CN107050242B - Traditional Chinese medicine composition for treating acute soft tissue injury, preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for treating acute soft tissue injury, preparation method and application thereof Download PDF

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CN107050242B
CN107050242B CN201710270186.6A CN201710270186A CN107050242B CN 107050242 B CN107050242 B CN 107050242B CN 201710270186 A CN201710270186 A CN 201710270186A CN 107050242 B CN107050242 B CN 107050242B
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CN107050242A (en
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时淑华
陈炜
潘小郑
何茶叶
黄锦荣
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Henan Institute of Science and Technology
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus

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Abstract

The invention discloses a traditional Chinese medicine composition for treating acute soft tissue injury, a preparation method and application thereof, wherein the traditional Chinese medicine composition for treating acute soft tissue injury comprises the following components in parts by weight: 100-120 parts of gardenia, 100-120 parts of rhubarb, 60-80 parts of angelica dahurica, 30-50 parts of frankincense, 30-50 parts of myrrh, 30-50 parts of pseudo-ginseng and 10-20 parts of dragon's blood. The traditional Chinese medicine is prepared from pure natural raw materials, various medicines are organically matched, synergy is realized, the preparation is reasonable, the raw materials are rich, the method is simple, the curative effect is good, the effect is quick, the efficiency is high, the cost is low, no side effect is caused, and the traditional Chinese medicine is a great innovation of traditional Chinese medicine products for treating acute soft tissue injury.

Description

Traditional Chinese medicine composition for treating acute soft tissue injury, preparation method and application thereof
Technical Field
The invention relates to a traditional Chinese medicine composition for treating acute soft tissue injury, a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines.
Background
In various physical exercises, accidental injuries of organisms occur, wherein soft tissue injuries are the most common, and comprise muscle, tendon, ligament, fascia, joint capsule and other soft tissue injuries, and the injuries belong to the category of muscle injuries in orthopedics in traditional Chinese medicine. After trauma of human body tissue, the meridians are damaged, and the blood stasis of the exiting meridians is stagnated between the tendons and muscles to block the meridians, so that swelling, pain and tenderness can occur locally. When blood stasis transforms into heat, local red swelling and fever occur, and qi and blood are stagnated; loss of moistening of tendons and vessels leads to restricted activity and dysfunction, and in the course of treatment in traditional Chinese medicine, it is mainly used to promote blood circulation and remove blood stasis, so as to achieve the purpose of detumescence and relieving pain.
At present, a plurality of medicines for treating soft tissue injury in the market, such as traumatic pills, pseudo-ginseng tablets and the like, are observed in a large number of cases, and most of the medicines have long treatment period, cannot directly act on affected parts, and have the problems of unsatisfactory effect or inconvenient use, pharmacological errors and the like. In the aspect of western medicine treatment, the anti-inflammatory and analgesic medicines are usually taken for treating human soft tissue injury, but the defects of long treatment period, temporary and permanent treatment, high recurrence, relatively high treatment cost and the like exist.
Disclosure of Invention
In order to solve the problems, the invention aims to provide the traditional Chinese medicine composition for treating acute soft tissue injury, the preparation method and the application thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
the traditional Chinese medicine composition for treating acute soft tissue injury comprises the following components in parts by weight: 100-120 parts of gardenia, 100-120 parts of rhubarb, 60-80 parts of angelica dahurica, 30-50 parts of frankincense, 30-50 parts of myrrh, 30-50 parts of pseudo-ginseng and 10-20 parts of dragon's blood.
Preferably, the traditional Chinese medicine composition for treating acute soft tissue injury comprises the following components in parts by weight: 100 parts of gardenia, 100 parts of rhubarb, 60 parts of angelica dahurica, 30 parts of frankincense, 30 parts of myrrh, 30 parts of pseudo-ginseng and 10 parts of dragon's blood.
A Chinese medicinal composition for treating acute soft tissue injury is prepared by weighing fructus Gardeniae, radix et rhizoma Rhei, radix Angelicae Dahuricae, Olibanum, Myrrha, Notoginseng radix and sanguis Draxonis by weight parts, pulverizing respectively, sieving with 100 mesh sieve, mixing the powders of fructus Gardeniae, radix et rhizoma Rhei, radix Angelicae Dahuricae, Olibanum, Myrrha, Notoginseng radix and sanguis Draxonis uniformly, and bottling in brown glass bottle.
The application of the traditional Chinese medicine composition in treating acute soft tissue injury.
Specifically, the traditional Chinese medicine composition is mixed with honey with the same volume, mixed into paste, and smeared on a gauze cotton pad to be externally applied to an affected part.
The pharmacological actions of the components are as follows:
in the formula, rhubarb and gardenia which are used as monarch drugs can clear heat and purge fire. Rhubarb is a plant of the Polygonaceae family, is bitter and cold in nature, has the functions of clearing heat and toxic materials, removing blood stasis and breaking food retention, and has the wonderful effect of stopping bleeding without retaining blood stasis especially for new blood stasis. According to the records of materia medica, rhubarb rapidly moves to directly reach the lower jiao and deeply enter the blood system without hardness, breaking, washing and scaling, has the function of sweeping the points of the courtyard, is unprocessed, has complete power, is rapidly like a pill, is not remained, and can eliminate pathogenic factors without damaging healthy qi. The rhubarb is unprocessed, so it has the action of removing blood stasis. Gardenia jasminoides ellis is a dry mature fruit of Gardenia jasminoides Ellis of Rubiaceae, is bitter and cold in nature, can clear heat and promote diuresis, relieve swelling and pain, cool blood and remove toxicity, purge fire and relieve restlessness, and is called as Gardenia jasminoides Ellis in Shen nong Ben Cao to purge triple energizer fire and induce diuresis to alleviate edema, so as to be suitable for traumatic injury and swelling. The frankincense and the myrrh which activate blood circulation to stop pain, reduce swelling and promote granulation are ministerial drugs. Olibanum is resin exuded from bark of Boswellia serrata of Burseraceae and other plants of the same genus, and can be broken into pieces, unprocessed, stir-baked for oral administration, pungent, bitter and warm in nature, and has effects of promoting blood circulation, activating qi-flowing, relieving pain, subsiding swelling and promoting granulation. The Myrrha is oleoresin exuded from bark of Commiphora molmol of Burseraceae or other plants of the same genus, and has effects of promoting blood circulation, relieving pain, eliminating swelling, and promoting granulation. The raw myrrh has stronger functions of removing blood stasis and relieving swelling. Radix Angelicae Dahuricae and Notoginseng radix can be added to remove blood stasis and detumescence, dispel pathogenic wind and relieve pain, dissipate stagnation of qi system, and remove blood stasis of blood system. Radix Angelicae Dahuricae is a plant of Angelica of Umbelliferae, and has effects of dispelling pathogenic wind, relieving pain, subsiding swelling, and dispelling stagnation of qi and blood. Notoginseng is the dry root and rhizome of Panax notoginseng belonging to Araliaceae, and has sweet, slightly bitter and warm nature. Has the functions of eliminating blood stasis, stopping bleeding, eliminating swelling, relieving pain, stopping bleeding and promoting blood circulation. Sanguis Draxonis is prepared from resin exuded from fruit of daemonorops draco of Palmaceae, and has sweet, salty and neutral taste. The external application of dragon's blood in the prescription can stop bleeding, promote tissue regeneration and heal wound, and is a common essential drug for traumatic injury, traumatic hemorrhage, improper wound and other trauma diseases, and is used as a guiding drug.
The honey used by the blending matrix is raw refined pure honey which can form high osmotic pressure and soften hardness and dissipate stagnation, and the pharmacological actions of the honey are ' Gaoping and non-toxic, tonifying qi and strengthening middle energizer, relieving pain and detoxifying, removing diseases and mixing with hundreds of drugs ' discussed in the compendium of materia medica '. Recently, the research of the medical center of the university of Amsterdam discovers that a protein called defensen-1 in honey has a good effect on infection caused by antibiotic-resistant bacteria, and a plurality of researches also prove that the anti-microbial activity and the effect of promoting wound healing of the honey are superior to those of other matrixes.
The traditional Chinese medicine is prepared from pure natural raw materials, various medicines are organically matched, synergy is realized, the preparation is reasonable, the raw materials are rich, the method is simple, the curative effect is good, the effect is quick, the efficiency is high, the cost is low, no side effect is caused, and the traditional Chinese medicine is a great innovation of traditional Chinese medicine products for treating acute soft tissue injury.
Detailed Description
The following examples further illustrate the embodiments of the present invention in detail.
Example 1
The invention relates to a traditional Chinese medicine composition for treating acute soft tissue injury, which comprises the following components in parts by weight: 100 parts of gardenia, 100 parts of rhubarb, 60 parts of angelica dahurica, 30 parts of frankincense, 30 parts of myrrh, 30 parts of pseudo-ginseng and 10 parts of dragon's blood.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing gardenia, rhubarb, angelica dahurica, frankincense, myrrh, pseudo-ginseng and dragon's blood in parts by weight, respectively crushing, sieving by a 100-mesh sieve, uniformly mixing the powder of gardenia, rhubarb, angelica dahurica, frankincense, myrrh, pseudo-ginseng and dragon's blood, and filling into a brown glass bottle for later use.
Example 2
The invention relates to a traditional Chinese medicine composition for treating acute soft tissue injury, which comprises the following components in parts by weight: 110 parts of gardenia, 110 parts of rhubarb, 70 parts of angelica dahurica, 40 parts of frankincense, 40 parts of myrrh, 40 parts of pseudo-ginseng and 15 parts of dragon's blood.
The preparation method of the traditional Chinese medicine composition is the same as that of example 1.
Example 3
The invention relates to a traditional Chinese medicine composition for treating acute soft tissue injury, which comprises the following components in parts by weight: 120 parts of gardenia, 120 parts of rhubarb, 80 parts of angelica dahurica, 50 parts of frankincense, 50 parts of myrrh, 50 parts of pseudo-ginseng and 20 parts of dragon's blood.
The preparation method of the traditional Chinese medicine composition is the same as that of example 1.
Clinical application
The Chinese medicinal composition of the invention obtains good effect through clinical application, and the relevant data are as follows:
1. the cases are as follows: typical cases of acute soft tissue injury, 300 cases, wherein 157 cases of male, 143 cases of female, the age is 15-70 years old, the time of injury is 15min-6h, and no fracture and dislocation are found through x-ray examination. The disease was classified into mild, moderate and severe 3 grades according to the grade of mild, moderate and severe, wherein 87 are mild, 121 are moderate and 92 are severe. Slight swelling, slight tenderness and free movement in the local area; moderate degree is local swelling and pain, the daily activity is limited, and the subcutaneous part has tenderness and blood stasis, which does not influence daily work and study; severe swelling, persistent severe pain in the local area, restricted life and work, and obvious subcutaneous blood stasis.
2. The treatment method comprises the following steps: the affected part is disinfected by a 75% alcohol cotton ball, then the traditional Chinese medicine composition (example 1) and honey with the same volume are mixed into paste according to the range of the affected part, the paste is evenly spread on a gauze cotton pad, the thickness is about 3mm, the paste is externally applied to the affected part and then bandaged and fixed, the medicine is changed 1 time every 1 day, and 3 times are a treatment course.
3. Observation of therapeutic effects
After a treatment course, the curative effect of the traditional Chinese medicine composition is evaluated according to the traditional Chinese medicine disease diagnosis curative effect standard. And (3) curing: pain, swelling and tenderness of the affected part disappear completely, and joint movement returns to normal; the effect is shown: pain, swelling and tenderness of affected parts are obviously relieved, and joint movement disorder is obviously improved; the method has the following advantages: the pain, swelling and tenderness of the affected part are relieved, and the joint movement disorder is improved to a certain extent; and (4) invalidation: no significant improvement in symptoms was seen after treatment (results are shown in table 1).
Table 1: statistics of 300 clinical treatment results
Item Cure of disease Show effect Is effective Invalidation
Number of examples 193 77 24 6
Percentage of 64 26 8 2
The results in table 1 show that 193 patients are cured (64%), 77 patients are remarkably effective (26%), 24 patients are effectively effective (8%), the total effective rate can reach 98%, and all cases have no adverse reaction in the treatment process.
The traditional Chinese medicine composition has good curative effect, no toxic or side effect, is simple, safe and reliable, is a great innovation of traditional Chinese medicine and pharmacy, and has good social and economic benefits.
The foregoing description is only a preferred embodiment of the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (5)

1. The traditional Chinese medicine composition for treating acute soft tissue injury is characterized by comprising the following components in parts by weight: 100-120 parts of gardenia, 100-120 parts of rhubarb, 60-80 parts of angelica dahurica, 30-50 parts of frankincense, 30-50 parts of myrrh, 30-50 parts of pseudo-ginseng and 10-20 parts of dragon's blood.
2. The traditional Chinese medicine composition for treating acute soft tissue injury according to claim 1, which is prepared from the following components in parts by weight: 100 parts of gardenia, 100 parts of rhubarb, 60 parts of angelica dahurica, 30 parts of frankincense, 30 parts of myrrh, 30 parts of pseudo-ginseng and 10 parts of dragon's blood.
3. A method for preparing the Chinese medicinal composition for treating acute soft tissue injury according to claim 1 or 2, which is characterized in that gardenia, rhubarb, angelica dahurica, frankincense, myrrh, pseudo-ginseng and dragon's blood are weighed according to the parts by weight, respectively crushed, sieved by a 100-mesh sieve, and then the powders of gardenia, rhubarb, angelica dahurica, frankincense, myrrh, pseudo-ginseng and dragon's blood are uniformly mixed and filled into a brown glass bottle to obtain the Chinese medicinal composition.
4. Use of a Chinese medicinal composition according to claim 1 or 2 in the preparation of a medicament for the treatment of acute soft tissue injury.
5. The use of claim 4, wherein the Chinese medicinal composition is mixed with honey of the same volume, concocted into paste, and applied on gauze cotton pad for topical application to the affected part.
CN201710270186.6A 2017-04-24 2017-04-24 Traditional Chinese medicine composition for treating acute soft tissue injury, preparation method and application thereof Active CN107050242B (en)

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Publication number Priority date Publication date Assignee Title
CN112206272A (en) * 2020-11-06 2021-01-12 李田来 External cold compress gel for closed soft tissue
CN114028487B (en) * 2021-09-08 2022-12-13 山东省运动康复研究中心 Pharmaceutical composition and preparation for treating acute soft tissue injury

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