CN109938301A - A kind of fermentation shaddock ped buccal tablet and preparation method thereof with hypoglycemic effect - Google Patents
A kind of fermentation shaddock ped buccal tablet and preparation method thereof with hypoglycemic effect Download PDFInfo
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Abstract
The present invention relates to a kind of fermentation shaddock ped buccal tablet and preparation method thereof with hypoglycemic effect, belong to food processing technology field, the buccal tablet is by weight, including shaddock ped 40-60 parts of fermentation, 1-7 parts of ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, 5-15 parts of fingered citron, 5-15 parts of honey raisin tree, 5-10 parts of starch, 2-5 parts of mannitol；Fermentation shaddock ped is carried out combined solid fermented by saccharomycete, aspergillus niger and microorganism Aspergillus aculeatus and is obtained to shaddock ped.The buccal tablet is pure and fresh tasty and refreshing, is rich in shaddock ped functional component, full of nutrition, has apparent blood sugar decreasing effect and has no toxic side effect.Its production method is simple, environmentally protective, is conducive to the popularization and use in food industry.
Description
Technical field
The invention belongs to food processing technology fields, and in particular to a kind of fermentation shaddock ped buccal tablet with hypoglycemic effect
And preparation method thereof.
Background technique
The case where being dealt with improperly with past agricultural product by-product on the contrary, the crop by-product of today minimum, recycling
It is just being received significant attention with the concept of recycling.At home, the agricultural such as bagasse, wheat bran, pericarp, seed or food industry by-product
The quantity of product gradually increases.In the past ten years, the residue yield of citrus fruit processing industry is in the trend increased rapidly, this
Mainly due to the fast development of citrus plant planting industry and beverage processing industry.2016, the country planted shaddock area and is about
105640 hectares, shaddock fruits output is about 4800000 tons, and wherein 30-40% is pomelo peel, and shaddock based food processing industry
The discarded object amount generated is between the 49-69% of initial fruit.And these by-products (pericarp, seed, residue etc.) are rich in effect
The dietary fibers polysaccharide such as the factor (polyphenol, flavones, limonene constituents etc.), cellulose, hemicellulose and lignin, grind both at home and abroad
Study carefully discovery, the diet rich in polyphenol, flavones, dietary fiber can improve gastrointestinal health, anti-oxidant, anti-aging, pre- anti-cancer
The generation of disease, heart disease, apoplexy, obesity and its related complication.Therefore, it converts " waste " to " gold " or " healthy and beneficial
Product " has become trend, and the raw material rich in antioxidant phenolics has been widely used for food, cosmetics in recent years
And pharmaceuticals industry.
Summary of the invention
In view of this, one of the objects of the present invention is to provide a kind of fermentation shaddock ped buccal tablet with hypoglycemic effect；
The second purpose is to provide a kind of preparation method of fermentation shaddock ped buccal tablet with hypoglycemic effect.
In order to achieve the above objectives, the invention provides the following technical scheme:
1, a kind of fermentation shaddock ped buccal tablet with hypoglycemic effect, by weight, the buccal tablet include such as the following group
Point: shaddock ped 40-60 parts of fermentation, 1-7 parts of ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, 5-15 parts of fingered citron, 5-15 parts of honey raisin tree,
5-10 parts of starch, 2-5 parts of mannitol；The fermentation shaddock ped combine to shaddock ped solid by saccharomycete, aspergillus niger and microorganism Aspergillus aculeatus
State is fermented and is obtained.
Preferably, by weight, the buccal tablet includes following component: 58.75 parts of shaddock ped of fermentation, ginger, Honeysuckle flower
With 6.25 parts of bunge pricklyash leaf mixture medicinal extract, 10 parts of fingered citron, 10 parts of honey raisin tree, 10 parts of starch, 5 parts of mannitol.
Preferably, the fermentation shaddock ped the preparation method is as follows: it is preferred by 1mL/100g shaddock ped with measuring effective viable bacteria
Number is 5 × 105-6×108The yeast bacterium suspension of a/mL, by 1mL/100g shaddock ped with to measure living bacteria count be 1.5 ×
106-3.6×108The aspergillus niger spore suspension of a/mL, by 1.5mL/100g shaddock ped with to measure living bacteria count be 1.2 ×
106-3.7×108The microorganism Aspergillus aculeatus spore suspension of a/mL, being uniformly sprayed on moisture content after then mixing three kinds of bacterium solutions is
The shaddock ped internal layer flesh surface of 12-28% is finally 75-80% in humidity, and temperature is fermented 32-40h under conditions of being 28-32 DEG C,
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Preferably, the preferred measurement living bacteria count of using for pressing 1mL/100g shaddock ped is 5.5 × 107The saccharomycete of a/mL is outstanding
Supernatant liquid, what it is by 1mL/100g shaddock ped is 2.7 × 10 with living bacteria count is measured7The aspergillus niger spore suspension of a/mL, is pressed
1.5mL/100g shaddock ped is 5.8 × 10 with living bacteria count is measured7The microorganism Aspergillus aculeatus spore suspension of a/mL, then by three
Kind bacterium solution is uniformly sprayed on the shaddock ped internal layer flesh surface that moisture content is 26% after mixing, be finally 78% in humidity, temperature is
Ferment 38h under conditions of 28 DEG C.
Preferably, the ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract the preparation method is as follows: by ginger, Honeysuckle flower
With bunge pricklyash leaf by weight acquisition mixture is crushed after 10:2:1 mixing, the water of 25-35 times of weight is added in Xiang Suoshu mixture,
It then is 100-200W in ultrasonic power, temperature is ultrasound 35-45min under conditions of 75-95 DEG C, last concentrated obtained life
Ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract.
Preferably, after the concentration, 1g medicinal extract is equivalent to 2.0-4.0g crude drug.
2, a kind of preparation method of fermentation shaddock ped buccal tablet with hypoglycemic effect, the method are as follows: first
First fermentation shaddock ped is crushed and obtains fermentation shaddock peel powder, then mixes the fermentation shaddock peel powder with ginger, Honeysuckle flower and bunge pricklyash leaf
Direct tablet compressing after object medicinal extract, fingered citron, honey raisin tree, starch and mannitol mix.
The beneficial effects of the present invention are: the fermentation shaddock ped buccal tablet that the present invention provides a kind of with hypoglycemic effect and
Preparation method, the fermentation shaddock ped in the buccal tablet carry out joint solid-state hair to shaddock ped by saccharomycete, aspergillus niger and microorganism Aspergillus aculeatus
Ferment and obtain, by combined solid fermented, can effectively improve Essential Oil From Citrus Grandis Peel retention rate, the more aurantiins of release and prevent its drop
Solution, while the content of soluble dietary fiber, fragrance component, polyphenol and reduced sugar isoreactivity ingredient can also be improved, prevent shaddock
The degradation of original bioactive ingredients in skin, the soluble dietary fiber and aurantiin of dissolution can preferably adjust blood glucose.
In addition, preparing medicinal extract after ginger, Honeysuckle flower and bunge pricklyash leaf are mixed, ultrasonic wave added heating is carried out after three kinds of raw material mixed powders are broken and is mentioned
It takes, active constituent therein can be made sufficiently to discharge, such as polysaccharide, gingerol, zingiberol, chlorogenic acid, quercitin and Hyperoside, this
A little ingredients are more likely formed stable compound or glucosides etc. during high temperature extracts, and preferably play collaboration hypoglycemic and make
With." essential oil, aurantiin and macromolecular pectin and polysaccharide " (from fermentation shaddock ped), " gingerol, zingiberol and compound glucosides " (come
From in mixture medicinal extract), " limonene, terpenoid, fingered citron flavones " (from fingered citron), " triterpenoid saponin, active polysaccharide and
Alkaloid " (from honey raisin tree) has synergistic effect, the reduction blood glucose effect of finished product is improved, so that the buccal tablet finally prepared
Have the function of apparent hypoglycemic.The buccal tablet is pure and fresh tasty and refreshing, is rich in shaddock ped functional component, full of nutrition, has apparent
It blood sugar decreasing effect and has no toxic side effect.Its production method is simple, environmentally protective, is conducive to the popularization and use in food industry.
Other advantages, target and feature of the invention will be illustrated in the following description to a certain extent, and
And to a certain extent, based on will be apparent to those skilled in the art to investigating hereafter, Huo Zheke
To be instructed from the practice of the present invention.Target of the invention and other advantages can be realized by following specification and
It obtains.
Detailed description of the invention
To make the objectives, technical solutions, and advantages of the present invention clearer, the present invention is made below in conjunction with attached drawing excellent
The detailed description of choosing, in which:
Fig. 1 is saccharomycetes to make fermentation shaddock ped in embodiment 4, fermentation of Aspergillus niger shaddock ped, microorganism Aspergillus aculeatus fermentation shaddock ped, embodiment 1
The fermentation shaddock ped of middle preparation and moisture content of not fermenting are soluble dietary fiber, the reduced sugar, aurantiin in 26% shaddock ped
Content measuring result figure.
Specific embodiment
Illustrate embodiments of the present invention below by way of specific specific example, those skilled in the art can be by this specification
Other advantages and efficacy of the present invention can be easily understood for disclosed content.The present invention can also pass through in addition different specific realities
The mode of applying is embodied or practiced, the various details in this specification can also based on different viewpoints and application, without departing from
Various modifications or alterations are carried out under spirit of the invention.
Embodiment 1
A kind of fermentation shaddock ped buccal tablet with hypoglycemic effect, by weight, which includes following component: hair
58.75 parts of ferment shaddock ped, 6.25 parts of ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, 10 parts of fingered citron, 10 parts of honey raisin tree, 10 parts of starch,
5 parts of mannitol.
The buccal tablet is prepared as follows: first fermentation shaddock ped being crushed acquisition fermentation shaddock peel powder at 4 DEG C, then will
The fermentation shaddock peel powder and ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, fingered citron, honey raisin tree, starch and mannitol are straight after mixing
Connect tabletting, 0.5 gram/piece of slice weight.
Wherein, ferment shaddock ped the preparation method is as follows: preferred by 1mL/100g shaddock ped is 5.5 with living bacteria count is measured
×107The yeast bacterium suspension of a/mL, what it is by 1mL/100g shaddock ped is 2.7 × 10 with living bacteria count is measured7The black song of a/mL
Mould spore suspension, what it is by 1.5mL/100g shaddock ped is 5.8 × 10 with living bacteria count is measured7The microorganism Aspergillus aculeatus spore of a/mL
Suspension is uniformly sprayed on the shaddock ped internal layer flesh surface that moisture content is 26%, finally wet after then mixing three kinds of bacterium solutions
Degree is 78%, and temperature is fermented 38h under conditions of being 28 DEG C.
Ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract the preparation method is as follows: by ginger, Honeysuckle flower and bunge pricklyash leaf by weight
Amount obtains mixture than crushing at 4 DEG C after 10:2:1 mixing, the water of 25 times of weight is added in Xiang Suoshu mixture, then super
Acoustical power is 160W, and temperature is ultrasound 40min under conditions of 85 DEG C, finally concentrated when being equivalent to 2.0g crude drug to 1g medicinal extract,
Ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract is made.
Embodiment 2
A kind of fermentation shaddock ped buccal tablet with hypoglycemic effect, by weight, which includes following component: hair
50 parts of ferment shaddock ped, 7 parts of ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, 5 parts of fingered citron, 5 parts of honey raisin tree, 10 parts of starch, mannitol 5
Part.
The buccal tablet is prepared as follows: first fermentation shaddock ped being crushed acquisition fermentation shaddock peel powder at 4 DEG C, then will
The fermentation shaddock peel powder and ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, fingered citron, honey raisin tree, starch and mannitol are straight after mixing
Connect tabletting, 0.5 gram/piece of slice weight.
Wherein, ferment shaddock ped the preparation method is as follows: it is preferred by 1mL/100g shaddock ped with to measure living bacteria count be 5 ×
105The yeast bacterium suspension of a/mL, what it is by 1mL/100g shaddock ped is 1.5 × 10 with living bacteria count is measured6The aspergillus niger of a/mL
Spore suspension, what it is by 1.5mL/100g shaddock ped is 1.2 × 10 with living bacteria count is measured6The microorganism Aspergillus aculeatus spore of a/mL is outstanding
Supernatant liquid is uniformly sprayed on the shaddock ped internal layer flesh surface that moisture content is 12%, finally in humidity after then mixing three kinds of bacterium solutions
It is 75%, temperature is fermented 32h under conditions of being 30 DEG C.
Ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract the preparation method is as follows: by ginger, Honeysuckle flower and bunge pricklyash leaf by weight
Amount obtains mixture than crushing at 4 DEG C after 10:2:1 mixing, the water of 30 times of weight is added in Xiang Suoshu mixture, then super
Acoustical power is 100W, and temperature is ultrasound 45min under conditions of 95 DEG C, finally concentrated when being equivalent to 4.0g crude drug to 1g medicinal extract,
Ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract is made.
Embodiment 3
A kind of fermentation shaddock ped buccal tablet with hypoglycemic effect, by weight, which includes following component: hair
40 parts of ferment shaddock ped, 1 part of ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, 15 parts of fingered citron, 15 parts of honey raisin tree, 5 parts of starch, mannitol 2
Part.
The buccal tablet is prepared as follows: first fermentation shaddock ped being crushed acquisition fermentation shaddock peel powder at 4 DEG C, then will
The fermentation shaddock peel powder and ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, fingered citron, honey raisin tree, starch and mannitol are straight after mixing
Connect tabletting, 0.5 gram/piece of slice weight.
Wherein, ferment shaddock ped the preparation method is as follows: it is preferred by 1mL/100g shaddock ped with to measure living bacteria count be 6 ×
108The yeast bacterium suspension of a/mL, what it is by 1mL/100g shaddock ped is 3.6 × 10 with living bacteria count is measured8The aspergillus niger of a/mL
Spore suspension, what it is by 1.5mL/100g shaddock ped is 3.7 × 10 with living bacteria count is measured8The microorganism Aspergillus aculeatus spore of a/mL is outstanding
Supernatant liquid is uniformly sprayed on the shaddock ped internal layer flesh surface that moisture content is 28%, finally in humidity after then mixing three kinds of bacterium solutions
It is 80%, temperature is fermented 40h under conditions of being 32 DEG C.
Ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract the preparation method is as follows: by ginger, Honeysuckle flower and bunge pricklyash leaf by weight
Amount obtains mixture than crushing at 4 DEG C after 10:2:1 mixing, the water of 35 times of weight is added in Xiang Suoshu mixture, then super
Acoustical power is 200W, and temperature is ultrasound 35min under conditions of 75 DEG C, finally concentrated when being equivalent to 3.0g crude drug to 1g medicinal extract,
Ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract is made.
Embodiment 4
What it is by 1mL/100g shaddock ped is 5.5 × 10 with living bacteria count is measured7The yeast bacterium suspension of a/mL is uniformly sprayed
It spills in the shaddock ped internal layer flesh surface that moisture content is 26%, is 78% in humidity, temperature is fermented 38h under conditions of being 28 DEG C, system
Obtain saccharomycetes to make fermentation shaddock ped.
What it is by 1mL/100g shaddock ped is 2.7 × 10 with living bacteria count is measured7The aspergillus niger spore suspension of a/mL,
The even shaddock ped internal layer flesh surface for being sprayed on moisture content and being 26% is 78% in humidity, and temperature is fermented under conditions of being 28 DEG C
Fermentation of Aspergillus niger shaddock ped is made in 38h.
What it is by 1.5mL/100g shaddock ped is 5.8 × 10 with living bacteria count is measured7The microorganism Aspergillus aculeatus spore suspension of a/mL
Liquid is uniformly sprayed on the shaddock ped internal layer flesh surface that moisture content is 26%, is 78% in humidity, temperature is sent out under conditions of being 28 DEG C
Microorganism Aspergillus aculeatus fermentation shaddock ped is made in ferment 38h.
Then test respectively above-mentioned preparation saccharomycetes to make fermentation shaddock ped, fermentation of Aspergillus niger shaddock ped, microorganism Aspergillus aculeatus fermentation shaddock ped,
The soluble dietary fiber in shaddock ped that the fermentation shaddock ped prepared in embodiment 1 and moisture content of not fermenting are 26%, reduced sugar,
The content of aurantiin, test results are shown in figure 1, and as shown in Figure 1, shaddock ped is combined solid through saccharomycete, aspergillus niger and microorganism Aspergillus aculeatus
After state fermentation, soluble dietary fiber, reduced sugar and naringin content are dramatically increased；Saccharomycetes to make fermentation poor effect, base
This does not increase soluble dietary fiber in shaddock ped, reduced sugar and naringin content；Aspergillus niger or microorganism Aspergillus aculeatus fermentation are production shaddocks
The effect of effective ways of glycosides enzyme can significantly reduce the content of aurantiin in shaddock ped, make shaddock ped is had a greatly reduced quality.Because using yeast
Bacterium, aspergillus niger and microorganism Aspergillus aculeatus are combined solid fermented, and the quick breeding and fermentation of saccharomycete will limit and inhibit aspergillus niger and spine
Decomposition of the naringinase that spore aspergillus generates to aurantiin, while the cellulase that aspergillus niger and microorganism Aspergillus aculeatus generate can make shaddock
Cellulose degradation in skin provides culture nutriment abundant to saccharomycetes to make fermentation, and the two is mutually promoted, in addition, shaddock ped is by two
Be grouped as: exodermis (outer layer is green) and internal layer flesh (white), wherein internal layer flesh quality is soft, has netted pore structure,
The strong adsorption characteristic of shaddock ped internal layer flesh is made full use of, saccharomycete, aspergillus niger and microorganism Aspergillus aculeatus are not only adsorbed on internal layer flesh surface,
And can be adsorbed among the netted hole of internal layer flesh, to improve fermentation efficiency.
Embodiment 5
The shaddock ped that 58.75 parts of moisture contents are 26%, 6.25 portions of gingers, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, 10 parts
Direct tablet compressing after fingered citron, 10 portions of honey raisin trees, 10 parts of starch and 5 portions of mannitol mix, is made containing the shaddock ped that do not ferment by 0.5 gram/piece of slice weight
Buccal tablet.
6.25 portions of gingers, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, 10 portions of fingered citrons, 10 portions of honey raisin trees, 10 parts of starch and 5 parts it is sweet
Reveal direct tablet compressing after alcohol mixes, 0.5 gram/piece of slice weight, the buccal tablet without shaddock ped is made.
After 140 mouse fasting 14h, wherein 120 are taken at random first, every is pressed the injection volume abdomen of 200mg/kg bwd
Chamber injects alloxan, as experimental group；Physiology salt is injected intraperitoneally in the remaining 20 every injection volume by 200mg/kg bwd
Water, as blank control group.After modeling 3d, fasting blood-glucose is surveyed in experimental group after each mouse fasting 12h, blood glucose value >=
11.1mmol/L is modeling success.Each mouse in experimental group after modeling success is randomly divided into 6 groups, every group 20, wherein
Each mouse every amount of feeding by 500mg/kg bwd feeds diabetes pill in 1st group, as model drug group；It is each in 2nd group
The mouse every amount of feeding by 200mg/kg bwd feeds the shaddock ped buccal tablet prepared in embodiment 1, as the shaddock ped containing fermentation
Buccal tablet low dose group；Each mouse every amount of feeding by 500mg/kg bwd feeds the shaddock prepared in embodiment 1 in 3rd group
Skin buccal tablet, as the shaddock ped buccal tablet high dose group containing fermentation；Every feeding by 500mg/kg bwd of each mouse in 4th group
Amount feeds the buccal tablet containing the shaddock ped that do not ferment, as the buccal tablet group containing the shaddock ped that do not ferment；Each mouse every is pressed in 5th group
The amount of feeding of 500mg/kg bwd feeds the buccal tablet without shaddock ped, as the buccal tablet group for being free of shaddock ped；It is each small in 6th group
The mouse every amount of feeding by 500mg/kg bwd feeds physiological saline, as model control group；Each mouse in blank control group
Every amount of feeding by 500mg/kg bwd feeds physiological saline.It is raised in a conventional manner after each group processing, during raising
Free water and feed, by the 28th day, each group mouse fasting 10h, excision eyeball took blood, serum was separated, using Rapid test
Box measurement blood glucose, total cholesterol, triglycerides, Serum glutathione peroxidase and serum superoxide dismutases items refer to
Mark, test result are shown in Table 1.
Table 1
Note: ns indicates that difference is not significant (P > 0.05) compared with model drug group, and * indicates poor compared with model drug group
Different significant (P < 0.05).
As shown in Table 1, the blood glucose level of all diabetic mices is all apparently higher than blank control group.Containing shaddock of not fermenting
The mouse blood sugar level of the buccal tablet group of skin and the buccal tablet group without shaddock ped and model control group are close, containing the shaddock ped that do not ferment
Buccal tablet group shows certain reduction blood glucose effect, but ineffective；Containing fermentation shaddock ped buccal tablet low dose group and containing hair
The mouse blood sugar level and model drug group of ferment shaddock ped buccal tablet high dose group are close, no conspicuousness compared with model drug group
Difference, and high dose group better effect.
Compared with model control group, the shaddock ped buccal tablet low dose group containing fermentation and the shaddock ped buccal tablet high dose group containing fermentation are small
The total cholesterol and triglyceride levels of mouse are substantially reduced, and are connect with the total cholesterol and triglyceride levels of model drug group mouse
Closely.The Serum glutathione peroxidase and serum super oxygen of solid state fermentation mouth shaddock ped lozenge mouth low dose group and high dose group
Object dismutase activity significantly improves.
The Serum glutathione of the shaddock ped buccal tablet low dose group containing fermentation and the shaddock ped buccal tablet high dose group mouse containing fermentation
Peroxidase and serum superoxide dismutases activity are not significantly different compared with blank control group, the mouth containing of the shaddock ped containing fermentation
Piece high dose group is better than model drug group to Serum glutathione peroxidase and superoxide dismutase activity reinforcing effect.
These results suggest that containing the buccal tablet by saccharomycete, aspergillus niger and the combined solid fermented shaddock ped of microorganism Aspergillus aculeatus to sugar
Urine disease model mouse blood sugar level has apparent reduction to act on, while can obviously adjust serum lipid overoxidation level and serum
Antioxidant status, this is mainly due to saccharomycete, aspergillus niger and the combined solid fermented effect of microorganism Aspergillus aculeatus, and shaddock ped passes through yeast
Bacterium, aspergillus niger and microorganism Aspergillus aculeatus it is combined solid fermented after, improve the content of soluble dietary fiber, reduced sugar, aurantiin,
The soluble dietary fiber and aurantiin of middle dissolution can preferably adjust blood glucose.
Embodiment 6
30 patients with diabetes mellitus is tested, wherein 18 people of male, 12 people of women average age 48 years old, are divided into A, B two at random
Group, every group of 15 people, A, B group take metformin hydrochloride tablet, each 0.25g, and 3 times/day；But B group takes the system of embodiment 1 simultaneously
Standby shaddock ped buccal tablet, 5 tablets each time, 3 times/day.B group diabetic deactivates after continuously taking buccal tablet 30 days, then observes 20
It.Respectively 1 day before taking buccal tablet, take after buccal tablet the 30th day, take buccal tablet after carry out blood drawing analysis within the 50th day, survey
Determine fasting blood glucose level.As a result it is indicated, result is analyzed using the statistical method that t is examined, P < with mean+SD
0.05 indicates significant difference.Two groups of patient's fasting blood-glucose (mmol/L) testing results are shown in Table 2.
Table 2
Note: * is indicated and is taken preceding comparing difference significantly (P < 0.05).
As shown in Table 2, for diabetes patient in the case where taking other hypoglycemic medicines, also taking the present invention reduces the shaddock of blood glucose
Skin buccal tablet, hypoglycemic effect are more preferable, more stable.
Finally, it is stated that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to compared with
Good embodiment describes the invention in detail, those skilled in the art should understand that, it can be to skill of the invention
Art scheme is modified or replaced equivalently, and without departing from the objective and range of the technical program, should all be covered in the present invention
Scope of the claims in.
Claims (7)
1. a kind of fermentation shaddock ped buccal tablet with hypoglycemic effect, which is characterized in that by weight, the buccal tablet includes
Following component: shaddock ped 40-60 parts of fermentation, 1-7 parts of ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, 5-15 parts of fingered citron, honey raisin tree 5-
15 parts, 5-10 parts of starch, 2-5 parts of mannitol；The fermentation shaddock ped joins shaddock ped by saccharomycete, aspergillus niger and microorganism Aspergillus aculeatus
It closes solid state fermentation and obtains.
2. a kind of fermentation shaddock ped buccal tablet with hypoglycemic effect as described in claim 1, which is characterized in that by weight
Meter, the buccal tablet includes following component: 58.75 parts of shaddock ped of fermentation, ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract 6.25
Part, 10 parts of fingered citron, 10 parts of honey raisin tree, 10 parts of starch, 5 parts of mannitol.
3. a kind of fermentation shaddock ped buccal tablet with hypoglycemic effect as claimed in claim 1 or 2, which is characterized in that described
Ferment shaddock ped the preparation method is as follows: preferred by 1mL/100g shaddock ped is 5 × 10 with living bacteria count is measured5-6×108A/
The yeast bacterium suspension of mL, what it is by 1mL/100g shaddock ped is 1.5 × 10 with living bacteria count is measured6-3.6×108A/mL's is black
Aspergillus spore suspension, what it is by 1.5mL/100g shaddock ped is 1.2 × 10 with living bacteria count is measured6-3.7×108The spine of a/mL
Spore aspergillus spore suspension is uniformly sprayed on the shaddock ped internal layer flesh that moisture content is 12-28% after then mixing three kinds of bacterium solutions
Surface is finally 75-80% in humidity, and temperature is fermented 32-40h under conditions of being 28-32 DEG C.
4. a kind of fermentation shaddock ped buccal tablet with hypoglycemic effect as claimed in claim 3, which is characterized in that first choice is pressed
1mL/100g shaddock ped is 5.5 × 10 with living bacteria count is measured7The yeast bacterium suspension of a/mL, by 1mL/100g shaddock ped
It is 2.7 × 10 with living bacteria count is measured7The aspergillus niger spore suspension of a/mL, by having with measurement for 1.5mL/100g shaddock ped
Imitating viable count is 5.8 × 107The microorganism Aspergillus aculeatus spore suspension of a/mL is uniformly sprayed on water after then mixing three kinds of bacterium solutions
The shaddock ped internal layer flesh surface that point content is 26% is finally 78% in humidity, and temperature is fermented 38h under conditions of being 28 DEG C.
5. a kind of fermentation shaddock ped buccal tablet with hypoglycemic effect as claimed in claim 1 or 2, which is characterized in that described
Ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract the preparation method is as follows: by ginger, Honeysuckle flower and bunge pricklyash leaf by weight 10:
It is crushed after 2:1 mixing and obtains mixture, the water of 25-35 times of weight is added in Xiang Suoshu mixture, is then in ultrasonic power
100-200W, temperature are ultrasound 35-45min under conditions of 75-95 DEG C, last concentrated obtained ginger, Honeysuckle flower and bunge pricklyash leaf
Mixture medicinal extract.
6. a kind of fermentation shaddock ped buccal tablet with hypoglycemic effect as claimed in claim 5, which is characterized in that the concentration
Afterwards, 1g medicinal extract is equivalent to 2.0-4.0g crude drug.
7. a kind of preparation method of fermentation shaddock ped buccal tablet with hypoglycemic effect described in any one of claims 1-6,
Be characterized in that, the method is as follows: fermentation shaddock ped being crushed obtain fermentation shaddock peel powder first, then by the fermentation shaddock peel powder and
Direct tablet compressing after ginger, Honeysuckle flower and bunge pricklyash leaf mixture medicinal extract, fingered citron, honey raisin tree, starch and mannitol mix.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910209463.1A CN109938301B (en) | 2019-03-19 | 2019-03-19 | Fermented pomelo peel buccal tablet with blood sugar reducing effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910209463.1A CN109938301B (en) | 2019-03-19 | 2019-03-19 | Fermented pomelo peel buccal tablet with blood sugar reducing effect and preparation method thereof |
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| Publication Number | Publication Date |
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