CN1931261B - Blood pressure and blood lipid lowering capsule and its preparation process - Google Patents
Blood pressure and blood lipid lowering capsule and its preparation process Download PDFInfo
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- CN1931261B CN1931261B CN2006100535327A CN200610053532A CN1931261B CN 1931261 B CN1931261 B CN 1931261B CN 2006100535327 A CN2006100535327 A CN 2006100535327A CN 200610053532 A CN200610053532 A CN 200610053532A CN 1931261 B CN1931261 B CN 1931261B
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Abstract
The blood pressure and blood lipid- lowering capsule is prepared with three kinds of Chinese medicinal materials, including cassia seed, haw and lotus leaf, in certain weight proportion. The medicine has the functions of clearing away heat, promoting blood circulation, falling turbid and relaxing the bowels, and possesses determined curative effect on hyperlipemia. It has high safety, short disintegrating period, small dosage, raised patient's compliance and high clinical curative effect.
Description
Technical field
The present invention relates to a kind of hypertension and hyperlipemia Chinese Traditional Medicines for the treatment of hypertension and hyperlipidemia and preparation method thereof that can be used for.
Background technology
Hypertension, hyperlipidemia are modal cardiovascular disease, and its prevalence is higher, can cause the serious heart, brain, kidney complication, are the main hazard factors of coronary heart disease, brain sudden death.At present, for the treatment of hypertension, hyperlipemia disease, though some compound recipes and single medicinal material have certain decompression lipid-lowering effect, curative effect is not good enough.One of its reason, mainly be the understanding of this pathogenetic pathogenesis is not also goed deep into main points, mainly take the method for enriching yin and nourishing kidney, suppressing the hyperactive liver and subsiding YANG, vigorate qi and replenish the blood, blood circulation promoting and blood stasis dispelling in decades, used medicine does not have fully at pathogeny, thereby has influenced curative effect.
Summary of the invention
Technical problem to be solved by this invention is to propose a kind of according to the preparation of modern medicine study achievement, the eutherapeutic blood pressure and blood lipid lowering capsule of treatment hypertension, hyperlipemia and preparation method thereof.
For solving the problems of the technologies described above, a kind of blood pressure and blood lipid lowering capsule of the present invention is prepared from by Semen Cassiae, Fructus Crataegi, Folium Nelumbinis three flavor crude drug, and the weight content of making the used Semen Cassiae of per thousand capsules is 1980-2970g, Fructus Crataegi 990-1480g, Folium Nelumbinis 670-1480g.
Above-mentioned a kind of blood pressure and blood lipid lowering capsule, making the used Semen Cassiae of per thousand capsules is that 2480g, Fructus Crataegi are that 1240g, Folium Nelumbinis are 840g.
A kind of preparation method of blood pressure and blood lipid lowering capsule comprises the steps: to depend on pine torch, Fructus Crataegi, Folium Nelumbinis three flavor raw medicinal materials, decocts with water each 1 hour three times, add 8 times of amounts of water, collecting decoction filters concentrating under reduced pressure at every turn, pulverize, add appropriate amount of auxiliary materials, dress up capsule promptly.
Modern study thinks that heart network, brain network, liver network, kidney network, spleen network, lung network are the important component parts in the channels system.They play important effect aspect the normal blood pressure of human body keeping, and the effect of its center network is the most key, and it participates in the adjusting of blood pressure directly, and other five network then is by to the adjusting of heart network and play a role indirectly.The generation of hypertension mainly is because due to the channels system suffered damage, self-regulating function gets muddled, wherein, " phlegm stagnation in collateral, damage of heart meridian by poison " was the important mechanism that hypertension takes place and develops.The present invention is with " phlegm stagnation in collateral; a damage of heart meridian by poison " important point of penetration as treatment hypertension, high fat of blood, with the Semen Cassiae is the monarch drug of medicine of the present invention, with Fructus Crataegi and Folium Nelumbinis is ministerial drug, effect with heat clearing and blood circulation promoting, the turbid descending relieving constipation, be used for hypertension, the hyperlipidemia of phlegm-turbidity and blood stasis due to stagnating, it is atherosis also to can be used for prevention of arterial.In the present invention's prescription, Semen Cassiae can reduce serum cholesterol level, delays and suppress the formation of atheromatous plaque, plays obvious reduction hyperlipidemia, hypertensive effect.Its contained anthraquinone aglycon (chrysophanol, emodin) also has the laxative action of loosening bowel to relieve constipation, and does not have stomachache, and chronic constipation patient's length is obeyed and had no side effect.Its loosening bowel to relieve constipation, utilization " leading to " method is discharged in the body stagnant.Fructus Crataegi extract (total flavones) is obvious to serum TG, TC and LDL-C regulating action, and blood vessel dilating and persistent hypotensive effect are arranged, and the arrhythmia that hawthorn extract causes pituitrin has certain inhibitory action; The arrhythmia that Fructus Crataegi extract (mainly being Fructus Crataegi flavone and saponin) has antagonism intravenous injection aconitine to cause has certain effect, and effect is stronger; Triterpene acids in the Fructus Crataegi can increase the coronary vasodilator blood flow, and can improve the effect sensitivity of cardiac muscle to cardiac glycoside, increases heart output, weakens myocardium irritability and conductivity, has effects such as anti-ventricular fibrillation, atrial fibrillation and paroxysmal arrhythmia.Fructus Crataegi for hyperlipidemia population have blood lipid regulation, prevention of arterial is atherosis and the effect of coronary heart disease.Its promoting digestion and removing stagnation, the circulation of qi promoting dissipating blood stasis, utilization " loosing " method, the stasis of blood stagnates in the row body.Lotus flavone, alkaloid part show the obvious suppression effect to hypercholesterolemia, and Folium Nelumbinis decocting liquid can reduce whole blood contrast viscosity, packed cell volume, thereby improves the dense sticking state of blood.It is to human body tool effect for reducing fat preferably, and does not find toxic and side effects.Its clearing away summer-heat and eliminating dampness, utilization " clearly " method, the expectorant that clears away the dampness and heat is turbid.Thereby three herbal medicines of the present invention at etiology and pathogenesis, are played heat clearing and blood circulation promoting, the merit of the turbid descending relieving constipation altogether.Simultaneously, the present invention adopts capsule preparations, makes preparation obtain concentrating, and has shortened disintegration time, has reduced the use amount of medicine, has improved the compliance that the patient takes medicine.Its supplementary product consumption is few, and the bioavailability height has been covered the bad smell of medicine, can regularly discharge medicine with locating, and profile is bright and clean, and is attractive in appearance, and medicine stability is strong, further improved the quality of the pharmaceutical preparations, strengthened clinical efficacy, enriched clinical needs, made this product can be patient's service better.Do not contain the toxicity medical material in the side, no eighteen incompatible medicaments, nineteen medicaments of mutual restraint incompatibility are applied to treat hyperlipemia determined curative effect and safe and reliable, have development prospect preferably.
Description of drawings
Fig. 1 is the process chart of blood pressure and blood lipid lowering capsule preparation method of the present invention.
The specific embodiment
Embodiment one is got 2480g Semen Cassiae, 1240g Fructus Crataegi and 840g Folium Nelumbinis three flavor crude drug as shown in Figure 1, decocts with water three times, each 1 hour, adds 8 times of amounts of water at every turn.Collecting decoction filters, and its filtrate is evaporated to thick paste under 60 ℃, 0.1Mpa condition.Reduced vacuum drying under 60 ℃, 0.1Mpa condition is ground into fine powder then, sieves.Extract powder is added magnesium stearate 40g, and mixing is dressed up 1000 of capsules, promptly gets blood pressure and blood lipid lowering capsule of the present invention.4 of this product are equivalent to crude drug 18.24g.Usage and dosage is: oral, one time 4,3 times on the one.
Embodiment two whole process of preparation are identical with embodiment one, and just the consumption of three flavor crude drug is as follows: Semen Cassiae is that 2000g, Fructus Crataegi are that 1450g, Folium Nelumbinis are 700g.
Embodiment three whole process of preparation are identical with embodiment one, and just the consumption of three flavor crude drug is as follows: Semen Cassiae is that 2900g, Fructus Crataegi are that 1000g, Folium Nelumbinis are 1450g.
Claims (1)
1. the preparation method of a blood pressure and blood lipid lowering capsule is characterized in that, it comprises the steps: to get 2480g Semen Cassiae, 1240g Fructus Crataegi and 840g Folium Nelumbinis three flavor crude drug, decocts with water three times, each 1 hour, adds 8 times of amounts of water at every turn; Collecting decoction filters, and its filtrate is evaporated to thick paste under 60 ℃, 0.1Mpa condition; Reduced vacuum drying under 60 ℃, 0.1Mpa condition is ground into fine powder then, sieves; Extract powder is added magnesium stearate 40g, and mixing is dressed up 1000 of capsules.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2006100535327A CN1931261B (en) | 2006-09-22 | 2006-09-22 | Blood pressure and blood lipid lowering capsule and its preparation process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2006100535327A CN1931261B (en) | 2006-09-22 | 2006-09-22 | Blood pressure and blood lipid lowering capsule and its preparation process |
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| CN1931261A CN1931261A (en) | 2007-03-21 |
| CN1931261B true CN1931261B (en) | 2010-09-15 |
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| CN2006100535327A Expired - Fee Related CN1931261B (en) | 2006-09-22 | 2006-09-22 | Blood pressure and blood lipid lowering capsule and its preparation process |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494277A (en) * | 2011-07-19 | 2014-01-08 | 江西江中制药(集团)有限责任公司 | Lipid-lowering weight-losing lotus leaf beverage and preparation method thereof |
| CN102423352B (en) * | 2011-12-13 | 2013-10-09 | 广东众生药业股份有限公司 | Preparation method of Chinese medicinal granules for treating cardio-cerebrovascular diseases |
| CN102940253A (en) * | 2012-11-28 | 2013-02-27 | 惠州市鑫福来实业发展有限公司 | Capsule for improving gastroenteric function and preparation method thereof |
| CN104042709A (en) * | 2014-06-04 | 2014-09-17 | 海南葫芦娃制药有限公司 | Hawthorn fruit lipid lowering tablet and preparation method thereof |
| CN105878517A (en) * | 2016-04-12 | 2016-08-24 | 陕西万维健康咨询服务有限公司 | Ointment capable of improving sleeping and preparation method of ointment |
| CN105963414A (en) * | 2016-05-27 | 2016-09-28 | 张媛 | Composition for regulating blood lipid and blood pressure in cardiology department and preparation method thereof |
| CN107115460B (en) * | 2017-04-21 | 2021-07-20 | 丽水市林业科学研究院 | Polygonatum sibiricum compound electuary with blood fat reducing effect and preparation method thereof |
| CN107213391A (en) * | 2017-07-21 | 2017-09-29 | 成都柏图生物科技有限公司 | One kind has strengthening spleen and nourishing stomach, and help digestion pharmaceutical composition of tune fat and preparation method thereof |
| CN107648514A (en) * | 2017-10-24 | 2018-02-02 | 贵州百科薏仁生物科技有限公司 | A kind of adlay blood fat-reducing blood pressure-decreasing powder and preparation method thereof |
| CN109568408A (en) * | 2019-01-22 | 2019-04-05 | 张淑敏 | A kind of health-caring capsule with treatment acute chemical liver injury function |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660287A (en) * | 2004-12-08 | 2005-08-31 | 郭来旺 | Capsule for descend of blood fat and preparing method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660287A (en) * | 2004-12-08 | 2005-08-31 | 郭来旺 | Capsule for descend of blood fat and preparing method |
Non-Patent Citations (3)
| Title |
|---|
| 中药成方制剂 第十九册.1998,23. * |
| 许迎春.中医药治疗高脂血症研究概况.吉林中医药24 9.2004,24(9),59-61. |
| 许迎春.中医药治疗高脂血症研究概况.吉林中医药24 9.2004,24(9),59-61. * |
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