.

Detailed Description

In order to make the present invention more comprehensible, the technical solutions of the present invention are further described below with reference to specific embodiments, but the present invention is not limited thereto.

Preparing a soapberry extracting solution: crushing soapberry shells to 0.5-3mm, sieving, adding water according to the mass volume ratio of 1g:6mL for soaking for 12 hours, then adding saccharifying enzyme (20 ten thousand units) according to the mass volume ratio of 3g/kg, carrying out enzymolysis for 2 hours under the conditions of pH value of 3.0-6.5 and temperature of 50 ℃, then carrying out enzyme deactivation treatment for 30 minutes at 95 ℃, placing the mixture into an ultracentrifuge after the mixture is cooled to room temperature, centrifuging at 1.6 ten thousand revolutions per minute, taking supernate and concentrating to 10%.

Preparation of ZPT solution: the zinc pyrithione was dispersed in a 1.5vol% aqueous solution of polyacrylic acid to prepare a suspension.

The charge density of the cationic guar used is between 0.72 and 0.73 meq/g.

Example 1

A dandruff removing composition containing soapberry extract comprises the following raw materials in percentage by weight: 1% of cationic guar gum with medium charge density, 20.0% of 10wt% of soapberry extract, 6% of 48wt% of ZPT solution and 73% of deionized water.

Example 2

A dandruff removing composition containing soapberry extract comprises the following raw materials in percentage by weight: 0.5 percent of cationic guar gum with medium charge density, 50.0 percent of 10 percent of soapberry extract, 2.5 percent of 48 percent of ZPT solution and 47 percent of deionized water.

Example 3

A dandruff removing composition containing soapberry extract comprises the following raw materials in percentage by weight: 2.5 percent of cationic guar gum with medium charge density, 10 percent of soapberry extract 15.0 percent, 48 percent of ZPT solution 10 percent and 74.5 percent of deionized water.

The preparation method of the dandruff removing composition containing the soapberry fruit extracting solution comprises the following steps: slowly adding 48wt% ZPT solution into 10wt% fructus Sapindi Mukouossi extractive solution at room temperature under the conditions of weak base (pH of 7.0-8.5) and stirring (80-120 r/min), and mixing thoroughly for 30 min; then adding cationic guar gum with medium charge density dissolved in deionized water, and continuing stirring for 60min to fully mix the raw materials.

Preparation of shampoo of application examples

A formula table:

the preparation method comprises the following steps:

1. weighing a certain amount of water into a suitable container, and then stirring at a low speed;

2. slowly dispersing carbomer in water, and stirring for 20 min;

3. adding sodium hydroxide dissolved by water into the polymer solution, adjusting the pH value to 7.0, and beginning to expand the polymer;

4. under the condition of stirring, adding sodium laureth sulfate, CAB, 6501 and the dandruff removing composition, and continuously stirring until the sodium laureth sulfate, the CAB, the 6501 and the dandruff removing composition are dissolved;

5. adding antiseptic and sodium chloride;

6. adding spice, and stirring for 30 min;

7. adjusting pH to required range, and stirring for 20min to obtain the shampoo.

Evaluation test of anti-dandruff efficacy (in vitro biological model method)

1. Primary reagents and instruments

Malassezia (ATCC 14521), Leeming-Notman medium base, cycloheximide solution; medicinal grade olive oil; pigskin; the dandruff removing agent is Zinc Pyrithione (ZPT) (wt% 0.1-0.2), is insoluble in water, and has MIC of 2.7 × 10 for Malassezia^-3g/L). The experimental group used the shampoo prepared in the application example (number 1 #), and the control group used the same type of shampoo (number 2 #) prepared without adding the anti-dandruff agent ZPT.

BSC-1100IIA2 biological safety cabinet; LRH-250A biochemical incubator; YX-280A hot steam sterilizer.

2. Test method

2.1 pretreatment of the vector: removing hair and fat from Corii Sus Domestica, cutting into 4 cm × 4 cm square pieces, and processing with Co⁶⁰-gamma irradiation sterilization treatment.

2.2 weighing Leeming-Notman medium base 44.0 g in 1L deionized water, boiling to dissolve completely, adding 1.6 mL olive oil per 80 mL, autoclaving, cooling to about 50 deg.C, adding 40 mg cycloheximide solution per 80 mL under aseptic condition, and preparing LN plate (90 mm × 15 mm) for use. 100. mu.L of 1X 10 beads were added dropwise to LN plates⁵～3×10⁵And (3) uniformly coating the Marasmius bacterial suspension of CFU/mL for later use.

2.3 testing the bacteriostatic effect: the shampoo test method comprises uniformly wiping the surface of Corii Sus Domestica with 0.5 g shampoo sample for 1 min by plate contact method, rinsing with 100 mL sterile water for 1 min for 2 times; after rinsing, placing the pigskin in a biological safety cabinet for ventilation and airing until no obvious water drops exist on the surface of the pigskin, then attaching the pigskin to a bacteria-contaminated flat plate (as shown in figure 3), wherein the attaching time is 15 min, removing the pigskin after the attaching is finished, placing the flat plate in a (32 +/-2) DEG C constant temperature box for culturing for 3-4 d, and observing the growth condition of malassezia. Parallel experiments within 2 groups were performed for each sample and the results of 2 independent experiments were compared in parallel between groups.

The effective index P is adopted to represent the result of the bacteriostasis test, and the calculation formula is as follows:

P=S1/S0，

wherein S1 is the area of the sterile region of the plate, and S0 is the bottom area of the plate. S1 is calculated by Image J software; s0 bottom area of LN flat plate (90 mm × 15 mm), 63.585 cm²Counting; the area of the pigskin is 16 cm²And (6) counting.

2.4 evaluation method of dandruff removing efficacy

2.5 results

Experiments prove that the shampoo containing ZPT has stronger effect of removing dandruff.

The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.

Claims

1. A dandruff-removing composition containing a soapberry extract is characterized in that: the raw materials comprise, by weight, 1.0% of cationic guar gum with medium charge density, 10% of soapberry extract 20%, 48% of ZPT solution 6% and 73% of deionized water;

the charge density of the cationic guar gum is 0.72-0.73 meq/g;

the ZPT solution is a suspension prepared by dispersing zinc pyrithione in 1.5vol% polyacrylic acid aqueous solution;

the soapberry fruit extract is prepared by crushing soapberry fruit shells to 0.5-3mm, sieving, adding water according to the mass volume ratio of 1g to 6mL for soaking for 12 hours, then adding 20 ten thousand units of saccharifying enzyme according to 3g/kg, carrying out enzymolysis for 2 hours under the conditions of pH value of 3.0-6.5 and temperature of 50 ℃, then carrying out enzyme deactivation treatment for 30 minutes at 95 ℃, cooling to room temperature, then placing into an ultracentrifuge, centrifuging at 1.6 ten thousand revolutions per minute, and concentrating the supernatant to 10%;

the preparation method of the anti-dandruff composition comprises the following steps: slowly adding 48wt% ZPT solution into 10wt% fructus Sapindi Mukouossi extractive solution under stirring at room temperature, pH of 7.0-8.5 and 80-120r/min, and mixing thoroughly for 30 min; then adding cationic guar gum with medium charge density dissolved in deionized water, and continuing stirring for 60min to fully mix the raw materials.

2. A dandruff removing shampoo product prepared from the dandruff removing composition comprising soapberry fruit extract according to claim 1.