CN111334429A - Modular multifunctional cell workstation - Google Patents
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- CN111334429A CN111334429A CN202010220552.9A CN202010220552A CN111334429A CN 111334429 A CN111334429 A CN 111334429A CN 202010220552 A CN202010220552 A CN 202010220552A CN 111334429 A CN111334429 A CN 111334429A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/22—Transparent or translucent parts
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
Abstract
The invention discloses a modular multifunctional cell workstation, belongs to the technical field of cell culture devices, solves the problem that the existing cell laboratory can not cause the sample to be far away from pollution, and has the technical key points that: including cell workstation main part, divide into observation room, A level control room, buffer room and A level toilet in the cell workstation main part, be provided with the microscope in the observation room, be provided with the incubator in the A level control room, the incubator is three gas incubators, and the negative pressure operating area that is provided with one-way air current in the cell workstation main part adopts clean pollution-free totally enclosed's design, provides the clean environment of aseptic experiment, and inside clean level can reach A level, has guaranteed the individuality accurate of cell, can effectually prevent sample cross contamination, collects cultivation, operation, microscope and observes in an organic whole, greatly improves the efficiency and the rate of accuracy of experiment for the cell laboratory is more swift, more high-efficient.
Description
Technical Field
The invention relates to the technical field of cell culture devices, in particular to a modular multifunctional cell workstation.
Background
In the cell culture experiment process, the general cell clean working laminar flow standard is operated through a biological safety cabinet and an ultra-clean workbench, although hundred-level laminar flow or ten-thousand-level laminar flow is provided, the cell culture, observation, centrifugation and other operations are all transferred to the outside to be operated or transferred out of a controllable environment, so the cell cannot be always in a good hundred-level laminar flow environment, and the infection of the outside cell can cause uncontrollable risk to the whole cell tissue.
Higher requirements for the worldwide strictest EUGMP standards to be consistent are proposed for such experiments according to international and domestic new standards, such as the table shown in FIG. 4; the A-level purification requires the static and dynamic particle numbers to be kept consistent, and the biological safety cabinet is a semi-open operating system and can only be ensured to be in a hundred-level laminar flow environment, but in the operating process, the hundred-level laminar flow environment is changed due to the inlet and outlet of a sample. Therefore, to meet class a cleanliness requirements, it must be done in such fully enclosed workstations.
Stem cell research is continuously warming, and clinical transformation becomes possible in the near future, providing the highest safety level equipment for stem cell research and clinical transformation, and the cells can grow in the environment with pleasure, and the trouble of pollution is avoided! The production of cells will be performed later in the multifunctional cell workstation and the whole research and production process will be completed in such a workstation.
The existing cell laboratory needs to purify the environment in a large area, needs more time for decoration and debugging, needs investment cost construction, and has the defects of high maintenance cost and the like in future.
Therefore, it is desirable to provide a modular multifunctional cell workstation as an experimental chamber, which can enter a culture environment in time after an experimenter completes culture, so as to provide powerful protection for cell culture, simplify a workflow environment to meet use requirements, reduce preparation and operation costs of cell therapy products, and meet various regulatory agencies (such as FDA, EUP, USP) and industrial standards (such as GMP, FDA).
Disclosure of Invention
In view of the shortcomings of the prior art, it is an object of the present invention to provide a modular multi-functional cell workstation to solve the above-mentioned problems in the prior art.
In order to achieve the purpose, the invention provides the following technical scheme:
the utility model provides a multi-functional cell workstation of modular, includes the cell workstation main part, divide into observation room, A level control room, surge chamber and A level clean room in the cell workstation main part, be provided with the microscope in the observation room, be provided with the incubator in the A level control room, the incubator is three gaseous incubators, is provided with the negative pressure operation area of one-way air current in the cell workstation main part, and air inlet on the cell workstation main part installs and just imitates filter and high efficiency filter one, and high efficiency filter two is installed to the air outlet on the cell workstation main part.
As a further scheme of the invention, the observation chamber, the class A operation chamber, the buffer chamber and the class A clean room are used in any combination.
As a further scheme of the invention, the microscope is an integrated microscope, and a PLC control screen is also arranged on the cell workstation main body; the PLC control screen is connected with the microscope and is connected with the Ethernet.
As a further scheme of the invention, the operation control panel of the PLC control screen is a 15-inch color touch screen, and a USB port is arranged in front of the touch screen of the PLC control screen.
As a further proposal of the invention, the three-gas incubator is embedded in the experimental cabin of the class-A operation room.
As a further scheme of the invention, a waste garbage bin and a centrifugal machine are further installed in the class-A operating chamber, the port of the waste garbage bin is a quick transmission port, the waste garbage bin is located below the partition, an opening is formed in a working area between the incubator and the microscope, and the opening is provided with a port connected with the waste garbage bin.
As a further scheme of the invention, the observation room, the class A operation room and the class A clean room are all provided with operation gloves.
As a further proposal of the invention, the incubator is internally provided with CO2Gas concentration detection device, O2Gas concentration detection and temperature detection apparatus, CO2The gas concentration detecting device is an ultrasonic sensor, O2The gas concentration detection device is an electrochemical oxygen sensor, and the temperature detection device is a PT1000 platinum film resistance temperature sensor.
In summary, compared with the prior art, the embodiment of the invention has the following beneficial effects:
the modular multifunctional cell workstation provided by the invention adopts a clean and pollution-free totally-enclosed design, provides a sterile experiment clean environment, has an internal clean level reaching A level, ensures the individual precision of cells, can effectively prevent sample cross contamination, integrates culture, operation and microscope observation, greatly improves the efficiency and accuracy of the experiment, enables a cell laboratory to be faster and more efficient, and can be used for picking up the incubator to be placed in a culture area for culture after the cell operation of the laboratory is finished and then loading the incubator prepared in advance for the next batch of experiments after the workstation is sterilized, thereby increasing the experiment times and improving the efficiency.
To more clearly illustrate the structural features and effects of the present invention, the present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.
Drawings
FIG. 1 is an elevation view of the modular intelligent cell workstation of the invention.
FIG. 2 is a top view of the inventive modular smart cell workstation.
FIG. 3 is a schematic diagram of the filter installation of the modular intelligent cell workstation of the invention.
FIG. 4 is a table of air cleanliness class standards according to the EUGMP standard.
Reference numerals: 1-incubator, 2-observation chamber, 3-A level operation chamber, 4-buffer chamber, 5-A level clean room, 6-operation glove, 7-microscope, 8-waste garbage can, 9-centrifuge, 10-PLC control screen, 11-negative pressure operation area, 12-primary filter, 13-high efficiency filter I, 14-high efficiency filter II, 15-cell workstation body.
Detailed Description
The technical solution of the present invention is further described with reference to the accompanying drawings and specific embodiments.
Referring to fig. 1 to 3, a modular multifunctional cell workstation comprises a cell workstation body 15, wherein the inside of the cell workstation body 15 is divided into an observation room 2, a class-a operation room 3, a buffer room 4 and a class-a clean room 5, in the embodiment of the invention, the observation room 2, the class-a operation room 3, the buffer room 4 and the class-a clean room 5 can be combined and used at will, and can meet GMP laboratory standards in a series of processes such as cell preparation, cell stripping culture and the like, and rolling casters can be further mounted at the bottom of the cell workstation body 15 of each part, so that the movement is easily realized, and the movement and the migration of the workstation are convenient.
The cell workstation composed of the cell workstation main body 15 is mainly used for integrating modules of cell culture, observation, operation (passage or liquid change) and the like, all spaces can be controlled by oxygen, carbon dioxide, humidity and temperature, cell experiments are performed in indoor uncleaned spaces, A-level cell experiment effects are provided in modular environmental equipment, and a group or set of safe and reliable environmental equipment is provided for cell culture stripping.
In order to conveniently and rapidly observe cell and tissue samples without leaving a clean area, a microscope 7 is arranged in the observation chamber 2, and the microscope 7 adopts an integrated microscope; in order to observe the sample in real time, a PLC control screen 10 is also arranged on the cell workstation main body 15; the PLC control screen 10 is connected with the microscope 7, the PLC control screen 10 is connected with the Ethernet, all images are stored in the network for later access, and all images can be viewed through the PLC control screen 10.
As shown in fig. 1 and 2, as a preferred embodiment of the present invention, the operation control panel of the PLC control screen 10 is a 15-inch color touch screen, and the PC can be accessed for parameter setting (by authorized personnel) and key parameter monitoring. The alarm information is also clearly displayed on the display.
The visual interface is intended to provide all necessary information to the user in a fast and reliable way for optimal control and security. The swing monitor can be freely rotated to always provide the user with optimal visibility.
The software in the PLC control screen 10 enables visualization of user-defined programs to reduce the risk of errors. To improve efficiency, the program may use two pedal navigations: no interruption of operation is required.
In an embodiment of the present invention, a USB port is provided in front of the touch screen of the PLC control screen 10, and a barcode connection may be preset, so as to finally realize data recording of material and product entering and exiting.
An incubator 1 is arranged in the A-level operation chamber 3, the incubator 1 is a three-gas incubator, and the three-gas incubator is embedded in an experiment bin of the A-level operation chamber 3; in the embodiment of the present invention, the incubator 1 is a custom designed device, suitable for isolated environment, and connected to a monitoring and data acquisition system to monitor all control parameters;
the class A operation room 3 is also internally provided with a waste garbage can 8 and a centrifuge 9, in the embodiment of the invention, the port of the waste garbage can 8 is a quick transmission port, and the waste garbage can is allowed to be disconnected and the sterile garbage can is allowed to be reconnected only when the port is closed, so that the sterility of the isolation device and the interior of the waste garbage can is not lost;
wherein the waste receptacle 8 is located below the partition and has an opening in the working area between the incubator 1 and the microscope 7, the opening being provided as a port to which the waste receptacle 8 is connected.
The buffer chamber 4 is used for transferring articles, and the observation chamber 2, the class A operation chamber 3 and the class A clean room 5 are all provided with operation gloves 6 which are used for carrying out sample operation on a working area in the cell workstation main body 15, and the samples do not need to be transferred into or carried out of the class A environment during the procedure.
In one embodiment of the invention, a negative pressure operation area 11 with one-way airflow is arranged in the cell workstation main body 15, a primary filter 12 and a high efficiency filter 13 are arranged at an airflow inlet on the cell workstation main body 15, after external air is filtered by the primary filter 12 and the high efficiency filter 13, the air entering the negative pressure operation area 11 is ensured to be kept sterile, and a high efficiency filter 14 is arranged at an airflow outlet on the cell workstation main body 15 to prevent any non-sterile air from flowing back;
the main working area formed by the negative pressure operation area 11 is kept in an ISO4.8 environment (class A), the pneumatic design is used for providing unidirectional flow in the main working area and the transfer area, the air flow in the transfer area is increased during the product inlet period so as to keep the internal environment clean, and the ISO4.8 environment (class A) can be quickly recovered.
In one embodiment of the invention, the incubator 1 contains CO2Gas concentration detection device, O2A gas concentration detection device and a temperature detection device, wherein the CO2The gas concentration detection device adopts an advanced ultrasonic sensor to measure the sound waves in different CO2The propagation velocity in the concentration gas is calculated to obtain CO2The gas concentration. When the sensor works, the sensor has no mechanical abrasion, high response speed, high reliability, good stability and long service life;
said O is2The gas concentration detection adopts an electrochemical oxygen sensor with a long inlet life, has the characteristics of good linearity, accurate detection and the like, has a long service life, and can fully meet the requirements of users;
the temperature detection device adopts all imported PT1000 platinum film resistance temperature sensors, and has stable performance and good linearity. The independent sleeve temperature and the door temperature are controlled, the sleeve temperature of 5 surfaces and the door temperature of one surface are combined into the temperature of the working chamber, and the accuracy is high;
O2when the gas concentration is less than 19.8%, advanced N is adopted2Gas to reach O2After the concentration set value, the CO is fed2By means of gas, ensuring CO2Gas concentration and O2Accuracy of concentration。
O2When the gas concentration is more than 23%, advanced O is adopted2Gas to reach O2After the concentration set value, the CO is fed2By means of gas, ensuring CO2Gas concentration and O2The accuracy of the concentration.
The incubator 1 adopts breeze circulation mode to make air circulation approach natural air convection, and shorten temperature, humidity and O2Concentration and CO2Recovery time of concentration, ensuring temperature, humidity, and O2Concentration and CO2The balance of concentration; when the box door of the incubator 1 is opened, the electromagnetic valve on the incubator 1 is automatically closed, the breeze circulation is automatically stopped, the gas loss is reduced, the gas source can be saved, and the pollution caused by the external air entering the box is reduced;
in one embodiment of the present invention, a separate door temperature control system is also used in the incubator 1, so that the thermostatic control in the incubator is rarely affected by the change of the ambient temperature. The temperature and the gas concentration in the incubator 1 are displayed by numbers, and the door heating, the water heating and the gas inlet are displayed by LEDs, so that the incubator is visual, clear and accurate;
in one embodiment of the present invention, the incubator 1 has a plurality of protection functions such as a cover temperature, a door temperature, a room temperature, a number, etc., and can automatically cut off all heating power when the display temperature exceeds a preset temperature. The device has an independent overtemperature relay protection function and ensures that the temperature does not exceed a preset value; a water tray is arranged in the incubator 1 for natural evaporation and humidification, the humidity reaches 95%, the water tray is made of 304 stainless steel, arcs have no dead angle, and the water tray is easy to clean; has enough water jacket volume and good heat preservation performance.
In one embodiment of the present invention, a sterilization system is further disposed in the incubator 1, and the sterilization system adopts an ultraviolet lamp for sterilization, which is flexible and controllable and has a short operation time.
In the embodiment of the invention, an LED fixed UVC ultraviolet lamp can be selected and matched, a HEPA high-efficiency filtering and sterilizing system is arranged in the UVC ultraviolet lamp, a high-precision bipolar pressure reducing valve can be selected and matched aiming at an electromagnetic valve, and the pressure range is 0-0.25MPa for 2 times.
In one embodiment of the invention, the technical parameters of the incubator 1 are as follows:
1. the temperature control range is room temperature plus 3 ℃ to 60 ℃ (for example, the temperature set value is 37 ℃, and the environmental temperature is less than 34 ℃);
2. the constant temperature control precision is +/-0.2 ℃;
3. the temperature uniformity is +/-0.2 ℃;
4.O2the concentration control range is 1.0% -19.8% and 23.0% -50.0% (up to 90%);
5.O2the concentration control precision is +/-0.2% when the concentration is 1-5%, and +/-0.3% when the concentration is 5-20%;
6.CO2the concentration control range is 0% -20%;
7.CO2the concentration control precision is +/-0.2% when the concentration is 0-5%, and +/-0.3% when the concentration is 5-20%;
8. the power of the power supply 220V 50HZ is less than 680W;
9.O2the time for the concentration to normally drop to a set value is less than 30 minutes (O)2At a concentration of 1%);
10.CO2the time for the concentration to normally rise to the set value is less than 10 minutes (only CO is controlled)2And CO2At a concentration of 5%);
in one embodiment of the invention, the dimensions and the dimensions of the incubator 1 are as follows:
the modular multifunctional cell workstation provided by the invention can effectively control the temperature and humidity (the temperature and humidity change in the cavity is tested by the sensor in the cavity, and the temperature and humidity in the cavity are controlled to be constant after the data are analyzed from the sensor to the controller, so that the constant temperature and humidity are kept), and all data are controlled in a controllable range.
In the examples of the present invention, in order to ensure a sterile environment, hydrogen peroxide was used for evaporative sterilization. The cell workstation body 15 (both the transfer zone and the work zone) or only the transfer zone may be sterilized. Can disinfect before the sample gets into the workspace fast, reduce reagent consumption, avoid the workflow to interrupt.
In one embodiment of the present invention, the cell workstation body 15 is connected to a hydrogen peroxide generator having an outlet and an inlet, and the PLC control panel 10 is further connected to the H2O2The data connection of the steam generator is controlled through a main interface;
after laboratory cell operation was accomplished, get into the incubator after, pluck the incubator and place the cultivation district and cultivate, then workstation disinfection back, load on the incubator that prepares in advance and carry out next batch experiment, more can increase the experiment number of times like this, raise the efficiency, need not original cell laboratory just can do next batch experiment after waiting for tens days to cultivate. The method ensures the individual precision of the cells, is not easy to cross, and ensures that the cell laboratory is quicker and more efficient.
The modular multifunctional cell workstation is mainly used for cell research, HIF research, stem cell research, tumor cell research, respiratory diseases, sleep disorder, altitude reaction, gene expression and other researches; it is also applicable to regenerative medicine, cell tissue therapy, gene therapy, stem cell therapy, and the like.
The technical principle of the present invention has been described above with reference to specific embodiments, which are merely preferred embodiments of the present invention. The protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. Other embodiments of the invention will occur to those skilled in the art without the exercise of inventive faculty, and such will fall within the scope of the invention.
Claims (8)
1. The utility model provides a multi-functional cell workstation of modular, includes cell workstation main part (15), its characterized in that, divide into observation room (2), A level control room (3), cushion chamber (4) and A level clean room (5) in cell workstation main part (15), be provided with microscope (7) in observation room (2), be provided with incubator (1) in A level control room (3), incubator (1) are three gas incubators, are provided with the negative pressure operation district (11) of one-way air current in cell workstation main part (15), and primary filter (12) and high efficiency filter (13) are installed to the air current entry on cell workstation main part (15), and air current outlet on cell workstation main part (15) installs high efficiency filter two (14).
2. The modular multi-functional cell workstation of claim 1, characterized in that the observation chamber (2), the class a operation chamber (3), the buffer chamber (4) and the class a clean room (5) are used in any combination.
3. The modular multifunctional cell workstation according to claim 2, characterized in that the microscope (7) is an integrated microscope, and the cell workstation body (15) is further provided with a PLC control screen (10); the PLC control screen (10) is connected with the microscope (7), and the PLC control screen (10) is connected with the Ethernet.
4. The modular multi-functional cell workstation of claim 3, characterized in that the operation control panel of the PLC control screen (10) is a 15-inch color touch screen with a USB port in front of the touch screen of the PLC control screen (10).
5. The modular multi-functional cell workstation of claim 1, characterized in that the three gas incubators are embedded in the laboratory chamber of the class a operating room (3).
6. The modular multi-functional cell workstation of claim 1, characterized in that the class a chamber (3) further houses a waste bin (8) and a centrifuge (9), the port of the waste bin (8) being a fast transfer port, the waste bin (8) being located below the partition and having an opening in the working area between the incubator (1) and the microscope (7), the opening being provided as a port to which the waste bin (8) is connected.
7. The modular multi-functional cell workstation of claim 2, characterized in that the observation chamber (2), the class a operation chamber (3) and the class a clean room (5) are all provided with operation gloves (6).
8. The modular multi-functional cell workstation of any one of claims 1 to 7, characterized in that the incubator (1) contains CO2Gas concentration detection device, O2Gas concentration detection and temperature detection apparatus, CO2The gas concentration detecting device is an ultrasonic sensor, O2The gas concentration detection device is an electrochemical oxygen sensor, and the temperature detection device is a PT1000 platinum film resistance temperature sensor.
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| CN202010220552.9A CN111334429A (en) | 2020-03-25 | 2020-03-25 | Modular multifunctional cell workstation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111748473A (en) * | 2020-07-23 | 2020-10-09 | 北京图腾猎技科技有限公司 | Medical cell culture equipment and cell culture method |
| CN113621568A (en) * | 2021-07-22 | 2021-11-09 | 江苏蒙彼利生物科技有限公司 | Umbilical cord mesenchymal stem cell serum-free culture equipment and culture method thereof |
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