CN110037986A - 森登-4纳米乳及其制备方法 - Google Patents

森登-4纳米乳及其制备方法 Download PDF

Info

Publication number
CN110037986A
CN110037986A CN201910488867.9A CN201910488867A CN110037986A CN 110037986 A CN110037986 A CN 110037986A CN 201910488867 A CN201910488867 A CN 201910488867A CN 110037986 A CN110037986 A CN 110037986A
Authority
CN
China
Prior art keywords
emulsion
nano
sen
deng
sen deng
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201910488867.9A
Other languages
English (en)
Other versions
CN110037986B (zh
Inventor
乌日娜
都日娜
赵鹏伟
武世奎
高耀星
杨丽敏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Mongolian Medical Hospital Of Inner Mongolia Autonomous Region (mongolian Medical Research Institute Of Inner Mongolia Autonomous Region)
Original Assignee
International Mongolian Medical Hospital Of Inner Mongolia Autonomous Region (mongolian Medical Research Institute Of Inner Mongolia Autonomous Region)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Mongolian Medical Hospital Of Inner Mongolia Autonomous Region (mongolian Medical Research Institute Of Inner Mongolia Autonomous Region) filed Critical International Mongolian Medical Hospital Of Inner Mongolia Autonomous Region (mongolian Medical Research Institute Of Inner Mongolia Autonomous Region)
Priority to CN201910488867.9A priority Critical patent/CN110037986B/zh
Publication of CN110037986A publication Critical patent/CN110037986A/zh
Application granted granted Critical
Publication of CN110037986B publication Critical patent/CN110037986B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/068—Microemulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种森登‑4纳米乳及其制备方法，该纳米乳由乙酸乙酯，无水乙醇，吐温‑80，森登‑4提取液，防腐剂，抗坏血酸和氮酮制备而成。本发明创新性的将传统口服蒙药通过新的制备工作制作成皮肤科外用制剂，用于治疗皮肤疾病和作为护肤品使用，扩大了药物的使用范围。

Description

森登-4纳米乳及其制备方法
技术领域
本发明涉及蒙药领域，具体涉及一种森登-4纳米乳及其制备方法。
背景技术
蒙药复方森登-4汤是蒙医临床常用的抗风湿药，收载于《内蒙古蒙成药标准》。该药由4味组成，按君臣佐使的顺序分别为文冠木15g，川楝子9g，栀子3g，诃子3g，具有清热、燥黄水的功能，用于治疗痛风、关节炎、水肿等病症，现有的中文文献报道除了传统的汤剂，还有胶囊剂，未见其他制剂报道，也未见将该制剂外用的文献报道。
发明内容
为解决上述问题，本发明提供了一种森登-4纳米乳及其制备方法，扩大了药物的使用范围。
为实现上述目的，本发明采取的技术方案为：
森登-4纳米乳，该纳米乳由乙酸乙酯，无水乙醇，吐温-80，森登-4水提液，防腐剂，抗坏血酸和氮酮制备而成。
优选地，由以下组分的原料制备而成：
1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，13.75ml森登-4水提液，0.05g防腐剂，0.05g抗坏血酸，0.5g氮酮。
优选地，由以下组分的原料制备而成：
1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，2.1ml森登-4水提液，3ml醇浸液，8.65ml蒸馏水，0.05g防腐剂，0.05g抗坏血酸，0.5g氮酮。
进一步地，所述森登-4提取液通过以下方法制备所得：
将文冠木、川楝子、诃子、栀子按质量比为5：3：1：1的比例混匀，粉碎，过1号筛，称取适量，加10倍体积的水浸泡24h,过滤，取滤液，即得。
进一步地，所述防腐剂为尼泊金甲酯。
本发明还提供了上述森登-4纳米乳的制备方法，包括如下步骤：
S1、按上述配方称取各组分；
S2、将吐温-80和乙酸乙酯混合搅拌均匀，水温保持在40-60度后，停止搅拌，加入无水乙醇，继续搅拌30min，停止搅拌，用胶头滴管滴加事先加热到40-60度的森登-4水提液，3-8h滴加完成后，于40-60度保温1h,关闭加热，降至常温，加入其他辅料，搅拌均匀，即得。
本发明具有以下有益效果：
创新性的将传统口服蒙药通过新的制备工作制作成皮肤科外用制剂，用于治疗皮肤疾病（修复受损皮肤屏障/痤疮/激素皮炎）和作为护肤品使用，扩大了药物的使用范围。
具体实施方式
下面结合具体实施例对本发明进行详细说明。以下实施例将有助于本领域的技术人员进一步理解本发明，但不以任何形式限制本发明。应当指出的是，对本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进。这些都属于本发明的保护范围。
以下实施例中，所述森登-4提取液通过以下方法制备所得：
将文冠木、川楝子、诃子、栀子按质量比为5：3：1：1的比例混匀，粉碎，过1号筛，称取适量，加10倍体积的水浸泡24h,过滤，取滤液，即得。
实施例1
一种森登-4纳米乳，通过以下方法制备所得：
S1、称取：1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，13.75ml森登-4提取液，0.05g防腐剂（尼泊金甲酯），0.05g抗坏血酸，0.5g氮酮
S2、将吐温-80和乙酸乙酯混合搅拌均匀，水温保持在40-60度后，停止搅拌，加入无水乙醇，继续搅拌30min，停止搅拌，用胶头滴管滴加事先加热到40-60度的森登-4提取液，3-8h滴加完成后，于40-60度保温1h,关闭加热，降至常温，加入其他辅料，搅拌均匀，即得。
实施例2
一种森登-4纳米乳，通过以下方法制备所得：
S1、称取：1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，2.1ml森登-4提取液，3ml醇浸液，8.65ml蒸馏水，0.05g防腐剂（尼泊金甲酯），0.05g抗坏血酸，0.5g氮酮。
S2、将吐温-80和乙酸乙酯混合搅拌均匀，水温保持在40-60度后，停止搅拌，加入无水乙醇，继续搅拌30min，停止搅拌，用胶头滴管滴加事先加热到40-60度的森登-4提取液，3-8h滴加完成后，于40-60度保温1h,关闭加热，降至常温，加入其他辅料，搅拌均匀，即得。
将实施例1和实施例2所得的纳米乳12000r·min-1离心20min,纳米乳液外观仍然澄明、均一，未见分层破乳和药物析出现象。在-4℃，室温，60℃条件下，密闭保存4个月，纳米乳外观未见异常，可见，本发明所得的纳米乳稳定性好。
以上对本发明的具体实施例进行了描述。需要理解的是，本发明并不局限于上述特定实施方式，本领域技术人员可以在权利要求的范围内做出各种变化或修改，这并不影响本发明的实质内容。在不冲突的情况下，本申请的实施例和实施例中的特征可以任意相互组合。

Claims (6)

1.森登-4纳米乳，其特征在于：该纳米乳由乙酸乙酯，无水乙醇，吐温-80，森登-4提取液，防腐剂，抗坏血酸和氮酮制备而成。
2.如权利要求1所述的森登-4纳米乳，其特征在于：由以下组分的原料制备而成：
1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，13.75ml森登-4水提液，0.05g防腐剂，0.05g抗坏血酸，0.5g氮酮。
3.如权利要求1所述的森登-4纳米乳，其特征在于：由以下组分的原料制备而成：
1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，2.1ml森登-4水提液，3ml醇浸液，8.65ml蒸馏水，0.05g防腐剂，0.05g抗坏血酸，0.5g氮酮。
4.如权利要求1-3任一项所述的森登-4纳米乳，其特征在于：所述森登-4提取液通过以下方法制备所得：
将文冠木、川楝子、诃子、栀子按质量比为5：3：1：1的比例混匀，粉碎，过1号筛，称取适量，加10倍体积的水浸泡24h,过滤，取滤液，即得。
5.如权利要求1-3任一项所述的森登-4纳米乳，其特征在于：所述防腐剂为尼泊金甲酯。
6.森登-4纳米乳的制备方法，其特征在于：包括如下步骤：
S1、按权利要求2-3所述的配方称取各组分；
S2、将吐温-80和乙酸乙酯混合搅拌均匀，水温保持在40-60度后，停止搅拌，加入无水乙醇，继续搅拌30min，停止搅拌，用胶头滴管滴加事先加热到40-60度的森登-4水提液，3-8h滴加完成后，于40-60度保温1h,关闭加热，降至常温，加入其他辅料，搅拌均匀，即得。
CN201910488867.9A 2019-06-06 2019-06-06 森登-4纳米乳及其制备方法 Expired - Fee Related CN110037986B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910488867.9A CN110037986B (zh) 2019-06-06 2019-06-06 森登-4纳米乳及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910488867.9A CN110037986B (zh) 2019-06-06 2019-06-06 森登-4纳米乳及其制备方法

Publications (2)

Publication Number Publication Date
CN110037986A true CN110037986A (zh) 2019-07-23
CN110037986B CN110037986B (zh) 2021-11-16

Family

ID=67284631

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910488867.9A Expired - Fee Related CN110037986B (zh) 2019-06-06 2019-06-06 森登-4纳米乳及其制备方法

Country Status (1)

Country Link
CN (1) CN110037986B (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110772572A (zh) * 2019-11-29 2020-02-11 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) 一种森登-4洗剂及其制备方法
CN111544387A (zh) * 2020-04-18 2020-08-18 内蒙古医科大学 一种复方槲皮素抗菌纳米乳及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040940A (zh) * 2007-04-25 2007-09-26 内蒙古医学院 三子洗液
CN101336991A (zh) * 2008-07-28 2009-01-07 内蒙古医学院 治疗妇科外阴瘙痒及阴道炎的药物
CN101721531A (zh) * 2009-12-31 2010-06-09 董玉 森登四味汤有效部位及其制备方法
CN101756988A (zh) * 2009-12-31 2010-06-30 西北农林科技大学 一种复方苦参碱和青藤碱纳米乳制剂及其制备方法
CN107929411A (zh) * 2017-12-22 2018-04-20 纳贡毕力格 一种治疗黄水病的煎膏剂及其制备方法
CN108851284A (zh) * 2018-07-16 2018-11-23 内蒙古医科大学 一种蒙医药物热敷护膝

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040940A (zh) * 2007-04-25 2007-09-26 内蒙古医学院 三子洗液
CN101336991A (zh) * 2008-07-28 2009-01-07 内蒙古医学院 治疗妇科外阴瘙痒及阴道炎的药物
CN101721531A (zh) * 2009-12-31 2010-06-09 董玉 森登四味汤有效部位及其制备方法
CN101756988A (zh) * 2009-12-31 2010-06-30 西北农林科技大学 一种复方苦参碱和青藤碱纳米乳制剂及其制备方法
CN107929411A (zh) * 2017-12-22 2018-04-20 纳贡毕力格 一种治疗黄水病的煎膏剂及其制备方法
CN108851284A (zh) * 2018-07-16 2018-11-23 内蒙古医科大学 一种蒙医药物热敷护膝

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
哈斯塔娜，等: "蒙药四味文冠木汤治疗女性外阴硬化性苔藓的临床疗效观察", 《中国民族医药杂志》 *
王乌云塔娜，等: "外用四味文冠木汤治疗足癣的临床研究", 《内蒙古民族大学学报：蒙医药学版》 *
琪格其图，等: "《现代蒙医学》", 31 July 2002, 辽宁民族出版社 *
蔡霞，等: "纳米乳在透皮给药系统中的应用概况", 《广东药学院学报》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110772572A (zh) * 2019-11-29 2020-02-11 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) 一种森登-4洗剂及其制备方法
CN111544387A (zh) * 2020-04-18 2020-08-18 内蒙古医科大学 一种复方槲皮素抗菌纳米乳及其制备方法
CN111544387B (zh) * 2020-04-18 2021-11-02 内蒙古医科大学 一种复方槲皮素抗菌纳米乳及其制备方法

Also Published As

Publication number Publication date
CN110037986B (zh) 2021-11-16

Similar Documents

Publication Publication Date Title
CN110037986A (zh) 森登-4纳米乳及其制备方法
CN103054008B (zh) 一种灵芝助眠胶囊及其制备方法
CN101795668A (zh) 成纤维细胞增殖剂
CN103054909B (zh) 一种缓解体力疲劳的胶囊及其制备方法
CN110101763A (zh) 森登-4霜剂及其制备方法
CN110123904A (zh) 森登-4喷雾
CN105919906A (zh) 一种美容保健组合物
CN108096091A (zh) 含冬虫夏草提取物的防脱发生发乌发组合物及制备方法
CN105232426A (zh) 一种快速嫩肤型美容组合物及其应用
CN110038061A (zh) 森登-4软膏及其制备方法
CN106916860A (zh) 一种食药用菌发酵产物的制备方法及其应用
CN107334894A (zh) 一种治疗脂溢性脱发的组合物
CN106867808A (zh) 一种复方茯苓保健酒的制备方法
CN105456144B (zh) 一种含茶褐素的洗发水及其制备方法
CN104083300A (zh) 护肤霜的制备方法及其制品
CN103340808B (zh) 一种三七药物晚霜的制备工艺
CN105997745A (zh) 一种具有保湿和防晒功能的粉底液
CN101084940A (zh) 金花葵保健软透明胶囊
CN113413326A (zh) 一种大米酒糟多肽面膜及制备方法和应用
CN107496604A (zh) 一种山茶油纳米乳口服液及其制备方法
CN106120354A (zh) 一种天然植物源防蚊驱蝇微胶囊整理剂及其制备方法和应用
CN105616299B (zh) 一种基于西藏红缨合耳菊的植物美白护肤品及其制备方法
CN105410281A (zh) 一种青钱柳银杏提取物复合茶的制备方法
CN107028847A (zh) 姜根提取物的制备方法和装置以及防脱洗发露组合物
CN1709351A (zh) 一种治疗心脑血管疾病的中药注射剂及其制备方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20211116

CF01 Termination of patent right due to non-payment of annual fee