CN109943484A - A kind of RTP carbon dioxide incubator - Google Patents
A kind of RTP carbon dioxide incubator Download PDFInfo
- Publication number
- CN109943484A CN109943484A CN201910257478.5A CN201910257478A CN109943484A CN 109943484 A CN109943484 A CN 109943484A CN 201910257478 A CN201910257478 A CN 201910257478A CN 109943484 A CN109943484 A CN 109943484A
- Authority
- CN
- China
- Prior art keywords
- rtp
- carbon dioxide
- main body
- culture box
- box main
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a kind of RTP carbon dioxide incubators, comprising: the RTP main valve being mounted on the service of connection devices；Inside is equipped with the culture box main body of interconnected main cavity and secondary cavity；It is mounted on the opening of the culture box main body, and the RTP pair valve being detachably connected with the RTP main valve；It is connected to the culture box main body, and the gas-tpe fitting for being passed through sterile carbon dioxide and compressed air；It is arranged in the heating coil that main chamber is external, for heating to main chamber body.To ensure that each single carbon dioxide incubator is to cultivate cell under sterile conditions, will not intersect pollution each other.
Description
Technical field
The present invention relates to incubator technical field, in particular to a kind of carbon dioxide incubator.
Background technique
The theme of regenerative medicine, such as organizational project, gene therapy, immune cell therapy, stem-cell therapy, increasingly at
For the object of research.In December, 2017 country's appearance-cell therapy product research and assessment technique guideline, therefore cell
When drug is very bright and clear, clear to supervise.
The maximum characteristic of cell drug is exactly non-final sterilising prods, while requiring whole Sterility Assurance.According to sterile
Pharmaceutical production requirement, the preparation production model of CAR-T and stem cell: 1.B+A；2.D/C+A+ isolator.
Cell individual is more distinct, and 1, the special CAR-T cell sample of people 1 is exactly 1 batch management, in B+A mode
Production preparation, manufacturing cycle 15 days entire workshops whole occupancy, cause workshop and facilities and equipment utilization rate low, cost
Investment is big, and occupied area is larger, is not suitable for producing on a large scale.
D/C+A+ isolator mode is applied in combination using RTP (quick passing interface) carbon dioxide incubator, provides one
Feasible solution, can also accomplish inside incubator sterile, all be entered in incubator by filtering with gas and water, guarantee it is thin
Born of the same parents' training quality greatly reduces the production cost of advanced treatment product.Carbon dioxide incubator in D or C level work environment,
Conjunction rule use plays the role of very big.But current carbon dioxide incubator on the market, it is impossible to ensure that internal cavity
It is after sterilization state of isolation with external environment, will not be contaminated again.Moreover, docking with the integral asepsis of isolator is also nothing
What method guaranteed.
Summary of the invention
The purpose of the present invention is to provide a kind of RTP carbon dioxide incubators, ensure that each single carbon dioxide training
Feeding case is to cultivate cell under sterile conditions, and will not intersect pollution each other.
Realizing the technical solution of above-mentioned purpose is:
A kind of RTP carbon dioxide incubator, comprising:
The RTP main valve being mounted on the service of connection devices；
Inside is equipped with the culture box main body of interconnected main cavity and secondary cavity；
It is mounted on the opening of the culture box main body, and the RTP pair valve being detachably connected with the RTP main valve；
It is connected to the culture box main body, and the gas-tpe fitting for being passed through sterile carbon dioxide and compressed air；And
It is arranged in the heating coil that main chamber is external, for heating to main chamber body.
Preferably, further includes: be arranged in the incubator bottom part body, be oriented to when being docked with the service of connection devices
Docking guide wheel.
Preferably, further includes:
The carriage rail being fixed in main chamber body；And
The bracket being slidably connected on the carriage rail.
Preferably, further includes:
It is arranged in the culture box main body, for acquiring the temperature sensor of the culture box main body medium temperature degree signal；
It is arranged in the culture box main body, for acquiring the dioxy of gas concentration lwevel signal in the culture box main body
Change concentration of carbon sensor；
It is arranged in the culture box main body, for acquiring the humidity sensor of moisture signal in the culture box main body；
And
It is arranged in the culture box main body, for acquiring the oxygen concentration of oxygen concentration signals in the culture box main body
Sensor.
Preferably, further include controller, the controller be electrically connected the temperature sensor, gas concentration lwevel sensor,
Humidity sensor, oxygen concentration sensor and heating coil, wherein
The controller carries out power regulation to the heating coil according to temperature signal；
The controller according to gas concentration lwevel signal, to the carbon dioxide electronic valve being connect with the gas-tpe fitting into
Row open and close control, with the flow of regulation of carbon dioxide；
The controller shows moisture signal；
The controller shows oxygen concentration signals.
Preferably, further includes:
It is mounted on the connectivity part of main chamber body and secondary cavity, for carrying out flow-disturbing to the incubator body interior air-flow
Flow-disturbing blower.
Preferably, further include power supply device for power supply.
The beneficial effects of the present invention are: the present invention is designed using RTP valve and effective structure, ensure that each single
The carbon dioxide incubator of individual cultivates always cell under sterile conditions, and will not intersect pollution each other, each
It is all that independent work uses, it can be achieved that repeating cleaning circulation.Meanwhile cell can carry out culture expansion under sterile environment
Increase, evades the contaminated risk of cell, securely and reliably.
Detailed description of the invention
Fig. 1 is the side perspective view of RTP carbon dioxide incubator of the invention；
Fig. 2 is the perspective view of RTP carbon dioxide incubator of the invention；
Fig. 3 is the structure chart of RTP main valve in the present invention.
Specific embodiment
The present invention will be further described with reference to the accompanying drawings.
Please refer to Fig. 1-3, RTP carbon dioxide incubator of the invention, comprising: RTP main valve 1, culture box main body 2, temperature
Sensor 3, humidity sensor 4, gas concentration lwevel sensor 5, oxygen concentration sensor 6, flow-disturbing blower 8, gas-tpe fitting 9,
Dock guide wheel 10, bracket 11, carriage rail 12 and RTP pair valve 13.
RTP main valve 1 is mounted on the service of connection devices.It cultivates and is equipped with interconnected main cavity 7 and secondary cavity inside box main body 2
14, the connectivity part of main cavity 7 and secondary cavity 14 is arranged in flow-disturbing blower 8.RTP pair valve 13 is mounted on the opening of culture box main body 2,
And it is detachably connected with RTP main valve 1.After RTP main valve 1 and RTP pair valve 13 dock, RTP pair valve 13 can be opened.
The connection culture box main body 2 of gas-tpe fitting 9, and for being passed through sterile carbon dioxide and compressed air.Heating coil
It is arranged in outside main cavity 7, for being heated to main cavity 7.
Temperature sensor 3 acquisition culture box main body 2 in temperature signal, by controller (not shown) to heating coil into
Row power regulation, so that incubator internal environment is stablized in 37 DEG C of ranges.
Gas concentration lwevel signal in the acquisition culture box main body 2 of gas concentration lwevel sensor 5, passes through controller pair and gas
Control is opened and closed in the carbon dioxide electronic valve that pipe fitting 9 connects, with the flow of regulation of carbon dioxide, to control internal environment
Concentration will maintain the 5% of internal environment.
Moisture signal in the acquisition culture box main body 2 of humidity sensor 4, shows on the controller.Oxygen concentration sensor 6 is adopted
Oxygen concentration signals in collection culture box main body 2, show on the controller., can be pre- if if going down in low-oxygen environment cultivates cell
Interface is stayed to be passed through nitrogen, to adjust oxygen content.
When being passed through gas into culture box main body 2, need to go by the flow-disturbing blower 8 of inside setting to internal air
Flow-disturbing is carried out, guarantees the uniformity of the gas of inside cavity.The main function for docking guide wheel 10 is exactly RTP carbon dioxide incubator
When docking other equipment, as the guiding that can stablize docking.Carriage rail 12 is fixed in main cavity 7, and sliding connects
Bracket 11 is connect, bracket 11 is made to draw or promote inner chamber body 7.Bracket 11 for put cell culture vector for example culture dish, culture bottle,
Culture bag etc..
In addition, setting power supply device, powers to whole device.
Above embodiments are used for illustrative purposes only, rather than limitation of the present invention, the technology people in relation to technical field
Member, without departing from the spirit and scope of the present invention, can also make various transformation or modification, therefore all equivalent
Technical solution also should belong to scope of the invention, should be limited by each claim.
Claims (7)
1. a kind of RTP carbon dioxide incubator characterized by comprising
The RTP main valve being mounted on the service of connection devices；
Inside is equipped with the culture box main body of interconnected main cavity and secondary cavity；
It is mounted on the opening of the culture box main body, and the RTP pair valve being detachably connected with the RTP main valve；
It is connected to the culture box main body, and the gas-tpe fitting for being passed through sterile carbon dioxide and compressed air；And
It is arranged in the heating coil that main chamber is external, for heating to main chamber body.
2. RTP carbon dioxide incubator according to claim 1, which is characterized in that further include: it is arranged in the incubator
Bottom part body, the docking guide wheel being oriented to when being docked with the service of connection devices.
3. RTP carbon dioxide incubator according to claim 1, which is characterized in that further include:
The carriage rail being fixed in main chamber body；And
The bracket being slidably connected on the carriage rail.
4. RTP carbon dioxide incubator according to claim 1, which is characterized in that further include:
It is arranged in the culture box main body, for acquiring the temperature sensor of the culture box main body medium temperature degree signal；
It is arranged in the culture box main body, for acquiring the carbon dioxide of gas concentration lwevel signal in the culture box main body
Concentration sensor；
It is arranged in the culture box main body, for acquiring the humidity sensor of moisture signal in the culture box main body；And
It is arranged in the culture box main body, for acquiring the oxygen concentration sensing of oxygen concentration signals in the culture box main body
Device.
5. RTP carbon dioxide incubator according to claim 4, which is characterized in that it further include controller, controller electricity
The temperature sensor, gas concentration lwevel sensor, humidity sensor, oxygen concentration sensor and heating coil are connected,
In,
The controller carries out power regulation to the heating coil according to temperature signal；
The controller opens the carbon dioxide electronic valve connecting with the gas-tpe fitting according to gas concentration lwevel signal
Control is closed, with the flow of regulation of carbon dioxide；
The controller shows moisture signal；
The controller shows oxygen concentration signals.
6. RTP carbon dioxide incubator according to claim 1, which is characterized in that further include:
It is mounted on the connectivity part of main chamber body and secondary cavity, is disturbed for carrying out flow-disturbing to the incubator body interior air-flow
Flow fan.
7. RTP carbon dioxide incubator according to claim 1, which is characterized in that further include the power supply dress for power supply
It sets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910257478.5A CN109943484A (en) | 2019-04-01 | 2019-04-01 | A kind of RTP carbon dioxide incubator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910257478.5A CN109943484A (en) | 2019-04-01 | 2019-04-01 | A kind of RTP carbon dioxide incubator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109943484A true CN109943484A (en) | 2019-06-28 |
Family
ID=67013358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910257478.5A Pending CN109943484A (en) | 2019-04-01 | 2019-04-01 | A kind of RTP carbon dioxide incubator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109943484A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112080423A (en) * | 2020-08-28 | 2020-12-15 | 浙江泰林医学工程有限公司 | Carbon dioxide incubator and method for butting carbon dioxide incubator with isolator |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040215362A1 (en) * | 2003-04-25 | 2004-10-28 | Mamoru Kokubo | Aseptic system and method for using the same |
| CN203546034U (en) * | 2013-10-29 | 2014-04-16 | 秦俊文 | Intelligent antigen presenting cell monitoring and standardization culture device |
| US20170022468A1 (en) * | 2015-04-23 | 2017-01-26 | Comecer S.P.A. | Modular Incubator |
| CN206069890U (en) * | 2016-08-31 | 2017-04-05 | 广州合众生物科技有限公司 | A kind of resistant to pollution CO2 gas incubator |
| CN206289262U (en) * | 2016-12-24 | 2017-06-30 | 上海姚氏仪器设备厂 | CO2gas incubator |
| CN206580840U (en) * | 2017-02-15 | 2017-10-24 | 沈宇 | A kind of low-oxygen environment carbon dioxide cell incubator |
| CN107828650A (en) * | 2017-09-21 | 2018-03-23 | 浙江泰林生物技术股份有限公司 | A kind of cellular immunotherapy work station |
| CN207738760U (en) * | 2017-12-19 | 2018-08-17 | 上海东富龙医疗装备有限公司 | A kind of cell processing whole station system |
| CN108587908A (en) * | 2017-12-27 | 2018-09-28 | 上海力申科学仪器有限公司 | It is uniformly distributed with gas and the use for laboratory incubator of high efficiency filter |
| CN208362316U (en) * | 2018-05-18 | 2019-01-11 | 昆山森信科学仪器有限公司 | A kind of temperature control incubator |
| CN109439544A (en) * | 2018-11-07 | 2019-03-08 | 郑州韦尔特生物科技有限公司 | A kind of carbon dioxide cell incubator |
-
2019
- 2019-04-01 CN CN201910257478.5A patent/CN109943484A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040215362A1 (en) * | 2003-04-25 | 2004-10-28 | Mamoru Kokubo | Aseptic system and method for using the same |
| CN203546034U (en) * | 2013-10-29 | 2014-04-16 | 秦俊文 | Intelligent antigen presenting cell monitoring and standardization culture device |
| US20170022468A1 (en) * | 2015-04-23 | 2017-01-26 | Comecer S.P.A. | Modular Incubator |
| CN206069890U (en) * | 2016-08-31 | 2017-04-05 | 广州合众生物科技有限公司 | A kind of resistant to pollution CO2 gas incubator |
| CN206289262U (en) * | 2016-12-24 | 2017-06-30 | 上海姚氏仪器设备厂 | CO2gas incubator |
| CN206580840U (en) * | 2017-02-15 | 2017-10-24 | 沈宇 | A kind of low-oxygen environment carbon dioxide cell incubator |
| CN107828650A (en) * | 2017-09-21 | 2018-03-23 | 浙江泰林生物技术股份有限公司 | A kind of cellular immunotherapy work station |
| CN207738760U (en) * | 2017-12-19 | 2018-08-17 | 上海东富龙医疗装备有限公司 | A kind of cell processing whole station system |
| CN108587908A (en) * | 2017-12-27 | 2018-09-28 | 上海力申科学仪器有限公司 | It is uniformly distributed with gas and the use for laboratory incubator of high efficiency filter |
| CN208362316U (en) * | 2018-05-18 | 2019-01-11 | 昆山森信科学仪器有限公司 | A kind of temperature control incubator |
| CN109439544A (en) * | 2018-11-07 | 2019-03-08 | 郑州韦尔特生物科技有限公司 | A kind of carbon dioxide cell incubator |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112080423A (en) * | 2020-08-28 | 2020-12-15 | 浙江泰林医学工程有限公司 | Carbon dioxide incubator and method for butting carbon dioxide incubator with isolator |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN204307646U (en) | A kind of integrated sterilizing storage cabinet | |
| US20190275519A1 (en) | System for the production of cells and/or cell products | |
| CN205275616U (en) | Carbon dioxide incubator | |
| CN205099688U (en) | Hypoxemia environment carbon dioxide cell culture case | |
| CN206481673U (en) | The controllable culturing frame of one plant growth | |
| CN109810896B (en) | Temperature regulation and control device for cell culture | |
| CN106635790A (en) | Fully-closed automatic cell culture system | |
| CN106701576A (en) | Fully-automatic cell culture room and control method thereof | |
| CN206438125U (en) | A kind of clinical laboratory controllable bacteriological incubator of intelligence | |
| CN107236669A (en) | A kind of the high efficiency culture systems and application process of mass cell production and culture | |
| CN110540937A (en) | Multi-compartment unit culture system suitable for GMP (good manufacturing practice) compliance automatic production | |
| CN109943484A (en) | A kind of RTP carbon dioxide incubator | |
| CN207362242U (en) | A kind of hickory chick breeding strain case | |
| CN203065461U (en) | Internal loop airlift microbial culture reactor | |
| CN110129199A (en) | A kind of three-dimensional artificial culture systems of stem cell | |
| CN206069890U (en) | A kind of resistant to pollution CO2 gas incubator | |
| CN111334429A (en) | Modular multifunctional cell workstation | |
| JP2016136856A (en) | incubator | |
| CN207619418U (en) | A kind of cell cultivation instrument that gas concentration lwevel is controllable | |
| CN206591135U (en) | A kind of full-automatic cell culturing room | |
| CN208933383U (en) | A kind of intelligent automation cell colony experimental facilities | |
| CN209113906U (en) | A kind of lactic acid bacteria anaerobic culture device | |
| CN206494925U (en) | The incubator for being easy to insulation to humidify | |
| CN207616624U (en) | Isolating device | |
| CN106281989A (en) | Laboratory combination type tray solid-state fermentation installation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190628 |