CN110037986B - 森登-4纳米乳及其制备方法 - Google Patents
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Abstract
本发明公开了一种森登‑4纳米乳及其制备方法，该纳米乳由乙酸乙酯，无水乙醇，吐温‑80，森登‑4提取液，防腐剂，抗坏血酸和氮酮制备而成。本发明创新性的将传统口服蒙药通过新的制备工作制作成皮肤科外用制剂，用于治疗皮肤疾病和作为护肤品使用，扩大了药物的使用范围。
Description
技术领域
本发明涉及蒙药领域，具体涉及一种森登-4纳米乳及其制备方法。
背景技术
蒙药复方森登-4汤是蒙医临床常用的抗风湿药，收载于《内蒙古蒙成药标准》。该药由4味组成，按君臣佐使的顺序分别为文冠木15g，川楝子9g，栀子3g，诃子3g，具有清热、燥黄水的功能，用于治疗痛风、关节炎、水肿等病症，现有的中文文献报道除了传统的汤剂，还有胶囊剂，未见其他制剂报道，也未见将该制剂外用的文献报道。
发明内容
为解决上述问题，本发明提供了一种森登-4纳米乳及其制备方法，扩大了药物的使用范围。
为实现上述目的，本发明采取的技术方案为：
森登-4纳米乳，该纳米乳由乙酸乙酯，无水乙醇，吐温-80，森登-4水提液，防腐剂，抗坏血酸和氮酮制备而成。
优选地，由以下组分的原料制备而成：
1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，13.75ml森登-4水提液，0.05g防腐剂，0.05g抗坏血酸，0.5g氮酮。
优选地，由以下组分的原料制备而成：
1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，2.1ml森登-4水提液，3ml醇浸液，8.65ml蒸馏水，0.05g防腐剂，0.05g抗坏血酸，0.5g氮酮。
进一步地，所述森登-4提取液通过以下方法制备所得：
将文冠木、川楝子、诃子、栀子按质量比为5：3：1：1的比例混匀，粉碎，过1号筛，称取适量，加10倍体积的水浸泡24h,过滤，取滤液，即得。
进一步地，所述防腐剂为尼泊金甲酯。
本发明还提供了上述森登-4纳米乳的制备方法，包括如下步骤：
S1、按上述配方称取各组分；
S2、将吐温-80和乙酸乙酯混合搅拌均匀，水温保持在40-60度后，停止搅拌，加入无水乙醇，继续搅拌30min，停止搅拌，用胶头滴管滴加事先加热到40-60度的森登-4水提液，3-8h滴加完成后，于40-60度保温1h,关闭加热，降至常温，加入其他辅料，搅拌均匀，即得。
本发明具有以下有益效果：
创新性的将传统口服蒙药通过新的制备工作制作成皮肤科外用制剂，用于治疗皮肤疾病（修复受损皮肤屏障/痤疮/激素皮炎）和作为护肤品使用，扩大了药物的使用范围。
具体实施方式
下面结合具体实施例对本发明进行详细说明。以下实施例将有助于本领域的技术人员进一步理解本发明，但不以任何形式限制本发明。应当指出的是，对本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进。这些都属于本发明的保护范围。
以下实施例中，所述森登-4提取液通过以下方法制备所得：
将文冠木、川楝子、诃子、栀子按质量比为5：3：1：1的比例混匀，粉碎，过1号筛，称取适量，加10倍体积的水浸泡24h,过滤，取滤液，即得。
实施例1
一种森登-4纳米乳，通过以下方法制备所得：
S1、称取：1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，13.75ml森登-4提取液，0.05g防腐剂（尼泊金甲酯），0.05g抗坏血酸，0.5g氮酮
S2、将吐温-80和乙酸乙酯混合搅拌均匀，水温保持在40-60度后，停止搅拌，加入无水乙醇，继续搅拌30min，停止搅拌，用胶头滴管滴加事先加热到40-60度的森登-4提取液，3-8h滴加完成后，于40-60度保温1h,关闭加热，降至常温，加入其他辅料，搅拌均匀，即得。
实施例2
一种森登-4纳米乳，通过以下方法制备所得：
S1、称取：1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，2.1ml森登-4提取液，3ml醇浸液，8.65ml蒸馏水，0.05g防腐剂（尼泊金甲酯），0.05g抗坏血酸，0.5g氮酮。
S2、将吐温-80和乙酸乙酯混合搅拌均匀，水温保持在40-60度后，停止搅拌，加入无水乙醇，继续搅拌30min，停止搅拌，用胶头滴管滴加事先加热到40-60度的森登-4提取液，3-8h滴加完成后，于40-60度保温1h,关闭加热，降至常温，加入其他辅料，搅拌均匀，即得。
将实施例1和实施例2所得的纳米乳12000r·min-1离心20min,纳米乳液外观仍然澄明、均一，未见分层破乳和药物析出现象。在-4℃，室温，60℃条件下，密闭保存4个月，纳米乳外观未见异常，可见，本发明所得的纳米乳稳定性好。
以上对本发明的具体实施例进行了描述。需要理解的是，本发明并不局限于上述特定实施方式，本领域技术人员可以在权利要求的范围内做出各种变化或修改，这并不影响本发明的实质内容。在不冲突的情况下，本申请的实施例和实施例中的特征可以任意相互组合。
Claims (2)
1.森登-4纳米乳，其特征在于：该纳米乳由乙酸乙酯，无水乙醇，吐温-80，森登-4提取液，防腐剂，抗坏血酸和氮酮制备而成；所述的森登-4纳米乳，由以下组分的原料制备而成：1.1g乙酸乙酯，3.75g无水乙醇，6.25g吐温-80，13.75ml森登-4水提液，0.05g防腐剂，0.05g抗坏血酸，0.5g氮酮；
所述森登-4提取液通过以下方法制备所得：将文冠木、川楝子、诃子、栀子按质量比为5：3：1：1的比例混匀，粉碎，过1号筛，称取适量，加10倍体积的水浸泡24h，过滤，取滤液，即得；
所述的森登-4纳米乳通过以下步骤制备所得：
S1、按配方称取各组分；
S2、将吐温-80和乙酸乙酯混合搅拌均匀，水温保持在40-60度后，停止搅拌，加入无水乙醇，继续搅拌30min，停止搅拌，用胶头滴管滴加事先加热到40-60度的森登-4水提液，3-8h滴加完成后，于40-60度保温1h,关闭加热，降至常温，加入其他辅料，搅拌均匀，即得。
2.如权利要求1所述的森登-4纳米乳，其特征在于：所述防腐剂为尼泊金甲酯。
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