CN103861039A - Bone-setting medicament and preparation method thereof - Google Patents
Bone-setting medicament and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a bone setting medicament. The bone setting medicament comprises the following components in parts by weight: 460 parts of bone powder, 2 parts of cornu cervi, 92 parts of native copper (calcined), 92 parts of frankincense, 55 parts of myrrh, 46 parts of safflower, 18 parts of dragon blood, 55 parts of curcuma zedoary, 230 parts of rhizoma drynariae, 230 parts of teasel root, 92 parts of ground beetle, 230 parts of salviae miltiorrhizae and 184 parts of Chinese angelica, wherein the bone powder is a mixture formed by burning dog bones, marmor serpentinatum and gypsum after being burnt with various herbs. Clinical application grouped researches find that the bone fracture clinical healing time of the oral preparation group is 22 days earlier than that of a control group; the medicament has a remarkably effect for promoting bone fracture curing, the course of treatment is shortened, and broad patients can return to work in advance, so that body pains can be reduced, and economical benefits can be increased.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of showy reiolaena root-bark and preparation method.
Background technology
At present, the sickness rate of trauma fracture is remarkable ascendant trend, is commonly encountered diseases, frequently-occurring disease, brings very large psychic pain and heavy financial burden to patient's daily life and normal work.Though modern medicine is very advanced, union of fracture after operative treatment and limb functional recover problem are lacked to systemic Drug therapy.And Chinese medicine has its definite, sure, unique and good abundant theory and clinical practice in this respect.Its Therapeutic Method and curative effect are that modern medicine is irreplaceable, are also incomparable, and this point is that clinical practice has proved repeatedly, does not need to doubt.
At present, on market, treat this class disease for oral administration, external application Chinese medicine goods are a lot, be a feast for the eyes, but also mix the genuine with the fictitious; Really eutherapeutic, or patient apply rear satisfaction seldom, still do not have a kind of medicine can effectively treat the Chinese medicine of trauma fracture.
Summary of the invention
The object of the invention is to overcome above-mentioned technical problem and a kind of eutherapeutic showy reiolaena root-bark and preparation method are provided.
For achieving the above object, the present invention adopts following technical scheme:
A kind of showy reiolaena root-bark, comprises following component by weight:
Bone meal 460 weight portions, Cornu Cervi Pantotrichum 2 weight portions, Pyritum (forging) 92 weight portions, Olibanum 92 weight portions, Myrrha 55 weight portions, Flos Carthami 46 weight portions, Sanguis Draxonis 18 weight portions, Rhizoma Curcumae 55 weight portions, Rhizoma Drynariae 230 weight portions, Radix Dipsaci 230 weight portions, Eupolyphaga Seu Steleophaga 92 weight portions, Radix Salviae Miltiorrhizae 230 weight portions, Radix Angelicae Sinensis 184 weight portions; Wherein, described bone meal is the mixture being mixed to form after BAICAO is fired by Os Canitis, Ophicalcitum, Gypsum Fibrosum.
Described Os Canitis, Ophicalcitum, the charge ratio of Gypsum Fibrosum in described bone meal are 4:3:3 by weight.
A preparation method for described showy reiolaena root-bark, comprises the following steps:
Os Canitis, Ophicalcitum, Gypsum Fibrosum are used through BAICAO roasting, and after roasting, Os Canitis becomes greyish white, and grey black is repeatedly fired, is burnt through into Ophicalcitum, Gypsum Fibrosum, and Os Canitis, Ophicalcitum, Gypsum Fibrosum after roasting are smashed, and mixes, and makes coarse powder, crosses 40 mesh sieves;
Get Rhizoma Curcumae, Rhizoma Drynariae, Radix Dipsaci, Olibanum, Myrrha and soak after 1 hour, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time; Collecting decoction, filters, for subsequent use after filtrate is concentrated;
Get Flos Carthami, Eupolyphaga Seu Steleophaga, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, with bone meal, Cornu Cervi Pantotrichum, Pyritum (forging), Sanguis Draxonis pulverization, cross 80 mesh sieves, and mix;
Get above-mentioned concentrated liquid flooding ball, 60 ℃ of oven dry, select ball, and ethane via epoxyethane sterilizing is placed and obtained described showy reiolaena root-bark after 7-10 days.
Described in roasting, Os Canitis, Ophicalcitum, Gypsum Fibrosum method are to fire 12 hours, dry and bury 12 hours.
We's perfect square compatibility is rigorous, and monarch is clear and definite, in rushing down, has benefit, mends and does not leak, and plays altogether effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of fractured tendons and bones.
Function cures mainly: blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of fractured tendons and bones.
Indication: for diseases such as each position fracture, bone does not connect, dislocation, soft tissue injurys.
Etiology and pathogenesis: External Force Acting is in body, cause bone break the muscle from, passages through which vital energy circulates breaks, qi depression to blood stasis, it closes bone dialysis, the injury of tendon and muscle is from its position, afunction.
The rule for the treatment of: blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, reunion of bone.
Described bone meal is synthetic, and by Os Canitis, Ophicalcitum, Gypsum Fibrosum form through weeds or crops straw common backed, are taupe after mixing, containing abundant calcium, potassium, phosphorus, plasma, has removing dampness, granulation promoting, sore, hemostasia effect.The required calcium of a large amount of union of fracture, Lin, Magnesium, zinc etc. are supplemented, the effect that this special process technology makes its removing toxic substances again with " Pulvis Fumi Carbonisatus ", " Terra Flava Usta ", hemostasis, spleen invigorating, calms the nerves.(Compendium of Material Medica is recorded: Pulvis Fumi Carbonisatus " digestion is stagnant ", " stopping upper and lower all blood ".Terra Flava Usta is that humus flava usta " is controlled pained mad insane ", " ecthyma is rotten for a long time ").
Pyritum is used as the medicine that synthetism cures the wound and has a long history in China, and occupies very large proportion in traditional synthetism side medicine, and oral administration and externally is all suitable, promotes that union of fracture effect is remarkable, is medicine indispensable in synthetism prescription.Experimentation, contains the elements such as a large amount of zinc, steel, ferrum, manganese, calcium in Pyritum medicinal liquid.After body absorbs, deposition mineralising, in callus, is conducive to collagen synthetic, and collagen fiber toughness is strengthened, and the insoluble increase of collagen, thereby enhances skeletal biomechanical strength, promote new osteogenesis.Bone meal and Pyritum large usage quantity in side, also just for callus formation provides sufficient raw material.
Cornu Cervi Pantotrichum kidney-replenishing, benefiting essence-blood, bone and muscle strengthening.Modern pharmacology proves that in Cornu Cervi Pantotrichum, pantocrine has certain anti-aging effects, and polyamines from pilose antler has antioxidation antler polypeptide can promote neuranagenesis and functional rehabilitation.Antler polypeptide is by promoting epidermis cell and fibroblast proliferation to accelerate skin wound healing.
Osteomiosis complementary energy promotes the absorption of bone to calcium, and improves blood calcium and serium inorganic phosphorus level, is conducive to the healing of fracture.Radix Dipsaci has invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia, the effect such as antiabortive.Shennong's Herbal is classified as top grade, and record this product " main typhoid fever, tonifying for the deficiency, incised wound, carbuncle and ulcer, folding falls, reuniting the fractured tendons and bones, married woman's breast is difficult, takes for a long time physical strength profiting "; " herbal decent " recorded, and " all diseases of all meridians muscles and bones blood vessels are led it to Radix Dipsaci invariably for suitable row hundred arteries and veins of energy, easing joint movement." Cornu Cervi Pantotrichum, Rhizoma Drynariae, the raw marrow of Radix Dipsaci Psoralen, strengthening the body resistance.To guarantee that body can absorb skeletonization raw material in time, promote callus formation.Compatibility exquisiteness, brings out the best in each other.
Olibanum, Myrrha are a pair of medicine of clinical conventional promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.And the pungent perfume (or spice) of Olibanum is walked to alter, enter the heart, Liver Channel.Bitter in the mouth is removed heat by catharsis into blood, can eliminating stasis to stop pain, and the eliminating carbuncle of invigorating blood circulation again, putrefaction-removing granulation-promoting, is external wounds key medicine.Control traumatic injury, often join the same use of medicine such as Myrrha, Sanguis Draxonis, Flos Carthami, as Anisodus carniolicoides C.Y.Wu et C.Chen (" good recipe liquid collecting "), often can play the effect of getting twice the result with half the effort.With the same use of medicine such as Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Myrrha, be famous Huoluo Xiaoling Dan, be that treatment congestion is stagnated the panacea of having a pain.(" Records of Tradition Chinese and Western Medicine in Combination ").The Compendium of Material Medica: " analgesic therapy of invigorating blood circulation." " Olibanum perfume (or spice) is altered, and can enter heart channel, and the analgesic therapy of invigorating blood circulation, therefore for treating injured, cardiac and abdominal pain key medicine.Get its loose blood evacuation of pus, ventilationization is stagnant is special merit ear.”
Sanguis Draxonis is the tradition medical material of invigorating blood circulation, there is " panacea of invigorating blood circulation " laudatory title, pertinent literature reports that it has very strong activity at treatment cardiovascular diseases, antiinflammatory and the hemostasis aspect such as invigorate blood circulation in recent years, and we get the effects such as its blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, astringing to arrest bleeding, hard masses softening and resolving, promoting tissue regeneration and ulcer healing.
Flos Carthami: function promoting blood circulation to restore menstrual flow, go the pain relieving of becoming silted up. cure mainly that amenorrhea, mass in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, congestion are had a pain, carbuncle, traumatic injury etc.
Eupolyphaga Seu Steleophaga: worm property is kind bores, can improve and the blood supply of enhancing body tissue. there is blood coagulation resisting function.
Rhizoma Curcumae: have promoting QI circulation for relieving depression, removing blood stasis with potent drugs, the function of pain relieving.For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea, traumatic injury is had a pain.Upper Six-element strengthens blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain act as adjuvant.
Radix Salviae Miltiorrhizae has activating blood circulation to dissipate blood stasis, freeing vessels and nourishing heart, removing heat from blood eliminating carbuncle, relieving restlessness effect such as calm the nerves, and Radix Angelicae Sinensis nourishes blood, is in harmonious proportion blood vessels effect, and two medicines share in we, has to calm the nerves relieving convulsionly, and QI and blood is adjusted and reached, and the spleen invigorating of nourishing heart, protects the use just consolidating.We have benefit in rushing down, mend and do not leak, play altogether effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of fractured tendons and bones.
In document ancient books and Modern Literature, the types of drugs research situation summary to about the present invention relates to:
Ophicalcitum famous in miraculous book of Ten Recipes is loose, for taking after mixing it with water at end, clinical in hemostasis, evident in efficacy after forging with Ophicalcitum.Modern age, the clinical treatment traumatic injury such as Olibanum, Myrrha, Lignum Sappan of often joining had removing blood stasis and relieving pain it [1], Os Canitis BAICAO roasting, and it,, containing trace element such as abundant calcium, phosphorus, potassium, is the indispensable material base of callus formation.Rhizoma Drynariae, " benefit is traumaticd fracture for main removing blood stasis, hemostasis in " Kaibao Bencao " record." recent studies application, its compatibility Radix Angelicae Sinensis, Flos Carthami, Radix Dipsaci etc., have the effect [2] of invigorating blood circulation analgesia accelerating union of bone fracture.Pyritum one medicine in side, real is the key medicine of Shangke bone-knitting, is longer than loose blood and relieving pain, promotes union of fracture.The Tang Dynasty pharmacy man solar corona for this product can " evacuation of pus, the congestion that disappears, reuniting the fractured tendons and bones." " Kaibao Bencao " also carry: " and treat injured, loose blood and relieving pain, removing mass is poly-." Cao Shi adopts effective JIEGU GAO handed down from one's ancestors to join other drug with Pyritum, additional plintlet fixation for treatment fracture delayed union, bone does not connect 38 examples, produce effects good [3].Experimental study in modern age, adopts Pyritum recurrence preparation to take 3 grams every day to rabbit, takes altogether 2-8 week, to the anti-pull strength of humeral fracture compared with matched group large [4].Radix Dipsaci one medicine, " book on Chinese herbal medicine is looked for the truth " thought: " promoting flow of QI and blood muscles and bones the first medicine also." " property of medicine opinion " explicitly points out this product " a surname's feeling pulse merit of stimulating the menstrual flow." modern age application for the treatment of traumatic injury, get its qualcomm meridian, the effect of reuniting the fractured tendons and bones.Compatibility Olibanum, Myrrha, Rhizoma Drynariae etc., can reducing swelling and alleviating pain, and reuniting the fractured tendons and bones is treated injured, has the effect [5] that promotes tissue regeneration.Olibanum, Myrrha two medicines, share in all pains of coagulation of QI-blood." book on Chinese herbal medicine is looked for the truth " thought and can be made: " gas work identical with blood." be the good merchantable brand of traumatology surgery in fact, " Huoluo Xiaoling Dan " that Zhang Xichun is famous is made up of two tastes.Sanguis Draxonis is longer than the loose all pains of stagnant blood, and modern age, pharmacological research had anastalsis, can significantly shorten plasma in rabbit recalcification time [6].Radix Salviae Miltiorrhizae one medicine, Li Shizhen (1518-1593 A.D.) is pointed out its " invigorate blood circulation, logical percardium ", has blood circulation promoting and blood stasis dispelling, the use of nourishing blood to tranquillize the mind.Modern age pharmacological research, Radix Salviae Miltiorrhizae have strengthen dredging microcirculatory effect [7].Hu Meizhu etc. pass through using isotope 51 chromium-sodium chromate tagged blood cells after 15 rabbit experiment forearm fracture, the variation of the Tissue Blood such as skeleton and the muscle capacity of research limbs, result shows, use the animal of Radix Salviae Miltiorrhizae, its fracture site congestion alleviates, local blood circulation improves, and reparation, healing to fracture have good facilitation [8].The product that medicine is all blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain is indispensable such as Rhizoma Curcumae, Flos Carthami, Radix Angelicae Sinensis, eupolyphaga, treatment traumatic injury often needs compatibility to use it.This Chinese medicine preparation prescription is rigorous, and compatibility is comprehensive, and monarch is proper, tonify without causing stagnation, row and do not let out.Play altogether blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the effect of reunion of bone.
List of references:
[1] Zhongshan Medical College is compiled: " Chinese medicine clinical practice " 265 pages, the Guangdong People's Press, 1975;
[2] Zhongshan Medical College is compiled: " Chinese medicine clinical practice " 366 pages, the Guangdong People's Press, 1975;
[3] Cao Yixun: " Shandong College of Traditional Chinese Medicine's report " (2): 45 pages, 1980;
[4] the new medical college in Jiangsu is compiled " Chinese medicine voluminous dictionary " (first volume) 878 pages, Shanghai People's publishing house, 1977;
[5] Chengdu Traditional Chinese Medical College compiles: " Chinese materia medica " 226 pages, Science and Technology of Shanghai publishing house, 1978;
[6] chief editor of the academy of traditional Chinese medicine: " national Chinese herbal medicine compilation " (volume two) 263 pages, People's Health Publisher, 1978;
[7] Hangzhou the 5th internal medicine in hospital department of neurology group: " Zhejiang Chinese medicine " (6): 200 pages, 1979 years;
[8] volume such as Hu Meizhu: " Chinese surgical magazine " (1), 33 pages, 1979 years.
Fracture of tibia and fibula, especially in hypomere fracture longer for reason clinical healing time because of its blood, very easily there is bone does not connect, according to statistics, before 1996, in this type of fracture 3 months, clinical healing rate is 30%, bone does not connect and delayed union rate reach 20%.Since self-application showy reiolaena root-bark treatment of the present invention, this group is observed 30 routine patients, and in 3 months, fracture of tibia and fibula clinical healing rate reaches 83.3%, none routine bone does not connect.Known from Grouping study, group for oral administration was than matched group clinical union of bone time advance 22 days, P < 0.01, difference has very significant, and obvious promotion union of fracture effect has been described, reunion of bone is played to good action, wherein contain Pyritum, can have activation to some enzyme, on the active group of enzyme in conjunction with copper ion, osteoblastic enlivening be can promote, the formation of bone matrix and the appearance in advance of calcification contributed to.Compare with the other medicines of the same indication for the treatment of, " showy reiolaena root-bark of the present invention has very significant clinical efficacy advantage.
Showy reiolaena root-bark of the present invention is pure Chinese medicinal preparation, at my institute's orthopedics department clinical more than 10 years, have no side effect, and taking convenience, economic effect is honest and clean, is deeply subject to surrounding area patient's favorable comment.Compare with the other medicines of the same indication for the treatment of, showy reiolaena root-bark of the present invention has very significant clinical efficacy advantage.
Showy reiolaena root-bark of the present invention does not add any antiseptic, can standardization (pressing Chinese medicine tradition method for making), scale, commercialization produce; Because its medicine source is wide and inexpensive, be again traditional Chinese medical science tradition method for making again, environment is not polluted substantially, also do not need complicated and expensive equipment, production cost is also lower, has very wide market prospect, has good Social benefit and economic benefit.
Known from clinical practice Grouping study, this preparation group for oral administration, than matched group clinical union of bone time advance 22 days, has obvious promotion union of fracture effect, shorten the course for the treatment of, be that extensive patients is resumed work in advance, both alleviated the misery of health, increased again economic benefit.
The specific embodiment
Below, in conjunction with example, substantive distinguishing features of the present invention and advantage are further described, but the present invention is not limited to listed embodiment.
Embodiment
A kind of showy reiolaena root-bark, comprises following component by weight:
Bone meal 460 weight portions, Cornu Cervi Pantotrichum 2 weight portions, Pyritum (forging) 92 weight portions, Olibanum 92 weight portions, Myrrha 55 weight portions, Flos Carthami 46 weight portions, Sanguis Draxonis 18 weight portions, Rhizoma Curcumae 55 weight portions, Rhizoma Drynariae 230 weight portions, Radix Dipsaci 230 weight portions, Eupolyphaga Seu Steleophaga 92 weight portions, Radix Salviae Miltiorrhizae 230 weight portions, Radix Angelicae Sinensis 184 weight portions; Wherein, described bone meal is the mixture being mixed to form after BAICAO is fired by Os Canitis, Ophicalcitum, Gypsum Fibrosum.
Wherein, described Os Canitis, Ophicalcitum, the charge ratio of Gypsum Fibrosum in described bone meal are 4:3:3 by weight.
In the present invention, described BAICAO refers to field weeds, or the material such as the straw stalk of Semen Maydis, Semen Tritici aestivi, Sorghum vulgare Pers..
A preparation method for described showy reiolaena root-bark, comprises the following steps:
Take raw material by above-mentioned weight portion, then Os Canitis, Ophicalcitum, Gypsum Fibrosum are used through BAICAO roasting, after roasting, Os Canitis becomes greyish white, grey black is repeatedly fired, is burnt through into Ophicalcitum, Gypsum Fibrosum, and Os Canitis, Ophicalcitum, Gypsum Fibrosum after roasting are smashed, and mixes, make coarse powder, (can cross 40 mesh sieves);
Get Rhizoma Curcumae, Rhizoma Drynariae, Radix Dipsaci, Olibanum, Myrrha and be ground into coarse powder (can cross 40 mesh sieves), soak after 1 hour, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time; Collecting decoction, filters, for subsequent use after filtrate is concentrated;
Get Flos Carthami, Eupolyphaga Seu Steleophaga, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, with bone meal, Cornu Cervi Pantotrichum, Pyritum (forging), Sanguis Draxonis pulverization, cross 80 mesh sieves (No. five sieves), and mix;
Get above-mentioned concentrated liquid flooding ball, 60 ℃ of oven dry, select ball, obtain 1000 grams of pills, and ethane via epoxyethane sterilizing is placed and obtained described showy reiolaena root-bark after 7-10 days.Be up to the standards, by 60 Chong Liang Fen ∕ bottle subpackages.
Described in roasting, Os Canitis, Ophicalcitum, Gypsum Fibrosum method are to fire 12 hours, dry and bury 12 hours.
Function of the present invention cures mainly: blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of fractured tendons and bones.For diseases such as each position fracture, bone does not connect, dislocation, soft tissue injurys.
Usage and dosage: oral, take for drawing with warm yellow wine.Alcohol user can not take by warm water.6 ~ 9 weight portions, 3 times on the one.Serveing on first quarter moon is a course for the treatment of.
Since nineteen ninety-six, in application, fixing and manual reduction adds on the basis of outer fixed reset, applies showy reiolaena root-bark of the present invention and treats all types of fracture, by clinical observation, can promote callus formation shortening healing time, obtains satisfied therapeutic effect for my institute.Now select clinically hypomere fracture 60 example analyses in the tibiofibula of more difficult healing to be summarized as follows:
1, clinical data
This group case is all hypomere fracture in tibiofibula.Treat 60 examples, the situation different according to patient, is divided into 2 treatment groups, i.e. we's group for oral administration 30 examples, matched group 30 examples (taking vitamin C, every day 2 times, each 0.2 gram).In 60 examples, male 44 examples, female's 16 examples; Age is 18-55 year, average 28.l year.Open fracture 36 examples, closed fracture 24 examples; Comminuted fracture 42 examples, simple fracture 18 examples; Stable fracture 14 examples, unstable fracture 46 examples (containing two section fracture 12 examples).60 example fracture are through 2 kinds of different treatments, the average natural law of clinical union of bone; Matched group is 102 days, and for oral administration group is 78 days.The acceptance rate of each group fracture late result: matched group is followed up a case by regular visits to 15 examples, excellent 9 examples, still can 6 examples, acceptance rate 60%; Follow up a case by regular visits to 15 examples for for oral administration group, excellent 13 examples, still can 2 examples, acceptance rate 86.7%.
2, Therapeutic Method
Suit the medicine to the illness and select application antibiotic except routine, red each 6 grams for the treatment of group Orally taken fracture setting, every day 3 times.Matched group oral vitamin C, every day 2 times, each 0.2 gram.Repositioning method is selected in table 1
| Number of cases | Fixing in operation | Manual reduction adds outer fixing | Continuing bone traction adds outer fixing |
| 60 | 48 | 7 | 5 |
Table 1
3, treatment time
The routine case for the treatment of group 30 is clinical healing all, none routine delayed union and bone does not connect.Each time period healing number of cases is in table 2
| Time | 4 weeks | 8 weeks | 12 weeks | 16 weeks | More than 20 weeks |
| Number of cases 30 | 3 | 12 | 10 | 5 | 0 |
Table 2
The routine case of matched group 30, the routine bone does not connect of 10 routine delayed union 2.Each time period healing number of cases is in table 3
| Time | 4 weeks | 8 weeks | 12 weeks | 16 weeks | More than 20 weeks |
| Number of cases 30 | 3 | 6 | 9 | 10 | 2 |
Table 3
4, clinical effectiveness
Fracture of tibia and fibula, especially middle hypomere fracture is longer for the reason clinical healing time because of its blood, and bone does not connect very easily occurs.According to my institute reference room statistics, before 1996, in this type of fracture 3 months, clinical healing rate is 30%, and bone does not connect and delayed union rate reach 20%.Since self-application Drug therapy of the present invention, this group is observed 30 routine patients, and in 3 months, fracture of tibia and fibula clinical healing rate reaches 83.3%, none routine bone does not connect.
Known from Grouping study, group for oral administration was than matched group clinical union of bone time advance 22 days, P < 0.01, difference has very significant, and obvious promotion union of fracture effect has been described, reunion of bone is played to good action, wherein contain Pyritum, can have activation to some enzyme, on the active group of enzyme in conjunction with copper ion, osteoblastic enlivening be can promote, the formation of bone matrix and the appearance in advance of calcification contributed to.Compare with the other medicines of the same indication for the treatment of, bone-setting medicament of the present invention has very significant clinical efficacy advantage.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (4)
1. a showy reiolaena root-bark, is characterized in that, comprises following component by weight:
Bone meal 460 weight portions, Cornu Cervi Pantotrichum 2 weight portions, Pyritum (forging) 92 weight portions, Olibanum 92 weight portions, Myrrha 55 weight portions, Flos Carthami 46 weight portions, Sanguis Draxonis 18 weight portions, Rhizoma Curcumae 55 weight portions, Rhizoma Drynariae 230 weight portions, Radix Dipsaci 230 weight portions, Eupolyphaga Seu Steleophaga 92 weight portions, Radix Salviae Miltiorrhizae 230 weight portions, Radix Angelicae Sinensis 184 weight portions; Wherein, described bone meal is the mixture being mixed to form after BAICAO is fired by Os Canitis, Ophicalcitum, Gypsum Fibrosum.
2. showy reiolaena root-bark according to claim 1, is characterized in that, described Os Canitis, Ophicalcitum, the charge ratio of Gypsum Fibrosum in described bone meal are 4:3:3 by weight.
3. a preparation method for showy reiolaena root-bark described in claim 1, is characterized in that, comprises the following steps:
Os Canitis, Ophicalcitum, Gypsum Fibrosum are used through BAICAO roasting, and after roasting, Os Canitis becomes greyish white, and grey black is repeatedly fired, is burnt through into Ophicalcitum, Gypsum Fibrosum, and Os Canitis, Ophicalcitum, Gypsum Fibrosum after roasting are smashed, and mixes, and makes coarse powder, crosses 40 mesh sieves;
Get Rhizoma Curcumae, Rhizoma Drynariae, Radix Dipsaci, Olibanum, Myrrha and soak after 1 hour, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time; Collecting decoction, filters, for subsequent use after filtrate is concentrated;
Get Flos Carthami, Eupolyphaga Seu Steleophaga, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, with bone meal, Cornu Cervi Pantotrichum, Pyritum (forging), Sanguis Draxonis pulverization, cross 80 mesh sieves, and mix;
Get above-mentioned concentrated liquid flooding ball, 60 ℃ of oven dry, select ball, and ethane via epoxyethane sterilizing is placed and obtained described showy reiolaena root-bark after 7-10 days.
4. the preparation method of showy reiolaena root-bark according to claim 3, is characterized in that, Os Canitis, Ophicalcitum, Gypsum Fibrosum method are to fire 12 hours described in roasting, dry and bury 12 hours.
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Application publication date: 20140618 |