CN110025671A - A kind of composition and its preparation method and application - Google Patents
A kind of composition and its preparation method and application Download PDFInfo
- Publication number
- CN110025671A CN110025671A CN201910384403.3A CN201910384403A CN110025671A CN 110025671 A CN110025671 A CN 110025671A CN 201910384403 A CN201910384403 A CN 201910384403A CN 110025671 A CN110025671 A CN 110025671A
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- Prior art keywords
- drug
- asarum
- toothache
- borneol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Alternative & Traditional Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of compositions, it includes 0.5~1.5 part of defatted croton seed powder, 8~12 parts of cloves, 8~12 parts of asarum, 0.5~2 part of borneol.The drug formed based on above-mentioned composition can effectively treat toothache caused by toothache, especially acute toothache and decayed tooth.
Description
Technical field
The present invention relates to natural medicine fields.
Background technique
Toothache refers to that tooth is one of symptom common in oral disease, it is seen that in dental caries because of pain caused by a variety of causes
Tooth, pulpitis, periapical inflammation, tooth trauma, hypersensitive dentin, wedge-shaped defect etc..
In Yi nationality, distributed over Yunnan, Sichuan and Guizhou's medicine, toothache is broadly divided into two classes:(branch) and(branch fruit).Wherein " branch " refers mainly to
Pain caused by the non-natural agings such as decayed tooth and acute toothache；" branch fruit " refers mainly to the discomfort as caused by tooth aging and pain.
Race's drug is the summary of experience and wisdom crystallization that the Yi nationality, distributed over Yunnan, Sichuan and Guizhou people struggle with disease for a long time, is that Chinese medicine is great precious
An important component in library.Drug number includes animal drugs, mineral drug, botanical medicine up to thousand kinds, wherein with botanical medicine and
Animal drugs are with relatively broad.
Summary of the invention
For this clinical problem of having a toothache, the present invention provides a kind of products theoretical based on Yi nationality's medicine.
Specifically, the present invention provides a kind of compositions, it includes 0.5~1.5 part of defatted croton seed powder, 8~12 parts of cloves, asarum
8~12 parts, 0.5~2 part of borneol.
It is pure and impure and malicious evil theoretical for guidance with Yi nationality doctor, it is believed that the disease of " branch " toothache is caused by exopathogen, therefore is used
(asarum), Yi nationality's text meaning are wind-damp dispelling, anodyne.In conjunction with crotons, the acrid flavours such as cloves, property heat medicine dispel exopathogen, take into account toothache companion
With inflammation even pyesis, using borneol it is clear in fiery anti-inflammatory.Eliminating evil is synchronous with heat-clearing, and fever and chills are all thrown.Pure and impure mutually auxiliary, crotons are with poison
Attack poison, phagedenoma apocenosis helps borneol to relieve inflammation or internal heat anti-inflammatory.
The drug formed based on above-mentioned composition, caused by can effectively treating toothache, especially acute toothache and decayed tooth
Toothache.
Defatted croton seed powder (Crotonis Semen Pulveratum) is the Preparation process product of crotons.Crotons are euphorbia plant
The dry mature fruit of crotons Croton tiglium L..It is roughly the same with Chinese medicine usage in the medical method of Yi nationality, takes its phagedenoma
The function of apocenosis hurts the treatment of pyogenic infections for sore.0.1-0.3 grams of every consumption per day.Enter ball more and dissipates use；Suitable amount used externally.
Cloves (Caryophylli Flos), this product are plant clove of myrtaceae Eugenia caryophyllata
Thunb. dry flower.Every 1~3g of consumption per day takes or grinds external application orally.
Asarum (Asari Radix et Rhizoma), this product are aristolochiaceae plant Herba Asari Asarum
Heterotropoides Fr.Schmidt var.mandshuricum (Maxim.) Kitag., Seoul asarum Asarum
The dry root and rhizome of sieboldii Miq.var.seoulense Nakai or asarum sieboldii Asarum sieboldii Miq..(asarum), Yi nationality's text meaning are wind-damp dispelling, anodyne.It is mainly used for the partner treatments rheumatism such as treatment and the radix saposhnikoviae of rheumatism,
Separately it is also used for relieving pain.0.5-9 grams of every consumption per day, powder is each taking 0.5~1g；Suitable amount used externally.
Borneol can use borneolum syntheticum, can also use natural borneol.Enter ball to dissipate, more external applications.Dosage 0.3-0.9g, enters
Ball, which dissipates, to be used.External application levigation point applies affected part.
The d-Bomeol of natural borneol: by lauraceae plant camphor tree (the Cinnamomum camphora (L) in main product Jiangxi, Hunan
Presl fresh branches and leaves) it is extracted processing and obtain.
The L-Borneol (for show in difference pharmacopeia also referred to as " L-Borneol ") of natural borneol: by the compositae plant in main product Guizhou
The fresh cauline leaf of Blumea balsamifera blumea balsamifera (L.) Dc. extracts through steam distillation and recrystallizes and obtain.
When treating acute toothache, also visually taken the circumstances into consideration to add the wind-dispellings such as radix saposhnikoviae, schizonepeta, fructus piperis longi, Chinese prickly ash by exopathogen invasion degree
Equal medicines, take Radix Paeoniae Alba orally.
The present invention also provides a kind of drug, the bulk pharmaceutical chemicals of the drug include composition above-mentioned.
It can also include auxiliary material, such as excipient, diluent, adhesive, profit other than above-mentioned raw materials medicine in drug
Lubrication prescription, surfactant etc. add different auxiliary materials according to different dosage forms.
Further, in a kind of drug provided by the invention, bulk pharmaceutical chemicals are 0.5~1.5 part of defatted croton seed powder, cloves 8~12
Part, 8~12 parts of asarum, 0.5~2 part of borneol.
The preparation method of the drug, including following content:
(1) defatted croton seed powder is taken；(2) cloves is taken；(3) asarum is taken；(4) borneol is taken；(5) it crushes；(6) it mixes.
In the above method, content (1)~(4) one or more can be combined with (5), i.e. expression bulk pharmaceutical chemicals can independent powder
It is broken, it is crushed again after can also mixing.For example, defatted croton seed powder and borneol is taken to crush, asarum and cloves is taken to crush, then by two groups of crushed materials
Mixing；Again or, individually crushing defatted croton seed powder, borneol, asarum, cloves, then 4 kinds of crushed materials are mixed；Etc..
The purpose crushed in the present invention is by the volume-diminished of bulk pharmaceutical chemicals, and mode includes but is not limited to hand lapping, machine
Tool crushing etc..
It, can also be according to different formulation requirements, using the preparation means of this field routine in the preparation method of drug.
Specific embodiment
Embodiment 1
Take defatted croton seed powder 0.1g, cloves 1g, asarum 1g, borneol 0.1g.
Be prepared into powder: defatted croton seed powder, borneol, which is placed in appropriate vessel, gently to be ground as end, and other two medicinal powder is broken into fine powder, crosses No. 5
Pharmacopeia sieve, is mixed into powder with aforementioned two tastes medicine.
External application after pain tooth hydrogen peroxide or 70% alcohol disinfecting, is dipped about 0.9 gram and is wrapped up with Medical cotton and filled in one time a day
At decayed tooth or at the gum of acute toothache, or paste is made with appropriate 70% alcohol and is applied with affected part.
Embodiment 2
Take defatted croton seed powder 0.5g, cloves 8g, asarum 12g, borneol 2g.
Be prepared into powder: defatted croton seed powder, borneol individually gently grind as end, and other two medicinal powder is broken into fine powder, cross No. 5 pharmacopeia
Sieve, is mixed into powder with aforementioned two tastes medicine.
Embodiment 3
Take defatted croton seed powder 1.5g, cloves 12g, asarum 8g, borneol 0.5g.
Be prepared into powder: defatted croton seed powder, borneol individually gently grind as end, and other two medicinal powder is broken into fine powder, cross No. 5 pharmacopeia
Sieve, is mixed into powder with aforementioned two tastes medicine.
In order to illustrate beneficial effects of the present invention, following material is provided:
Clinical treatment statistics
Gender and the range of age: covering men and women, old and young, suffer from acute toothache and decayed tooth 1 week of medical history by nearly 10 years not
It Deng accepting 120 patients for medical treatment altogether, all fully recovers, cure rate is up to all can normal diet after 100%, the topical application of drug 15 minutes.Wherein 80 moths
Tooth patient.40 are acute toothache patient.(wherein 1, because of long-term alcohol, eat barbecue.The topical application of drug is recurred after January, then the topical application of drug
And be cured).Note: non-inflammation teeth roots can not be spread on, skin can be corroded.
Typical case
Patient, female, 58 years old, it was 3 years existing to suffer from decayed tooth when patient's first visit, during which there is teeth roots inflammation suppuration tonsillotome hair
Inflammation such as has a decayed tooth one side of something face in side is too fat to move switch to more from previous one at complication, the tooth of making amends for one's faults, still in vain, decayed tooth.Medication
After 15 days, teeth roots are suppurated out, purulence blood outflow.The topical application of drug second day, the too fat to move mitigation of face, tonsils inflammation mitigated, Ke Yizheng
Normal diet.There is abatement at the black position of Effect of follow-up visit by telephone after January, the infection of readme plaque, and 1 year and a half has not yet to see recurrence so far.
Claims (10)
1. a kind of composition, it is characterised in that: it includes 0.5~1.5 part of defatted croton seed powder, 8~12 parts of cloves, 8~12 parts of asarum, ice
0.5~2 part of piece.
2. composition according to claim 1, it is characterised in that: it include 1 part of defatted croton seed powder, 10 parts of cloves, 10 parts of asarum,
1 part of borneol.
3. composition according to claim 1 or 2, it is characterised in that: it further includes radix saposhnikoviae, schizonepeta, fructus piperis longi, Chinese prickly ash, white
The mixture of one or more of Chinese herbaceous peony.
4. a kind of drug, it is characterised in that: its bulk pharmaceutical chemicals includes composition described in claim 1-3 any one.
5. drug according to claim 4, it is characterised in that: its bulk pharmaceutical chemicals is 0.5~1.5 part of defatted croton seed powder, cloves 8~12
Part, 8~12 parts of asarum, 0.5~2 part of borneol.
6. the preparation method of drug described in claim 5, it is characterised in that: it includes following content:
(1) defatted croton seed powder is taken；(2) cloves is taken；(3) asarum is taken；(4) borneol is taken；(5) it crushes；(6) it mixes.
7. the production that composition described in claims 1 to 3 any one or the drug of claim 4 or 5 are had a toothache in preparation treatment
Purposes in product.
8. purposes according to claim 7, it is characterised in that: the product is in the product for treat non-natural aging toothache
Purposes.
9. purposes according to claim 7 or 8, it is characterised in that: the product is caused by treatment acute toothache or saprodontia
The product of toothache.
10. the production that composition described in claims 1 to 3 any one or the drug of claim 4 or 5 treat saprodontia in preparation
Purposes in product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910384403.3A CN110025671A (en) | 2019-05-09 | 2019-05-09 | A kind of composition and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910384403.3A CN110025671A (en) | 2019-05-09 | 2019-05-09 | A kind of composition and its preparation method and application |
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| Publication Number | Publication Date |
|---|---|
| CN110025671A true CN110025671A (en) | 2019-07-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910384403.3A Pending CN110025671A (en) | 2019-05-09 | 2019-05-09 | A kind of composition and its preparation method and application |
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| Country | Link |
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| CN (1) | CN110025671A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857502A (en) * | 2006-03-14 | 2006-11-08 | 傅建熙 | Chinese medicine liniment for treating toothache and its preparing method |
| CN101077403A (en) * | 2007-05-05 | 2007-11-28 | 赵启坤 | Plaster for treating retention of food and dysmenorrhea |
-
2019
- 2019-05-09 CN CN201910384403.3A patent/CN110025671A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857502A (en) * | 2006-03-14 | 2006-11-08 | 傅建熙 | Chinese medicine liniment for treating toothache and its preparing method |
| CN101077403A (en) * | 2007-05-05 | 2007-11-28 | 赵启坤 | Plaster for treating retention of food and dysmenorrhea |
Non-Patent Citations (2)
| Title |
|---|
| 张文康: "《中西医结合医学》", 30 June 2000, 中国中医药出版社 * |
| 徐国榕: "《口腔科常用中药指南》", 31 October 1992, 人民军医出版社 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190719 |
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| RJ01 | Rejection of invention patent application after publication |