CN109966438A - A kind of antiparasite drugs for animals ivermectin injection and preparation method thereof - Google Patents
A kind of antiparasite drugs for animals ivermectin injection and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of antiparasite drugs for animals ivermectin injections and preparation method thereof, belong to veterinary formulations field, be grouped as by the group of following parts by weight: 1-3 parts of ivermectin B1,2-5 parts of vitamin E, 1-4 parts of vitamine D3,50-100 parts of dehydrated alcohol, 1-5 parts of glycerol formal, 0.1-2 parts of ginkgo biloba p.e, 0.5-2 parts of crane grass roots bud extract, 0.1-3 parts of betelnut extract, 0.1-2 parts of Omphalia extract, 0.2-1 parts of Radix Stemonae extract.The present invention is added with vitamin and plant extracts, absorbs convenient for animal, expands pest-resistant spectrum, reduce drug resistance, reduce side effect, be conducive to the growth of animal, and production method is simple, is suitble to promote the use of.
Description
Technical field
The present invention relates to veterinary formulations technical field more particularly to a kind of antiparasite drugs for animals ivermectin injections
And preparation method thereof.
Background technique
Helminth (parasite) refers to pathogenic lower eukaryotes, can be used as pathogen, also can be used as medium
It spreads the disease.Helminth feature is in vivo or to be attached in host or host (host) and maintain its existence, development in vitro to obtain
The either all living things of the nutrition needed for breeding or protection.Many toys are survived in a manner of parasitic, are attached to than them
With bigger animal.
Ivermectin is novel wide spectrum, efficient, less toxic antibiotics antiparasitic agent, is especially to internal epizoa
Nematode and arthropod, which have, well kills effect.But it is invalid to tapeworm, fluke and protozoan.The anti-parasitism of macrolides
Worm medicine kills effect to nematode and arthropod, is to increase releasing for inhibitory transmitter γ-aminobutyric acid (GABA) of polypide
It puts, and opens the Cl ion channel of glutamic acid control, enhance neu to the permeability of Cl, thus the biography of block nerves signal
It passs, final neural paralysis makes muscle cell lose contractility, so as to cause polypide death.
The insecticidal effect of existing ivermectin injection is less desirable, it is difficult to kill removing to tapeworm, and tapeworm is posted
It is raw to seriously affect the growth of animal in enteron aisle, for this purpose, the present invention proposes a kind of antiparasite drugs for animals ivermectin note
Penetrate liquid and preparation method thereof.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and a kind of anti-parasite medicine for animal use proposed
Object ivermectin injection and preparation method thereof.
To achieve the goals above, present invention employs following technical solutions:
A kind of antiparasite drugs for animals ivermectin injection, is grouped as by the group of following parts by weight: ivermectin B1 1-3
Part, 2-5 parts of vitamin E, 1-4 parts of vitamine D3,50-100 parts of dehydrated alcohol, 1-5 parts of glycerol formal, ginkgo biloba p.e
0.1-2 parts, 0.5-2 parts of crane grass roots bud extract, 0.1-3 parts of betelnut extract, 0.1-2 parts of Omphalia extract, Radix Stemonae extract
0.2-1 parts.
Preferably, it is grouped as by the group of following parts by weight: 1-2 parts of ivermectin B1,3-4 parts of vitamin E, vitamine D3
2-4 parts, 80-90 parts of dehydrated alcohol, 2-4 parts of glycerol formal, 0.5-1 parts of ginkgo biloba p.e, crane grass roots bud extract 1-2
Part, 0.5-1 parts of betelnut extract, 0.5-1 parts of Omphalia extract, 0.4-0.8 parts of Radix Stemonae extract.
Preferably, it is grouped as by the group of following parts by weight: 1 part of ivermectin B1,2 parts of vitamin E, vitamine D3 2
Part, 90 parts of dehydrated alcohol, 2 parts of glycerol formal, 0.5 part of ginkgo biloba p.e, 1 part of crane grass roots bud extract, betelnut extract
0.5 part, 0.5 part of Omphalia extract, 0.5 part of Radix Stemonae extract.
A kind of preparation method of antiparasite drugs for animals ivermectin injection, includes the following steps,
S1 takes ginkgo biloba p.e, crane grass roots bud extract, betelnut extract, Omphalia extract and the tuber of stemona of above-mentioned parts by weight
Extract is placed in agitating device and stirs, and is after mixing evenly put into mixture in the dehydrated alcohol of above-mentioned parts by weight, again
It is stirred mixing, obtains mixture A；
Ivermectin class drug and vitamine D3 are added into mixture A by S2, stirring to after dissolving, add vitamin E,
Dehydrated alcohol and glycerol formal are stirred mixing, obtain antiparasite drugs for animals ivermectin injection；
S3 checks antiparasite drugs for animals ivermectin injection, packing, Zha Gai, labeling, dress after passed examination
Case, storage.
Compared with prior art, the beneficial effects of the present invention are: during actual injection, desinsection effect is effectively improved
Fruit, at the same by the extraction to a variety of medicinal materials, side effect is reduced, is absorbed convenient for animal, and crane grass roots is added in the present invention
Bud extract can drive away fowl tapeworm, by the setting of betelnut extract and Radix Stemonae extract, can drive away chicken tapeworm, duck and goose
Sword belt tapeworm, stone-like omphalia are then the important components for driving away expelling parasite fowl tapeworm, can be further improved the effect for killing tapeworm, the present invention
Production method is simple, is conducive to the growth of animal, and aquaculture cost is low, is suitble to promote the use of.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.
Embodiment one
Antiparasite drugs for animals ivermectin injection in the present embodiment is grouped as: ivermectin by the group of following parts by weight
1 part of B1,2 parts of vitamin E, 1 part of vitamine D3,50 parts of dehydrated alcohol, 1 part of glycerol formal, 0.1 part of ginkgo biloba p.e,
0.5 part of crane grass roots bud extract, 0.1 part of betelnut extract, 0.1 part of Omphalia extract, 0.2 part of Radix Stemonae extract.
The preparation method of the present embodiment antiparasite drugs for animals ivermectin injection, includes the following steps,
S1 takes ginkgo biloba p.e, crane grass roots bud extract, betelnut extract, Omphalia extract and the tuber of stemona of above-mentioned parts by weight
Extract is placed in agitating device and stirs, and is after mixing evenly put into mixture in the dehydrated alcohol of above-mentioned parts by weight, again
It is stirred mixing, obtains mixture A；
Ivermectin class drug and vitamine D3 are added into mixture A by S2, stirring to after dissolving, add vitamin E,
Dehydrated alcohol and glycerol formal are stirred mixing, obtain antiparasite drugs for animals ivermectin injection；
S3 checks antiparasite drugs for animals ivermectin injection, packing, Zha Gai, labeling, dress after passed examination
Case, storage.
Embodiment two
Antiparasite drugs for animals ivermectin injection in the present embodiment is grouped as: ivermectin by the group of following parts by weight
3 parts of B1,4 parts of vitamin E, 4 parts of vitamine D3,100 parts of dehydrated alcohol, 5 parts of glycerol formal, ginkgo biloba p.e 1.5
Part, 2 parts of crane grass roots bud extract, 1 part of betelnut extract, 1.3 parts of Omphalia extract, 0.8 part of Radix Stemonae extract.
The preparation method of the present embodiment antiparasite drugs for animals ivermectin injection, includes the following steps,
S1 takes ginkgo biloba p.e, crane grass roots bud extract, betelnut extract, Omphalia extract and the tuber of stemona of above-mentioned parts by weight
Extract is placed in agitating device and stirs, and is after mixing evenly put into mixture in the dehydrated alcohol of above-mentioned parts by weight, again
It is stirred mixing, obtains mixture A；
Ivermectin class drug and vitamine D3 are added into mixture A by S2, stirring to after dissolving, add vitamin E,
Dehydrated alcohol and glycerol formal are stirred mixing, obtain antiparasite drugs for animals ivermectin injection；
S3 checks antiparasite drugs for animals ivermectin injection, packing, Zha Gai, labeling, dress after passed examination
Case, storage.
Embodiment three
Antiparasite drugs for animals ivermectin injection in the present embodiment is grouped as: ivermectin by the group of following parts by weight
1.6 parts of B1,3 parts of vitamin E, 2 parts of vitamine D3,95 parts of dehydrated alcohol, 2 parts of glycerol formal, ginkgo biloba p.e 0.5
Part, 0.8 part of crane grass roots bud extract, 0.5 part of betelnut extract, 0.5 part of Omphalia extract, 0.5 part of Radix Stemonae extract.
The preparation method of the present embodiment antiparasite drugs for animals ivermectin injection, includes the following steps,
S1 takes ginkgo biloba p.e, crane grass roots bud extract, betelnut extract, Omphalia extract and the tuber of stemona of above-mentioned parts by weight
Extract is placed in agitating device and stirs, and is after mixing evenly put into mixture in the dehydrated alcohol of above-mentioned parts by weight, again
It is stirred mixing, obtains mixture A；
Ivermectin class drug and vitamine D3 are added into mixture A by S2, stirring to after dissolving, add vitamin E,
Dehydrated alcohol and glycerol formal are stirred mixing, obtain antiparasite drugs for animals ivermectin injection；
S3 checks antiparasite drugs for animals ivermectin injection, packing, Zha Gai, labeling, dress after passed examination
Case, storage.
Example IV
Antiparasite drugs for animals ivermectin injection in the present embodiment is grouped as: ivermectin by the group of following parts by weight
2.5 parts of B1,5 parts of vitamin E, 2.5 parts of vitamine D3,80 parts of dehydrated alcohol, 3 parts of glycerol formal, ginkgo biloba p.e 1
Part, 1.5 parts of crane grass roots bud extract, 2.5 parts of betelnut extract, 2 parts of Omphalia extract, 1.0 parts of Radix Stemonae extract.
The preparation method of the present embodiment antiparasite drugs for animals ivermectin injection, includes the following steps,
S1 takes ginkgo biloba p.e, crane grass roots bud extract, betelnut extract, Omphalia extract and the tuber of stemona of above-mentioned parts by weight
Extract is placed in agitating device and stirs, and is after mixing evenly put into mixture in the dehydrated alcohol of above-mentioned parts by weight, again
It is stirred mixing, obtains mixture A；
Ivermectin class drug and vitamine D3 are added into mixture A by S2, stirring to after dissolving, add vitamin E,
Dehydrated alcohol and glycerol formal are stirred mixing, obtain antiparasite drugs for animals ivermectin injection；
S3 checks antiparasite drugs for animals ivermectin injection, packing, Zha Gai, labeling, dress after passed examination
Case, storage.
Embodiment five
Antiparasite drugs for animals ivermectin injection in the present embodiment is grouped as: ivermectin by the group of following parts by weight
2 parts of B1,3.6 parts of vitamin E, 3 parts of vitamine D3,90 parts of dehydrated alcohol, 4 parts of glycerol formal, 2 parts of ginkgo biloba p.e,
1 part of crane grass roots bud extract, 3 parts of betelnut extract, 1 part of Omphalia extract, 0.4 part of Radix Stemonae extract.
The preparation method of the present embodiment antiparasite drugs for animals ivermectin injection, includes the following steps,
S1 takes ginkgo biloba p.e, crane grass roots bud extract, betelnut extract, Omphalia extract and the tuber of stemona of above-mentioned parts by weight
Extract is placed in agitating device and stirs, and is after mixing evenly put into mixture in the dehydrated alcohol of above-mentioned parts by weight, again
It is stirred mixing, obtains mixture A；
Ivermectin class drug and vitamine D3 are added into mixture A by S2, stirring to after dissolving, add vitamin E,
Dehydrated alcohol and glycerol formal are stirred mixing, obtain antiparasite drugs for animals ivermectin injection；
S3 checks antiparasite drugs for animals ivermectin injection, packing, Zha Gai, labeling, dress after passed examination
Case, storage.
In the present invention, during actual injection, insecticidal effect is effectively improved, while by mentioning to a variety of medicinal materials
It takes, reduces side effect, absorbed convenient for animal, and be added with crane grass roots bud extract in the present invention, fowl tapeworm can be driven away, passed through
The setting of betelnut extract and Radix Stemonae extract, can drive away chicken tapeworm, duck and goose sword belt tapeworm, and stone-like omphalia is then to drive away expelling parasite fowl
The important component of tapeworm can be further improved the effect for killing tapeworm, and production method of the present invention is simple, is conducive to the life of animal
Long, aquaculture cost is low, is suitble to promote the use of.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (4)
1. a kind of antiparasite drugs for animals ivermectin injection, which is characterized in that be grouped as by the group of following parts by weight: she
Tie up 1-3 parts of rhzomorph B1,2-5 parts of vitamin E, 1-4 parts of vitamine D3,50-100 parts of dehydrated alcohol, 1-5 parts of glycerol formal,
0.1-2 parts of ginkgo biloba p.e, 0.5-2 parts of crane grass roots bud extract, 0.1-3 parts of betelnut extract, Omphalia extract 0.1-2
Part, 0.2-1 parts of Radix Stemonae extract.
2. a kind of antiparasite drugs for animals ivermectin injection according to claim 1, which is characterized in that by following
The group of parts by weight is grouped as: 1-2 parts of ivermectin B1,3-4 parts of vitamin E, 2-4 parts of vitamine D3, dehydrated alcohol 80-90
Part, 2-4 parts of glycerol formal, 0.5-1 parts of ginkgo biloba p.e, 1-2 parts of crane grass roots bud extract, 0.5-1 parts of betelnut extract,
0.5-1 parts of Omphalia extract, 0.4-0.8 parts of Radix Stemonae extract.
3. a kind of antiparasite drugs for animals ivermectin injection according to claim 1, which is characterized in that by following
The group of parts by weight is grouped as: 1 part of ivermectin B1,2 parts of vitamin E, 2 parts of vitamine D3,90 parts of dehydrated alcohol, glycerol acetonide
2 parts of formaldehyde, 0.5 part of ginkgo biloba p.e, 1 part of crane grass roots bud extract, 0.5 part of betelnut extract, 0.5 part of Omphalia extract,
0.5 part of Radix Stemonae extract.
4. a kind of preparation method of antiparasite drugs for animals ivermectin injection described in claim 1, which is characterized in that
Include the following steps,
S1 takes ginkgo biloba p.e, crane grass roots bud extract, betelnut extract, Omphalia extract and the tuber of stemona of above-mentioned parts by weight
Extract is placed in agitating device and stirs, and is after mixing evenly put into mixture in the dehydrated alcohol of above-mentioned parts by weight, again
It is stirred mixing, obtains mixture A；
Ivermectin class drug and vitamine D3 are added into mixture A by S2, stirring to after dissolving, add vitamin E and
Glycerol formal is stirred mixing, obtains antiparasite drugs for animals ivermectin injection；
S3 checks antiparasite drugs for animals ivermectin injection, packing, Zha Gai, labeling, dress after passed examination
Case, storage.
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| CN111920765A (en) * | 2020-09-24 | 2020-11-13 | 河北新世纪药业有限公司 | Compound ivermectin injection and preparation method thereof |
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