CN109939201A - Composition of relieving alcoholism and protecting liver and its preparation method and application - Google Patents
Composition of relieving alcoholism and protecting liver and its preparation method and application Download PDFInfo
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Abstract
The present invention relates to compositions of a kind of relieving alcoholism and protecting liver and its preparation method and application.The composition of the relieving alcoholism and protecting liver is formulated by the raw material of following parts by weight: the turmeric of 30-70 parts by weight, the moringa seeds of 10-40 parts by weight, the pepper of 5-20 parts by weight, the ginseng of 10-20 parts by weight, 1-20 parts of fructus amomis, 1-20 parts by weight rde bean and the dry slice food made from Amorphophallus rivieri of 1-40 parts by weight.Compared with the existing technology, the composition of relieving alcoholism and protecting liver of the present invention carries out overall process intervention in human body metabolism to alcohol, product is rapid-action, bioavilability is high, the comprehensive protect liver characteristic for playing turmeric and moringa seeds, auxiliary are conducive to alcohol discharge, the synergistic effects that fructus amomi is warming spleen and stopping diarrha with ginseng relieving alcoholism, konjaku absorption alcohol, rde bean, and composition is finally made to obtain excellent relieving alcoholism and protecting liver effect.
Description
Technical field
The present invention relates to biomedicine fields, and in particular to a kind of composition of relieving alcoholism and protecting liver and preparation method thereof and answers
With.
Background technique
Since ancient times, Characters of Chinese Alcoholic Drink Culture is prevailing, and fatigue can be eliminated, alleviate nervous, channels and collaterals of releiving by suitably drinking, however
Drink beyond one's capacity, human health produced bigger effect, the dizzy, clinical symptoms such as inverse, thirsty of vomitting gently then occur, it is heavy then may be right
Gastrointestinal tract and hepatic tissue generate injury, eventually lead to the diseases such as alcoholic fatty liver, cirrhosis even liver cancer.World health group
Alcohol is clearly classified as a kind of carcinogenic substance for having clear carcinogenicity to human body already by the international cancer research institute for knitting subordinate.2012
Year, alcohol consumption causes about 3,300,000 death, accounts for the 5.9% of global dead sum.
Therefore, suitable food, health care product or drug are selected realize sober up, relieve the effect of alcohol and reduce alcohol to gastrointestinal tract,
The damage of liver is most important for compatriots.Disintoxicating product can substantially be divided into four classes (Chai Zheng, compound solution both at home and abroad at present
The research of wine protect liver dispersible tablet, He'nan University, 2016), as shown in table 1 below:
Table 1
It can be seen that by upper table 1, doctor trained in Western medicine is relieved the effect of alcohol multi-purpose chemical synthetic drug, though quick, there are certain side effects；And
Chinese medicine then commonly uses pueraria lobata, hoveniae semoveniae semen is used as antialcoholic drug, utilizes the characteristic relieve muscle fever and thirst of pueraria lobata, Shengyang Zhixie, auxiliary
Hoveniae semoveniae semen relieving alcoholism, relieving restlessness of quenching the thirst, preventing or arresting vomiting, sharp stool and urine.A variety of compound formulations based on pueraria lobata, hoveniae semoveniae semen are developed.Such as: one
It plants anti-alcoholism liver protecting compound preparation and applies (CN101658618B), a kind of relieving alcoholism and protecting liver preparation (CN103191214B) etc..Although
Pueraria lobata, hoveniae semoveniae semen have certain dispelling effects of alcohol, but not all groups are applicable in, this two tastes medicine is not to deficiency-cold in spleen and stomach person
Applicable.Can albumen peptides and the health care product price for improving alcohol metabolism related enzyme activity be relatively high, it is low to develop safety
Poison, adaptation population are wider, more preferably natural plant composition disintoxicating product becomes grinding for many scientists to relieving alcoholism and protecting liver effect
Study carefully hot spot.
In recent years, outstanding representation of some integration of drinking and medicinal herbs substances in disease treatment field causes people and greatly closes
Note.If the curcumin in turmeric is in anti-inflammatory (Brouet.I, et al.Curcumin, an anti-tumour promoter and
anti-inflammatory agent,inhibits induction of nitric oxide synthase in
Activated macrophages.Biochem.Biophys.Res.Commun.1995,206,533-540), liver protection (Kiso,
Y.et al,Antihepatotoxic principles of curcuma longa rhizomes.Planta Med.1983,
49,185-187), anti-cancer field (Divya, C.S., Antitumor action of curcumin in human
papillomavirus associated cells involves downregulation of viral oncogenes,
prevention of NF-kB and AP-1 transloction,and modulation of
Apoptosis.Mol.Carcinog.2006,45,320-332) it has excellent performance, become health care new lover at present.For another example Moringa has
Preferable anti arteriosclerosis, anti-oxidation characteristics (Chumark P, et al.The in vitro and exvivo
antioxidant properties,hypolipidaemic and antiatherosclerotic activities of
water extract of Moringa oleifera Lam leaves.Journal of Ethnopharmacology,
2008,116 (3): 439-446), furthermore there are preferable therapeutic effect (Hzmza A.A, Ameliorative to hepatic injury
effects of Moringa oleifera Lam seed extract on liver fibrosis in rats. Food
And Chemical Toxicology, 2010,48 (1): 345-355), once become research field nova.
Turmeric originates from India, about 700 years Christian eras incoming China.One secretary of Tang Materia Medica carries: " turmeric, acrid flavour is bitter,
Temperature, returns spleen, Liver Channel.There are breaking blood and promoting the circulation of qi, the function of relieving pain of dysmenorrhea." one of the extract of turmeric is curcumin, be plant kingdom very
Rare diones pigment.Since curcumin is unique medicinal and health benefits, such as anti-oxidant, anti-inflammatory, anticancer, protection nerve,
Reparation and liver function protecting etc., it paid close attention to by people in recent years.Researches show that curcumins can excite liver (research table at double
Bright is 1.5 times or more) generation acetaldehyde dehydrogenase to accelerated decomposition acetaldehyde, and then show as promoting capacity for liquor, mitigate after drinking
Internal inoxidizability can be improved in various malaise symptoms, improves metabolism of the liver to alcohol, inhibits liver inflammation, thus
It blocks, alleviate hepatic injury, had a better effect for relieving the effect of alcohol.But since curcumin itself is fat-soluble, poorly water-soluble, inhale
It receives less, be metabolized fastly, so the bioavilability for improving curcumin is the important means for playing its function maximum.
Moringa is the plant most cultivated extensively in Moringa, record of ancient Roman's period with regard to existing edible Moringa, Moringa
Either leaf, flower, pod, root, seed, bark and natural gum have medicinal function, therefore are referred to as " tree of mystery ".Moringa seeds have
Hepatoprotective effect, can improve the function of liver and kidney, have therapeutic effect to acute liver damage.Wherein rich in single unsaturation Omega-
9 fatty acid oleic acid, to reducing, total cholesterol and bad cholesterol in blood are helpful, additionally contain (14.0 ± 0.6) mg/
The VC and VA of 100g and (24.8 ± 0.7) mg/100g, (Asghari G., Palizban A., et al., Quantitative
analysis of the nutritional components in leaves and seeds of the Persian
Moringa peregrina (Forssk.) .Pharmacognosy Research, 2015,7 (3): 242-248.) it can effectively help
Help others supplement the vitamin of needed by human body.But it is single with moringa seeds come relieving alcoholism and protecting liver due to sensory issues, often people connect
It is relatively low by spending, therefore effect is had a greatly reduced quality.
In conclusion the advantages of comprehensive utilization curcumin and moringa seeds are in terms of relieving alcoholism and protecting liver, makes up respective disadvantage, benefit
When becoming new with new thinking exploitation safety and low toxicity, the wider crowd of adaptation and the composition with more excellent relieving alcoholism and protecting liver effect
For the developing direction for research of relieving the effect of alcohol.
Summary of the invention
To solve the above-mentioned problems, the present invention provides compositions of a kind of relieving alcoholism and protecting liver and its preparation method and application.
The present invention provides a kind of composition of relieving alcoholism and protecting liver, is formulated by the raw material of following parts by weight:
The turmeric of 30-70 parts by weight, the moringa seeds of 10-40 parts by weight, the peppers of 5-20 parts by weight, 10-20 parts by weight
Ginseng, 1-20 part fructus amomi, 1-20 parts by weight rde bean and the dry slice food made from Amorphophallus rivieri of 1-40 parts by weight.
Further, the composition of the relieving alcoholism and protecting liver is formulated by the raw material of following parts by weight: 30 parts by weight
Turmeric, the moringa seeds of 30 parts by weight, the pepper of 5 parts by weight, the ginseng of 10 parts by weight, 5 parts by weight fructus amomis, 10 parts by weight rde beans
With the dry slice food made from Amorphophallus rivieri of 10 parts by weight.
The present invention also provides a kind of preparation methods of the composition of relieving alcoholism and protecting liver, comprising the following steps:
Raw material is weighed according to following parts by weight: the turmeric of 30-70 parts by weight, the moringa seeds of 10-40 parts by weight, 5-20
The pepper of parts by weight, the ginseng of 10-20 parts by weight, 1-20 part fructus amomi, 1-20 parts by weight rde bean and the dry konjaku of 1-40 parts by weight
Extract or fine powder is respectively made in piece again after grinding above-mentioned raw materials respectively, then after gains are mixed and pharmacy is added can connect
The auxiliary material received is mixed and made into acceptable any dosage form.
Further, the process that extract or fine powder is respectively made after the raw material being ground respectively again includes following step
Suddenly, wherein following steps in no particular order sequence:
(1) it takes turmeric to be ground into coarse powder, 5-8 times of amount and concentration is added and is heated for the ethyl alcohol of 80-85%, extracts three times, often
It is 1.5-2 hours secondary, the ethyl alcohol soaked extracting solution that 2-3 times of amount and concentration are 80%~85% is added, stirring stands 24~48
Hour, supernatant is taken, heating filtrate is concentrated into saturated solution in decompression and at 65-75 DEG C, stands, precipitates crystal, take crystal
Dry curcumin, it is spare；
(2) it is ground into just powder after moringa seeds peeling, crosses 50-100 mesh, 5-8 times of amount is added and concentration is 80%-85%'s
Three times, ethyl alcohol is recovered under reduced pressure in ethyl alcohol heating extraction, is concentrated into saturated solution, stand, precipitate crystal, take crystal dry moringa seeds
Benevolence powder, it is spare；
(3) it takes pepper to be ground into the coarse powder of 20-200 mesh, 5-8 times of amount and concentration is added and is mentioned for the ethyl alcohol heating of 80-85%
It takes three times, 1.5-2 hours each, combined extract, filters, adjust pH value to 7, recycle ethyl alcohol to no alcohol taste, be further continued for being concentrated
To relative density 1.25-1.30 (70 DEG C), the 8-10 times of water measured then is added, stirs evenly, stand, filtration, filtrate is concentrated into relatively
Density 1.15-1.20 (70 DEG C), ethyl alcohol, which is then added, makes concentration of alcohol up to 70%, stands, filtration, filtrate recycling ethanol, concentration,
It is dried in vacuo to obtain Fructus Piperis extract, it is spare；
(4) it is sliced and crushes after ginseng wash clean dries, the ethyl alcohol that ethyl alcohol is measured in 5-8 times of addition and concentration is 50%-80% adds
Thermal extraction is three times, 1.5-2 hours each, is then centrifuged for collecting supernatant liquor, is concentrated under reduced pressure into saturated solution, is freeze-dried to obtain people
Join powder, it is spare；
(5) fructus amomi is peeled and washed afterwards by pulverizer crushing, it is ground into the powder of 20-200 mesh, separates and obtains by impurity
Amomum powder；
(6) rde bean, which is cleaned, dries the powder that 20-200 mesh is ground into pulverizer, and 5-8 times of amount is added and concentration is 80%-
85% ethyl alcohol extracts three times, and 1.5-2 hours each, ethyl alcohol is recovered under reduced pressure in centrifuging and taking supernatant, is concentrated into saturated solution, quiet
It sets, precipitates crystal, crystal is taken to be drying to obtain, it is spare；
(7) after dry slice food made from Amorphophallus rivieri is crushed by pulverizer, then it is ground into the powder of 20-200 mesh, is separated using impurity and obtains evil spirit
Taro fine powder, it is spare.
Further, the pharmaceutically acceptable auxiliary material include one of bonding agent, filler, lubricant and disintegrating agent or
It is several.
Further, the bonding agent includes syrup, Arabic gum, gel, D-sorbite, xanthan gum and polyvinyl pyrrole
One or more of alkanone；The filler includes lactose, carbohydrate, cornstarch, calcium phosphate, D-sorbite and DEXTROSE ANHYDROUS
One or more of；The lubricant includes one of magnesium stearate, talcum powder, polyethylene glycol and silica or several
Kind；The disintegrating agent includes one or more of potato starch and sodium carboxymethylcellulose.
Further, the dosage form of the composition is tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule
Agent, hard capsule, soft capsule, oral solution, buccal tablet, granule, pill, liposome, powder, paste, sublimed preparation or ointment.
The present invention provides a kind of application of the composition of relieving alcoholism and protecting liver in terms of relieving alcoholism and protecting liver again.
Compared with the existing technology, it is dry to carry out overall process in human body metabolism to alcohol for the composition of relieving alcoholism and protecting liver of the present invention
In advance, product is rapid-action, and bioavilability is high, and the comprehensive protect liver characteristic for playing turmeric and moringa seeds, auxiliary are with ginseng relieving alcoholism, evil spirit
Taro adsorbs alcohol, rde bean is conducive to alcohol discharge, the synergistic effects that fructus amomi is warming spleen and stopping diarrha, and composition is finally made to obtain excellent solution
Wine protect liver effect.
Detailed description of the invention
Fig. 1 is the schematic diagram of each component synergistic effect relieving alcoholism and protecting liver in the composition of relieving alcoholism and protecting liver of the present invention.
Specific embodiment
The principle of the invention and feature are described below in conjunction with drawings and examples, illustrated embodiment is served only for explaining this
Invention, not limits the scope of the invention.
Natural materials used in the present invention, which are given from alcohol in body metabolism overall process, intervenes (principle is as shown in Figure 1), finally
Obtain excellent relieving alcoholism and protecting liver effect.Each component of the present invention is cooperateed in different internal organs and is played a role, wherein the turmeric in liver
Element, moringa seeds, pepper and ginseng play a role, and play a role in gastrointestinal tract konjaku, fructus amomi and rde bean, play relieve the effect of alcohol altogether
It is wonderful.Curcumin can prevent many factors because of its mechanism with inoxidizability and inhibition NF- κ B transcription factor in liver
Liver is damaged, furthermore can also effectively prevent hepatitis generation, protect liver.Moringa seeds main component contains unsaturated fatty acid, recklessly
Main component, which contains piperine, in green pepper can promote the dissolution and absorption of curcumin in vivo, to further increase curcumin people
Intracorporal bioavilability maximizes the effect of playing curcumin.In addition, moringa seeds itself can also acceleration of alcohol decompose, promote
Ethyl alcohol conversion, further avoids the formation of alcoholic fatty liver.Ginseng can be shortened the duration of ethyl alcohol anesthesia in formula, increase
Alcohol dehydrogenase related with alcohol metabolism has the good toxic action that relieves the effect of alcohol.Dietary fiber is rich in konjaku, the dietary fiber is molten
The colloid with strong adsorptivity is formed after swollen in vivo, alcohol can be adsorbed in gastrointestinal wall, slow down the speed that alcohol enters blood,
To realize that physics relieves the effect of alcohol.Contain more saponin in rde bean, stimulate enteron aisle, there is good diuresis, to help
Body of helping others wine of dispelling is wet.Fructus amomi can then disappear in it is stagnant, it is warming spleen and stopping diarrha.Above-mentioned each component is respectively being good at field cooperation, can make
Relieving alcoholism and protecting liver efficacy exertion is to maximum.
The features of the present invention:
1, the present invention is filtered out from natural plants with strong solution wine hepatoprotective activity substance, carried out scientific compatible combination and
At composition.Furthermore the present invention also intervenes alcohol metabolism overall process in different internal organs using each component of composition,
It is final to obtain dispelling effects of alcohol more superior than compound formulation based on traditional pueraria lobata, hoveniae semoveniae semen.
2, each equal safety and low toxicity of ingredient in natural plant composition selected by the present invention, it is without side-effects.
3, the moringa seeds that the present invention selects in natural plant composition can effectively improve the bioavilability of curcumin, favorably
Maximum protect liver effect is played in curcumin.
4, the present invention uses modern plants medicine extractive technique, and each component in prescription is extracted respectively, clean, is refined into standard
Extract, the effective component of each component or position are clear, and active constituent content is high, have stringent quality standard, analysis method
Consistency make system easy to control the quality, there is pharmacodynamic substances basis and specific pharmacological activity, curative effect is stablized, and administration absorbs can
Through target position.
For the present invention by studying a large amount of natural drugs, filtering out clinical be used for a long time confirms effective relieving alcoholism and protecting liver
Natural plant extracts, it is natural plant extracts curcumin of the invention, moringa seeds benevolence powder, pepper, ginseng pulverate, amomum powder, red
The comprehensive composition of red bean, konjaku powder, is described in detail below present invention preparation embodiment and effect test is of the invention to facilitate
Understand:
One, present composition embodiment is utilized
Embodiment 1 (capsule)
It takes the turmeric of 30 parts by weight to be ground into coarse powder, the ethyl alcohol that 6 times of amounts and concentration are 80% is added and heats, extracts three times,
1.5 hours every time, the ethyl alcohol soaked extracting solution that 2 times of amounts and concentration are 80% is added, stirring stands 24 hours, supernatant is taken,
Decompression and at 65 DEG C heat filtrate be concentrated into saturated solution, stand, precipitate crystal, take crystal dry curcumin, it is spare；
It is ground into just powder after taking the moringa seeds of 30 parts by weight to remove the peel, crosses 50 meshes, the second that 5 times of amounts and concentration are 80% is added
Three times, ethyl alcohol is recovered under reduced pressure in alcohol heating extraction, is concentrated into saturated solution, stand, precipitate crystal, take crystal dry moringa seeds benevolence
Powder, it is spare；
It takes the pepper of 5 parts by weight to be ground into the coarse powder of 20-200 mesh, the ethyl alcohol heating that 5 times of amounts and concentration are 80% is added and mentions
It takes three times, 1.5 hours every time, combined extract, filters, adjust pH value to 7, recycle ethyl alcohol to no alcohol taste, be further continued for being concentrated into
Relative density 1.25 (70 DEG C) is then added the water of 8 times of amounts, stirs evenly, and stands, and filtration, filtrate is concentrated into relative density 1.15 (70
DEG C), ethyl alcohol, which is then added, makes concentration of alcohol up to 70%, stands, filtration, filtrate recycling ethanol, concentration, be dried in vacuo pepper mentions
Object is taken, it is spare；
It is sliced and crushes after taking the ginseng wash clean of 10 parts by weight to dry, 5 times of amount ethyl alcohol and concentration are added as 50% ethyl alcohol
Heating extraction three times, 1.5 hours every time, is then centrifuged for collecting supernatant liquor, is concentrated under reduced pressure into saturated solution, is freeze-dried to obtain people
Join powder, it is spare；
It is crushed after taking 5 parts by weight fructus amomis peeled and washed by pulverizer, is ground into the powder of 20-200 mesh, is separated by impurity
Amomum powder is obtained, it is spare；
It takes the rde bean of 10 parts by weight to clean and dries the powder for being ground into 20-200 mesh with pulverizer, 5 times of amounts and concentration is added
It is extracted three times for 80% ethyl alcohol, 1.5 hours every time, ethyl alcohol was recovered under reduced pressure in centrifuging and taking supernatant, is concentrated into saturated solution, quiet
It sets, precipitates crystal, crystal is taken to be drying to obtain, it is spare；
After taking the dry slice food made from Amorphophallus rivieri of 10 parts by weight to crush by pulverizer, then it is ground into the powder of 20-200 mesh, using impurity
Separation obtains konjaku powder, spare；
It extracts according to the method described above and respectively obtains curcumin, moringa seeds benevolence powder, Fructus Piperis extract, ginseng pulverate, amomum powder, red
After red bean extract and konjaku powder, 1 parts by weight of magnesium stearate, 1 parts by weight of superfine silica gel powder, dextrin is added and fits 3 weight deal tune
Whole total amount mixes, is filled into capsule after pellet through sieves are made.
Embodiment 2 (tablet)
It takes the turmeric of 40 parts by weight to be ground into coarse powder, the ethyl alcohol that 7 times of amounts and concentration are 82% is added and heats, extracts three times,
1.75 hours every time, the ethyl alcohol soaked extracting solution that 2.5 times of amounts and concentration are 82% is added, stirring stands 36 hours, takes
Clear liquid, decompression and at 70 DEG C heat filtrate be concentrated into saturated solution, stand, precipitate crystal, take crystal dry curcumin,
It is spare；
It is ground into just powder after taking the moringa seeds of 20 parts by weight to remove the peel, crosses 70 meshes, the second that 6 times of amounts and concentration are 82% is added
Three times, ethyl alcohol is recovered under reduced pressure in alcohol heating extraction, is concentrated into saturated solution, stand, precipitate crystal, take crystal dry moringa seeds benevolence
Powder, it is spare；
It takes the pepper of 7 parts by weight to be ground into the coarse powder of 20-200 mesh, the ethyl alcohol heating that 7 times of amounts and concentration are 82% is added and mentions
It takes three times, 1.75 hours every time, combined extract, filters, adjust pH value to 7, recycle ethyl alcohol to no alcohol taste, be further continued for being concentrated into
Relative density 1.275 (70 DEG C) is then added the water of 9 times of amounts, stirs evenly, and stands, and filtration, filtrate is concentrated into relative density 1.18
(70 DEG C), ethyl alcohol, which is then added, makes concentration of alcohol up to 70%, stands, filtration, filtrate recycling ethanol, concentration, is dried in vacuo recklessly
Green pepper extract, it is spare；
It is sliced and crushes after taking the ginseng wash clean of 10 parts by weight to dry, 7 times of amount ethyl alcohol and concentration are added as 70% ethyl alcohol
Heating extraction three times, 1.75 hours every time, is then centrifuged for collecting supernatant liquor, is concentrated under reduced pressure into saturated solution, is freeze-dried
Ginseng pulverate, it is spare；
It is crushed after taking 8 parts by weight fructus amomis peeled and washed by pulverizer, is ground into the powder of 20-200 mesh, is separated by impurity
Amomum powder is obtained, it is spare；
It takes the rde bean of 3 parts by weight to clean and dries the powder for being ground into 20-200 mesh with pulverizer, 7 times of amounts are added and concentration is
82% ethyl alcohol extracts three times, and 1.75 hours every time, ethyl alcohol was recovered under reduced pressure in centrifuging and taking supernatant, is concentrated into saturated solution, quiet
It sets, precipitates crystal, crystal is taken to be drying to obtain, it is spare；
After taking the dry slice food made from Amorphophallus rivieri of 12 parts by weight to crush by pulverizer, then it is ground into the powder of 20-200 mesh, using impurity
Separation obtains konjaku powder, spare；
It extracts according to the method described above and respectively obtains curcumin, moringa seeds benevolence powder, Fructus Piperis extract, ginseng pulverate, amomum powder, red
After red bean extract and konjaku powder, addition 10 parts by weight of lactose, 15 parts by weight of cornstarch are uniformly mixed, and it is hard that lubricant is added
3 parts by weight of fatty acid magnesium are uniformly mixed, and whole grain, then tablet is made in tabletting.
Embodiment 3 (granule)
It takes the turmeric of 50 parts by weight to be ground into coarse powder, the ethyl alcohol that 8 times of amounts and concentration are 85% is added and heats, extracts three times,
2 hours every time, the ethyl alcohol soaked extracting solution that 3 times of amounts and concentration are 85% is added, stirring stands 48 hours, supernatant is taken,
Depressurize and at 75 DEG C heat filtrate be concentrated into saturated solution, stand, precipitate crystal, take crystal dry curcumin, it is spare；
It is ground into just powder after taking the moringa seeds of 10 parts by weight to remove the peel, sieves with 100 mesh sieve, 8 times of amounts are added and concentration is 85%
Three times, ethyl alcohol is recovered under reduced pressure in ethyl alcohol heating extraction, is concentrated into saturated solution, stand, precipitate crystal, take crystal dry moringa seeds
Benevolence powder, it is spare；
It takes the pepper of 10 parts by weight to be ground into the coarse powder of 20-200 mesh, the ethyl alcohol that 8 times of amounts and concentration are 85% is added and heats
It extracts three times, 2 hours every time, combined extract, filtering, adjusts pH value to 7, recycle ethyl alcohol to no alcohol taste, be further continued for being concentrated into
Relative density 1.30 (70 DEG C) is then added the water of 10 times of amounts, stirs evenly, and stands, and filtration, filtrate is concentrated into relative density 1.20
(70 DEG C), ethyl alcohol, which is then added, makes concentration of alcohol up to 70%, stands, filtration, filtrate recycling ethanol, concentration, is dried in vacuo recklessly
Green pepper extract, it is spare；
It is sliced and crushes after taking the ginseng wash clean of 20 parts by weight to dry, 8 times of amount ethyl alcohol and concentration are added as 80% ethyl alcohol
Heating extraction three times, 2 hours every time, is then centrifuged for collecting supernatant liquor, is concentrated under reduced pressure into saturated solution, is freeze-dried to obtain ginseng
Powder, it is spare；
It is crushed after taking 5 parts by weight fructus amomis peeled and washed by pulverizer, is ground into the powder of 20-200 mesh, is separated by impurity
Amomum powder is obtained, it is spare；
It takes the rde bean of 2 parts by weight to clean and dries the powder for being ground into 20-200 mesh with pulverizer, 8 times of amounts are added and concentration is
85% ethyl alcohol extracts three times, and 2 hours every time, ethyl alcohol was recovered under reduced pressure in centrifuging and taking supernatant, is concentrated into saturated solution, stands, analysis
Crystal out takes crystal to be drying to obtain, spare；
After taking the dry slice food made from Amorphophallus rivieri of 3 parts by weight to crush by pulverizer, then it is ground into the powder of 20-200 mesh, using impurity point
It is spare from acquisition konjaku powder；
It extracts according to the method described above and respectively obtains curcumin, moringa seeds benevolence powder, Fructus Piperis extract, ginseng pulverate, amomum powder, red
After red bean extract and konjaku powder, 20 parts by weight of lactose are added, 10 parts by weight of cornstarch are uniformly mixed, whole grain, dry, system
At granule.
Two, below by way of zoopery and the next natural composition that the present invention is further explained of clinical trial in relieving alcoholism and protecting liver
The application of aspect.
Influence of the embodiment of the present invention 1 to mice drunk
1, experimental method
1.1 experiment purposes: influence of the embodiment of the present invention 1 to mouse is determined
2 materials and method:
2.1 tested materials and model comparison
Tested material title and source: the embodiment of the present invention 1.
Model comparison: distilled water amendment pueraria lobata trifoliate orange Dulcis soft capsule
2.2 experimental animal
It is 60, weight 18-22g, SPF grade, limited purchased from Beijing dimension tonneau China experimental animal technology at grade's healthy mice
Company.
Material is used in 2.3 experiments
Experiment wine is from Beijing along 52 degree of cattle pen mountain strong, colourless liquor distilled from sorghum of prosperous agriculture limited liability company.Experiment contrast model
Pueraria lobata trifoliate orange Dulcis soft capsule is corrected using amendment medicine company.
The composition and warm water (40 degrees Celsius) of relieving alcoholism and protecting liver carry out the group of the relieving alcoholism and protecting liver of stomach-filling various concentration to mouse
Close object
2.4 feeding environment
60 mouse conventional base feeds were given before on-test to raise 5 days~7 days.It raises in barrier environment, temperature is
26~28 DEG C (78~820F), relative humidity 40~60%.Experiment starts first 12 hours to mouse fasting, and it is small that experiment starts preceding 4
When to mouse prohibit water.
2.5 grouping and administration
By mouse be randomly divided into normal group, pueraria lobata trifoliate orange Dulcis control group, administration high dose group, administration middle dose group, administration it is low
Dosage group, every group each 12.After normally group gives the physiological saline of same amount, control group smashs pueraria lobata trifoliate orange Dulcis soft capsule to pieces, press
50mg/kg is to intragastric administration on mice.Embodiment 1 is administered mouse by high, medium and low dosage (100,50,10mg/kg) and fills by administration group
Stomach.After above-mentioned each group stomach-filling 30 minutes, each group gives 52 degree of cattle pen mountain strong, colourless liquor distilled from sorghum of intragastric administration on mice 0.20ml/10g weight, sees
Examine the activity condition and righting reflex situation of mouse.
1.6 data processing
Take mouse trailing position in cage, if mouse was backwards to the holding of lower posture 30 seconds or more, then it is assumed that righting reflex loss,
I.e. mouse is in state of intoxication.It is state of sobering up if righting reflex restores.Specific time, drunk of the record stomach-filling to wine respectively
The specific time that the specific time and righting reflex that the number of elements of mouse, righting reflex loss start restore.
Wherein define that drunk incubation period=righting reflex loss starts when m- stomach-filling to wine the specific time
The time of m- righting reflex loss when drunk time=righting reflex recovery
Whole process has no dead mouse.
Data are all made of SPSS software and do statistical procedures, and statistical method is t inspection processing, and data are indicated with X ± S, and p <
0.05 and p < 0.01 all have statistical significance.
The drunk incubation period of 2 mouse of table administration and time comparison sheet of sobering up
* p < 0.01 compared with normal group p < 0.05** compared with normal group
As can be seen that the drunk incubation period of administration group is than normal group, pueraria lobata trifoliate orange Dulcis soft capsule control group from above-mentioned table 2
It grows, and dose dependent is presented, the time administration group time of furthermore sobering up is most short.It can be seen that the present invention is for relieving alcoholism and protecting liver
Effect is substantially better than normal group and pueraria lobata trifoliate orange Dulcis soft capsule group.
2, clinical efficacy
The solution of the present embodiment is respectively taken before and after selecting patient 50 often to have a headache, observation to drink in long-term alcohol crowd
The composition of wine protect liver, in 50 patients drinking amount with usually have a headache before drinking amount it is suitable.With SPSS software frequency statistics result
Such as the following table 3:
Table 3 takes the effect of the present embodiment
The results show that headache complete incidence graph patient is 30, part after taking the composition of the relieving alcoholism and protecting liver of the present embodiment
Reduction of patient is 10, for minor responses patient 7, refractory patient 3.Objective effective percentage is 80%.
It is above-mentioned statistics indicate that, the present invention is preferable for drunk antialcoholism action.
Typical case is only chosen below to be introduced.
Case 1: Mr. Lin, male, 45 years old, 2 days before drinking, according to 2 times a day, 3 tablets once, and every 0.5g takes implementation
2 relieving alcoholism and protecting liver compounded plate of example, symptoms of emesis of having a headache after drinking cattle pen mountain strong, colourless liquor distilled from sorghum 500ml completely disappear.
Case 2: week certain, male, 30 years old, usually working, it is more to treat with courtesy, needs heavy drinking, and clinical diagnosis is in Chronic Alcohol
Poison, according to 1 time a day, 3 packet, every packet 2g adhere to after taking the present embodiment 3 one months every time, and symptom and sign disappears.
Case 3: Wang Mouyou, male, 35 years old.Readme is according to 3 times a day, and 2 tablets each time, every 0.5g takes the present embodiment 1 one
There is capacity for liquor after week improves to a certain degree, and drunk number is reduced after drinking.
The upper only presently preferred embodiments of the present invention, is not intended to limit the invention, all in spirit and original of the invention
Within then, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of composition of relieving alcoholism and protecting liver, which is characterized in that be formulated by the raw material of following parts by weight:
The turmeric of 30-70 parts by weight, the moringa seeds of 10-40 parts by weight, the pepper of 5-20 parts by weight, 10-20 parts by weight ginseng,
1-20 parts of fructus amomis, 1-20 parts by weight rde bean and the dry slice food made from Amorphophallus rivieri of 1-40 parts by weight.
2. the composition of relieving alcoholism and protecting liver as described in claim 1, which is characterized in that by the raw material preparation of following parts by weight
At: the turmeric of 30 parts by weight, the moringa seeds of 30 parts by weight, the pepper of 5 parts by weight, the ginseng of 10 parts by weight, 5 parts by weight fructus amomis,
10 parts by weight rde beans and the dry slice food made from Amorphophallus rivieri of 10 parts by weight.
3. a kind of preparation method of the composition of relieving alcoholism and protecting liver, which comprises the following steps:
Raw material is weighed according to following parts by weight: the turmeric of 30-70 parts by weight, the moringa seeds of 10-40 parts by weight, 5-20 parts by weight
Pepper, 10-20 parts by weight ginseng, 1-20 parts of fructus amomis, 1-20 parts by weight rde bean and the dry slice food made from Amorphophallus rivieri of 1-40 parts by weight, will be upper
It states and extract or fine powder is respectively made after raw material is ground respectively again, then after gains are mixed and pharmaceutically acceptable auxiliary material is added
It is mixed and made into acceptable any dosage form.
4. the preparation method of the composition of relieving alcoholism and protecting liver as claimed in claim 3, which is characterized in that grind the raw material respectively
Extract is respectively made again after broken or the process of fine powder includes the following steps, wherein following steps in no particular order sequence:
(1) it takes turmeric to be ground into coarse powder, 5-8 times of amount and concentration is added and is heated for the ethyl alcohol of 80-85%, extracts three times, every time
1.5-2 hours, the ethyl alcohol soaked extracting solution that 2-3 times of amount and concentration are 80%~85% is added, stirring, standing 24~48 are small
When, supernatant is taken, heating filtrate is concentrated into saturated solution in decompression and at 65-75 DEG C, stands, precipitates crystal, and takes crystal dry
Dry curcumin, it is spare；
(2) it is ground into just powder after moringa seeds peeling, crosses 50-100 mesh, the ethyl alcohol that 5-8 times of amount of addition and concentration are 80%-85%
Three times, ethyl alcohol is recovered under reduced pressure in heating extraction, is concentrated into saturated solution, stand, precipitate crystal, take crystal dry moringa seeds benevolence
Powder, it is spare；
(3) it takes pepper to be ground into the coarse powder of 20-200 mesh, 5-8 times of amount and concentration is added as the ethyl alcohol heating extraction three of 80-85%
Secondary, 1.5-2 hours each, combined extract, filtering adjusts pH value to 7, recycles ethyl alcohol to no alcohol taste, be further continued for being concentrated into phase
To density 1.25-1.30 (70 DEG C), the 8-10 times of water measured then is added, stirs evenly, stand, filtration, filtrate is concentrated into relative density
1.15-1.20 (70 DEG C), ethyl alcohol, which is then added, makes concentration of alcohol up to 70%, stands, filtration, filtrate recycling ethanol, concentration, vacuum
Dry Fructus Piperis extract, it is spare；
(4) it is sliced and crushes after ginseng wash clean dries, the ethyl alcohol heating that ethyl alcohol is measured in 5-8 times of addition and concentration is 50%-80% mentions
It takes three times, it is 1.5-2 hours each, it is then centrifuged for collecting supernatant liquor, is concentrated under reduced pressure into saturated solution, is freeze-dried to obtain ginseng
Powder, it is spare；
(5) fructus amomi is peeled and washed afterwards by pulverizer crushing, it is ground into the powder of 20-200 mesh, is separated by impurity and obtains fructus amomi
Powder；
(6) rde bean, which is cleaned, dries the powder that 20-200 mesh is ground into pulverizer, and 5-8 times of amount is added and concentration is 80%-85%
Ethyl alcohol extract three times, 1.5-2 hour each, ethyl alcohol is recovered under reduced pressure in centrifuging and taking supernatant, be concentrated into saturated solution, stand, analyse
Crystal out takes crystal to be drying to obtain, spare；
(7) after dry slice food made from Amorphophallus rivieri is crushed by pulverizer, then it is ground into the powder of 20-200 mesh, is separated using impurity and obtains konjaku essence
Powder, it is spare.
5. the preparation method of the composition of relieving alcoholism and protecting liver as claimed in claim 3, which is characterized in that described pharmaceutically acceptable
Auxiliary material includes one or more of bonding agent, filler, lubricant and disintegrating agent.
6. the preparation method of the composition of relieving alcoholism and protecting liver as claimed in claim 5, which is characterized in that the bonding agent includes sugar
One or more of slurry, Arabic gum, gel, D-sorbite, xanthan gum and polyvinylpyrrolidone；The filler includes cream
One or more of sugar, carbohydrate, cornstarch, calcium phosphate, D-sorbite and DEXTROSE ANHYDROUS；The lubricant includes tristearin
One or more of sour magnesium, talcum powder, polyethylene glycol and silica；The disintegrating agent includes potato starch and carboxymethyl
One or more of sodium cellulosate.
7. the preparation method of the composition of relieving alcoholism and protecting liver as claimed in claim 3, which is characterized in that the dosage form of the composition
For tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral solution, buccal tablet,
Granule, pill, liposome, powder, paste, sublimed preparation or ointment.
8. a kind of application of composition of relieving alcoholism and protecting liver as claimed in claim 1 or 2 in terms of relieving alcoholism and protecting liver.
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Application publication date: 20190628 |