CN109952341A - 衍生自天然来源的冷适应海洋物种的明胶聚合物及其用途 - Google Patents

衍生自天然来源的冷适应海洋物种的明胶聚合物及其用途 Download PDF

Info

Publication number
CN109952341A
CN109952341A CN201780050860.8A CN201780050860A CN109952341A CN 109952341 A CN109952341 A CN 109952341A CN 201780050860 A CN201780050860 A CN 201780050860A CN 109952341 A CN109952341 A CN 109952341A
Authority
CN
China
Prior art keywords
gelatin
salmon
composition
amino acid
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780050860.8A
Other languages
English (en)
Chinese (zh)
Inventor
哈维尔·恩里昂·卡塞雷斯
保罗·迪亚兹-卡尔德隆
亚历山大·佐帕
胡安·巴勃罗·阿塞韦多·考克斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Showsford Cell Co
Original Assignee
Showsford Cell Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Showsford Cell Co filed Critical Showsford Cell Co
Publication of CN109952341A publication Critical patent/CN109952341A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00Compositions of proteins; Compositions of derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23PSHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10Coating with edible coatings, e.g. with oils or fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222Gelatin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00Materials specially adapted for additive manufacturing
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08HDERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00Macromolecular products derived from proteins
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075Macromolecular gels
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00Use of organic ingredients
    • C08K5/04Oxygen-containing compounds
    • C08K5/10Esters; Ether-esters
    • C08K5/101Esters; Ether-esters of monocarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02Polyalkylene oxides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04Products derived from waste materials, e.g. horn, hoof or hair
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09HPREPARATION OF GLUE OR GELATINE
    • C09H7/00Preparation of water-insoluble gelatine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00Characterised by the use of proteins; Derivatives thereof
    • C08J2389/04Products derived from waste materials, e.g. horn, hoof or hair
    • C08J2389/06Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00Crosslinking

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Artificial Filaments (AREA)
  • Polymerisation Methods In General (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Wood Science & Technology (AREA)
CN201780050860.8A 2016-06-17 2017-06-19 衍生自天然来源的冷适应海洋物种的明胶聚合物及其用途 Pending CN109952341A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16175153.2 2016-06-17
EP16175153 2016-06-17
PCT/IB2017/053637 WO2017216780A1 (en) 2016-06-17 2017-06-19 Gelatin polymer derived from natural sources of cold-adapted marine species and uses thereof

Publications (1)

Publication Number Publication Date
CN109952341A true CN109952341A (zh) 2019-06-28

Family

ID=56368780

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780050860.8A Pending CN109952341A (zh) 2016-06-17 2017-06-19 衍生自天然来源的冷适应海洋物种的明胶聚合物及其用途

Country Status (11)

Country Link
US (1) US11566133B2 (enExample)
EP (1) EP3472229B1 (enExample)
JP (1) JP2019525990A (enExample)
KR (1) KR20190086655A (enExample)
CN (1) CN109952341A (enExample)
AU (1) AU2017285384A1 (enExample)
CA (1) CA3028114A1 (enExample)
CL (3) CL2018003648A1 (enExample)
IL (1) IL263733A (enExample)
RU (1) RU2019101011A (enExample)
WO (1) WO2017216780A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112679593A (zh) * 2020-12-28 2021-04-20 华中农业大学 酸处理结合壳聚糖絮凝回收鱼糜漂洗液中的肌浆蛋白的方法及应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018131003A1 (en) 2017-01-16 2018-07-19 Cells For Cells, S.A Composition comprising a substantially pure population of multipotent stromal cells encapsulated in platelet-poor plasma (ppp)
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
EP3719057A1 (en) 2019-04-03 2020-10-07 Tessenderlo Group NV A gelatin and uses thereof
US12180374B2 (en) 2019-06-18 2024-12-31 University Of Washington Protein-based resins for additive manufacturing
US20220331477A1 (en) * 2019-09-18 2022-10-20 National Institute For Materials Science Biological tissue adhesive sheet, biological tissue reinforcement material kit, and method for producing biological tissue adhesive sheet
JP7604801B2 (ja) * 2019-12-19 2024-12-24 artience株式会社 細胞培養用インクジェットインキ、細胞培養用部材及びその製造方法、細胞培養パターンの形成方法
KR102463107B1 (ko) * 2020-07-14 2022-11-03 바오밥헬스케어 주식회사 줄기세포 대량생산용 배양배드 및 이의 제조 방법
CN112071660B (zh) * 2020-08-03 2021-08-24 陕西国防工业职业技术学院 一种超长聚吡咯纳米线型电极材料的制备方法
US20240368447A1 (en) * 2021-07-16 2024-11-07 The Regents Of The University Of California Reusable environmentally friendly food cooling technology
EP4582439A1 (en) 2022-09-01 2025-07-09 Cells For Cells S.A. Method for obtainingmethod for obtaining a porous injectable scaffold based on similar biopolymers with different melting temperatures
WO2024113021A1 (en) * 2022-12-02 2024-06-06 Gelomics Pty Ltd Modified gelatins, hydrogels, and processes for their production
DE102023120769A1 (de) 2023-08-04 2025-02-06 Cellbricks Gmbh Verfahren zur herstellung einer tinte für den 3d-druck unter verwendung eines polypeptids auf basis von menschlichem kollagen mit reduziertem hydroxyprolin-anteil
CN117045846A (zh) * 2023-08-21 2023-11-14 天津工业大学 一种高分子量壳聚糖皮芯结构微纳米纤维敷料

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2839658A1 (fr) * 2002-05-17 2003-11-21 Protex Nouveau procede de preparation de microcapsules a base de gelatine, contenant un liquide hydrophobe et microcapsules obtenues
US20120220691A1 (en) * 2010-09-29 2012-08-30 Rutgers, The State University Of New Jersey Process for the synthesis of methacrylate-derivatized type-1 collagen and derivatives thereof
CN103319729A (zh) * 2013-06-04 2013-09-25 武汉工程大学 一种功能明胶改性的方法
CN104448161A (zh) * 2014-12-05 2015-03-25 四川大学 一种改性明胶纳米微球交联的有机复合水凝胶及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2124537C1 (ru) 1996-07-04 1999-01-10 Научно-исследовательский институт военной медицины Композиция и способ изготовления контактной линзы
JPH10195169A (ja) 1997-01-13 1998-07-28 Showa Denko Kk 重合性を付与した天然有機高分子化合物の製造方法
US6458386B1 (en) 1997-06-03 2002-10-01 Innogenetics N.V. Medicaments based on polymers composed of methacrylamide-modified gelatin
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
AT501700B1 (de) 2005-04-14 2011-03-15 Univ Wien Tech Mit strahlung härtbare, biologisch abbaubare zusammensetzungen und deren verwendung als stützmaterialien für den knochenersatz
EP2120971B1 (en) 2006-12-04 2017-10-04 Johns Hopkins University Imidated biopolymer adhesive and hydrogel
EP1961414A1 (en) 2007-02-21 2008-08-27 FUJIFILM Manufacturing Europe B.V. A controlled release composition comprising a recombinant gelatin
EP1961411A1 (en) 2007-02-21 2008-08-27 FUJIFILM Manufacturing Europe B.V. A controlled release composition
CA2728187C (en) 2008-06-18 2014-04-29 Lifebond Ltd Improved cross-linked compositions
GB0907323D0 (en) 2009-04-29 2009-06-10 Dynea Oy Composite material comprising crosslinkable resin of proteinous material
GB201305281D0 (en) * 2013-03-22 2013-05-01 Univ Leeds Improvements in and relating to collagen based materials
RU2564824C1 (ru) 2014-07-11 2015-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарёва" Биоразлагаемая пленка
AU2016337557A1 (en) 2015-10-13 2018-05-31 Francisca ALCAYAGA Anti-angiogenic therapy based on exosomes derived from menstrual stem cells
EP3361986B1 (en) 2015-10-14 2021-01-06 Universidad de los Andes Automated fabrication of layer-by-layer tissue engineered complex tubes
WO2017064670A2 (en) 2015-10-14 2017-04-20 Cells For Cells, S.P.A. Treatment for infection composed of menstrual stem cells
WO2018131003A1 (en) 2017-01-16 2018-07-19 Cells For Cells, S.A Composition comprising a substantially pure population of multipotent stromal cells encapsulated in platelet-poor plasma (ppp)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2839658A1 (fr) * 2002-05-17 2003-11-21 Protex Nouveau procede de preparation de microcapsules a base de gelatine, contenant un liquide hydrophobe et microcapsules obtenues
US20120220691A1 (en) * 2010-09-29 2012-08-30 Rutgers, The State University Of New Jersey Process for the synthesis of methacrylate-derivatized type-1 collagen and derivatives thereof
CN103319729A (zh) * 2013-06-04 2013-09-25 武汉工程大学 一种功能明胶改性的方法
CN104448161A (zh) * 2014-12-05 2015-03-25 四川大学 一种改性明胶纳米微球交联的有机复合水凝胶及其制备方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BOR-SEN CHIOU等: ""Cold water fish gelatin films:Effect of cross-lingking on thermal,mechanical,barrier,and biodegradation properties"", 《EUROPEAN POLYMER JOURNAL》 *
BOR-SEN CHIO等: ""Rheological and mechanical properties of cross-linked fish gelatins"", 《POLYMER》 *
J.B.YI等: ""Influence of Transglutaminase-Induced Cross-Linking on Properties of Fish Gelatin Films"", 《E:FOOD ENGINEERING AND PHYSICAL PROPERTIES》 *
JASON W.NICHOL: ""Cell-laden microengineered gelatin methacrylate hydrogels"", 《BIOMATERIALS》 *
KAN YUE等: ""synthesis,properties,and biomedical applications of gelatin methacryloyl(GelMA) hydrogels"", 《BIOMATERIALS》 *
NAOZUMI TERAMOTO等: ""Preparation and Mechanical Properties of Photo-Crosslinked Fish Gelatin/Imogolite Nanofiber Composite Hydrogel"", 《MATERIALS》 *
郑俊民主编: "《药用高分子材料学》", 31 January 2009, 中国医药科技出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112679593A (zh) * 2020-12-28 2021-04-20 华中农业大学 酸处理结合壳聚糖絮凝回收鱼糜漂洗液中的肌浆蛋白的方法及应用

Also Published As

Publication number Publication date
CL2021000763A1 (es) 2021-10-22
US20190194460A1 (en) 2019-06-27
AU2017285384A1 (en) 2019-02-07
CA3028114A1 (en) 2017-12-21
KR20190086655A (ko) 2019-07-23
EP3472229A1 (en) 2019-04-24
CL2021000762A1 (es) 2021-10-22
RU2019101011A (ru) 2020-07-17
US11566133B2 (en) 2023-01-31
RU2019101011A3 (enExample) 2020-10-06
CL2018003648A1 (es) 2019-05-31
WO2017216780A1 (en) 2017-12-21
IL263733A (en) 2019-01-31
EP3472229B1 (en) 2022-02-16
JP2019525990A (ja) 2019-09-12

Similar Documents

Publication Publication Date Title
CN109952341A (zh) 衍生自天然来源的冷适应海洋物种的明胶聚合物及其用途
CN110240712B (zh) 一种组织粘合用的高拉伸、高粘性、自愈合双网络水凝胶及其制备方法和应用
Zhang et al. Dynamic covalent polymers for biomedical applications
Li et al. Self-healing supramolecular self-assembled hydrogels based on poly (L-glutamic acid)
Agheb et al. Novel electrospun nanofibers of modified gelatin-tyrosine in cartilage tissue engineering
Abandansari et al. In situ formation of interpenetrating polymer network using sequential thermal and click crosslinking for enhanced retention of transplanted cells
Sosnik et al. Semi-synthetic collagen/poloxamine matrices for tissue engineering
Huang et al. A tannin-functionalized soy protein-based adhesive hydrogel as a wound dressing
Suvarnapathaki et al. Synthesis and characterization of photocrosslinkable hydrogels from bovine skin gelatin
Truong et al. In situ-forming click-crosslinked gelatin based hydrogels for 3D culture of thymic epithelial cells
Panahi et al. Protein-based hydrogels
Zhou et al. Injectable muscle-adhesive antioxidant conductive photothermal bioactive nanomatrix for efficiently promoting full-thickness skeletal muscle regeneration
US20100190704A1 (en) Structure comprising chitosan and collagen
Ren et al. Alginate/polyacrylamide host-guest supramolecular hydrogels with enhanced adhesion
O'Connor et al. Dextran hydrogels by crosslinking with amino acid diamines and their viscoelastic properties
Zhou et al. Poly (glutamic acid‐lysine) hydrogels with alternating sequence resist the foreign body response in rodents and non‐human primates
Ganjalinia et al. PLLA scaffolds surface-engineered via poly (propylene imine) dendrimers for improvement on its biocompatibility/controlled pH biodegradability
Zhang et al. Thermoresponsive dendronized chitosan-based hydrogels as injectable stem cell carriers
Mao et al. Charge and receptor functional injectable hydrogels as cytokine-releasing reservoirs for wound healing
Khoshnood et al. Development of novel alginate‐polyethyleneimine cell‐laden bioink designed for 3D bioprinting of cutaneous wound healing scaffolds
CN112646202B (zh) 一种功能化双网络水凝胶及其制备方法和应用
US12403646B2 (en) Method for 3D printing with a bio-ink
Chen ColMA/PEGDA bioink for digital light processing 3D printing in biomedical engineering
BE1031493B1 (nl) Gebruik van gelatine in een ondersteuningsmateriaal voor ingebed printen
EP3862016B1 (en) Angiogenesis promoter for use in treating a peripheral artery disease

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20190628

WD01 Invention patent application deemed withdrawn after publication