CN106701576A - Fully-automatic cell culture room and control method thereof - Google Patents
Fully-automatic cell culture room and control method thereof Download PDFInfo
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- CN106701576A CN106701576A CN201710120122.8A CN201710120122A CN106701576A CN 106701576 A CN106701576 A CN 106701576A CN 201710120122 A CN201710120122 A CN 201710120122A CN 106701576 A CN106701576 A CN 106701576A
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- culturing room
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- automatic cell
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- 238000000034 method Methods 0.000 title claims abstract description 12
- 238000004113 cell culture Methods 0.000 title abstract description 20
- 238000003860 storage Methods 0.000 claims abstract description 22
- 238000004140 cleaning Methods 0.000 claims abstract description 10
- 238000012258 culturing Methods 0.000 claims description 84
- 239000000463 material Substances 0.000 claims description 40
- 210000004027 cell Anatomy 0.000 claims description 22
- 230000007246 mechanism Effects 0.000 claims description 11
- 239000001963 growth medium Substances 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 239000006285 cell suspension Substances 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 235000015097 nutrients Nutrition 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 3
- 210000004748 cultured cell Anatomy 0.000 claims description 3
- 238000000151 deposition Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000007599 discharging Methods 0.000 abstract description 3
- 238000007789 sealing Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Computer Hardware Design (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to the technical field of cell culture, in particular to a fully-automatic cell culture room and a control method thereof. The fully-automatic cell culture room comprises a culture room, a feeding device, a discharging device, a cleaning device, a storage room device, a proportioning room device, a low-temperature storage device, a constant temperature device, a transfer device, a centrifugal machine device, a culture dish device and a robot device, wherein the feeding device and the discharging device are mounted on the culture room; the cleaning device, the storage room device, the proportioning room device, the low-temperature storage device, the constant temperature device, the transfer device, the centrifugal machine device, the culture dish device and the robot device are mounted in the culture room. The fully-automatic cell culture room and the control method thereof provided by the invention have the benefit that the culture room is completely sealed in the cell culture process without the need for personnel entry and participation, so that the entry of pollution sources can be avoided, and a sterile and dust-free environment in the culture room is kept, so that cells are free from pollution, and the smooth cell culture is ensured.
Description
Technical field
The present invention relates to technical field of cell culture, more particularly to a kind of full-automatic cell culturing room and its control method.
Background technology
Cell culture is an essential process for biotechnology, is most crucial in biotechnology, is also
Most basic technology.Cell culture is high for the requirement of environment, and the carelessness of a certain link can cause final cell cultivation to fail,
Existing cell culture technology is usually to be carried out in Cell Culture Lab, needs several staff's wearing clean garments, mouth
The protective articles such as cover simultaneously enter in toilet after thorough disinfection and carry out cell culture.But unavoidable, person works' mistake
Cheng Zhonghui produces the flowing of some bacteriums, personnel also to bring dust and bacterium into laboratory, so as to pollute.Artificial operation
Also excessive labour can be taken, operating efficiency is relatively low, the gnotobasis in laboratory and some toxic pharmaceuticals and sharp equipment
The increasing of personnel labor intensity and danger can be caused.
The content of the invention
According to above the deficiencies in the prior art, it is necessary to provide it is a kind of be fully sealed, do not need personnel enter participate in it is complete
Automated cell culturing room and its control method.
The present invention solve the technical scheme that uses of its technical problem for：
A kind of full-automatic cell culturing room is provided, it is characterised in that including：
Culturing room；
In culturing room, for the feed arrangement that material is conveyed in culturing room；
Cleaning device in culturing room, for culturing room and material to be cleaned, sterilize, sterilized；
Storage chamber device in culturing room, for depositing material；
Proportioning chamber device in culturing room, for carrying out material proportion；
The low-temperature storage device of material is stored in culturing room, for low temperature；
In culturing room, for the thermostat of heated at constant temperature material；
In culturing room, for transferring the material into the transfer device in centrifuge tube；
Centrifuge apparatus in culturing room, for being centrifuged to material；
Culture dish device in culturing room, for cultivating；
Robot device in culturing room, for material to be moved to required position；
Drawing mechanism in culturing room, for the material in culturing room to be exported.
Further, it is tightly connected between the feed arrangement and culturing room.
Further, it is tightly connected between the drawing mechanism and culturing room.
Further, the low-temperature storage device is refrigerator and/or liquid nitrogen storage device.
Further, the robot device includes the machine of the track and track-movable in culturing room
Device hand.
Further, also including the controller for controlling each device action.
The present invention solve another technical scheme for using of its technical problem for：
A kind of control method of full-automatic cell culturing room is provided, is comprised the following steps：
Step 100：Cleaning device is pre-actuated, culturing room is cleaned, sterilized and is sterilized；
Step 200：Material is delivered in culturing room by feed arrangement, and is moved each material by robot device
The position needed for；
Step 300：The nutrient solution in storage chamber device, serum and secondary antibody is will be stored in by robot device to take out and move
Move and carry out disinfection and match to proportioning chamber device, form culture medium；
Step 400：The cell in low-temperature storage device is will be stored in by robot device to take out and be moved to constant temperature dress
Putting carries out heating for dissolving, forms cell suspension；
Step 500：By transfer device by the cell suspension in the culture medium and step 400 in step 300 be transferred to from
It is centrifuged in the centrifuge tube of scheming device, is formed mixed solution；
Step 600：The mixed solution in step 500 is moved in culture dish device by robot device is trained
Support；
Step 700：Cultured cell and unclassified stores are delivered to culture by drawing mechanism outdoor.
The beneficial effects of the invention are as follows：
A kind of full-automatic cell culturing room and its control method that the present invention is provided, culturing room is complete in cell cultivation process
Sealing, it is not necessary to which personnel enter participation, can avoid the entrance of pollution sources, keep the bacteria-and dust-free environment in culturing room, make thin
Born of the same parents are from pollution, it is ensured that cell culture is smoothed out.Each device uses Automated condtrol simultaneously, realizes cell cultivation process
Full-automatic words production, can realize continuous production work, improve operating efficiency, reduce the labour intensity of personnel.
Brief description of the drawings
Fig. 1 is structural representation of the invention.
Specific embodiment
The invention will be further described below in conjunction with the accompanying drawings：
A kind of full-automatic cell culturing room that Fig. 1 is provided for the present invention.The full-automatic cell culturing room includes：
Culturing room, for example, grow 6 meters, wide 2.3 meters, 2.8 meters high of cuboid seal case.
In culturing room, for the feed arrangement that material is conveyed in culturing room, the feed arrangement and culturing room
Between be tightly connected, it is ensured that feed arrangement in culturing room convey material during culturing room keep sealing state.For example, it is described enter
Material device is the pipeline transporter for being provided with multistage dense closure door.
Cleaning device in culturing room, for culturing room and material to be cleaned, sterilize, sterilized.For example, institute
Stating cleaning device includes cleaning device, ultraviolet sterilizer and chlorination equipment.
Storage chamber device in culturing room, for depositing material.
Proportioning chamber device in culturing room, for carrying out material proportion.
The low-temperature storage device of material is stored in culturing room, for low temperature, such as described low-temperature storage device is
Refrigerator and the liquid nitrogen storage device for torage cell for storing culture medium.
In culturing room, for the thermostat of heated at constant temperature material, such as described thermostat is 37 DEG C of water-baths
Thermostat.
In culturing room, for transferring the material into the transfer device in centrifuge tube.
Centrifuge apparatus in culturing room, for being centrifuged to material.
Culture dish device in culturing room, for cultivating.
Robot device in culturing room, for material to be moved to required position, such as described robot dress
Put including the track on culturing room's inner bottom plating and the six degree of freedom mechanical hand that can be moved in orbit.
Drawing mechanism in culturing room, for the material in culturing room to be exported, the drawing mechanism and culture
It is tightly connected between room, it is ensured that culturing room keeps sealing state during drawing mechanism outwards conveys material.For example, the discharging dress
It is set to the pipeline transporter for being provided with multistage dense closure door.
Also include the controller for controlling feed arrangement, drawing mechanism and each device action in culturing room.
A kind of control method of the above-mentioned full-automatic cell culturing room of application, comprises the following steps：
Step 100：Cleaning device is pre-actuated, culturing room and material are cleaned, sterilized and sterilized；
Step 200：Such as inventionculture tools, nutrient solution, cell, alcohol, serum, SA material will pass through feed arrangement
It is delivered in culturing room, and each material is moved to by required position by robot device；
Step 300：The nutrient solution in storage chamber device, serum and secondary antibody is will be stored in by robot device to take out and move
Move carries out alcohol disinfecting and proportioning to proportioning chamber device, forms culture medium；
Step 400：The cell in low-temperature storage device is will be stored in by robot device to take out and be moved to constant temperature dress
Putting carries out heating for dissolving, forms cell suspension；
Step 500：By transfer device by the cell suspension in the culture medium and step 400 in step 300 be transferred to from
It is centrifuged in the centrifuge tube of scheming device, is formed mixed solution；
Step 600：The mixed solution in step 500 is moved in culture dish device by robot device is trained
Support；
Step 700：Cultured cell and unclassified stores are delivered to culture by drawing mechanism outdoor.
A kind of full-automatic cell culturing room and its control method that the present invention is provided, culturing room is complete in cell cultivation process
Sealing, it is not necessary to which personnel enter participation, can avoid the entrance of pollution sources, keep the bacteria-and dust-free environment in culturing room, make thin
Born of the same parents are from pollution, it is ensured that cell culture is smoothed out.Each device uses Automated condtrol simultaneously, realizes cell cultivation process
Full-automatic words production, can realize continuous production work, improve operating efficiency, reduce the labour intensity of personnel.
Certainly, the above is only presently preferred embodiments of the present invention, it is impossible to be considered as limiting to implementation of the invention
Example scope.The present invention is also not limited to the example above, and those skilled in the art are in essential scope of the invention
Interior made impartial change and improvement etc., all should belong in patent covering scope of the invention.
Claims (7)
1. a kind of full-automatic cell culturing room, it is characterised in that including：
Culturing room；
In culturing room, for the feed arrangement that material is conveyed in culturing room；
Cleaning device in culturing room, for culturing room and material to be cleaned, sterilize, sterilized；
Storage chamber device in culturing room, for depositing material；
Proportioning chamber device in culturing room, for carrying out material proportion；
The low-temperature storage device of material is stored in culturing room, for low temperature；
In culturing room, for the thermostat of heated at constant temperature material；
In culturing room, for transferring the material into the transfer device in centrifuge tube；
Centrifuge apparatus in culturing room, for being centrifuged to material；
Culture dish device in culturing room, for cultivating；
Robot device in culturing room, for material to be moved to required position；
Drawing mechanism in culturing room, for the material in culturing room to be exported.
2. full-automatic cell culturing room according to claim 1, it is characterised in that between the feed arrangement and culturing room
It is tightly connected.
3. full-automatic cell culturing room according to claim 1, it is characterised in that between the drawing mechanism and culturing room
It is tightly connected.
4. full-automatic cell culturing room according to claim 1, it is characterised in that the low-temperature storage device is refrigerator
And/or liquid nitrogen storage device.
5. full-automatic cell culturing room according to claim 1, it is characterised in that the robot device includes peace
The mechanical hand of track and track-movable in culturing room.
6. full-automatic cell culturing room according to claim 1, it is characterised in that also including for controlling each device action
Controller.
7. a kind of control method of full-automatic cell culturing room, comprises the following steps：
Step 100：Cleaning device is pre-actuated, culturing room is cleaned, sterilized and is sterilized；
Step 200：Material is delivered in culturing room by feed arrangement, and each material is moved to by institute by robot device
Need position；
Step 300：The nutrient solution in storage chamber device, serum and secondary antibody is will be stored in by robot device to take out and be moved to
Carry out disinfection and match in proportioning chamber device, form culture medium；
Step 400：The cell in low-temperature storage device is will be stored in by robot device to take out and be moved to thermostat
Row heating for dissolving, forms cell suspension；
Step 500：Cell suspension in culture medium and step 400 in step 300 is transferred to by centrifuge by transfer device
It is centrifuged in the centrifuge tube of device, is formed mixed solution；
Step 600：The mixed solution in step 500 is moved in culture dish device by robot device is cultivated；
Step 700：Cultured cell and unclassified stores are delivered to culture by drawing mechanism outdoor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710120122.8A CN106701576A (en) | 2017-03-02 | 2017-03-02 | Fully-automatic cell culture room and control method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710120122.8A CN106701576A (en) | 2017-03-02 | 2017-03-02 | Fully-automatic cell culture room and control method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN106701576A true CN106701576A (en) | 2017-05-24 |
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| CN201710120122.8A Pending CN106701576A (en) | 2017-03-02 | 2017-03-02 | Fully-automatic cell culture room and control method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108611271A (en) * | 2018-05-10 | 2018-10-02 | 朱丹 | Totally enclosed type intelligent biology production system and production method |
| CN108611264A (en) * | 2018-05-10 | 2018-10-02 | 朱丹 | A kind of system and method that multiple batches of biological products party-line basis is standby |
| WO2020000533A1 (en) * | 2018-06-26 | 2020-01-02 | 深圳市北科生物科技有限公司 | High-adaptive full-automatic cell culture system and method therefor |
| CN110643577A (en) * | 2018-06-26 | 2020-01-03 | 深圳市北科生物科技有限公司 | Full-automatic cell culture method and system based on mechanical arm |
| CN113073052A (en) * | 2021-06-03 | 2021-07-06 | 南京艾尔普再生医学科技有限公司 | Full-automatic cell production line |
| CN114216758A (en) * | 2020-09-04 | 2022-03-22 | 徕卡显微系统有限公司 | Preparation of samples for high pressure freezing |
| CN116125085A (en) * | 2023-04-04 | 2023-05-16 | 南京艾尔普再生医学科技有限公司 | Automatic change cell detection device |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108611271A (en) * | 2018-05-10 | 2018-10-02 | 朱丹 | Totally enclosed type intelligent biology production system and production method |
| CN108611264A (en) * | 2018-05-10 | 2018-10-02 | 朱丹 | A kind of system and method that multiple batches of biological products party-line basis is standby |
| WO2020000533A1 (en) * | 2018-06-26 | 2020-01-02 | 深圳市北科生物科技有限公司 | High-adaptive full-automatic cell culture system and method therefor |
| CN110643577A (en) * | 2018-06-26 | 2020-01-03 | 深圳市北科生物科技有限公司 | Full-automatic cell culture method and system based on mechanical arm |
| CN110643509A (en) * | 2018-06-26 | 2020-01-03 | 深圳市北科生物科技有限公司 | High-adaptability full-automatic cell culture system and method thereof |
| CN114216758A (en) * | 2020-09-04 | 2022-03-22 | 徕卡显微系统有限公司 | Preparation of samples for high pressure freezing |
| CN113073052A (en) * | 2021-06-03 | 2021-07-06 | 南京艾尔普再生医学科技有限公司 | Full-automatic cell production line |
| WO2022252325A1 (en) * | 2021-06-03 | 2022-12-08 | 南京艾尔普再生医学科技有限公司 | Full-automatic cell production line |
| JP2023546524A (en) * | 2021-06-03 | 2023-11-02 | 南京艾爾普再生医学科技有限公司 | Fully automatic cell production line |
| JP7462371B2 (en) | 2021-06-03 | 2024-04-05 | 南京艾爾普再生医学科技有限公司 | Fully automated cell production line |
| CN116125085A (en) * | 2023-04-04 | 2023-05-16 | 南京艾尔普再生医学科技有限公司 | Automatic change cell detection device |
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Effective date of registration: 20190821 Address after: 518000 Guangdong city of Shenzhen province Qianhai Shenzhen Hong Kong cooperation zone before Bay Road No. 1 building 201 room A (located in Shenzhen Qianhai business secretary Co. Ltd.) Applicant after: Shenzhen Weichuang Rio Tinto Industrial Development Co.,Ltd. Address before: 518022 Guangdong city of Shenzhen province Luohu District Garden Street Shennan East Road, Shun Hing Square, the most expensive land business center 6201 Applicant before: SHENZHEN HUAYUN INTELLIGENT EQUIPMENT TECHNOLOGY Co.,Ltd. |
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