CN107334894A - 一种治疗脂溢性脱发的组合物 - Google Patents
一种治疗脂溢性脱发的组合物 Download PDFInfo
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- CN107334894A CN107334894A CN201611155550.6A CN201611155550A CN107334894A CN 107334894 A CN107334894 A CN 107334894A CN 201611155550 A CN201611155550 A CN 201611155550A CN 107334894 A CN107334894 A CN 107334894A
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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Abstract
本发明公开了一种治疗脂溢性脱发的组合物及其制备方法,组合物是由下述重量份的原料制得牡丹皮提取物0.1‑5份、侧柏叶提取物0.1‑5份、迷迭香提取物0.1‑5份、茶树提取物0.1‑5份、当归提取物0.1‑5份、黄芪提取物0.1‑5份,墨旱莲提取物0.1‑5份、鼠尾草提取物0.01‑2份、锯棕榈提取物0.01‑2份、啤酒花提取物0.01‑2份、诺丽提取物0.01‑2份、生物素0.01‑0.05份、肌醇0.1‑2份、水解小麦蛋白0.1‑1份、燕麦葡聚糖0.1‑1份、葡萄酸锌0.1‑5份、薄荷0.1‑5份、生物酚乙酸酯0.01‑1份、富勒烯及其相应衍生物0.001‑10份,所述组合物具有预防或治疗脂溢性脱发和雄激素依赖性遗传性脱发的作用。
Description
技术领域
本发明涉及一种医药、化工领域,尤其是涉及一种刺激毛囊促进头发快速生长治疗脂溢性脱发的组合物。
背景技术
脱发(alopecia)是临床常见毛发病,随着生活水平的提高,人们对美容美发的要求日益迫切,现代医学和传统医学对此的研究也越来越受到重视。
脱发,虽不属严重疾病,但却对人们的精神、心理产生较大的影响。随着生活水平的提高,人们对美容美发的要求日益迫切,现代医学和传统医学也越来越重视对脱发的研究。目前临床常见的脱发有以下几种:1、雄激素性脱发(AGA)有家族史,是雄激素依赖性的遗传性脱发病,病理特点是生长期毛囊与休止期毛囊的比例由正常的12:1降低到5:1,毛囊逐渐缩小及毛囊密度由正常成年人的326个cm2,减少到278个cm2。2、斑秃(alopeciaareata)一种功能性疾病,可突然发生于身体任何部位的局限性斑状脱发,神经系统紊乱是重要因素。3、脂溢性脱发也被称为早秃,主要发病机理与遗传、雄性素、皮脂溢出等相关。由于头部油脂分泌过多,头发油腻,从而导致头皮潮湿油腻,空气中的尘埃与头皮屑混杂,几天不洗头就很脏,并散发臭味。
目前,市场上治疗脱发的药物有多种,大体可分为合成药、中药及混合药剂,现有的治疗脱发的产品由于其制备成本高、生发配方合理性方面有缺陷、不能够快速的促进头发的生长,达不到立竿见影的效果。有的药物在使用时还具有一定的疗效,但是患者一旦停药,病情就会复发。例如专利CN200910071736公开了一种治疗脱发的中药组合物,包括熟地、当归、川芎、白术、夜交藤、女贞子、菟丝子、鸡血藤、首乌、鸡内金、山萸肉、仙灵脾、五味子、茯苓、白芍、丹参、侧柏叶、旱莲草、黑芝麻、桑葚子、远志、酸枣仁、合欢皮、羌活、紫草、黄连、黄芪、桃仁、生甘草等组成,治疗斑秃、普秃、全秃及脂溢性脱发有较好疗效。CN201310347018公开一种治疗脱发的中药组合物,其包括15种原料,熟地黄、何首乌、生地黄、山茱萸、墨旱莲、山药、侧柏叶、人参、党参、茯苓、牡丹皮、泽泻、知母、地骨皮、银柴胡。上述专利申请均在秃发、脂溢性皮炎有疗效,对雄激素依赖性的遗传性脱发病疗效不明显。
专利201610482648公开一种生发滋养露及其制备方法,通过从啤酒花、桑椹、何首乌、毛喉鞘蕊花、藏红花、牡丹皮按照合理配比组成的混合料中提取有效成分,改善脱发及改善发质的作用。CN201510025222一种防脱发的洗发护发组合物,含有锯棕榈提取物和柠檬草精作为主要成分,所述组合物有效防止或减少脱发。上述专利仍然没有改善雄激素依赖性的遗传性脱发病疗效不明显。
发明内容
为了解决上述技术问题,本发明提供一种治疗脱发的组合物,该组合物不仅能够治疗秃发,还能治疗脂溢性皮炎性脱发,尤其是对雄激素依赖性的遗传性脱发病有疗效。
本发明一个目的提供该组合物的可接受的剂型。
本发明一个目的是提供了该组合物的制备方法。
本发明还有一个目的是该组合物的用途。
本发明是通过下述技术方案实现的:
一种治疗脂溢性脱发的组合物,其是由下述重量份的原料制得:
牡丹皮提取物0.1-5份、侧柏叶提取物0.1-5份、迷迭香提取物0.1-5份、茶树提取物0.1-5份、当归提取物0.1-5份、黄芪提取物0.1-5份,墨旱莲提取物0.1-5份、鼠尾草提取物0.01-2份、锯棕榈提取物0.01-2份、啤酒花提取物0.01-2份、诺丽提取物0.01-2份、生物素0.01-0.05份、肌醇0.1-2份、水解小麦蛋白0.1-1份、燕麦葡聚糖0.1-1份、葡萄酸锌0.1-5份、薄荷0.1-5份、生物酚乙酸酯0.01-1份、富勒烯及其相应衍生物0.001-10份。
进一步优选,一种治疗脂溢性脱发的组合物,是由下述重量份的原料制得:牡丹皮提取物0.3-3份、侧柏叶提取物0.3-3份、迷迭香提取物0.2-3份、茶树提取物0.1-3份、当归提取物0.2-2份、黄芪提取物0.2-2份,墨旱莲提取物0.2-2份、鼠尾草提取物0.1-2份、锯棕榈提取物0.05-1.5份、啤酒花提取物0.05-1.5份、诺丽提取物0.1-1份、生物素0.01-0.03份、肌醇0.1-1份、水解小麦蛋白0.1-0.5份、燕麦葡聚糖0.1-0.5份、葡萄酸锌0.5-3份、薄荷1-3份、生育酚乙酸酯0.03-0.06份、富勒烯及其相应衍生物0.01-5份。
进一步优选,一种治疗脂溢性脱发的组合物,其是由下述重量份的原料制得:牡丹皮提取物0.3-2.5份、侧柏叶提取物0.3-2.5份、迷迭香提取物0.2-2.5份、茶树提取物0.1-2份、当归提取物0.2-1.5份、黄芪提取物0.2-1.5份,墨旱莲提取物0.2-1.5份、鼠尾草提取物0.1-1.5份、锯棕榈提取物0.08-1.5份、啤酒花提取物0.08-1.5份、诺丽提取物0.08-1份、生物素0.01-0.03份、肌醇0.1-0.5份、水解小麦蛋白0.2-0.4份、燕麦葡聚糖0.2-0.4份、葡萄酸锌2-3份、薄荷1-3份、生育酚乙酸酯0.03-0.06份、富勒烯及其相应衍生物0.01-2份。
更进一步优选,一种治疗脂溢性脱发的组合物,其是由下述重量份的原料制得:牡丹皮提取物0.5-2份、侧柏叶提取物0.5-2份、迷迭香提取物0.5-2份、茶树提取物0.3-1份、当归提取物0.3-1份、黄芪提取物0.3-1份,墨旱莲提取物0.3-1份、鼠尾草提取物0.3-1份、锯棕榈提取物0.1-1份、啤酒花提取物0.1-1份、诺丽提取物0.5-1份、生物素0.01份、肌醇0.1份、水解小麦蛋白0.3份、燕麦葡聚糖0.3份、葡萄酸锌1份、薄荷2份、生物酚乙酸酯0.05份、富勒烯及其相应衍生物0.03-0.6份。
最佳的,一种治疗脂溢性脱发的组合物,其是由下述重量份的原料制得:牡丹皮提取物1份、侧柏叶提取物1份、迷迭香提取物1份、茶树提取物1份、当归提取物1份、黄芪提取物1份,墨旱莲提取物1份、鼠尾草提取物1份、锯棕榈提取物0.3份、啤酒花提取物0.7份、诺丽提取物0.8份、生物素0.01份、肌醇0.1份、水解小麦蛋白0.3份、燕麦葡聚糖0.3份、葡萄酸锌1份、薄荷2份、生物酚乙酸酯0.05份、富勒烯及其相应衍生物0.01份。
本发明另一个技术方案是该治疗脂溢性脱发的组合物与药剂上可接受的载体制成可接受的剂型。本发明的组合物,在制成药剂时,单位剂量的药剂可含有本发明的药物活性物质0.1-1000mg,其余为药学上可接受的载体。药学上可接受的载体以重量计可以是制剂总重量的0.1-99.9%。
本发明治疗脱发的组合物,优选的是单位剂量的药物制剂形式,在制成药物制剂时可以制成任何可药用的剂型。
根据本发明的实施方式之一,本发明的组合物是外用剂型,如凝胶剂、软膏剂、乳剂、敷剂、膏剂等。
本发明的组合物,根据需要可以加入一些药物可接受的载体,可以采用制剂学常规技术制备该药物制剂,如将药物活性物质与药物可接受的载体混合。所述药物可接受的的载体选自:甘露醇、山梨醇、山梨酸或钾盐、焦亚硫酸钠、亚硫酸氢钠、硫代硫酸钠、盐酸半胱氨酸、巯基乙酸、蛋氨酸、维生素A、维生素C、维生素E、维生素D、氮酮、EDTA二钠、EDTA钙钠,一价碱金属的碳酸盐、醋酸盐、磷酸盐或其水溶液、盐酸、醋酸、硫酸、磷酸、氨基酸、氯化钠、氯化钾、乳酸钠、木糖醇、麦芽糖、葡萄糖、果糖、右旋糖苷、甘氨酸、淀粉、蔗糖、乳糖、甘露糖醇、硅衍生物、纤维素及其衍生物、藻酸盐、明胶、聚乙烯吡咯烷酮、甘油、丙二醇、乙醇、土温60-80、司班-80、蜂蜡、羊毛脂、液体石蜡、十六醇、没食子酸酯类、琼脂、三乙醇胺、碱性氨基酸、尿素、尿囊素、碳酸钙、碳酸氢钙、表面活性剂、聚乙二醇、环糊精、β-环糊精、磷脂类材料、高岭土、滑石粉、硬脂酸钙、硬脂酸镁等。
本发明优选所述剂型为水凝胶剂,其组合物与基质重量比(1-5):(5-10),优选3-5:5-7。
所述的基质包括1,3-丁二醇、甲基纤维素,羟乙基纤维素、柠檬酸、透明质酸、LRI(PPG-26丁醇聚醚-26、PEG-40氢化蓖麻油)、EDTA-2Na、卡波姆、阿拉伯胶,安息香胶,琼脂,糊精,明胶,果胶,海藻酸钠,聚丙烯酸、聚乙烯醇、玻璃酸钠中一种或几种。
本发明治疗脂溢性脱发水凝胶剂,其包括下述重量份的原料制成:牡丹皮提取物0.1-5份、侧柏叶提取物0.1-5份、迷迭香提取物0.1-5份、茶树提取物0.1-5份、当归提取物0.1-5份、黄芪提取物0.1-5份,墨旱莲提取物0.1-5份、鼠尾草提取物0.01-2份、锯棕榈提取物0.01-2份、啤酒花提取物0.01-2份、诺丽提取物0.01-2份、生物素0.01-0.05份、肌醇0.1-2份、水解小麦蛋白0.1-1份、燕麦葡聚糖0.1-1份、葡萄酸锌0.1-5份、薄荷0.1-5份、生物酚乙酸酯0.01-1份、富勒烯及其相应衍生物0.001-10份、1,3-丁二醇0.1%-10份、羟乙基纤维素0.01-1份、柠檬酸0.01-1份、透明质酸0.1-10份、LRI 3-20份、EDTA-2Na 0.01-1份,去离子水补充至100%。
进一步优选,本发明治疗脂溢性脱发水凝胶剂,其包括下述重量份的原料:牡丹皮提取物0.3-3份、侧柏叶提取物0.3-3份、迷迭香提取物0.2-3份、茶树提取物0.1-3份、当归提取物0.2-2份、黄芪提取物0.2-2份,墨旱莲提取物0.2-2份、鼠尾草提取物0.1-2份、锯棕榈提取物0.05-1.5份、啤酒花提取物0.05-1.5份、诺丽提取物0.1-1份、生物素0.01-0.03份、肌醇0.1-1份、水解小麦蛋白0.1-0.5份、燕麦葡聚糖0.1-0.5份、葡萄酸锌0.5-3份、薄荷1-3份、生育酚乙酸酯0.03-0.06份、富勒烯及其相应衍生物0.01-2份,1,3-丁二醇0.1%-10份、羟乙基纤维素0.01-1份、柠檬酸0.01-1份、透明质酸2-6份、LRI 4-15份、EDTA-2Na 0.5-1份,去离子水补充至100%。
进一步优选,本发明治疗脱发水凝胶剂,其包括下述重量份的原料药制成:牡丹皮提取物0.5-2份、侧柏叶提取物0.5-2份、迷迭香提取物0.5-2份、茶树提取物0.3-1份、当归提取物0.3-1份、黄芪提取物0.3-1份,墨旱莲提取物0.3-1份、鼠尾草提取物0.3-1份、锯棕榈提取物0.1-1份、啤酒花提取物0.1-1份、诺丽提取物0.5-1份、生物素0.01份、肌醇0.1份、水解小麦蛋白0.3份、燕麦葡聚糖0.3份、葡萄酸锌1份、薄荷2份、生物酚乙酸酯0.05份、富勒烯及其相应衍生物0.03-0.6份。1,3-丁二醇4份、羟乙基纤维素0.1份、柠檬酸0.3份、透明质酸1.5份、LRI 7份、EDTA-2Na 1份、去离子水补充至100%。
本发明的一种治疗脂溢性脱发组合物的制备方法,包括如下步骤:
(1)取侧柏叶提取物,迷迭香提取物,茶树提取物,当归提取物,鼠尾草提取物,黄芪提取物混合均匀得混合物提取物;
(2)将富勒烯及其相应衍生物加入步骤(1)混合提取物中,再加入生育酚乙酸酯和薄荷醇得富勒烯混合物,然后用增溶剂进行增增溶,充分增溶好后,放置过夜,过滤,取上清液I备用;
(3)将牡丹皮提取物,墨旱莲提取物,锯棕榈提取物,啤酒花提取物,诺丽提取物混合均匀后,用水超声提取,然后离心过滤,上清液II备用;
(4)将生物素,肌醇,水解小麦蛋白,燕麦葡聚糖,葡糖酸锌溶解于水得溶液III;
(5)将上述上清液I、上清液II、溶液III混合均匀即得组合物。
上述步骤(2)中上所述的富勒烯及其衍生物可溶解于步骤(1)混合提取物中,优选混合提取物为脂溶性成分。
所述增溶剂为LRI(PPG-26丁醇聚醚-26、PEG-40氢化蓖麻油)。
本发明还提供一种治疗脱发的凝胶剂,包括步骤如下:
(1)将羟乙基纤维素先溶于水中充分溶胀;
(2)将上述组合物中加入上述羟乙基纤维素水溶液中,加入柠檬酸、EDTA-2Na和透明质酸,充分均质,充分陈化后形成凝胶。
上述组合物,制备方法及制剂中,所述的牡丹皮提取物、侧柏叶提取物、迷迭香提取物、茶树提取物、当归提取物、墨旱莲提取物、鼠尾草提取物、锯棕榈提取物、啤酒花提取物、诺丽提取物、薄荷提取物,生物素、肌醇、水解小麦蛋白、燕麦葡聚糖、葡糖酸锌、生育酚乙酸酯均为现有技术制备或者市购。
为了更好的发挥本发明的有益效果,优选包括侧柏叶提取物、侧柏叶提取物、迷迭香提取物、茶树提取物、当归提取物、鼠尾草提取物分别为挥发油成分即侧柏油,迷迭香精油,茶树油,当归精油,鼠尾草精油,黄芪精油。优选牡丹皮提取物,墨旱莲提取物,锯棕榈提取物,啤酒花提取物,诺丽提取物分别为水提取物,例如用水煎煮液。
具体如下:
所述牡丹皮提取物:水浸提物,有抗炎作用,抗菌、抗炎、抗氧化,去屑,止痒。
所述当归提取物:当归精油,造血作用,抗氧化、清除自由基,抗炎镇痛。
所述黄芪提取物:黄芪精油,补气固表,利尿托毒,排脓,敛疮生肌。用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,痈疽难溃,久溃不敛,血虚痿黄,内热消渴。
所述诺丽提取物:诺丽果粉,可活化细胞,滋养脑部。
所述侧柏叶提取物:侧柏油,可减少头屑、缓解皮肤炎症、湿疹、霉菌感染、调理头皮油腻分泌、减少掉头发。
所述迷迭香提取物:迷迭香精油,具有较强的收敛作用,调理油腻不洁的肌肤,促进血液循环。
所述墨旱莲提取物:水浸提物,提高细胞免疫和体液免疫,养肝益肾、凉血止血。
所述鼠尾草提取物:鼠尾草精油,镇定紧张情绪,改善头疼和偏头痛,舒缓焦虑的心情。
所述锯棕榈提取物:水浸提物,有效抑制5a—还原酶活性,减少双氢睾酮生成拮抗前列腺组织中的雄激素与雄激素受体结合,利肝肾。
所述啤酒花提取物:健胃消食,安神利尿,有效抑制5a—还原酶活性。
所述茶树提取物:茶树油,祛痘消炎,控油收敛,抑菌,强化免疫力。
所述薄荷:薄荷脑,调理阻塞肌肤,舒缓肌肤,收缩微血管。
所述富勒烯及其富勒烯衍生物为空心富勒烯及富勒烯衍生物。所述富勒烯包含C60、C70、C76、C84中一种或几种,优选C60或C70或C60和C70的混合物。所述富勒烯衍生物包括但不限于:
C60-(OH)n,C70-(OH)n,C60-(COOH)n,C70-(COOH)n(n为4-30间)
本发明组合物中,将中西医理论相结合,将各组分科学合理的结合,配合利于组合物功效充分发挥的凝胶剂型,实现对脂溢性脱发的有效治疗。人体毛发生长分为三个周期,生长期,退行期,休止期,三个周期一次循环。当某些干扰因素扰乱了正常毛发的循环周期,使得生长期缩短,毛发变细,由长毛变为毫毛,大毛囊变为小毛囊,渐渐形成脱发。脂溢性脱发,多数是雄性激素在头皮部位的过多聚集有关,迷迭香,墨旱莲,鼠尾草,锯棕榈,啤酒花为皮脂调节剂,并可以很好的抑制5a—还原酶活性,缓解脂溢性脱发。脂溢性脱发多伴随严重的皮炎,茶树油和薄荷油具有抑菌消炎舒缓皮肤的作用。同时,根据中医学基础知识,发之营养来源于血,肝主血气,生根于肾气,肾主骨,其荣在发,因此发的生产与脱落,与肾和肝的精气盛衰及其疏泄息息相关,因此组方中侧柏叶提取物为君药滋阴升发,牡丹皮、黄芪提取物、当归提取物为臣药,补气补血功效,诺丽为佐药,加强消炎抑菌活化细胞之功效。加入富勒烯更能增强组合物生发抗炎活化细胞激活毛囊的作用。富勒烯是一种长效抗氧化剂,自由基清除剂,与多种精油类植提物复配,可以稳定精油类活性成分的功效,同时还可以清除头皮部位的自由基,激活毛囊。本方通过补气活血结合皮脂调节成分,又加以一款长效自由基清除剂,保证了活性成分的稳定性,进而保证了功效。
本发明剂型可根据患者需要进行定量使用。脱发患者在使用本产品前,先用干净毛巾对头皮进行清洁,再用干净热毛巾对头皮进行热敷20-30分钟(温度控制40℃左右),通过热敷能够让毛孔张开有利于药物的渗透,用手指蘸取少许生发产品,于脱发部位进行均匀涂抹按摩,作用脱发部位一定时间后用清水将脱皮清洗干净,每天早晚各一次,经过7-15天后,会发现原来的脱发部位有不同程度的新发长出。由于个体差异的问题,患者在使用的时候应根据自己使用的情况,对所需用量有一定的调动,是因为脱发部位经过长年暴露在外面,头皮角质层普遍偏厚,对药物的渗透有较大的屏障作用,因此对于药物的渗透产生的差异。建议脱发史长的患者使用浓度较高的产品或者增加使用量和使用次数,有利于头发的再生。
为了更好的体现本发明的有益效果,通过下述试验例来阐述
试验例一脂溢性脱发的治疗
1.1实验方法
实验模型为脂溢性脱发模型:C57/B6黑鼠,除空白组外,其余各组在小鼠背部平行于脊柱区的皮下注射丙酸睾酮造模,浓度为25mg/ml,注射计量5mg/kg/day,注射时间为五周。第五周后小鼠背部毛发出现不同程度的脱落,小鼠背部皮肤丙酸睾酮注射区出现红斑,糜烂,毛发结块现象,从第36天开始,通过外用给药的方式进行治疗。第9周时停止实验,取血及小鼠背部皮肤进行生化指标及病理分析。
1.2实验分组
第一组.空白组不给药:正常喂养,不进行任何处理;
第二组.模型组不给药:按上述脂溢性脱发模型步骤进行造模,不给予任何药物;
第三组.实施例7组合物每天一次于脱毛区域:按上述脂溢性脱发模型步骤造模后,外用给药,涂抹于小鼠背部脱毛区域;
第四组.纯富勒烯每天一次于脱毛区域:按上述脂溢性脱发模型步骤造模后,外用给药。由于富勒烯是粉末状态,并且溶解性较差,不能直接涂抹在小鼠背部,为了将富勒烯能涂抹于小鼠背部,参考专利申请号200580049615.2的方法制备了C60-PVP复合物,已知的是富勒烯在此复合物中是活性物质,PVP是惰性的且无外用刺激性。将C60-PVP水溶液涂抹于小鼠背部脱毛区域来验证纯富勒烯的功效;
第五组.植提物混合物(不含有富勒烯及其衍生物)每天一次于脱毛区域:将生育酚乙酸酯和薄荷醇溶解于侧柏油,迷迭香精油,茶树油,当归精油,鼠尾草精油的混合物中,利用增溶剂进行增溶,然后将增溶后的水溶液和植提物(牡丹皮提取物,墨旱莲提取物,锯棕榈提取物,啤酒花提取物,诺丽提取物分散于水中)的水溶液混合,再与将生物素,肌醇,水解小麦蛋白,燕麦葡聚糖,葡糖酸锌水溶液混合即可;
第六组.3%米诺地尔(阳性对照组)每天一次于脱毛区域;
第七组.生理盐水组每天一次于脱毛区域;
3结果
3.1病理分析:由图1七组实验的小鼠背部病例H&E染色图片,可以看出不同实验组的小鼠背部毛皮内毛囊的状况,组合物的在给模型小鼠使用后,小鼠背部毛皮的毛囊黑色素含量高,毛囊数量多,健康状况和空白组接近,效果远远优于纯富勒烯组、植提物组、米诺地尔组,充分说明了本发明的组合物的也就是加入富勒烯后对中药提取物产生了协调作用,在生发抗炎活化细胞激活毛囊的作用效果明显。
3.2用睾酮试剂盒对各组小鼠血清中激素水平测定,结果见表1
表1各组小鼠血清测试结果,用睾酮试剂盒进行测试各组激素水平
分组 | N | 睾酮T(μmol/L) |
空白组 | 10 | 0.6528±0.0201 |
本专利组合物组 | 9 | 1.3339±0.0291 |
纯富勒烯组 | 9 | 1.9739±0.0311 |
植提物组(不含富勒烯) | 8 | 2.9327±0.0373 |
米诺地尔组 | 10 | 3.1119±0.0300 |
生理盐水组 | 8 | 3.2003±0.0391 |
模型组(不给药) | 8 | 3.1339±0.0311 |
从表1中可以得知,本专利组合物组的小鼠睾酮激素水平要明显低于模型组和米诺地尔组,说明本发明的组合物具有降低睾酮激素水平,可预防或治疗脱发的作用。本发明的组合物降低睾酮激素水平的作用明显高于纯富勒烯组、植提物组的降低睾酮激素水平作用具有协同作用,充分说明了本发明的组合物对于脂溢性脱发的显著效果。
试验例2临床病例:
固某,男,48岁。患者秃发5年左右。家族遗传性脱发,并因个人工作压力大,熬夜加班,饮食偏肉食较多,喜饮酒,采用较多方法后无明显效果,通过试用本发明药剂(实施例3)后7天头发长出,15天后明显看出秃发部位所长头发变黑变粗。见效后,提高了患者的信息,主动调节工作作息时间,按时睡眠,多做室外运动,减少肉的摄入,不再饮酒。本发明的组合物具有治疗遗传性脱发作用。
孙某,男,50岁,患者秃发10年左右。为典型的油性皮肤。其前额和头顶为甚,毛发干枯,伴面色少华,神疲乏力,爪甲不荣,失眠多梦,试用本发明药剂(实施例5)后11天观察,秃发有头发长出,30天后秃发部位变黑变粗,并且夜寐安,精神足,心情悦。本发明的组合物具有抗炎作用,对脂溢性脱发有疗效。
试验例三雄激素依赖性的遗传性脱发病的治疗
收集雄激素性脱发(AGA)有家族史即雄激素依赖性的遗传性脱发病例,经过通过对不同年龄段人群进行了统计见附图1:年龄在40-50岁之间50人试用(实施例8),经过7-15天试用后,有47人成功长出新发;年龄在50-60岁之间40人试用,经过7-15天试用后,有35人成功长出新发;年龄在60以上岁40人试用,经过7-15天试用后,有30人成功长出新发;可见,对于遗传性脱发,本发明组合物整体有效率达到86%以上。从中我们可以得出,脱发部位经过长年暴露在外面,头皮角质层普遍偏厚,对药物的渗透有较大的屏障作用,药物不易透皮吸收,因此对于药物的渗透产生差异。对于没有达到预期的患者可以通过增加用药量来得以实现。
本发明权利要求书范围及所有实施例都具有上述试验例效果,具有治疗脂溢性脱发及遗传性脱发作用。
附图说明
图1七组实验的小鼠背部病例H&E染色图片,
其中,a)空白组,b)本专利组合物,c)纯富勒烯组,d)植提物(不含富勒烯),e)米诺地尔,f)生理盐水,g)模型组(不给药)
图2不同年龄段人群试用后生发统计图
具体实施方式
下面结合附图,对本发明的具体实施方式进行详细描述,但应当理解本发明的保护范围并不受具体实施方式的限制。
实施例1
一种治疗脂溢性脱发的组合物,取由下述重量份的原料备用:
牡丹皮提取物0.1g、侧柏叶提取物0.1g、迷迭香提取物0.1g、茶树提取物0.1g、当归提取物0.1g、黄芪提取物0.1g,墨旱莲提取物0.1g、鼠尾草提取物0.01g、锯棕榈提取物0.01g、啤酒花提取物0.01g、诺丽提取物0.01g、生物素0.01g、肌醇0.1g、水解小麦蛋白0.1g、燕麦葡聚糖0.1g、葡萄酸锌0.1g、薄荷0.1g、生物酚乙酸酯0.01g、富勒烯及其相应衍生物0.001g。
(1)取侧柏叶提取物,迷迭香提取物,茶树提取物,当归提取物,鼠尾草提取物,黄芪提取物混合均匀得混合物提取物;
(2)将富勒烯及其相应衍生物溶解于步骤(1)混合提取物中,再加入生育酚乙酸酯和薄荷醇得富勒烯混合物,然后用增溶剂进行增容,充分增容好后,放置过夜,过滤,取上清液I备用;
(3)将牡丹皮提取物,墨旱莲提取物,锯棕榈提取物,啤酒花提取物,诺丽提取物混合均匀后,用水超声提取,然后离心过滤,上清液II备用;
(4)将生物素,肌醇,水解小麦蛋白,燕麦葡聚糖,葡糖酸锌溶解于水得溶液III;
(5)将上述上清液I、上清液II、溶液III混合均匀即可。
实施例2
一种治疗脂溢性脱发的组合物,取由下述重量份的原料备用:
牡丹皮提取物5g、侧柏叶提取物5g、迷迭香提取物5g、茶树提取物5g、当归提取物5g、黄芪提取物5g,墨旱莲提取物5g、鼠尾草提取物2g、锯棕榈提取物2g、啤酒花提取物2g、诺丽提取物2g、生物素0.05g、肌醇2g、水解小麦蛋白1g、燕麦葡聚糖1g、葡萄酸锌5g、薄荷5g、生物酚乙酸酯1g、富勒烯及其相应衍生物3g。
(1)取侧柏叶提取物,迷迭香提取物,茶树提取物,当归提取物,鼠尾草提取物,黄芪提取物混合均匀得混合物提取物;
(2)将富勒烯及其相应衍生物溶解于步骤(1)混合提取物中,再加入生育酚乙酸酯和薄荷醇得富勒烯混合物,然后用增溶剂进行增容,充分增容好后,放置过夜,过滤,取上清液I备用;
(3)将牡丹皮提取物,墨旱莲提取物,锯棕榈提取物,啤酒花提取物,诺丽提取物混合均匀后,用水超声提取,然后离心过滤,上清液II备用;
(4)将生物素,肌醇,水解小麦蛋白,燕麦葡聚糖,葡糖酸锌溶解于水得溶液III;
(5)将上述上清液I、上清液II、溶液III混合均匀即可。
实施例3
一种治疗脂溢性脱发的组合物,取由下述重量份的原料备用:牡丹皮提取物0.3g、侧柏叶提取物0.3g、迷迭香提取物0.2g、茶树提取物0.1g、当归提取物0.2g、黄芪提取物0.2g,墨旱莲提取物0.2g、鼠尾草提取物0.1g、锯棕榈提取物0.05g、啤酒花提取物0.05g、诺丽提取物0.1g、生物素0.01g、肌醇0.1g、水解小麦蛋白0.1g、燕麦葡聚糖0.1g、葡萄酸锌0.5g、薄荷1g、生育酚乙酸酯0.03g、富勒烯及其相应衍生物0.01g。
(1)取侧柏叶提取物,迷迭香提取物,茶树提取物,当归提取物,鼠尾草提取物,黄芪提取物混合均匀得混合物提取物;
(2)将富勒烯及其相应衍生物溶解于步骤(1)混合提取物中,再加入生育酚乙酸酯和薄荷醇得富勒烯混合物,然后用增溶剂进行增容,充分增容好后,放置过夜,过滤,取上清液I备用;
(3)将牡丹皮提取物,墨旱莲提取物,锯棕榈提取物,啤酒花提取物,诺丽提取物混合均匀后,用水超声提取,然后离心过滤,上清液II备用;
(4)将生物素,肌醇,水解小麦蛋白,燕麦葡聚糖,葡糖酸锌溶解于水得溶液III;
(5)将上述上清液I、上清液II、溶液III混合均匀即可。
实施例4
一种治疗脂溢性脱发的组合物,取由下述重量份的原料备用:牡丹皮提取物3g、侧柏叶提取物3g、迷迭香提取物3g、茶树提取物3g、当归提取物2g、黄芪提取物2g,墨旱莲提取物2g、鼠尾草提取物2g、锯棕榈提取物1.5g、啤酒花提取物1.5g、诺丽提取物1g、生物素0.03g、肌醇1g、水解小麦蛋白0.5g、燕麦葡聚糖0.5g、葡萄酸3g、薄荷3g、生育酚乙酸酯0.06g、富勒烯及其相应衍生物2g。
(1)取侧柏叶提取物,迷迭香提取物,茶树提取物,当归提取物,鼠尾草提取物,黄芪提取物混合均匀得混合物提取物;
(2)将富勒烯及其相应衍生物溶解于步骤(1)混合提取物中,再加入生育酚乙酸酯和薄荷醇得富勒烯混合物,然后用增溶剂进行增容,充分增容好后,放置过夜,过滤,取上清液I备用;
(3)将牡丹皮提取物,墨旱莲提取物,锯棕榈提取物,啤酒花提取物,诺丽提取物混合均匀后,用水超声提取,然后离心过滤,上清液II备用;
(4)将生物素,肌醇,水解小麦蛋白,燕麦葡聚糖,葡糖酸锌溶解于水得溶液III;
(5)将上述上清液I、上清液II、溶液III混合均匀即可。
实施例5
一种治疗脂溢性脱发的组合物,取由下述重量份的原料备用:牡丹皮提取物0.3g、侧柏叶提取物0.3g、迷迭香提取物0.2g、茶树提取物0.1g、当归提取物0.2g、黄芪提取物0.2g,墨旱莲提取物0.2g、鼠尾草提取物0.1g、锯棕榈提取物0.08g、啤酒花提取物0.08g、诺丽提取物0.08g、生物素0.01g、肌醇0.1g、水解小麦蛋白0.2g、燕麦葡聚糖0.2g、葡萄酸锌2g、薄荷1g、生育酚乙酸酯0.03g、富勒烯及其相应衍生物0.01g。
(1)取侧柏叶提取物,迷迭香提取物,茶树提取物,当归提取物,鼠尾草提取物,黄芪提取物混合均匀得混合物提取物;
(2)将富勒烯及其相应衍生物溶解于步骤(1)混合提取物中,再加入生育酚乙酸酯和薄荷醇得富勒烯混合物,然后用增溶剂进行增容,充分增容好后,放置过夜,过滤,取上清液I备用;
(3)将牡丹皮提取物,墨旱莲提取物,锯棕榈提取物,啤酒花提取物,诺丽提取物混合均匀后,用水超声提取,然后离心过滤,上清液II备用;
(4)将生物素,肌醇,水解小麦蛋白,燕麦葡聚糖,葡糖酸锌溶解于水得溶液III;
(5)将上述上清液I、上清液II、溶液III混合均匀即可。
实施例6
一种治疗脂溢性脱发的组合物是由牡丹皮提取物2.5g、侧柏叶提取物2.5g、迷迭香提取物2.5g、茶树提取物2g、当归提取物1.5g、黄芪提取物1.5g,墨旱莲提取物1.5g、鼠尾草提取物1.5g、锯棕榈提取物1.5g、啤酒花提取物1.5g、诺丽提取物1g、生物素0.03g、肌醇0.5g、水解小麦蛋白0.4g、燕麦葡聚糖0.4g、葡萄酸锌3g、薄荷3g、生育酚乙酸酯0.06g、富勒烯及其相应衍生物1g制备,制备方法按照实施例1.
实施例7
一种治疗脂溢性脱发的组合物是由牡丹皮提取物0.5g、侧柏叶提取物0.5g、迷迭香提取物0.5g、茶树提取物0.3g、当归提取物0.3g、黄芪提取物0.3g,墨旱莲提取物0.3g、鼠尾草提取物0.3g、锯棕榈提取物0.1g、啤酒花提取物0.1g、诺丽提取物0.5g、生物素0.01g、肌醇0.1g、水解小麦蛋白0.3g、燕麦葡聚糖0.3g、葡萄酸锌1g、薄荷2g、生物酚乙酸酯0.05g、富勒烯及其相应衍生物0.03g,按照实施例1方法制备。
实施例8
一种治疗脂溢性脱发的组合物是由牡丹皮提取物2g、侧柏叶提取物2g、迷迭香提取物2g、茶树提取物1g、当归提取物1g、黄芪提取物1g,墨旱莲提取物1g、鼠尾草提取物1g、锯棕榈提取物1g、啤酒花提取物1g、诺丽提取物1g、生物素0.01g、肌醇0.1g、水解小麦蛋白0.3g、燕麦葡聚糖0.3g、葡萄酸锌1g、薄荷2g、生物酚乙酸酯0.05g、富勒烯及其相应衍生物0.6g,按照实施例1方法制备。
实施例9:
一种治疗脂溢性脱发水凝胶剂包括牡丹皮植提物0.5%、侧柏叶植提物0.5%、迷迭香植提物0.5%、茶树植提物0.3%、当归植提物0.3%、锯棕榈植提物0.15%、墨旱莲植提物0.3%、鼠尾草植提物0.3%、啤酒花植提物0.1%、生物素0.01%、肌醇0.1%、水解小麦蛋白0.3%、燕麦葡聚糖0.3、葡萄酸锌1%、1,3-丁二醇4%、羟乙基纤维素0.05%、柠檬酸0.3%、透明质酸3%、薄荷2%、生物酚乙酸酯0.5%、LRI-80 30%、EDTA-2Na 1%、吐温-8035%、EDTA-2Na 0.5%、富勒烯及其相应衍生物6%等主要活性原料,去离子水补充到100%。
实施例10:
一种治疗脂溢性脱发水凝胶剂包括以下组分:所述配方包首乌植提物0.3%、牡丹皮植提物0.3%、侧柏叶植提物0.15%、黄芪植提物0.15%、诺丽植提物0.15%、当归植提物0.15%、锯棕榈植提物0.15%、芦荟植提物0.05%、生物素0.01%、肌醇0.1%、水解小麦蛋白0.3%、燕麦葡聚糖0.3、葡萄酸锌1%、1,3-丁二醇4%、羟乙基纤维素0.05%、柠檬酸0.3%、透明质酸3%、薄荷2%、生物酚乙酸酯0.5%、LRI-80 20%、EDTA-2Na 1%、富勒烯及其相应衍生物4%等主要活性原料,去离子水补充到100%。
实施例11
一种治疗脂溢性脱发水凝胶剂包括下述组分:牡丹皮提取物0.5-2份、侧柏叶提取物0.5-2份、迷迭香提取物0.5-2份、茶树提取物0.3-1份、当归提取物0.3-1份、黄芪提取物0.3-1份,墨旱莲提取物0.3-1份、鼠尾草提取物0.3-1份、锯棕榈提取物0.1-1份、啤酒花提取物0.1-1份、诺丽提取物0.5-1份、生物素0.01份、肌醇0.1份、水解小麦蛋白0.3份、燕麦葡聚糖0.3份、葡萄酸锌1份、薄荷2份、生物酚乙酸酯0.05份、富勒烯及其相应衍生物0.03-0.6份。1,3-丁二醇4份、羟乙基纤维素0.1份、柠檬酸0.3份、透明质酸1.5份、LRI 7份、EDTA-2Na1份、去离子水补充至100%。
实施例12
一种治疗脂溢性脱发的组合物,其是由下述重量份的原料制得:牡丹皮提取物1份、侧柏叶提取物1份、迷迭香提取物1份、茶树提取物1份、当归提取物1份、黄芪提取物1份,墨旱莲提取物1份、鼠尾草提取物1份、锯棕榈提取物0.3份、啤酒花提取物0.7份、诺丽提取物0.8份、生物素0.01份、肌醇0.1份、水解小麦蛋白0.3份、燕麦葡聚糖0.3份、葡萄酸锌1份、薄荷2份、生物酚乙酸酯0.05份、富勒烯及其相应衍生物0.01份。
实施例13
一种治疗脂溢性脱发的组合物,取由下述重量份的原料备用:
牡丹皮提取物5g、侧柏叶提取物5g、迷迭香提取物5g、茶树提取物5g、当归提取物5g、黄芪提取物5g,墨旱莲提取物5g、鼠尾草提取物2g、锯棕榈提取物2g、啤酒花提取物2g、诺丽提取物2g、生物素0.05g、肌醇2g、水解小麦蛋白1g、燕麦葡聚糖1g、葡萄酸锌5g、薄荷5g、生物酚乙酸酯1g、富勒烯及其相应衍生10g。
实施例14
一种治疗脂溢性脱发的组合物是由牡丹皮提取物2.5g、侧柏叶提取物2.5g、迷迭香提取物2.5g、茶树提取物2g、当归提取物1.5g、黄芪提取物1.5g,墨旱莲提取物1.5g、鼠尾草提取物1.5g、锯棕榈提取物1.5g、啤酒花提取物1.5g、诺丽提取物1g、生物素0.03g、肌醇0.5g、水解小麦蛋白0.4g、燕麦葡聚糖0.4g、葡萄酸锌3g、薄荷3g、生育酚乙酸酯0.06g、富勒烯及其相应衍生物5g制备,制备方法按照实施例1.
前述对本发明的具体示例性实施方案的描述是为了说明和例证的目的。这些描述并非想将本发明限定为所公开的精确形式,并且很显然,根据上述教导,可以进行很多改变和变化。对示例性实施例进行选择和描述的目的在于解释本发明的特定原理及其实际应用,从而使得本领域的技术人员能够实现并利用本发明的各种不同的示例性实施方案以及各种不同的选择和改变。本发明的范围意在由权利要求书及其等同形式所限定。
Claims (10)
1.一种治疗脂溢性脱发的组合物,其是由下述重量份的原料制得:
牡丹皮提取物0.1-5份、侧柏叶提取物0.1-5份、迷迭香提取物0.1-5份、茶树提取物0.1-5份、当归提取物0.1-5份、黄芪提取物0.1-5份,墨旱莲提取物0.1-5份、鼠尾草提取物0.01-2份、锯棕榈提取物0.01-2份、啤酒花提取物0.01-2份、诺丽提取物0.01-2份、生物素0.01-0.05份、肌醇0.1-2份、水解小麦蛋白0.1-1份、燕麦葡聚糖0.1-1份、葡萄酸锌0.1-5份、薄荷0.1-5份、生物酚乙酸酯0.01-1份、富勒烯及其相应衍生物0.001-10份。
2.如权利要求1所述的一种治疗脂溢性脱发的组合物,是由下述重量份的原料制得:牡丹皮提取物0.3-3份、侧柏叶提取物0.3-3份、迷迭香提取物0.2-3份、茶树提取物0.1-3份、当归提取物0.2-2份、黄芪提取物0.2-2份,墨旱莲提取物0.2-2份、鼠尾草提取物0.1-2份、锯棕榈提取物0.05-1.5份、啤酒花提取物0.05-1.5份、诺丽提取物0.1-1份、生物素0.01-0.03份、肌醇0.1-1份、水解小麦蛋白0.1-0.5份、燕麦葡聚糖0.1-0.5份、葡萄酸锌0.5-3份、薄荷1-3份、生育酚乙酸酯0.03-0.06份、富勒烯及其相应衍生物0.01-5份。
3.如权利要求2所述的一种治疗脂溢性脱发的组合物,其是由下述重量份的原料制得:牡丹皮提取物0.3-2.5份、侧柏叶提取物0.3-2.5份、迷迭香提取物0.2-2.5份、茶树提取物0.1-2份、当归提取物0.2-1.5份、黄芪提取物0.2-1.5份,墨旱莲提取物0.2-1.5份、鼠尾草提取物0.1-1.5份、锯棕榈提取物0.08-1.5份、啤酒花提取物0.08-1.5份、诺丽提取物0.08-1份、生物素0.01-0.03份、肌醇0.1-0.5份、水解小麦蛋白0.2-0.4份、燕麦葡聚糖0.2-0.4份、葡萄酸锌2-3份、薄荷1-3份、生育酚乙酸酯0.03-0.06份、富勒烯及其相应衍生物0.01-3份。
4.如权利要求3所述的一种治疗脂溢性脱发的组合物,其是由下述重量份的原料制得:牡丹皮提取物0.5-2份、侧柏叶提取物0.5-2份、迷迭香提取物0.5-2份、茶树提取物0.3-1份、当归提取物0.3-1份、黄芪提取物0.3-1份,墨旱莲提取物0.3-1份、鼠尾草提取物0.3-1份、锯棕榈提取物0.1-1份、啤酒花提取物0.1-1份、诺丽提取物0.5-1份、生物素0.01份、肌醇0.1份、水解小麦蛋白0.3份、燕麦葡聚糖0.3份、葡萄酸锌1份、薄荷2份、生物酚乙酸酯0.05份、富勒烯及其相应衍生物0.03-0.6份。
5.如权利要求1-4任一项所述的组合物可以制成药学或保健或日化可接受的剂型。
6.如权利要求5所述的剂型,其特征在于,为水凝胶剂,其组合物与基质重量比(1-5):(5-10)。
7.如权利要求6所述的剂型,其特征在于,所述的水凝胶剂是由下述重量份的原料制成:牡丹皮提取物0.1-5份、侧柏叶提取物0.1-5份、迷迭香提取物0.1-5份、茶树提取物0.1-5份、当归提取物0.1-5份、黄芪提取物0.1-5份,墨旱莲提取物0.1-5份、鼠尾草提取物0.01-2份、锯棕榈提取物0.01-2份、啤酒花提取物0.01-2份、诺丽提取物0.01-2份、生物素0.01-0.05份、肌醇0.1-2份、水解小麦蛋白0.1-1份、燕麦葡聚糖0.1-1份、葡萄酸锌0.1-5份、薄荷0.1-5份、生物酚乙酸酯0.01-1份、富勒烯及其相应衍生物0.001-10份、1,3-丁二醇0.1%-10份、羟乙基纤维素0.01-1份、柠檬酸0.01-1份、透明质酸0.1-10份、LRI 3-20份、EDTA-2Na0.01-1份,去离子水补充至100%。
8.如权利要求1所述的组合物的制备方法,其特征在于,包括如下步骤:
(1)取侧柏叶提取物,迷迭香提取物,茶树提取物,当归提取物,鼠尾草提取物,黄芪提取物混合均匀得混合物提取物;
(2)将富勒烯及其相应衍生物加入步骤(1)混合提取物中,再加入生育酚乙酸酯和薄荷醇得富勒烯混合物,然后用增溶剂进行增容,放置过夜,过滤,取上清液I备用;
(3)将牡丹皮提取物,墨旱莲提取物,锯棕榈提取物,啤酒花提取物,诺丽提取物混合均匀后,用水超声提取,然后离心过滤,上清液II备用;
(4)将生物素,肌醇,水解小麦蛋白,燕麦葡聚糖,葡糖酸锌溶解于水得溶液III;
(5)将上述上清液I、上清液II、溶液III混合均匀即可。
9.如权利要求1-4任意一项所述的组合物在制备预防或治疗脂溢性脱发产品中的应用。
10.如权利要求1-4任意一项所述的组合物在制备预防或治疗雄激素依赖性的遗传性脱发产品中的应用。
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