CN1857502A - Chinese medicine liniment for treating toothache and its preparing method - Google Patents
Chinese medicine liniment for treating toothache and its preparing method Download PDFInfo
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- CN1857502A CN1857502A CN 200610041929 CN200610041929A CN1857502A CN 1857502 A CN1857502 A CN 1857502A CN 200610041929 CN200610041929 CN 200610041929 CN 200610041929 A CN200610041929 A CN 200610041929A CN 1857502 A CN1857502 A CN 1857502A
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Abstract
The present invention discloses Chinese medicine liniment for treating toothache and its preparation process, and the Chinese medicine liniment consists of sesame oil or other edible oil and the effective components of ten kinds of Chinese medicinal materials. The Chinese medicinal materials include pine pollen, pricklyash, borneol, clove, menthol, etc. The preparation process of the Chinese medicine liniment includes the steps of: extracting effective components from seven kinds of Chinese medicinal materials with sesame oil or other edible oil as solvent, extracting liposoluble component of pine pollen with n-hexane or petroleum ether, mixing the extracted effective components, the liposoluble component, borneol and menthol, filtering, and adding sesame oil or other edible oil to required volume. The Chinese medicine liniment has fast pain stopping, high curative rate and no toxic side effect.
Description
Technical field
The invention belongs to Chinese medicine preparation of field of medicaments and preparation method thereof, particularly a kind of Chinese medicinal liniment that is used for the treatment of toothache and preparation method thereof.
Background technology
Toothache is commonly encountered diseases, frequently-occurring disease.Be a kind of very worried disease in people's life, bring very big misery usually for people's life.The treatment of odontopathy divides western medical treatment and Chinese traditional treatment.
Doctor trained in Western medicine thinks that toothache mainly is that inflammation causes, as gingivitis, pulpitis, periodontitis, pericoronitis and sharp pericoronitis etc. take place, so Therapeutic Method adopts the bactericidal antiphlogistic medicine more, as metronidazole, tinidazole, penicillin, Da Lixin and ofloxacin etc., and the special-purpose medicaments that is used to have a toothache is rarely found.
The method of Chinese traditional treatment toothache has three kinds of acupuncture, Chinese medicine dietetic therapy (as with the boxthorn root boiled egg, control toothache etc. with salty lean meat, Mytilus, the Radix Rehmanniae medicated porridge of stewing) and Drug therapys.The method of traditional Chinese medical science Drug therapy toothache is a lot, and folk prescription, proved recipe and patent medicine are arranged.Too numerous to enumerate to the one-tenth side of treatment toothache in various medicine books of China's successive dynasties.The traditional Chinese medical science thinks that meridian of Hand-YANG MING is gone into lower tooth, and sufficient Yangming Channel go into to be gone up tooth, as the bright internal organs heat of sun, with through on disturb and then can cause toothache; Or outside ailment said due to cold or exposure attacked, interior Yu Yang was bright, stomach-fire upward flaming along the meridian; Or the kidney explicit loss is decreased hyperactivity of deficient fire; Or the sweet acid of polyphagia, ability to speak is unclean, and dirty dirty erosion tooth all can cause toothache.So it is dissimilar that toothache divides acute toothache, toothache due to stomach-fire, toothache caused by fire of deficiency type and worm tooth (being dental caries) toothache etc. on the traditional Chinese medical science, treatment is the employing clearing away heat-fire mostly, the medicine of loose wind pain relieving, removing pathogenic heat from blood and toxic substance from the body, and it is few to be directly used in antiodontalgic medicine.For example; the medicine treatment toothache of heat clearing away reducing internal heat such as YIQING KELI commonly used, cow-bezoar anti-toxic bolus, xiongju shangqing pill, Fructus Gardeniae JINHUA ball, plum blossom tongue ball, coptos bolus for clearing the upper heat and xinqingning tablet in Chinese traditional patent formulation that Chinese Pharmacopoeia (an one) is upward announced and the preparation, the Chinese traditional patent formulation of directly controlling toothache on the Chinese Pharmacopoeia (an one) has only toothache killer pill and BINGPENG SAN.The compound recipe that Fu Jianxi invention is produced by the Xi'an miracle pharmaceutical Co. Ltd new drug of peaceful liniment (the accurate word Z20026989 of traditional Chinese medicines) of having a toothache for another direct treatment toothache.
The data-searching of carrying out according to the applicant, the patent of the control toothache of announcing in China has at present: prescription of the prescription of the prescription of the prescription of specific liquid for periodontitis and method for making thereof (patent No. 87101653), a kind of Yatongsan powder for curing toothache and manufacture method (patent No. 91105043.4), a kind of gargle of having a toothache and manufacture method (patent No. 94105618.X), a kind of prescription for the treatment of toothache external Chinese medicine and preparation method thereof (patent No. 97119118.2), a kind of medicine for the treatment of toothache, odontopathy and preparation method thereof (patent No. 99117634.0).
The applicant is through thinking that to the conscientiously research of above-mentioned prior art there is following weak point in these technology:
1. because doctor trained in Western medicine is controlled the main method that adopts bactericidal antiphlogistic of toothache, these medicines are no doubt fine for the radical cure toothache, but can not directly remove tooth pain, need the long period just can prove effective with the antibiotic medicine, so treatment cycle is long, can not in time solve odontopathy patient misery at that time, and this class Western medicine is easy to generate toxic and side effects and drug resistance, injure one's stomach influence digestion easily as metronidazole; Antibacterial have drug resistance to penicillium sp, necessary heavy dose and the medication of long period etc.
2. because middle treatment toothache is most ofly adopted clearing away heat-fire, the medicine of loose wind pain relieving, removing pathogenic heat from blood and toxic substance from the body, and these medicines are no doubt also effective for the radical cure toothache, but also need the long time just can work, it is for the moment painful to solve the odontopathy patient; Though the medicine that has in the Chinese medicine contains Cinnabaris, Venenum Bufonis, Realgar as the toothache killer pill detumescence of easing pain, BINGPENG SAN also contains Cinnabaris, and is poisonous, can only external, and can pain relieving but can not dig up the roots; In addition, oral Chinese medicine is overeated and is not only injured one's stomach, and will drop, and many patients, particularly child are difficult for accepting the treatment of this mode.
3. the disclosed several patents of controlling toothache of above-mentioned Chinese patent all also do not change into production at present, do not have formal product, are difficult to comment on the quality of its effect, only say some weak point of their existence here simply:
1. the prescription of specific liquid for periodontitis and method for making thereof, the patent No. 87101653 contains Arsenicum sablimatum in its formula material, and is poisonous;
2. a kind of prescription of Yatongsan powder for curing toothache and manufacture method, the patent No. 91105043.4, it is inconvenient that its preparation is that a kind of powder uses;
3. a kind of prescription of the gargle of having a toothache and manufacture method, the patent No. 94105618. its preparations are a kind of collutory, can not classify the medicine class as, its curative effect is difficult to confirm.
Toothache is commonly encountered diseases, frequently-occurring disease.Be a kind of very worried disease, as the saying goes that " toothache is not disease, ache what an awful nuisance " is so toothache often brings very big misery to people's life in people life.The sickness rate of China's odontopathy is ascendant trend year by year, and adult's odontopathy sickness rate reaches more than 90%, and child's odontopathy sickness rate reaches 75%.The harm of odontopathy is tooth itself head and shoulders above, and it tends to have influence on histoorgan generation pathological changes such as the heart, brain, lung, and for example, odontopathy can cause multiple diseases such as heart disease, nephropathy, pneumonia, arthritis, even can exert an influence to anemia of pregnant woman and fetus.Thereby odontopathy becomes the major incentive of the high disease of some mortality rate.Therefore, research quickly alleviating pain, anti-inflammation detumescence, the pure natural remedy,toothache that has no side effect are imperative.
Summary of the invention
The object of the present invention is to provide a kind of can quickly alleviating pain, fast anti-inflammation detumescence and have no side effect be used for the treatment of Chinese medicinal liniment of toothache and preparation method thereof, Chinese medicinal liniment of the present invention is the Chinese traditional compound medicine of pure natural, belong to nontoxic level medicine, but not only oral administration but also external.
In order to realize above-mentioned task, the present invention takes following technical solution:
A kind of Chinese medicinal liniment that is used for the treatment of toothache is characterized in that the Chinese medicinal liniment that makes is made of Oleum Sesami or other edible oil and raw material the effective elements of the medicine, and wherein crude drug and percentage by weight are: Pollen Pini, 35%～40%, Pericarpium Zanthoxyli, 25%～35%, Borneolum Syntheticum, 5%～10%, Flos Caryophylli, 3%～6%, Mentholum, 3%～6%, Herba Schizonepetae, 2%～4%, Fructus Piperis Longi, 2%～4%, Herba Artemisiae Scopariae, 2%～4%, Radix Glycyrrhizae, 2%～4%, Fructus Anisi Stellati, 2%～4%; The percentage by weight sum of above-mentioned raw materials medicine is 100%.
The preparation method of above-mentioned Chinese medicinal liniment: it is characterized in that, comprise the following steps:
1) composition of crude drug and prescription (percentage by weight)
Pollen Pini, 35%～40%; Pericarpium Zanthoxyli, 25%～35%; Borneolum Syntheticum, 5%～10%; Flos Caryophylli, 3%～6%; Mentholum, 3%～6%; Herba Schizonepetae, 2%～4%; Fructus Piperis Longi, 2%～4%, Herba Artemisiae Scopariae, 2%～4%, Radix Glycyrrhizae, 2%～4%, Fructus Anisi Stellati, 2%～4%.
2) take by weighing Pericarpium Zanthoxyli, Flos Caryophylli, Fructus Piperis Longi, Herba Schizonepetae, Radix Glycyrrhizae, Herba Artemisiae Scopariae and Fructus Anisi Stellati seven flavor crude drug according to above-mentioned prescription and be ground into fine powder, under 50 ℃ of conditions, extract twice, extracted 16 hours at every turn, filter, merge filtrate twice, get Oleum Sesami filtrate with Oleum Sesami;
3) take by weighing Pollen Pini according to above-mentioned formula proportion, extract twice with normal hexane or with petroleum ether (60 ℃～90 ℃) under 50 ℃ of conditions, extracted 4 hours at every turn, filter, merging filtrate reclaims normal hexane or petroleum ether, makes pollen essence;
4) under 40 ℃ condition, pollen essence is dissolved in the above-mentioned Oleum Sesami filtrate, mixing, static, filter, obtain standby filtrate;
5) Borneolum Syntheticum and the Mentholum of adding formula ratio in above-mentioned standby filtrate, stirring and dissolving filters, and adds Oleum Sesami to the prescribed volume amount, packing, promptly.
The present invention is the Chinese medicinal liniment that is used for the treatment of toothache, through clinical trial certificate, has following medical effect:
(1) pain relieving rapidly.Clinical trial shows that toothache can relieve the pain after medication 1-5 minute.
(2) can take stopgap measures, can effect a permanent cure again.Outside the decapacitation pain relieving immediately, periodontal disease and redness get final product antiinflammatory, detumescence behind the medication several hrs.
(3) cure rate and effective percentage height.Clinical trial proves, the compound recipe peaceful liniment of having a toothache is 79.8% to the cure rate of gingivitis, periodontitis and tooth pain, and total effective rate is 99.5%.
(4) has very strong bacteriostasis.Pharmacodynamics test shows, the compound recipe peaceful liniment of having a toothache all has obvious bacteriostasis to first streptococcus, escherichia coli, bacillus pyocyaneus, Candida albicans, staphylococcus aureus, and can keep 48 hours.
(5) pure natural has no side effect.Have a toothache most raw materials of peaceful liniment of compound recipe all are medicine-food two-purposes, the toxicity test result, and the per kilogram rat is once taken the compound recipe peaceful liniment 38.4g that has a toothache and any ill symptoms do not occurred, so it belongs to nontoxic level medicine, but not only oral administration but also external.
(6) clinical trial shows, compound recipe is had a toothache peaceful liniment except treating gingivitis, periodontitis and tooth pain disease, can also treat intraoral inflammation, as aphtha, tongue boil and oral ulcer etc.
The specific embodiment
The Chinese medicinal liniment that is used for the treatment of toothache of the present invention is named as " compound recipe have a toothache peaceful liniment " in applicant's implementation process according to the requirement of new drug.Below be the specific embodiment that the inventor provides, need to prove to the invention is not restricted to this embodiment, also can amplify and produce in optional ratio in prescription scope of the present invention.
1. the compound recipe prescription of peaceful liniment of having a toothache:
Crude drug: Pollen Pini 120g, Pericarpium Zanthoxyli 90g, Borneolum Syntheticum 22g, Flos Caryophylli 15g, Mentholum 13g, Herba Schizonepetae 10g, Fructus Piperis Longi 10g, Herba Artemisiae Scopariae 10g, Radix Glycyrrhizae 10g, Fructus Anisi Stellati 10g;
From above-mentioned prescription as can be seen, but wherein part be the crude drug of the medicine-food two-purpose of Ministry of Public Health announcement.
2. adjuvant (solvent): Oleum Sesami or other edible oil 1200ml; Described other edible oil select wheat germ oils, maize embryo oil, walnut oil, Oleum Arachidis hypogaeae semen, Oleum Hippophae, safflower oil one of them.
3. the compound recipe preparation method of peaceful liniment of having a toothache:
Take by weighing Pericarpium Zanthoxyli, Flos Caryophylli, Fructus Piperis Longi, Herba Schizonepetae, Radix Glycyrrhizae, Herba Artemisiae Scopariae, Fructus Anisi Stellati seven flavor crude drug by above-mentioned prescription, mix homogeneously is ground into fine powder, adds 700mL Oleum Sesami or other edible oil, extracts 16h earlier under 50 ℃ of temperature conditions, filters; In filtering residue, add 500mL Oleum Sesami or other edible oil then again, under 50 ℃ of temperature conditions, repeat to extract 16h, filter, merge filtrate twice, obtain Oleum Sesami or other edible oil solution for standby.
Take by weighing the 120g Pollen Pini, be ground into fine powder, add 600mL normal hexane or petroleum ether (60-90 ℃), under 50 ℃ of temperature, extract 4h, filter; In filtering residue, add 500mL normal hexane or petroleum ether (60-90 ℃) again, under 50 ℃ of temperature, repeat to extract 4h, filter, merge filtrate twice, and reclaim petroleum ether, make pollen essence, standby.
In the time of 40 ℃, the pollen essence that makes is dissolved in the above-mentioned Oleum Sesami solution, mixing, static, filter filtrate for later use.(4) require to add 22g Borneolum Syntheticum and 13g Mentholum according to formula proportion in above-mentioned filtrate, stirring and dissolving is filtered, and adds Oleum Sesami or other edible oil to 1000mL, and packing promptly gets the compound recipe peaceful liniment of having a toothache.
Compound recipe have a toothache peaceful liniment assay and analyze discrimination method, carry out according to officinal regulation.
Below be toxicology and the pharmacodynamics test that the applicant provides.
1) toxicology test:
Toxicology test is undertaken by Traditional Chinese Medicine Research Institute, Shanxi Province herbal pharmacology research department, and the study director is the Xu Qingyuan professor.
Tried thing and be the compound recipe peaceful liniment of having a toothache, this liniment is pale brown color oil preparation, and every milliliter is equivalent to the 0.64g crude drug.
Experimental animal is a white mice ICR kind, and 20, male and female half and half are provided by zooscopy center, Traditional Chinese Medicine Research Institute, Shanxi Province, body weight 18～22g, and 20, freely absorb feedstuff and drinking-water, room temperature is kept between 15～20 ℃.
After the fasting 12 hours, divide within one day and irritate stomach for 2 times and give the compound recipe peaceful liniment 38.4g/kg that has a toothache, observed the change and the death toll of record mice ordinary circumstance continuously 7 days.
The result shows: mice diet, drinking-water, defecation and activity etc. are all normal, do not see any toxic reaction, also none dead mouse, and it is all no abnormal to dissect outward appearances such as the back institute finding heart, liver, spleen, lung, kidney, stomach, thymus, adrenal gland.This amount is equivalent to 600～1000 times of clinical consumption.
2) pharmacodynamics test:
Pharmacodynamics test is undertaken by Traditional Chinese Medicine Research Institute, Shanxi Province herbal pharmacology research department, and the study director is the Xu Qingyuan professor.
Tried thing and be the compound recipe peaceful liniment of having a toothache, this liniment is pale brown color oil preparation, and every milliliter is equivalent to the 0.64g crude drug.
Experimental animal still is a white mice ICR kind, body weight 18～22g, and male and female half and half are freely absorbed feedstuff and drinking-water, and room temperature is kept between 15～20 ℃.
(1). bacteriostasis
Test method:
1. medicament selection culture medium dilution commonly used, dilution are to experimentize after 1/10,1/40,1/80,1/160,1/320.
2. strain selects pathogenic bacterium common in the oral cavity: alpha streptococcus, escherichia coli, bacillus pyocyaneus, Candida albicans, staphylococcus aureus, strain was cultivated 8 hours through meat soup, 1/10 diluting effect.
3. different medicinal liquid and 1/10 bacterial cultures immixtures of diluting.
4. the effect of getting 5min, 30min, 60min, 24h, 48h medicine bacterium mixture are observed the medicine fungistatic effect.
Result of the test:
This medicine and bacterial action 30min to alpha streptococcus 1: 10, escherichia coli 1: 320, bacillus pyocyaneus 1: 10, Candida albicans 1: 10, staphylococcus aureus 1: 40, have very strong bacteriostasis.Medicine and bacterial action 48h still have obvious bacteriostasis.This test is through repeated authentication, and drug effect is remarkable, reliable effect.This medicine also can be prevented and treated pharynx, oral cavity infection disease in the treatment toothache.
2) analgesic activity experiment
(1) crooks method: mice ICR kind, body weight 18～22g, male and female half and half, matched group is given isometric tap water, the administration group is had a toothache after the dosage of peaceful liniment: 0.96g/kg, 1.92g/kg, 3.84g/kg gives mouse stomach administration 40min with compound recipe, and every mouse peritoneal is injected 0.7% glacial acetic acid 0.2mL/kg, injects to begin in back 5 minutes to observe, note down the writhing response number of times that occurs in every mice 10min, ask the analgesia suppression ratio.In addition, also make comparisons with the ZHENTONGDING group, the ZHENTONGDING administration is 0.01g/kg.The results are shown in Table 1.
The influence of peaceful liniment of having a toothache of table 1 compound recipe to mouse writhing reaction
| Group | Dosage (g/kg) | Number of animals (only) | Turn round the body number of times (inferior/10min) | Analgesia suppression ratio (%) |
| Normal control | 12 | 43.4±9.35 | ||
| Compound recipe toothache peaceful (the present invention) | 0.96 1.92 3.84 | 13 15 15 | 32.9±8.87*** 22.4±8.14*** 19.7±8.43*** | 24.2 48.4 54.8 |
| ZHENTONGDING | 0.01 | 12 | 11.3±3.84*** | 73.9 |
Compare with matched group, the symbol material * in the table represents P＜0.001.
Result of the test shows that the compound recipe toothache rather can significantly reduce the writhing response number of times that acetic acid causes, is dose dependent.Prove that compound recipe toothache of the present invention rather has significant analgesia role.
(2) hot plate method: select 45 of mices in the pain valve 10～30 seconds, male, be divided into 3 groups, matched group is given isometric tap water, the administration group is with the have a toothache dosage gastric infusion of peaceful liniment 0.96g/kg, 1.92g/kg of compound recipe, interval 30min surveys once pain valve behind the single administration, totally 2 times, the results are shown in Table 2.
The toothache of table 2 compound recipe rather causes the influence of pain to the mice hot plate
| Group | Dosage g/kg | Basis pain valve S ' | Pain valve after the administration | |
| 30minS’ | 60minS’ | |||
| Normal control | 21.4±5.4 | 17.8±3.1 | 24.0±4.28 | |
| Compound recipe toothache peaceful (the present invention) | 0.96 1.92 | 19.2±4.0 17.7±3.4 | 23.5±11.6*** 38.8±7.8*** | 30.3±13.8 33.7±7.92*** |
Compare with matched group, the symbol material * in the table represents P＜0.001
Result of the test shows, the have a toothache dosed administration of peaceful 0.96～1.92g/kg of compound recipe, the effect of the pain valve that is significantly improved.
Claims (4)
1. Chinese medicinal liniment that is used for the treatment of toothache is characterized in that the Chinese medicinal liniment that makes is made of Oleum Sesami or other edible oil and raw material the effective elements of the medicine, and wherein the percentage by weight of crude drug is: Pollen Pini, 35%～40%; Pericarpium Zanthoxyli, 25%～35%; Borneolum Syntheticum, 5%～10%; Flos Caryophylli, 3%～6%; Mentholum, 3%～6%; Herba Schizonepetae, 2%～4%; Fructus Piperis Longi, 2%～4%; Herba Artemisiae Scopariae, 2%～4%; Radix Glycyrrhizae, 2%～4%; Fructus Anisi Stellati, 2%～4%; The percentage by weight sum of above-mentioned raw materials medicine is 100%.
2. the Chinese medicinal liniment that is used for the treatment of toothache as claimed in claim 1 is characterized in that, described other edible oil be wheat germ oil, maize embryo oil, walnut oil, Oleum Arachidis hypogaeae semen, Oleum Hippophae and Flos Carthami oil one of them.
3. preparation method that is used for the treatment of the Chinese medicinal liniment of toothache: it is characterized in that, comprise the following steps:
1) crude drug effective ingredient prescription
Pollen Pini, 35%～40%; Pericarpium Zanthoxyli, 25%～35%; Borneolum Syntheticum, 5%～10%; Flos Caryophylli, 3%～6%; Mentholum, 3%～6%; Herba Schizonepetae, 2%～4%; Fructus Piperis Longi, 2%～4%, Herba Artemisiae Scopariae, 2%～4%, Radix Glycyrrhizae, 2%～4%, Fructus Anisi Stellati, 2%～4%; The percentage by weight sum of crude drug is 100%;
2) take by weighing Pericarpium Zanthoxyli, Flos Caryophylli, Fructus Piperis Longi, Herba Schizonepetae, Radix Glycyrrhizae, Herba Artemisiae Scopariae and Fructus Anisi Stellati seven flavor crude drug according to above-mentioned prescription percentage ratio and be ground into fine powder, extract twice under 50 ℃ of conditions with Oleum Sesami or other edible oil, the each extraction 16 hours, filter, merge filtrate twice, get Oleum Sesami or other edible oil filtrate;
3) take by weighing Pollen Pini according to above-mentioned formula proportion, extract twice with normal hexane or petroleum ether (60 ℃～90 ℃) under 50 ℃ of conditions, extracted 4 hours at every turn, filter, merging filtrate reclaims normal hexane or petroleum ether, makes pollen essence;
4) under 40 ℃ condition, pollen essence is dissolved in above-mentioned Oleum Sesami or other edible oil filtrate, mixing, static, filter, obtain standby filtrate;
5) Borneolum Syntheticum and the Mentholum of adding formula ratio in above-mentioned standby filtrate, stirring and dissolving filters, and adds Oleum Sesami or other edible oil to the prescribed volume amount, packing, promptly.
4. method as claimed in claim 3 is characterized in that, described other edible oil be wheat germ oil, maize embryo oil, walnut oil, Oleum Arachidis hypogaeae semen, Oleum Hippophae and Flos Carthami oil one of them.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102090462A (en) * | 2010-12-31 | 2011-06-15 | 万勤劳 | Preparation technology for soft beancurd containing Chinese medicinal herbs |
| CN104069239A (en) * | 2014-06-16 | 2014-10-01 | 刘玉莲 | Traditional Chinese medicine composition for treating toothache |
| CN105878664A (en) * | 2016-01-27 | 2016-08-24 | 张立红 | Chinese and western medicine combined prescription for treating dental ulcer |
| CN110025671A (en) * | 2019-05-09 | 2019-07-19 | 西南民族大学 | A kind of composition and its preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244358C (en) * | 2003-12-10 | 2006-03-08 | 陈少华 | Exterior coating medicine for relieving toothache |
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2006
- 2006-03-14 CN CNB2006100419294A patent/CN100350931C/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102090462A (en) * | 2010-12-31 | 2011-06-15 | 万勤劳 | Preparation technology for soft beancurd containing Chinese medicinal herbs |
| CN104069239A (en) * | 2014-06-16 | 2014-10-01 | 刘玉莲 | Traditional Chinese medicine composition for treating toothache |
| CN104069239B (en) * | 2014-06-16 | 2016-05-18 | 刘玉莲 | A kind of Chinese medicine composition for the treatment of toothache |
| CN105878664A (en) * | 2016-01-27 | 2016-08-24 | 张立红 | Chinese and western medicine combined prescription for treating dental ulcer |
| CN110025671A (en) * | 2019-05-09 | 2019-07-19 | 西南民族大学 | A kind of composition and its preparation method and application |
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| Publication number | Publication date |
|---|---|
| CN100350931C (en) | 2007-11-28 |
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