CN109925466A - A kind of enteral microecological formulation and preparation method thereof adjusting man's diarrhea - Google Patents
A kind of enteral microecological formulation and preparation method thereof adjusting man's diarrhea Download PDFInfo
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Abstract
The invention discloses a kind of enteral microecological formulations for adjusting man's diarrhea, the raw material of the enteral microecological formulation forms and mass fraction are as follows: 5~10 parts of ginseng, 40~60 parts of pueraria lobata, 5~10 parts of Radix Glycyrrhizae, 5~10 parts of rhizoma polygonati, 5~10 parts of fructus alpiniae oxyphyllae, 5~10 parts of inulin, 1~2 part of sea-buckthorn, 0.2~2 part of probiotics.The present invention provides a kind of enteral microecological formulations for adjusting man's diarrhea, can effectively adjust man's intestinal flora, treat man's diarrhea.Adjusting efficiency of the present invention also by further increasing biological agent to the regulation of component.The present invention also provides a kind of preparation methods of enteral microecological formulation for adjusting man's diarrhea.
Description
Technical field
The present invention relates to probiotics field more particularly to it is a kind of adjust man's diarrhea enteral microecological formulation and
Preparation method.
Background technique
There are symbiosis with human body for intestinal microecology, are the indispensable important components of human body, modern science is ground
Study carefully display, intestinal microecology is to the biosynthesis such as vitamin of human body synthesis, enhancing development and metabolism and is immunized
Defense function etc. has important role, has tremendous influence to physiology, is to maintain the necessary factor of human health, and reflect
The mirror of body homeostasis.Intestinal microecology is unbalance and many diseases, particularly related with most of chronic diseases
Connection.Have scientific basis show intestinal microecology it is unbalance can cause enterogastric diseases, hepatopathy, the nervous system disease, mental disease,
The generation of the diseases such as respiratory disease, cardiovascular disease, autoimmune disease, metabolic disease and tumour.
Probiotics are the microorganism systems for using microflora or promoting to live made of the substance of microorganism growth
Agent.That is, all can promote normal microflora growth and breeding and inhibition pathogenic bacteria growth and breeding preparation to be referred to as
" probiotics ".The effect of adjusting enteron aisle due to it, rapid build intestinal microecology balance, no matter in baby, old man is gone back
It is that newborn livestock and poultry can prevent and treat diarrhea, constipation.Probiotics have the advantages that its other medicine is irreplaceable, i.e., " illness is controlled
Disease, not sick diseases prevention, disease-free health care " effect.It can also be taken even if Healthy People, to improve health conditions, and diarrhea patient
It can take, constipation patient can also take.
Recently studies have shown that: live in the microorganism in male and female enteron aisle, to the reaction of diet difference,
Even identical diet.It due to the influence of male's life habit, such as drinks, smoke, edible carnism, may all lead
Cause its enteron aisle more fragile.However the rare enteral microecological formulation for man's diarrhea on the market.
Summary of the invention
The present invention is to solve current technology shortcoming, provides a kind of intestinal microecology system for adjusting man's diarrhea
Agent can effectively adjust man's intestinal flora, treat man's diarrhea.
Adjusting efficiency of the present invention also by further increasing biological agent to the regulation of component.
The present invention also provides a kind of preparation methods of enteral microecological formulation for adjusting man's diarrhea.
Technical solution provided by the invention are as follows: a kind of enteral microecological formulation for adjusting man's diarrhea, the micro- life of enteron aisle
The raw material of state preparation forms and mass fraction are as follows:
5~10 parts of ginseng, 40~60 parts of pueraria lobata, 5~10 parts of Radix Glycyrrhizae, 5~10 parts of rhizoma polygonati, 5~10 parts of fructus alpiniae oxyphyllae, inulin 5
~10 parts, 1~2 part of sea-buckthorn, 0.2~2 part of probiotics.
Preferably, the viable bacteria concentration in the probiotics is 108~1010CFU/g。
Preferably,
The form of the enteral microecological formulation is dry powder doses, tablet, capsule or suppository.
Preferably, the probiotics is lactobacillus class.
Preferably, pulverization process is carried out to the ginseng, pueraria lobata, Radix Glycyrrhizae, rhizoma polygonati, fructus alpiniae oxyphyllae, after crushing and crosses 100
Mesh.
Preferably, the sea-buckthorn carries out broken wall pulverization process, smashes it through 80 meshes.
Preferably, the mass fraction of the ginseng changes, the weight of ginseng according to the parts by weight content of remaining component
Measure number w1Are as follows:
In formula, m1For the parts by weight of Radix Glycyrrhizae, m2For the parts by weight of rhizoma polygonati, m3For the parts by weight of probiotics, m4For
The parts by weight of pueraria lobata.
A kind of preparation method for the enteral microecological formulation adjusting man's diarrhea, comprising the following steps:
Step 1: raw material ginseng, pueraria lobata, Radix Glycyrrhizae, rhizoma polygonati, fructus alpiniae oxyphyllae, inulin, sea-buckthorn and probiotics are placed in multinomial mixed
Mixed raw material is mixed to obtain in conjunction machine；
Step 2: the mixed raw material is added in high-speed mixing granulating machine, under rotation status, distilled water profit is added
It is wet, softwood is made；
Step 3: the softwood is placed in oscillating granulator, 20 mesh sieve are crossed, and screens and is greater than 20 mesh and less than 16
Purpose whole grain；
Step 4: obtaining enteral microecological formulation after the whole grain is placed in round as a ball in spheronizator and drying.
Preferably, in the step 1, the mass fraction of each raw material are as follows:
5~10 parts of ginseng, 40~60 parts of pueraria lobata, 5~10 parts of Radix Glycyrrhizae, 5~10 parts of rhizoma polygonati, 5~10 parts of fructus alpiniae oxyphyllae, inulin 5
~10 parts, 1~2 part of sea-buckthorn, 0.2~2 part of probiotics.
Preferably, in the step 2, the mass fraction w of distilled water is added2Are as follows:
In formula, ω is the viable bacteria concentration in probiotics, and m is mixed raw material gross mass number.
It is of the present invention the utility model has the advantages that the present invention provides it is a kind of adjust man's diarrhea enteral microecological formulation,
Function of spleen and stomach regulating, Yang nourishing-strengthening and formation intestinal microecology balance are realized in the common conditioning that Chinese medicine, probiotics, fruit can be passed through,
Man's intestinal flora is targetedly adjusted, man's diarrhea, quick, good effect are treated.The present invention also passes through the tune to component
It controls to further increase the adjusting efficiency of biological agent, keeps the distribution of its each component more reasonable, improve the adjusting of biological agent
Effect.
Specific embodiment
The present invention is described in further detail below, to enable those skilled in the art's refer to the instruction text can
Implement accordingly.
The present invention provides a kind of enteral microecological formulation for adjusting man's diarrhea, the raw material of the enteral microecological formulation
Composition and mass fraction are as follows:
5~10 parts of ginseng, 40~60 parts of pueraria lobata, 5~10 parts of Radix Glycyrrhizae, 5~10 parts of rhizoma polygonati, 5~10 parts of fructus alpiniae oxyphyllae, inulin 5
~10 parts, 1~2 part of sea-buckthorn, 0.2~2 part of probiotics.
The effect of raw material that the present invention uses and pharmacology analysis are as follows:
Ginseng: ginseng is adjustable the balance of central nervous system stimulant process and process of inhibition.By ginseng to animal brain
The research that electrical activity influences, the results showed that it has an impact to excited and two kinds of nerve processes of inhibition, but mainly reinforces brain
The excited process of cortex.Due to simultaneously act on process of inhibition, therefore make inhibit tend to concentrate, make differentiation accelerate and more completely.People
Join adjustable nervous function, enables anxiety that the nerve process of disorder to be caused to restore.Influence of the ginseng to learning and memory has two-way
Property and Composition Dependence.Ginseng can promote the synthesis of protein, the synthesis of RNA and the synthesis of DNA.Ginseng easily changes the work of memory
With may be mainly related with intracerebral nucleic acid and protein synthesis.It reinforces vital energy, reinforces the spleen to benefit the lung, promote the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence, gently
Body macrobiosis.
Pueraria lobata: 1) cough-relieving antidiarrheal: pueraria lobata, which gently rises clearly, to be dissipated, and pharmacological property rises hair, and willow lifts yang-energy, and inspiring body, A healthy wind prevails, body fluid
Cloth row.It rises hair taste air positive clearly and quenches the thirst, antidiarrheal dysentery.Therefore it is usually used in treating Heat Diabetes, measles without adequate eruption, diarrhea, dysentery
The illnesss such as disease.2) adjust body temperature human body and cause the abnormal activity of humoral immunity since the invasion of virus has, phagocyte it is big
Amount activity generates a large amount of thermal energy to internal body, forms high temperature.Pueraria Flavonid, which has the raising of toxin cause body temperature, to be held
Long and apparent cooling effect, can effectively control body temperature, and clinically pueraria lobata always is the main of fever caused by exogenous pathogens symptom
One of drug.3) hypoglycemic: adrenaline can not only act on and muscle, moreover it is possible to act on pancreas, have and promote pancreas hyperglycemia
The effect of element secretion, can increase blood glucose.Puerarin, which has, resists adrenergic effect, can inhibit pancreas in certain degree
The secretion of glucagons has certain hypoglycemic effect.4) extend blood vessel: Pueraria Flavonid and Puerarin can improve cardiac muscle
Oxygen metabolism generates beneficial effect to myocardial metabolism, while can expand blood vessel, improves microcirculation, reduces vascular resistence, makes blood flow
Amount increases, therefore can use prevention and treatment myocardial ischemia, myocardial infarction, arrhythmia cordis, hypertension, the illnesss such as artery sclerosis.
Radix Glycyrrhizae: 1) relieving cough and reducing sputum: licorice tablet clinically not merely contains only licorice ingredient in fact, also contains camphor, eight
Its effective component such as erect hypecoum oil, sodium benzoate, wherein the stream infiltrative paste of Radix Glycyrrhizae can be adhered to throat, be adhered to inflammation
Position can cover local sensory nerve ending, less to swallow, therefore the stimulation to inflammation part mucous membrane such as breathing has
Good antitussive action；2) tonifying Qi benefit spleen: Radix Glycyrrhizae is mild-natured, sweet in flavor, and inside Chinese medicine, Radix Glycyrrhizae has multiple efficacies, possesses to more
The therapeutic effect of kind disease, while Radix Glycyrrhizae is also to have effects that tonifying Qi benefit spleen to nourish drug；3) analgesic activity: Radix Glycyrrhizae
Piece has the function of easing pain and anaesthetize.
Rhizoma polygonati: antibacterial: to typhoid bacillus, staphylococcus aureus, gypsum sample trichophyta, Ke Shi type Epidermophyton etc.
There is inhibiting effect.Strengthening by means of tonics effect.Tonifying Qi, invigorating the spleen, moistening lung, kidney-nourishing.
Fructus alpiniae oxyphyllae: 1) intelligence pungent-warm enters the spleen channel, can warm spleen cold dispelling, abdominal pain caused by catching cold suitable for taste vomits and diarrhoea,
Crymodynia in abdomen；2) whet the appetite: intelligence development also has effects that saliva is taken the photograph in appetizing, can be used for that the middle deficiency of vital energy is cold, the more salivas of deficiency of food；3) kidney controlling nocturnal emission with astringent drugs is warmed up:
Intelligence development nature and flavor Wen Xin, enters kidney channel, has effects that warm kidney is supporing yang, astringent sperm contracting urine, is suitable for the kidney qi cold of insufficiency type, spermatorrhea, the enuresis, urine
The symptom for thering is the heeltap, enuresis nocturna to increase；4) promote metabolism: vitamin B1 rich in, B2, vitamin C, vitamin E in intelligence development
And a variety of amino acid, it may participate in the anabolism of human body cell, taking fructus alpiniae oxyphyllae can promote body metabolism, increase memory
Power, strengthen immunity.
Inulin: 1) reduce blood glucose: inulin is that one kind not will lead to the raised carbohydrate of glucose in urine.It is in intestines
The top in road will not be hydrolyzed into monosaccharide, because without increasing blood glucose level and insulin content.Nowadays studies have shown that on an empty stomach
The reduction of blood glucose is the result of oligofructose short chain fatty acids caused by colon fermentation；2) promote the absorption of minerals: chrysanthemum
Powder can greatly improve Ca2+、Mg2+、Zn2+、Cu2+、 Fe2+" etc. minerals absorption, dietary fiber can combine metal in alimentary canal
Ion.Any inulin and mineral complex are degraded in fermentation, release minerals, thus obtain metal ion
It is effective to absorb.In addition, the acid caused by fermenting reduces l-2 unit of pH value of colon, make the dissolution of many minerals
Degree/biological effectiveness (such as calcium phosphate) greatly improves.Moreover, studies have shown that short chain fatty acids, especially butyrate, can pierce
The growth for swashing colonic mucosal cells, improves the absorbability of intestinal mucosa.Inulin can also improve certain section of colon calcium to the knot of protein
It closes；3) intestinal bifidobacteria is enable to increase: studies have shown that inulin of ingesting daily makes the beneficial bacterium in colon increase (about 10 significantly
Times), reduce pathogen and spoilage organisms, such as salmonella, Listeria, staphylococcus aureus, coliform.Its mechanism
It is that inulin is not digested absorption and is directly entered large intestine and is preferentially utilized by Bifidobacterium, generates acetate and lactate, reduce
The pH value of large intestine, to inhibit the growth of harmful bacteria.So inulin is the proliferation factor of Bifidobacterium；4) anti-constipation:
Dietary fiber reduces food in the residence time of stomach and intestine, and increases excrement amount, effectively treats constipation.Its antiobesity action is
The viscosity of content is improved, food is reduced and enters the speed of small intestine from stomach, to reduce hunger, reduce the food ration of food.
Sea-buckthorn: 1) sea buckthorn fruit has apparent enhancing immunity of organisms, can be improved body at low ambient temperatures cold-resistant
Ability and hypoxia-bearing capability.Its Seabuckthorm Seed Oil can comprehensively enhance body energy, there is certain Antiradiation injury and antitumor
Effect；2) protection is cardiovascular: sea-buckthorn can reduce serum total cholesterol, increase serum High Density Lipoprotein Cholesterol and liver
Total cholesterol, allevating angina pectoris breaking-out play the role of preventing and treating coronary atherosclerotic heart disease；3) relieving cough and asthma: sea-buckthorn
There are apparent eliminating the phlegm, antitussive and antiasthmatic, can be used for treating chronic bronchitis；4) reinforcing spleen to promote digestion: sea-buckthorn can be disappeared with invigorating the spleen
Food, be suitable for alleviate indigestion, dyspeptic abdominalgia, the digestive systems such as gastritis, enteritis and gastric duodenal ulcer not by
Symptom.
Probiotics: cholesterol level in blood plasma is reduced, inhibits pathogen, alleviate irritable bowel syndrome, treatment functionality just
Secret, blood pressure lowering alleviates liver and intestinal tract injury, slows down enteritis, adjusts and is immunized, and anti-infective, reduction body fat accumulation is adjusted
Save bowel movement function.
Pueraria lobata and ginseng compatibility are used to treat the mechanism of syndrome of deficiency of spleen qi and stomach qi: taste are with coke placed in the middle, and the relationship of the two is close, water
Gu Nayun phase, ascending or descending movement of vital Qi phase factor, yin-yang interdependence between drying and moistening, be all source of generating QI and blood, the foundation of acquired constitution.Deficiency of spleen-QI and stomach-QI can be led
Cause the generation, such as fatigue and weakness, abdominal pain, dysentery, vomiting etc. of various diseases.Therefore treatment is based on air making-up and spleen enlivening.Ginseng Pueraria lobota
Both roots match, on the one hand, and for the interpretation of the cause, onset and process of an illness that the clear sun of taste is sagging, ginseng has the function of that tonifying Qi liter mentions, and on the other hand,
Scattered property, direct hair tonic taste yang-energy can be risen then with it by being equipped with expelling wind drug pueraria lobata, be mentioned so that dirty essence derived from food be enable to rise.In addition,
Can be relaxed liver with expelling wind drug, and liver Shu Ze facilitates transporting and transforming function of the spleen and stomach and ascending or descending movement of vital Qi, and " wind can clear damp ", can also dispel spleen with pueraria lobata
The water-wet generated after void because transporting is powerless.Therefore it is bigger to join the Pueraria lobota matching power that then QI invigorating liter proposes.Pueraria lobata category diaphoretic medicine, may
Because its diverging power caused by healthy tendency damage, as Chen Shiyi mentions " pueraria lobata consumes people's vigour, and original is invisible ".But by with ginseng
Compatibility, the property of the diverging of pueraria lobata can be restricted with the power of the astringent method of ginseng, to carry out Synergy and attenuation.
Viable bacteria concentration in probiotics is 108~1010CFU/g。
The form of the enteral microecological formulation is dry powder doses, tablet, capsule or suppository.
The probiotics is lactobacillus class.
Pulverization process is carried out to the ginseng, pueraria lobata, Radix Glycyrrhizae, rhizoma polygonati, fructus alpiniae oxyphyllae, after crushing and crosses 100 meshes.
The sea-buckthorn carries out broken wall pulverization process, smashes it through 80 meshes.
The mass fraction of the ginseng changes, the parts by weight w of ginseng according to the parts by weight content of remaining component1
Are as follows:
In formula, m1For the parts by weight of Radix Glycyrrhizae, m2For the parts by weight of rhizoma polygonati, m3For the parts by weight of probiotics, m4For
The parts by weight of pueraria lobata.
The present invention also provides a kind of preparation methods of enteral microecological formulation for adjusting man's diarrhea, comprising the following steps:
Step 1: raw material ginseng, pueraria lobata, Radix Glycyrrhizae, rhizoma polygonati, fructus alpiniae oxyphyllae, inulin, sea-buckthorn and probiotics are placed in multinomial mixed
Mixed raw material is mixed to obtain in conjunction machine；
Step 2: the mixed raw material is added in high-speed mixing granulating machine, under rotation status, distilled water profit is added
It is wet, softwood is made；
Step 3: the softwood is placed in oscillating granulator, crosses the screening of 20 mesh sieve and be greater than 20 mesh and less than 16 purposes
Whole grain；
Step 4: obtaining enteral microecological formulation after the whole grain is placed in round as a ball in spheronizator and drying.
In the step 1, the mass fraction of each raw material are as follows:
5~10 parts of ginseng, 40~60 parts of pueraria lobata, 5~10 parts of Radix Glycyrrhizae, 5~10 parts of rhizoma polygonati, 5~10 parts of fructus alpiniae oxyphyllae, inulin 5
~10 parts, 1~2 part of sea-buckthorn, 0.2~2 part of probiotics.
In the step 2, the mass fraction w of distilled water is added2Are as follows:
In formula, ω is the viable bacteria concentration in probiotics, and m is mixed raw material gross mass number.
Embodiment 1,
A kind of preparation method for the enteral microecological formulation adjusting man's diarrhea, comprising the following steps:
Step 1: raw material ginseng, pueraria lobata, Radix Glycyrrhizae, rhizoma polygonati, fructus alpiniae oxyphyllae, inulin, sea-buckthorn and probiotics are placed in multinomial mixed
Mixed raw material is mixed to obtain in conjunction machine；Wherein, the mass fraction of raw material are as follows:
5 parts of ginseng, 40 parts of pueraria lobata, 5 parts of Radix Glycyrrhizae, 5 parts of rhizoma polygonati, 5 parts of fructus alpiniae oxyphyllae, 5 parts of inulin, 1 part of sea-buckthorn, probiotics 0.2
Part.Viable bacteria concentration in probiotics is 108CFU/g。
Step 2: the mixed raw material is added in high-speed mixing granulating machine, under rotation status, distilled water profit is added
It is wet, softwood is made；
Step 3: the softwood is placed in oscillating granulator, crosses the screening of 20 mesh sieve and be greater than 20 mesh and less than 16 purposes
Whole grain；
Enteral microecological formulation is obtained Step 4: the whole grain is placed in after round as a ball in spheronizator and drying, vacuum packaging.
Embodiment 2,
A kind of preparation method for the enteral microecological formulation adjusting man's diarrhea, comprising the following steps:
Step 1: raw material ginseng, pueraria lobata, Radix Glycyrrhizae, rhizoma polygonati, fructus alpiniae oxyphyllae, inulin, sea-buckthorn and probiotics are placed in multinomial mixed
Mixed raw material is mixed to obtain in conjunction machine；The mass fraction of raw material are as follows:
It is 10 parts of ginseng, 60 parts of pueraria lobata, 10 parts of Radix Glycyrrhizae, 10 parts of rhizoma polygonati, 10 parts of fructus alpiniae oxyphyllae, 10 parts of inulin, 2 parts of sea-buckthorn, prebiotic
2 parts of bacterium.Viable bacteria concentration in probiotics is 1010CFU/g。
Step 2: the mixed raw material is added in high-speed mixing granulating machine, under rotation status, distilled water profit is added
It is wet, softwood is made；
Step 3: the softwood is placed in oscillating granulator, crosses the screening of 20 mesh sieve and be greater than 20 mesh and less than 16 purposes
Whole grain；
Enteral microecological formulation is obtained Step 4: the whole grain is placed in after round as a ball in spheronizator and drying, vacuum packaging.
Embodiment 3,
A kind of preparation method for the enteral microecological formulation adjusting man's diarrhea, comprising the following steps:
Step 1: raw material ginseng, pueraria lobata, Radix Glycyrrhizae, rhizoma polygonati, fructus alpiniae oxyphyllae, inulin, sea-buckthorn and probiotics are placed in multinomial mixed
Mixed raw material is mixed to obtain in conjunction machine；
The mass fraction of each raw material are as follows:
It is 8.17 parts of ginseng, 50 parts of pueraria lobata, 6 parts of Radix Glycyrrhizae, 8 parts of rhizoma polygonati, 7 parts of fructus alpiniae oxyphyllae, 8 parts of inulin, 1.5 parts of sea-buckthorn, prebiotic
1 part of bacterium.Viable bacteria concentration in probiotics is 109CFU/g。
Wherein the mass fraction of ginseng changes, the parts by weight w of ginseng according to the parts by weight content of remaining component1
Are as follows:
In formula, m1For the parts by weight of Radix Glycyrrhizae, m2For the parts by weight of rhizoma polygonati, m3For the parts by weight of probiotics, m4For
The parts by weight of pueraria lobata.
Step 2: the mixed raw material is added in high-speed mixing granulating machine, under rotation status, distilled water is added
40.81 parts of wettings, are made softwood；
The mass fraction w of distilled water is added2Are as follows:
In formula, ω is the viable bacteria concentration in probiotics, and m is mixed raw material gross mass number.
Step 3: the softwood is placed in oscillating granulator, 20 mesh sieve are crossed, screening is greater than 20 mesh and less than 16 mesh
Whole grain；
Step 4: obtaining enteral microecological formulation after the whole grain is placed in round as a ball in spheronizator and drying.
For the effect for further verifying the enteral microecological formulation for adjusting man's diarrhea prepared in the present invention, abdomen is found
The man rushed down 200, is randomly divided into 5 groups, every group of 40 people, respectively blank control group (not taking any probiotics), right
(embodiment 2 is taken according to group (taking physiological saline), experimental group 1 (probiotics for taking the preparation of embodiment 1), experimental group 2
The probiotics of preparation), experimental group 3 (taking probiotics prepared with embodiment 3), and calculate take 4 after corresponding preparation
Defecation frequency and diarrhea rate (percentage that the number of defecation accounts for this group of people's sum) are corresponded in hour, as shown in table 1.
The defecation frequency and diarrhea rate of 1 different experiments group of table
| Project | Blank control group | Control group | Experimental group 1 | Experimental group 2 | Experimental group 3 |
| Defecation frequency | 35 | 20 | 17 | 16 | 10 |
| Diarrhea rate | 87.5% | 50% | 42.5% | 40% | 25% |
After from experimental data as can be seen that taking probiotics, diarrhea is significantly reduced, and comparison is generally applicable on the market
Probiotics, the enteral microecological formulation for preparing is adjusted man's enteron aisle with capable of having face in the present invention, with
Reach adjustment effect.
Although the embodiments of the present invention have been disclosed as above, but its institute not only in the description and the implementation
Column use, it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can hold
It changes places and realizes other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously
Be not limited to specific details and shown here as with description example.
Claims (10)
1. a kind of enteral microecological formulation for adjusting man's diarrhea, which is characterized in that the raw material group of the enteral microecological formulation
At and mass fraction are as follows:
5~10 parts of ginseng, 40~60 parts of pueraria lobata, 5~10 parts of Radix Glycyrrhizae, 5~10 parts of rhizoma polygonati, 5~10 parts of fructus alpiniae oxyphyllae, inulin 5~10
Part, 1~2 part of sea-buckthorn, 0.2~2 part of probiotics.
2. the enteral microecological formulation according to claim 1 for adjusting man's diarrhea, which is characterized in that
Viable bacteria concentration in the probiotics is 108~1010CFU/g。
3. the enteral microecological formulation according to claim 2 for adjusting man's diarrhea, which is characterized in that
The form of the enteral microecological formulation is dry powder doses, tablet, capsule or suppository.
4. the enteral microecological formulation according to claim 3 for adjusting man's diarrhea, which is characterized in that
The probiotics is lactobacillus class.
5. the enteral microecological formulation according to claim 1 for adjusting man's diarrhea, which is characterized in that
Pulverization process is carried out to the ginseng, pueraria lobata, Radix Glycyrrhizae, rhizoma polygonati, fructus alpiniae oxyphyllae, after crushing and is sieved with 100 mesh sieve.
6. the enteral microecological formulation according to claim 5 for adjusting man's diarrhea, which is characterized in that
The sea-buckthorn carries out broken wall pulverization process, smashes it through 80 meshes.
7. the enteral microecological formulation according to claim 1 for adjusting man's diarrhea, which is characterized in that the matter of the ginseng
Amount number changes, the parts by weight w of ginseng according to the parts by weight content of remaining component1Are as follows:
In formula, m1For the parts by weight of Radix Glycyrrhizae, m2For the parts by weight of rhizoma polygonati, m3For the parts by weight of probiotics, m4For pueraria lobata
Parts by weight.
8. a kind of preparation method for the enteral microecological formulation for adjusting man's diarrhea, which comprises the following steps:
Step 1: raw material ginseng, pueraria lobata, Radix Glycyrrhizae, rhizoma polygonati, fructus alpiniae oxyphyllae, inulin, sea-buckthorn and probiotics are placed in multinomial mixing machine
Mix to obtain mixed raw material；
Step 2: the mixed raw material is added in high-speed mixing granulating machine, under rotation status, distilled water wetting, system is added
Obtain softwood；
Step 3: the softwood is placed in oscillating granulator, 20 mesh sieve are crossed, and screens and is greater than 20 mesh and whole less than 16 purposes
Grain；
Step 4: obtaining enteral microecological formulation after the whole grain is placed in round as a ball in spheronizator and drying.
9. the preparation method of the enteral microecological formulation according to claim 8 for adjusting man's diarrhea, which is characterized in that institute
It states in step 1, the mass fraction of each raw material are as follows:
5~10 parts of ginseng, 40~60 parts of pueraria lobata, 5~10 parts of Radix Glycyrrhizae, 5~10 parts of rhizoma polygonati, 5~10 parts of fructus alpiniae oxyphyllae, inulin 5~10
Part, 1~2 part of sea-buckthorn, 0.2~2 part of probiotics.
10. the preparation method of the enteral microecological formulation according to claim 9 for adjusting man's diarrhea, which is characterized in that
In the step 2, the mass fraction w of distilled water is added2Are as follows:
In formula, ω is the viable bacteria concentration in probiotics, and m is mixed raw material gross mass number.
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Cited By (2)
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|---|---|---|---|---|
| CN112999305A (en) * | 2021-02-26 | 2021-06-22 | 上海铮信生物科技有限公司 | Solid preparation for regulating intestinal flora disturbance and preparation method thereof |
| CN113416608A (en) * | 2021-06-29 | 2021-09-21 | 中国热带农业科学院热带作物品种资源研究所 | Extraction method of intelligence-developing essential oil for inhibiting listeria monocytogenes and intelligence-developing essential oil |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112999305A (en) * | 2021-02-26 | 2021-06-22 | 上海铮信生物科技有限公司 | Solid preparation for regulating intestinal flora disturbance and preparation method thereof |
| CN113416608A (en) * | 2021-06-29 | 2021-09-21 | 中国热带农业科学院热带作物品种资源研究所 | Extraction method of intelligence-developing essential oil for inhibiting listeria monocytogenes and intelligence-developing essential oil |
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