CN109984948A - One kind containing fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract - Google Patents

Abstract

The invention discloses one kind to contain fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, the anti-ageing Essence includes: deionized water, butanediol, glycerol, monkey-bread tree pulp extract, glycine betaine, beta glucan, double-PEG-18 methyl ether dimethylsilanes, oligopeptides -1, acetyl group hexapeptide -1, propylene glycol, decoyl hydroximic acid, glycerol caprylate, parahydroxyacet-ophenone, 1, 2- hexylene glycol, Arabic gum natural gum, xanthan gum, Wild soybean seed extract, fullerene, haematococcus pluvialis extract, olea europaea fruit extract, the present invention contains a variety of extracted form natural plant essence, all maintenance skin ingredients are all made of pure Chinese medicine formula and are made, containing a variety of anti-oxidant, inhibit TYR enzyme, no added any hormone, product is natural, mildly, safety is good and maintenance skin significant effect, preparation Method is simple.

Description

One kind containing fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract

Technical field

The present invention relates to pharmaceutical technology fields, specifically a kind of to mention containing fullerene, haematococcus pluvialis and olea europaea fruit Take the anti-ageing Essence of object.

Background technique

The essential characteristic of body aging is that histoorgan " atrophy " and " decline " its essence is the bases for constituting histoorgan The loss of this ingredient-cell and extracellular matrix.Skin is also such as a histoorgan of body.According to each year The measurement of age group skin biopsies, thickness every ten years of skin about successively decrease 6%.However it is this successively decrease between individuals there is Very big difference, some people fail slower, but some people are quickly, this is because inside and outside heredity or posteriori environment etc. What factor was determined.These internal and external factors eventually lead to two main results: one is decline (increasing of cell bio-activity itself It grows and declines with the ability of synthetic cell epimatrix);Secondly enhancing for body catabolism, extracellular matrix is degraded.In face of declining Numerous extracellular matrixs is degraded when old, a kind of degradation for the macromolecular fibrous protein being referred to as elastin laminin, same to skin Aging it is closely related.

It can be seen that importance of the prevention and treatment elastin degradation to delay skin aging, prevention and treatment elastin degradation can be in terms of two Start with: first is that inhibiting degradation of the elastoser to elastin laminin;Second is that increasing what skin fibroblasts synthesis function perfected Elastin laminin rebuilds elastomer structure.In terms of inhibition elastoser is to the degradation of elastin laminin, it is most useful that using Elastatinal.It is some artificial synthesized among these other than the elastatinal of synthesis of natural in inductor Elastatinal be just developed, the natural enzyme inhibitor extracted in plant is paid attention to by people extensively in recent years.Such as Flavanones and anthocyanin same clan compound have inhibiting effect to a variety of enzymes;They can be the same as collagen and elastomer phase interaction simultaneously With to protect these azelons not by enzyme hydrolysis.In other natural substances for having inhibiting effect to elastoser, Its catabolite-elastin laminin can not be ignored the inhibiting effect of elastoser, its rejection ability and its molecular weight are at just Than.In addition, elastin laminin, which has, rebuilds skin elasticity institutional framework and moisture-keeping functions, therefore anti-aging cosmetics have been added into it In.

Fullerene, which mainly passes through, absorbs the intracorporal free radical of people, plays the role of anti-ageing oxidation resistant, organism metabolism is ultraviolet The factors such as line generate free radicals human body, and free radical can grab the electronics in normal cell, make normal cell lesion, death, rich Le alkene essence enters in human body adsorbs free radical as sponge, and when the free radical of absorption is even number, free radical can be tied two-by-two Conjunction is quenched, and excretes with sweat body fluid etc., and then improves collagenic protein in skin, the content of moisture, reaches anti-aging, resists Oxidation, refinement wrinkle, anti-acne, whitening, uvioresistant and other effects.The benefit of fullerene essence has protection cell and antioxygen to be turned into With, antibacterial activity, anti HIV-1 virus activity, these be mainly still attributed to the fact that fullerene essence can affine free radical, have it is extremely strong Oxidation resistance, activating skin cells can be played the role of, prevention skin decline, fullerene essence has unique antioxygen The property changed, the inoxidizability of fullerene essence are familiar to people as vitamin A, C or E and natural carotenoid, class are yellow Hundreds and thousands of times of the antioxidants such as ketone.Result of study shows that the fullerene essence containing low dose of hydration fullerene essence has Extensive and universal biological effect.

Haematococcus pluvialis is called the raw haematococcus in lake or lake green blood ball algae again, is a kind of generally existing green alga, belongs to group Cutleriales, haematococcus section.This seeds algae that it is now know that is widely present in nature under conditions of being suitable for its growth.Haematococcus pluvialis It is considered producing one of the best biology of natural astaxanthin in nature, therefore, extracting astaxanthin using this microalgae has Vast potential for future development, it has also become the research hotspot that natural astaxanthin produces in the world in recent years.Haematococcus pluvialis just replaces B- Carrotene, anthocyanidin, lycopene etc. become the strongest element of anti-aging ability so far.Showing its anti-aging energy While power, haematococcus pluvialis is for aoxidizing caused systemic disease, such as cancer, ishemic stroke, inflammation, eyes disease Disease, diabetes, cardiovascular disease, central nervous system disease and hematologic disease and respiratory disease etc. have well Prevention or therapeutic effect, the aging of human body, the mainly oxidation due to caused by free radical institute extremely, since its is powerful anti-oxidant Property, ingredient of the haematococcus pluvialis extract as its superpower antioxidant, and the natural astaxanthin in haematococcus pluvialis then can be with Human body cell outer wall is passed through, the oxygen radical in direct scavenger-cell enhances cytothesis ability, protects cell and DNA strong Health reduces senile cell accumulation, plays the role of anti-aging.

Olea europaea fruit has thousands of years history in Mediterranean country, is known as " liquid golden ", " vegetable oil in west Queen ", " mediterranean sweet dew ", reason are that its splendid natural health effect, beauty functions and ideal cooking use. High-grade olive oil that can be edible is the natural fruit extracted with just ripe or mature olive fresh fruit by the cold squeezing process of physics Oil juice is the xylophyta oil uniquely eaten in the form of nature for the mankind in the world.Olive oil is rich in affine with skin Power splendid squalene and essential fatty acid, absorption rapidly, effectively keep skin elasticity and moisten；It is contained rich in olive oil Rich monounsaturated fatty acids and vitamin E, K, A, D etc. and phenols antioxidant, can eliminate facial wrinkles, prevent skin from declining Always, there are skin or hair care and prevention and treatment hand and foot from chapping and other effects, be the cosmetics and skincare product that " can be eaten ", in addition smear skin with olive oil Ultraviolet light, which can be resisted, prevents cutaneum carcinoma.

Wild soybean seed extract has maintaining beauty and keeping young, and specific isoflavones rich in is (for powerful antioxidants and flesh Beautiful dose of skin) and gleditsia sinensis, contained phytosterol, helping improves collagenic protein concentration, also can antagonist surfactant it is negative Face is rung.

Oligopeptides -1 is a kind of classification of oligopeptides, and amino acid is protein minimum composition unit, is made of two amino acid Peptide is known as dipeptides, and 10 peptides hereinafter referred to as oligopeptides, 11 peptides are referred above to polypeptide, and 50 peptides are referred above to protein.50 peptides are particularly below It is oligopeptides, on the one hand keeps consistent with protein in configuration, on the other hand since molecule is small, be primarily present in blood and function Property cell in, be not required to digest in human body, can directly absorb, because having strong rush proliferation and Mitosis to cell, Lead scientific circles to the redefinition of cell growth molecule, at present to be widely used in cell repair, traditional protein disappears Change, absorption approach thinks: protein generates free amino acid and oligopeptides in enteric cavity, by peptide protease and chymotrypsin effect (containing 2 ~ 6 amino acid residues), oligopeptides is hydrolyzed into free amino acid completely under the action of peptase, and with free amino acid shape Formula enters blood circulation, can achieve whitening effect, and oligopeptides will enter skin, can play the role of improving skin, growth because Son can repair skin texture, can play a role.

Acetyl hexapeptide -1 significantly anti-skin sagging, promotion skin consolidation can cope with potentially harmful object in immune system naturally In the reaction of matter and environment, kallikrein and antimicrobial compound such as antibacterial peptide play very important effect, they can be lured Lead the release of interleukins (interleukins, IL), but to may cause skin of face rubescent for excessive interleukins And telangiectasis.Erythema and blood vessel dilatation dermatoses, such as rosacea, all abnormal height of the expression of LL-37, it is once A large amount of inflammatory reaction will lead to the increase of proinflammatory metabolin after being activated, wherein just including IL-6 and IL-8.Extracellular base After matter such as collagen are hydrolyzed by MMPs, the connection tissue of corium can be deteriorated, therefore the region of rubefaction can become more It is obviously clear to, capillary becomes fragile and permeability enhancing, inflammation are easier to lead to vessel enlargement.

The present invention is directed to by research and develop it is a kind of containing fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract with The relationship of skin maintenance, to seek the research and development countermeasure of such skin repair stoste.

Summary of the invention

Influenced that (such as extraneous physical chemical factor, the variation of autologous hormones level is mechanical in order to solve existing by many factors Pressure, Neuropsychical facto), cause normal skin dysfunction occur, skin collagen textural anomaly becomes fragile, and occurs Related skin damage problem, treatment present in existing treatment product is not thorough, Yi Fanfu, side effect is strong, easily forms drug resistance Or effect it is unobvious the defects of, the present invention proposes a kind of containing fullerene, haematococcus pluvialis and the anti-ageing essence of olea europaea fruit extract Liquid charges to skin, promotes cellular energy and dermostenosis, enhances skin cohesive force, reinforces focal adhesion, promotes flesh immediately Skin maintenance effect simultaneously has long-term efficacy, and thorough maintenance improves skin.

Maintenance skin may be implemented using the composition containing fullerene, haematococcus pluvialis and olea europaea fruit extract in the present invention Function problem also shows that maintenance skin function problem quite or even more preferably therapeutic effect.

One kind contain fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, anti-ageing Essence contain from Sub- water, butanediol, glycerol, monkey-bread tree pulp extract, glycine betaine, beta glucan, double-PEG-18 methyl ether dimethyl-silicons Alkane, oligopeptides -1, acetyl group hexapeptide -1, propylene glycol, decoyl hydroximic acid, glycerol caprylate, parahydroxyacet-ophenone, 1,2- hexylene glycol, Arabic gum natural gum, xanthan gum, Wild soybean seed extract, fullerene, haematococcus pluvialis extract, olea europaea fruit extract, institute The anti-ageing Essence stated includes following component count by weight percentage: deionized water 81.15%wt ~ 89.46%wt, fourth two Alcohol 3%wt ~ 5%wt, glycerol 3.03%wt ~ 5.06%wt, monkey-bread tree pulp extract 1%wt ~ 2.5%wt, glycine betaine 0.5%wt ~ 1%wt, beta glucan 0.5%wt ~ 1%wt, double-PEG-18 methyl ether dimethylsilane 0.5%wt ~ 1%wt, oligopeptides -1 0.5% Wt ~ 1%wt, -1 0.5%wt of acetyl group hexapeptide ~ 1%wt, propylene glycol 0.15%wt ~ 0.25%wt, decoyl hydroximic acid 0.1%wt ~ 0.15% Wt, glycerol caprylate 0.1%wt ~ 0.15%wt, parahydroxyacet-ophenone 0.2%wt ~ 0.3%wt, 1,2- hexylene glycol 0.15%wt ~ 0.2%wt, Arabic gum natural gum 0.05%wt ~ 0.09%wt, xanthan gum 0.05%wt ~ 0.09%wt, Wild soybean seed extract 0.03% Wt ~ 0.06%wt, fuller olefinic carbon 60 .06%wt ~ 0.12%wt, haematococcus pluvialis extract 0.06%wt ~ 0.12%wt, olea europaea fruit mention Take object 0.06%wt ~ 0.12%wt.

One kind includes following containing fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, anti-ageing Essence Component count by weight percentage: deionized water 81.15%wt ~ 89.46%wt, butanediol 3%wt ~ 5%wt, glycerol 3.03%wt ~ 5.06%wt, monkey-bread tree pulp extract 1%wt ~ 2.5%wt, glycine betaine 0.5%wt ~ 1%wt, beta glucan 0.5%wt ~ 1%wt, double-PEG-18 methyl ether dimethylsilane 0.5%wt ~ 1%wt, -1 0.5%wt of oligopeptides ~ 1%wt, acetyl group - 1 0.5%wt of hexapeptide ~ 1%wt, propylene glycol 0.15%wt ~ 0.25%wt, decoyl hydroximic acid 0.1%wt ~ 0.15%wt, glycerol caprylate 0.1%wt ~ 0.15%wt, parahydroxyacet-ophenone 0.2%wt ~ 0.3%wt, 1,2- hexylene glycol 0.15%wt ~ 0.2%wt, Arabic gum Gummy 0.05%wt ~ 0.09%wt, xanthan gum 0.05%wt ~ 0.09%wt, Wild soybean seed extract 0.03%wt ~ 0.06%wt, fowler Alkene 0.06%wt ~ 0.12%wt, haematococcus pluvialis extract 0.06%wt ~ 0.12%wt, olea europaea fruit extract 0.06%wt ~ 0.12%wt。

One kind includes following containing fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, anti-ageing Essence Component count by weight percentage: deionized water 82.49%wt ~ 86.74%wt, butanediol 3.5%wt ~ 4.5%wt, glycerol 3.54%wt ~ 4.55%wt, monkey-bread tree pulp extract 1.5%wt ~ 2%wt, glycine betaine 0.7%wt ~ 0.9%wt, beta glucan 0.7%wt ~ 0.9%wt, double-PEG-18 methyl ether dimethylsilane 0.7%wt ~ 0.9%wt, -1 0.7%wt of oligopeptides ~ 0.9%wt, It is -1 0.7%wt of acetyl group hexapeptide ~ 0.9%wt, propylene glycol 0.2%wt ~ 0.23%wt, decoyl hydroximic acid 0.12%wt ~ 0.13%wt, sweet Oily caprylate 0.12%wt ~ 0.13%wt, parahydroxyacet-ophenone 0.22%wt ~ 0.28%wt, 1,2- hexylene glycol 0.16%wt ~ 0.18%wt, Arabic gum natural gum 0.06%wt ~ 0.08%wt, xanthan gum 0.06%wt ~ 0.08%wt, Wild soybean seed extract 0.04%wt ~ 0.05%wt, fuller olefinic carbon 60 .08%wt ~ 0.1%wt, haematococcus pluvialis extract 0.08%wt ~ 0.1%wt, olive Berry extract 0.08%wt ~ 0.1%wt.

One kind includes following containing fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, anti-ageing Essence Component count by weight percentage: deionized water 84.04%wt, butanediol 4.5%wt, glycerol 4.2%wt, monkey-bread tree Pulp extract 2.0%wt, glycine betaine 0.8%wt, beta glucan 0.8%wt, double-PEG-18 methyl ether dimethylsilanes 0.8%wt, -1 0.7%wt of oligopeptides, -1 0.7%wt of acetyl group hexapeptide, propylene glycol 0.20%wt, decoyl hydroximic acid 0.12%wt, glycerol Caprylate 0.13%wt, parahydroxyacet-ophenone 0.26%wt, 1,2- hexylene glycol 0.18%wt, Arabic gum natural gum 0.07%wt, Huang Virgin rubber 0.08%wt, Wild soybean seed extract 0.07%wt, fuller olefinic carbon 60 .1%wt, haematococcus pluvialis extract 0.13%wt, oil Olive berry extract 0.12%wt.

One kind contain fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, by deionized water 81.15%wt ~ It is 100 degrees Celsius that 89.46%wt, which pours into reaction kettle and is heated to temperature, keeps the temperature 30 minutes, it is 70 degrees Celsius that stirring, which is cooled to temperature,； Then Arabic gum natural gum 0.05%wt ~ 0.09%wt, xanthan gum 0.05%wt ~ 0.09%wt, butanediol 3%wt ~ 5%wt, sweet is added Oily 3%wt ~ 5%wt is stirred to being completely dissolved, and it is 50 degrees Celsius that stirring, which is cooled to temperature, is then respectively adding monkey-bread tree pulp and is mentioned Take object 1%wt ~ 2.5%wt, glycine betaine 0.5%wt ~ 1%wt, beta glucan 0.5%wt ~ 1%wt, double-PEG-18 methyl ether diformazans Base silane 0.5%wt ~ 1%wt, -1 0.5%wt of oligopeptides ~ 1%wt, -1 0.5%wt of acetyl group hexapeptide ~ 1%wt, 1,2- hexylene glycol 0.15%wt ~ 0.2%wt, glycerol 0.03%wt ~ 0.06%wt, Wild soybean seed extract 0.03%wt ~ 0.06%wt, fullerene 0.06%wt ~ 0.12%wt, haematococcus pluvialis extract 0.06%wt ~ 0.12%wt, olea europaea fruit extract 0.06%wt ~ 0.12% Wt is stirred to being completely dissolved；Then propylene glycol 0.15%wt ~ 0.25%wt, decoyl hydroximic acid 0.1%wt ~ 0.15%wt, glycerol is added Caprylate 0.1%wt ~ 0.15%wt, parahydroxyacet-ophenone 0.2%wt ~ 0.3%wt stirring and dissolving, detection is qualified, discharging.

One or more embodiments according to the present invention, the final ph of the anti-ageing Essence composition liquid, 2.3-8.2, for example, it is preferable to which pH value is 4.2-7.5, alternatively, such as preferable ph is 4.3-7.2.

One or more embodiments according to the present invention, the deionized water, butanediol, glycerol, monkey-bread tree pulp Extract, glycine betaine, beta glucan, double-PEG-18 methyl ether dimethylsilanes, oligopeptides -1, acetyl group hexapeptide -1, the third two Alcohol, decoyl hydroximic acid, glycerol caprylate, parahydroxyacet-ophenone, 1,2- hexylene glycol, Arabic gum natural gum, xanthan gum, Wild soybean seed Extract, fullerene, haematococcus pluvialis extract, olea europaea fruit extract can be conventional purchase from the market.

One or more embodiments according to the present invention give combination according to the present invention to subject in need Object, the composition be by deionized water, butanediol, glycerol, monkey-bread tree pulp extract, glycine betaine, beta glucan, it is double- It is PEG-18 methyl ether dimethylsilane, oligopeptides -1, acetyl group hexapeptide -1, propylene glycol, decoyl hydroximic acid, glycerol caprylate, right Hydroxy acetophenone, 1,2- hexylene glycol, Arabic gum natural gum, xanthan gum, Wild soybean seed extract, fullerene, haematococcus pluvialis mention Take object, olea europaea fruit extract composition.

One or more embodiments according to the present invention, the deionized water, butanediol, glycerol, monkey-bread tree pulp Extract, glycine betaine, beta glucan, double-PEG-18 methyl ether dimethylsilanes, oligopeptides -1, acetyl group hexapeptide -1, the third two Alcohol, decoyl hydroximic acid, glycerol caprylate, parahydroxyacet-ophenone, 1,2- hexylene glycol, Arabic gum natural gum, xanthan gum, Wild soybean seed Extract, fullerene, haematococcus pluvialis extract, olea europaea fruit extract can be and be mixed in composition.

Drug percutaneous skin for skin maintenance function of the present invention containing above-mentioned composition of plant extracts pierces Swash test (multiple) and Skin allergy test, test result are respectively as follows: skin irritatin strength grading and belong to nonirritant；By cause Quick strength grading standard, is judged to have no skin allergic reaction.

The invention reside in the combination of the plant extracts of skin maintenance, the use in conjunction of each ingredient generates each component effect Synergistic effect, so that making the function of the composition skin maintenance is enhanced, achievees the purpose that skin maintenance with low dosage, and prevent Itch and allergy in skin skin repair process are stopped.

It is not added with glucocorticoid substance and antibiotic in formula of the invention, uses no dependence for a long time, does not have Toxic side effect.

The present invention can not only generate good skin maintenance function in relatively low-dose, but also not have when used for a long time continuously There is the generation of allergic stimulated symptom.It charges from many aspects to skin, promotes cellular energy and dermostenosis, enhance skin cohesive force, Reinforce focal adhesion, promotes skin immediately and repair effect and have long-term efficacy.

Specific embodiment

It is illustrated to make the objectives, technical solutions, and advantages of the present invention clearer, it is With reference to embodiment, right The present invention is further described.

A kind of preparation method containing fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract includes following step It is rapid:

1. it is 100 degrees Celsius that deionized water 81.15%wt ~ 89.46%wt, which is poured into reaction kettle to be heated to temperature, 30 minutes are kept the temperature, It is 70 degrees Celsius that stirring, which is cooled to temperature,；

2. be separately added into Arabic gum natural gum 0.05%wt ~ 0.09%wt, xanthan gum 0.05%wt ~ 0.09%wt, butanediol 3%wt ~ 5%wt, glycerol 3%wt ~ 5%wt are stirred to being completely dissolved, and it is 50 degrees Celsius that stirring, which is cooled to temperature,

3. being separately added into monkey-bread tree pulp extract 1%wt ~ 2.5%wt, glycine betaine 0.5%wt ~ 1%wt, beta glucan again 0.5%wt ~ 1%wt, double-PEG-18 methyl ether dimethylsilane 0.5%wt ~ 1%wt, -1 0.5%wt of oligopeptides ~ 1%wt, acetyl group - 1 0.5%wt of hexapeptide ~ 1%wt, 1,2- hexylene glycol 0.15%wt ~ 0.2%wt, glycerol 0.03%wt ~ 0.06%wt, Wild soybean seed extract Object 0.03%wt ~ 0.06%wt, fuller olefinic carbon 60 .06%wt ~ 0.12%wt, haematococcus pluvialis extract 0.06%wt ~ 0.12%wt, oil Olive berry extract 0.06%wt ~ 0.12%wt is stirred to being completely dissolved；Then propylene glycol 0.15%wt ~ 0.25%wt, decoyl is added Hydroximic acid 0.1%wt ~ 0.15%wt, glycerol caprylate 0.1%wt ~ 0.15%wt, parahydroxyacet-ophenone 0.2%wt ~ 0.3%wt stirring Dissolution, detection is qualified, discharges to get anti-ageing Essence.

Following embodiment to be illustrated for repairing the composition of skin barrier, but not limited to this, aforementioned present invention mentions The product of the various anti-ageing Essences comprising fullerene, haematococcus pluvialis extract and olea europaea fruit extract out is suitable for The present invention.

A kind of embodiment 1: preparation method containing fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract.

It is 100 degrees Celsius that deionized water 81.15%wt ~ 89.46%wt, which is poured into reaction kettle to be heated to temperature, keeps the temperature 30 points Clock, it is 70 degrees Celsius that stirring, which is cooled to temperature,；Then Arabic gum natural gum 0.05%wt ~ 0.09%wt, xanthan gum 0.05%wt is added ~ 0.09%wt, butanediol 3%wt ~ 5%wt, glycerol 3%wt ~ 5%wt are stirred to being completely dissolved, and it is 50 Celsius that stirring, which is cooled to temperature, Degree, is then respectively adding monkey-bread tree pulp extract 1%wt ~ 2.5%wt, glycine betaine 0.5%wt ~ 1%wt, beta glucan 0.5%wt ~ 1%wt, double-PEG-18 methyl ether dimethylsilane 0.5%wt ~ 1%wt, -1 0.5%wt of oligopeptides ~ 1%wt, acetyl group - 1 0.5%wt of hexapeptide ~ 1%wt, 1,2- hexylene glycol 0.15%wt ~ 0.2%wt, glycerol 0.03%wt ~ 0.06%wt, Wild soybean seed extract Object 0.03%wt ~ 0.06%wt, fuller olefinic carbon 60 .06%wt ~ 0.12%wt, haematococcus pluvialis extract 0.06%wt ~ 0.12%wt, oil Olive berry extract 0.06%wt ~ 0.12%wt is stirred to being completely dissolved；Then propylene glycol 0.15%wt ~ 0.25%wt, decoyl is added Hydroximic acid 0.1%wt ~ 0.15%wt, glycerol caprylate 0.1%wt ~ 0.15%wt, parahydroxyacet-ophenone 0.2%wt ~ 0.3%wt stirring Dissolution, detection is qualified, discharges to get anti-ageing Essence.

A kind of embodiment 2: preparation method containing fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract.

It is 100 degrees Celsius that deionized water 84.04%wt, which is poured into reaction kettle to be heated to temperature, keeps the temperature 30 minutes, stirring cooling It is 70 degrees Celsius to temperature；Then Arabic gum natural gum 0.07%wt, xanthan gum 0.08%wt, butanediol 4.5%wt, glycerol is added 4.2%wt is stirred to being completely dissolved, and it is 50 degrees Celsius that stirring, which is cooled to temperature, is then respectively adding monkey-bread tree pulp extract 2.0%wt, glycine betaine 0.8%wt, beta glucan 0.8%wt, double-PEG-18 methyl ether dimethylsilane 0.8%wt, oligopeptides -1 0.7%wt, -1 0.7%wt, 1,2- hexylene glycol 0.18%wt of acetyl group hexapeptide, glycerol 0.05%wt, Wild soybean seed extract 0.07%wt, fuller olefinic carbon 60 .1%wt, haematococcus pluvialis extract 0.13%wt, olea europaea fruit extract 0.12%wt.Baobab Set pulp extract 1%wt ~ 2.5%wt, glycine betaine 0.5%wt ~ 1%wt, beta glucan 0.5%wt ~ 1%wt, double-PEG-18 first Base ether dimethylsilane 0.5%wt ~ 1%wt, -1 0.5%wt of oligopeptides ~ 1%wt, -1 0.5%wt of acetyl group hexapeptide ~ 1%wt, 1,2- oneself Glycol 0.15%wt ~ 0.2%wt, glycerol 0.03%wt ~ 0.06%wt, Wild soybean seed extract 0.03%wt ~ 0.06%wt, fullerene 0.06%wt ~ 0.12%wt, haematococcus pluvialis extract 0.06%wt ~ 0.12%wt, olea europaea fruit extract 0.06%wt ~ 0.12% Wt is stirred to being completely dissolved；Then be added propylene glycol 0.20%wt, decoyl hydroximic acid 0.12%wt, glycerol caprylate 0.13%wt, Parahydroxyacet-ophenone 0.26%wt stirring and dissolving, detection is qualified, discharges to get anti-ageing Essence.

Anti-ageing Essence skin repair process:

It collects 80 volunteers and participates in test, smear daily 2 times, 7 days as a course for the treatment of, pays a return visit after 4 courses for the treatment of and records skin and repairs Protect situation:

Skin elasticity and skin consolidation: being 3.3% using the maximum value added of elasticity after 30 minutes, consolidation maximum value added is 6.2%； After 28 days, elasticity maximum value added is 13.3%, and consolidation maximum value added is 12.2%.

Skin tightening effect: it is i.e. effective after using 30 minutes, in 28 days of test always effectively.

Skin surface feature: reducing wrinkle depth 16% using 30 minutes contoured skins, and crow's feet is 37% and wrinkle now Maximum degree of improvement be 32%.

Skin gloss and skin hydration: increase by 13% using skin gloss after 28 days, skin hydration increases by 15%.

Skin moisture-keeping: using increasing by 15.2% after 28 days.

Wrinkle & smoothness (optical grating projection): it uses 28 days, smears daily 2 times, the white vs blank containing 5% Sirtalice.

In vitro-skin microarray transcription group: sirtuin-3 increases by 12%；Talin-1 increases by 12%, external-skin Cell charging: ATP increases 33%(0.5 mg/ml).

In vitro-control oxidative damage, external-collagen increase: increasing by 32% tropocollagen I(0.1 mg/ Ml), external-protection extracellular matrix protein: inhibiting 71% elastoser (0.1 mg/ml), in vitro-to induce and stablize line Plastochondria breathing and reinforcing Focal adhesions: increase mitochondrial aconitase 63%, increase vinculin 121%.

As it can be seen that after containing fullerene, haematococcus pluvialis and olea europaea fruit extract one course for the treatment of of anti-ageing Essence using one kind, Skin symptom has clear improvement, and charges to skin, promotes cellular energy and dermostenosis, enhances skin cohesive force, reinforces burnt Point adhesion promotes effect immediately and has long-term efficacy.It proves to contain fullerene, haematococcus pluvialis and the anti-ageing essence of olea europaea fruit extract Magnificent liquid has the function of significantly repairing skin aging.

The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore All contents without departing from technical solution of the present invention any are simply repaired to what the above implementation was done according to the technical essence of the invention Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.

Claims (5)

1. one kind contains fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, which is characterized in that the anti-ageing essence Magnificent liquid contains deionized water, butanediol, glycerol, monkey-bread tree pulp extract, glycine betaine, beta glucan, double-PEG-18 first Base ether dimethylsilane, oligopeptides -1, acetyl group hexapeptide -1, propylene glycol, decoyl hydroximic acid, glycerol caprylate, para hydroxybenzene second Ketone, 1,2- hexylene glycol, Arabic gum natural gum, xanthan gum, glycerol, Wild soybean seed extract, fullerene, haematococcus pluvialis extract Object, olea europaea fruit extract, the anti-ageing Essence include following component count by weight percentage: deionized water 81.15%wt ~ 89.46%wt, butanediol 3%wt ~ 5%wt, glycerol 3.03%wt ~ 5.06%wt, monkey-bread tree pulp extract 1% Wt ~ 2.5%wt, glycine betaine 0.5%wt ~ 1%wt, beta glucan 0.5%wt ~ 1%wt, double-PEG-18 methyl ether dimethylsilanes 0.5%wt ~ 1%wt, -1 0.5%wt of oligopeptides ~ 1%wt, -1 0.5%wt of acetyl group hexapeptide ~ 1%wt, propylene glycol 0.15%wt ~ 0.25% Wt, decoyl hydroximic acid 0.1%wt ~ 0.15%wt, glycerol caprylate 0.1%wt ~ 0.15%wt, parahydroxyacet-ophenone 0.2%wt ~ 0.3%wt, 1,2- hexylene glycol 0.15%wt ~ 0.2%wt, Arabic gum natural gum 0.05%wt ~ 0.09%wt, xanthan gum 0.05%wt ~ 0.09%wt, Wild soybean seed extract 0.03%wt ~ 0.06%wt, fuller olefinic carbon 60 .06%wt ~ 0.12%wt, haematococcus pluvialis extract Object 0.06%wt ~ 0.12%wt, olea europaea fruit extract 0.06%wt ~ 0.12%wt.

2. one kind according to claim 1 contains fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, It is characterized in that, the anti-ageing Essence includes following component count by weight percentage: deionized water 81.15%wt ~ 89.46%wt, butanediol 3%wt ~ 5%wt, glycerol 3.03%wt ~ 5.06%wt, monkey-bread tree pulp extract 1%wt ~ 2.5%wt, Glycine betaine 0.5%wt ~ 1%wt, beta glucan 0.5%wt ~ 1%wt, double-PEG-18 methyl ether dimethylsilane 0.5%wt ~ 1% Wt, -1 0.5%wt of oligopeptides ~ 1%wt, -1 0.5%wt of acetyl group hexapeptide ~ 1%wt, propylene glycol 0.15%wt ~ 0.25%wt, decoyl hydroxyl oxime Sour 0.1%wt ~ 0.15%wt, glycerol caprylate 0.1%wt ~ 0.15%wt, parahydroxyacet-ophenone 0.2%wt ~ 0.3%wt, 1,2- oneself Glycol 0.15%wt ~ 0.2%wt, Arabic gum natural gum 0.05%wt ~ 0.09%wt, xanthan gum 0.05%wt ~ 0.09%wt, Wild soybean Seed extract 0.03%wt ~ 0.06%wt, fuller olefinic carbon 60 .06%wt ~ 0.12%wt, haematococcus pluvialis extract 0.06%wt ~ 0.12%wt, olea europaea fruit extract 0.06%wt ~ 0.12%wt.

3. one kind according to claim 1 contains fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, It is characterized in that, the anti-ageing Essence includes following component count by weight percentage: deionized water 82.49%wt ~ 86.74%wt, butanediol 3.5%wt ~ 4.5%wt, glycerol 3.54%wt ~ 4.55%wt, monkey-bread tree pulp extract 1.5%wt ~ 2%wt, glycine betaine 0.7%wt ~ 0.9%wt, beta glucan 0.7%wt ~ 0.9%wt, double-PEG-18 methyl ether dimethylsilanes 0.7%wt ~ 0.9%wt, -1 0.7%wt of oligopeptides ~ 0.9%wt, -1 0.7%wt of acetyl group hexapeptide ~ 0.9%wt, propylene glycol 0.2%wt ~ 0.23%wt, decoyl hydroximic acid 0.12%wt ~ 0.13%wt, glycerol caprylate 0.12%wt ~ 0.13%wt, parahydroxyacet-ophenone 0.22%wt ~ 0.28%wt, 1,2- hexylene glycol 0.16%wt ~ 0.18%wt, Arabic gum natural gum 0.06%wt ~ 0.08%wt, xanthan gum The raw red ball of 0.06%wt ~ 0.08%wt, Wild soybean seed extract 0.04%wt ~ 0.05%wt, fuller olefinic carbon 60 .08%wt ~ 0.1%wt, rain Algae extract 0.08%wt ~ 0.1%wt, olea europaea fruit extract 0.08%wt ~ 0.1%wt.

4. one kind according to claim 1 contains fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, It is characterized in that, the anti-ageing Essence includes following component count by weight percentage: deionized water 84.04%wt, fourth two Alcohol 4.5%wt, glycerol 4.2%wt, monkey-bread tree pulp extract 2.0%wt, glycine betaine 0.8%wt, beta glucan 0.8% Wt, double-PEG-18 methyl ether dimethylsilane 0.8%wt, -1 0.7%wt of oligopeptides, -1 0.7%wt of acetyl group hexapeptide, propylene glycol 0.20%wt, decoyl hydroximic acid 0.12%wt, glycerol caprylate 0.13%wt, parahydroxyacet-ophenone 0.26%wt, 1,2- hexylene glycol 0.18%wt, Arabic gum natural gum 0.07%wt, xanthan gum 0.08%wt, Wild soybean seed extract 0.07%wt, fuller olefinic carbon 60 .1% Wt, haematococcus pluvialis extract 0.13%wt, olea europaea fruit extract 0.12%wt.

5. one kind according to claim 1 contains fullerene, haematococcus pluvialis and the anti-ageing Essence of olea europaea fruit extract, It is characterized in that, it is 100 degrees Celsius that the deionized water 81.15%wt ~ 89.46%wt, which pours into reaction kettle and is heated to temperature, heat preservation 30 Minute, it is 70 degrees Celsius that stirring, which is cooled to temperature,；Then Arabic gum natural gum 0.05%wt ~ 0.09%wt, xanthan gum 0.05% is added Wt ~ 0.09%wt, butanediol 3%wt ~ 5%wt, glycerol 3%wt ~ 5%wt are stirred to being completely dissolved, and stirring is cooled to temperature and takes the photograph for 50 Family name's degree is then respectively adding monkey-bread tree pulp extract 1%wt ~ 2.5%wt, glycine betaine 0.5%wt ~ 1%wt, beta glucan 0.5%wt ~ 1%wt, double-PEG-18 methyl ether dimethylsilane 0.5%wt ~ 1%wt, -1 0.5%wt of oligopeptides ~ 1%wt, acetyl group - 1 0.5%wt of hexapeptide ~ 1%wt, 1,2- hexylene glycol 0.15%wt ~ 0.2%wt, glycerol 0.03%wt ~ 0.06%wt, Wild soybean seed extract Object 0.03%wt ~ 0.06%wt, fuller olefinic carbon 60 .06%wt ~ 0.12%wt, haematococcus pluvialis extract 0.06%wt ~ 0.12%wt, oil Olive berry extract 0.06%wt ~ 0.12%wt is stirred to being completely dissolved；Then propylene glycol 0.15%wt ~ 0.25%wt, decoyl is added Hydroximic acid 0.1%wt ~ 0.15%wt, glycerol caprylate 0.1%wt ~ 0.15%wt, parahydroxyacet-ophenone 0.2%wt ~ 0.3%wt stirring Dissolution, detection is qualified, discharging.