CN104524511B - A kind of medicine for treating infantile abdominal distension abdomen pain and preparation method thereof - Google Patents
A kind of medicine for treating infantile abdominal distension abdomen pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of medicine for being used to treat infantile abdominal distension abdomen pain, the raw material matched by following portions by weight is made：Evodia rutaecarpa 10-15, Chinese cassia tree 10-15, in one's early teens 10-20, finish and pull out 10-15, root of Dahurain angelica 10-15, the root of herbaceous peony 10 12, pepper 10-15, fennel seeds 10-15, the dried immature fruit of citron orange 10-15, nutmeg 10-15, the bark of official magnolia 5-10, honey-fried licorice root 3-9, ginseng 3-6, cloves 9 12, rhizoma zingiberis 69.Present invention has the advantages that by external application, i.e. percutaneous drug delivery, overcoming the intrinsic defect of children's traditional Chinese medicine for oral administration, treatment infantile abdominal distension abdomen pain instant effect, evident in efficacy, cure rate are high, particularly more facilitate to pediatric pharmaceuticalses.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method, more particularly to a kind of medicine for treating infantile abdominal distension abdomen pain
And preparation method thereof.
Background technology
Abdominal distension abdomen pain category modern Western medicine acute pancreatitis, anaphylactoid purpura, the insane disease of abdomen type, neurosis, mesenterium
Lymphnoditis etc., doctor trained in Western medicine aches method to the organic disease such as good effect such as appendicitis, intestinal obstruction, pancreatitis for feature abdomen
Seldom.Current Chinese traditional treatment infantile abdominal distension abdomen pain, usually using tonifying spleen and the medicine of stomach, and the mainly medicine for oral administration used
Thing.Such as Fuzi Lizhong Wan, Fuzi Lizhong Wan can warming middle-JIAO and strengthening the spleen, be mainly used in deficiency-cold in spleen and stomach, coldness and pain in the epigastrium, vomiting and diarrhea, brothers
It is not warm.But, simple not notable using tonifying spleen and stomach effect of drugs, it is only effective to incoordination between the spleen and the stomach abdominal distension, and takes orally
Chinese medicine has the shortcomings that its is intrinsic, and such as poor taste, amount are big, so as to cause patient acceptance relatively low, and particularly children's traditional Chinese medicine for oral administration is more
Plus it is difficult.Simultaneously as oral drugs will inevitably produce toxic side effect and adverse reaction in vivo so that patient is reluctant
Meaning uses these medicines.We have accumulated abundant Couple herbs by constantly this disease of exploration Coryza Treated by Syndrome Differentiation, draw the application
In technical scheme, especially by external application, i.e. percutaneous drug delivery, overcome the intrinsic defect of traditional Chinese medicine for oral administration, treat infantile abdominal distension
The characteristics of abdomen pain has instant effect, evident in efficacy, cure rate is high；But also preparation method is simple, particularly to pediatric pharmaceuticalses more
Plus conveniently.
The content of the invention
Present invention solves the technical problem that being：A kind of medicine for treating infantile abdominal distension abdomen pain and preparation method thereof is provided.Should
Drug therapy infantile abdominal distension abdomen pain not only can instant effect, evident in efficacy, cure rate it is high, but also preparation method is simple, particularly
Can also more it facilitate to pediatric pharmaceuticalses.
The technical scheme is that:A kind of medicine for treating infantile abdominal distension abdomen pain, it is characterized in that, by following portions by weight
The raw material of proportioning is made：Evodia rutaecarpa 10-15, Chinese cassia tree 10-15, in one's early teens 10-20, finish pull out 10-15, root of Dahurain angelica 10-15, it is white
Chinese herbaceous peony 10-12, pepper 10-15, fennel seeds 10-15, the dried immature fruit of citron orange 10-15, nutmeg 10-15, the bark of official magnolia 5-10, honey-fried licorice root 3-9,
Ginseng 3-6, cloves 9-12, rhizoma zingiberis 6-9.
It is preferred that each raw material parts by weight proportioning be：Evodia rutaecarpa 12, Chinese cassia tree 12, in one's early teens 15, finish pull out the 13, root of Dahurain angelica 13,
The root of herbaceous peony 10, pepper 14, fennel seeds 14, the dried immature fruit of citron orange 13, nutmeg 13, the bark of official magnolia 6, honey-fried licorice root 6, ginseng 5, cloves 10, rhizoma zingiberis 8.
The preferred formulation formulation of present invention treatment infantile abdominal distension abdomen pain medicine is patch.
A kind of preparation method for the medicine for treating infantile abdominal distension abdomen pain, it is characterized in that：The preparation method of the patch, including
Following step：
A, by above-mentioned raw materials parts by weight proportioning weigh respectively：Evodia rutaecarpa, Chinese cassia tree, in one's early teens, finish pull out, the root of Dahurain angelica, the root of herbaceous peony, Hu
Green pepper, fennel seeds, the dried immature fruit of citron orange, nutmeg, the bark of official magnolia, honey-fried licorice root, ginseng, cloves, rhizoma zingiberis are standby；
B, each bulk drug mixing that step A is prepared fried with slow fire to micro- Jiao, it is cool after to smash 100 mesh sieves standby；
C, the medicinal powder 4-5g for taking step B to cross 100 mesh sieves every time when using, and reconciled with vinegar or ginger juice and be made as medicine cake.
Application method：The medicine cake that the present invention is made is pasted on SHENQUE acupoint, ZHONGWAN acupoint 6-8 hours, once a day,
It is used in conjunction 3-5 days；Note during sticking warming, it is to avoid suffer from cold, careful diet prevents from eating and drinking immoderately, in order to avoid impairing the spleen and stomach vigour.
First, prescription foundation, the prescription principle of invention
Inventor thinks：Forward position means of the invention by using modern scientific research, it is theoretical with reference in differential diagnosis in tcm
Medicine pharmacological research, i.e., strictly defer to the dialectical system of principle-method-recipe-medicines of the traditional Chinese medical science, emphasize again based on the etiology and pathology of doctor trained in Western medicine, with reference to
Chinese medicine active chemical, is the basic further investigated Chinese traditional treatment rule of pharmacokinetics according to herbal pharmacology, drug effect, in discussion
Cure Treatment rules.According to abdomen pain morbidity using cold-evil's internal resistance, stagnant gas aeration, the middle empty cold syndrome in infant, eating accumulation as principle pathological mechanism, knot
Close herbal pharmacology, effect, the Chinese medicine of selection can wet middle cold dispelling, warming middle-Jiao and tonifying deficiency and inner emergency, based on promoting digestion.
2nd, the effect of each material medicine and mechanism
Evodia rutaecarpa：Nature and flavor heat, taste is pungent, hardship, and treatment deficiency-cold in spleen and stomach, stomach Qi upward reversal, shortage appetite, underbelly are twitched, pain；
Also there is degrading the channel, analgesic, warming spleen and stomach and digestion promoting function simultaneously.
Chinese cassia tree：Pungent, sweet, big heat returns kidney, spleen, the heart, Liver Channel；With mends fire supporing yang, let the fire back to its origin, eliminating cold to stop pain, promoting blood circulation is logical
Effect of warp；Cassia oil has powerful bactericidal action simultaneously, and the effect to Gram's staining is better than negative patient, and external application may be used also
Treatment stomachache, flatulence angina.
In one's early teens：It is pungent, temperature.Warming spleen and stomach for dispelling cold, promoting qi circulation and relieving pain is drying damp and strengthening spleen；Control trusted subordinate's crymodynia, feeling of fullness food stagnation, dysphagia and regurgitation,
Cold-dampness is vomited and diarrhoea, phlegm and retained fluid accumulation.
Bi is dialled：Warming spleen and stomach for dispelling cold, the analgesic of lower gas；Bi dials contained volatile oil to staphylococcus aureus, hay bacillus, waxy
Bacillus, tubercle bacillus, shigella dysenteriae, salmonella typhi T and B, yolk color eight folds bacterium etc. and influenza virus suppression
Effect.
The root of Dahurain angelica：With having obvious refrigeration function, spasmolysis, antibacterial action；The root of Dahurain angelica to Escherichia coli, shigella dysenteriae,
Proteus, typhoid bacillus, paratyphosum Bacterium, Pseudomonas aeruginosa, comma bacillus, Bacillus tuberculosis etc. have inhibitory action.
The root of herbaceous peony：Adjust body immune system；The root of herbaceous peony has protective effect to liver, has inhibitory action to gastric secretion；Chinese herbaceous peony
Glucoside has significant analgesic effect；The root of herbaceous peony has bacteriostasis to Shigella shigae, also has suppression to make some pathogenic funguses
With.
Pepper：Middle benefit gas, lower gas, dissolving phlegm, removing toxic substances.Cold phlegm dyspepsia is controlled, clear water, diarrhea, cold dysentery are vomitted in coldness and pain in the epigastrium, gastric disorder causing nausea.
Fennel seeds：With antiulcer action, choleretic effect, fennel seeds can promote choleresis, and make bile solid composition
Increase.
The dried immature fruit of citron orange：Stomach excess specially is let out, hard knot is convinced by patient analysis, therefore the main middle part of gastric cavity, to control blood system, treating the interventral reality of navel expires, and dissolving phlegm addiction is dispelled and cut off the water, by
Place is eaten, and breaks accumulation of pathogens in chest, and defaecation is closed.
Nm：Pungent-warm and it is puckery, enter middle Jiao, can warming spleen and stomach, solid large intestine, antidiarrheal dysentery, for the key medicine for the treatment of deficient cold type rush down dysentery；
Stomach cold distending pain, deficiency of food vomiting.Pungent fragrant temperate-dryness, can middle benefit gas reason spleen, promoting qi circulation and relieving pain；Control the stomach cold stagnation of the circulation of vital energy, abdominal distention, deficiency of food vomiting etc.
Card.
The bark of official magnolia：Meridian distribution of property and flavor, hardship, pungent, temperature, returns spleen, stomach, lung, middle benefit gas, lower gas, eliminating dampness, dissolving phlegm, control chest and abdomen feeling of fullness distending pain,
Gastric disorder causing nausea, vomiting, place food do not disappear, cold-dampness rush down dysentery；The bark of official magnolia has resisting pathogenic microbes effect, and the bark of official magnolia is to staphylococcus, hemolytic chain
The gram positive bacterias such as coccus, pneumococcus, Bordetella pertussis and bacillus anthracis, shigella dysenteriae, typhoid bacillus, paratyphosum Bacterium,
The gram negative bacillis such as comma bacillus, Escherichia coli, proteus, hay bacillus have antibacterial action；The bark of official magnolia is to violet hair tinea
The dermatophytes such as bacterium, Trichophyton concentricum, Trichophyton rubrum have inhibitory action.
Honey-fried licorice root：It is clearing heat and detoxicating with invigorating the spleen and benefiting qi, expelling phlegm and arresting coughing, relieving spasm to stop pain, effect of coordinating the drug actions of a prescription.For spleen
Stomach is weak, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviates drug toxicity, strong
Property.
Ginseng：With reinforcing vital energy, prevent prolapse and engender liquid is calmed the nerves.Control internal lesion caused by overexertion deficient, deficiency of food, burnout, regurgitation and emesis, stool is slided
Let out, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, palpitate with fear, forgetful, dizziness and headache, impotence, frequent micturition is quenched one's thirst, woman uterine bleeding, infantile chronic fright, and long
It is empty not multiple, the card of all qi-blood-body fluid deficiencies；Ginseng can also adjust central nervous system, improve the excitement of brain with suppressing
Journey, is allowed to tend to balance；The mental ability with manual labor can be improved, operating efficiency is improved, and play the role of antifatigue.
Cloves:Middle benefit gas warms up kidney and drops inverse, and caryophyllus oil is contained in cloves, there is the effect such as local anaesthesia, analgesia.
Rhizoma zingiberis：With warming spleen and stomach for dispelling cold, Back to Yang Tongmai, the effect of eliminating dampness dissolving phlegm；Rhizoma zingiberis adds to stress ulcer, Indomethacin
Alcohol repellency, salt acidic and ligation pylorus gastric ulcer has obvious inhibiting effect；Rhizoma zingiberis volatile oil containing armaticity, has to alimentary canal
Slight stimulation is acted on, and can make intestines tension force, the rhythm and pace of moving things and enhancing of wriggling, so as to promote the digestive function of stomach and intestine.
As described above, the principle pathological mechanism of abdominal distension abdomen pain is cold-evil's internal resistance, cold obstruction causing qi stagnation, the middle empty cold syndrome in infant, eating accumulation.
Selected above-mentioned evodia rutaecarpa of the invention, pepper, rhizoma zingiberis, the taste Chinese medicine of fennel seeds four are monarch drug in a prescription, for treating deficiency-cold in spleen and stomach, stomach Qi
Inverse, abdominal distension abdomen pain, warm taste, stomach strengthening and digestion promoting, dispelling cold and removing dampness, dissipating bind of cooling down promotes choleresis, the motion of regulation stomach, raising
The digestive function of stomach and intestine；Bi dial warming spleen and stomach for dispelling cold, cloves middle benefit gas warm up kidney and drop inverse, and nutmeg is controlled the stomach cold stagnation of the circulation of vital energy, abdominal distention, deficiency of food and vomitted
Tell, the root of herbaceous peony has inhibitory action to gastric secretion, Paeoniflorin has significant analgesic effect, root of Dahurain angelica middle benefit gas promoting the circulation of qi, relieving spasm to stop pain, Pork and beans
The cool, root of herbaceous peony, the root of Dahurain angelica and Bi are dialled, cloves is ministerial drug altogether, and principal drug assistance builds middle-jiao yang, function of the spleen and stomach, and dispelling cold and removing dampness, warm kidney drop are inverse, Gu large intestine, dissipates inverse gas,
Analgesia, analgesic, which are put down, vomits, further the motion of regulation stomach, improves the digestive function of stomach and intestine, elimination abdominal distension abdomen pain；Trusted subordinate is controlled in one's early teens
Crymodynia, feeling of fullness food stagnation, dysphagia and regurgitation, the dried immature fruit of citron orange specially let out stomach excess, convince hard knot by patient analysis, and in one's early teens, principal drug assistance regulation stomach is moved the dried immature fruit of citron orange altogether,
Stomach strengthening and digestion promoting, improves the digestive function of stomach and intestine；The bark of official magnolia controls chest and abdomen feeling of fullness distending pain, cold-dampness rush down dysentery and helps the solid large intestine of ministerial drug, dissipates inverse gas, only
Pain is flat to vomit；Chinese cassia tree eliminating cold to stop pain, invigorate blood circulation, honey-fried licorice root has the effect for relieving spasm to stop pain of invigorating the spleen and benefiting qi, effect of coordinating the drug actions of a prescription, people
Ginseng have reinforce vital energy, adjust central nervous system, antifatigue effect；Chinese cassia tree, honey-fried licorice root, people participate in all medicines share and carried jointly
The immunocompetence of high human body, further improves the physiological function of human body, and up to warming middle-Jiao and tonifying deficiency, eliminating cold to stop pain, invigorate blood circulation, strengthening the essence are supported
Gas, dispelling cold and removing dampness, dissipating bind of cooling down, warming spleen and stomach, stomach strengthening and digestion promoting improve the digestive function of stomach and intestine, and treatment infantile abdominal distension abdomen pain takes effect
Hurry up, evident in efficacy, cure rate it is high.
3rd, observation of curative effect method of the present invention
In research process of the present invention, all from our hospital's traditional chinese medical science clinic outpatients, all infantile abdominal distension stomachache patients,
120 patients, the wherein people of male patient 79, the people of women 41, between 2-8 years old ages are screened altogether.The course of disease is in ratio in March-half, by just
The following treatment groups being successively divided into, two groups of patients of control group are examined in infant clinical manifestation and sex, age, the course of disease state of an illness, conjunction
And there was no significant difference for the contrast of the basic document such as disease, with comparativity, (p>0.05)
Treatment method,
Treatment group：Children's SHENQUE acupoint, ZHONGWAN acupoint are pasted on using patch of the present invention 6-8 hours, typically once a day, even
With five days；
Control group：Oral 1/3 ball of Fuzi Lizhong Wan 2-4 Sui, 2 times |/day；5-7 Sui 1/2 ball, 2 times |/day；More than 8 years old 1
Ball/time, 2 times |/day.
Criterion of therapeutical effect compares
Therapeutic effect comparison table one after treatment group, control group treatment
Effective 42 for the treatment of group in table one, effective 13, invalid 5, total effective rate 93.33%；Effective 25 of control group,
Effective 18, invalid 17, total effective rate 71.67%；Two groups are compared, and obvious effective rate has statistics meaning with total effective rate comparing difference
Justice (P<0.05).Treatment group's obvious effective rate, efficient and total effective rate, which are can be seen that, from the data of above table is superior to control
Group.
Medical record is illustrated
1st, patient Zhang, man 3 years old, suffers from abdominal pain 1 year half because of paroxysmal and aggravated 3 days, application cephalo, VcVb groups treatment 6 outside
My god, curative effect is not substantially and to examine.When medical, infant abdominal distension, suffer from abdominal pain, receive it is poor, without vomiting and diarrhoea.Have a medical check-up：Infant abdominal distension, kowtows drum, navel week
Tenderness, abdominal B-scan ultrasonography city：Mesenteric adenophyma is big, blood routine WBC6.1 × 109/ L, N%78.1%.This patch of external application, one day
Once, it is each 4-6 hours, it is used in conjunction five, infant abdominal distension disappears, feed improves, follow-up January is without recurrence.
2nd, patient Liu so-and-so, female, 6 years old, because paroxysmal is suffered from abdominal pain 2 months, 6 days causes were suffered from cold postemphasis, and oral corydalis tuber stops outside
Pain piece, treats 3 days DeGrains, to examine.When medical, infant stomachache, no diarrhoea, no vomiting, no heating.Have a medical check-up：Abdomen is slightly swollen,
Drum is kowtowed, without obvious tenderness.Abdomen is had an X-rayed：Enteric cavity flatulence is obvious.This patch is given, once a day, Shenque, Guanyuan point is affixed on, every time
4-6 hours, it is used in conjunction 3, infant abdominal pain and distension disappears, follow-up January is without recurrence.
Present invention has the advantages that：Chinese medicine that the present invention is selected can wet middle cold dispelling, warming middle-Jiao and tonifying deficiency and inner emergency, help digestion and lead
It is stagnant.By external application, i.e. percutaneous drug delivery, the intrinsic defect of children's traditional Chinese medicine for oral administration is overcome, treatment infantile abdominal distension abdomen pain, which has, to take effect
It hurry up, the characteristics of evident in efficacy, cure rate is high；But also preparation method is simple, medicine is easy to use, particularly to pediatric pharmaceuticalses more
Plus conveniently；It is currently a kind of newtype drug for treating abdominal distension abdomen pain.
Embodiment
The specific embodiment of the invention is：
Embodiment 1,
A, weigh 10 grams of evodia rutaecarpa, 10 grams of Chinese cassia tree, 20 grams in one's early teens, finish pull out 14 grams, 10 grams of the root of Dahurain angelica, 10 grams of the root of herbaceous peony, pepper
15 grams, 10 grams of fennel seeds, 10 grams of the dried immature fruit of citron orange, 15 grams of nutmeg, 5 grams of the bark of official magnolia, 9 grams of honey-fried licorice root, 6 grams of ginseng, 12 grams of cloves, rhizoma zingiberis 6
It is gram standby；
B, each bulk drug mixing that step A is prepared fried with slow fire to micro- Jiao, it is cool after to smash 100 mesh sieves standby；
C, the medicinal powder 4-5g for taking step B to cross 100 mesh sieves every time when using, and reconciled with vinegar or ginger juice and be made as medicine cake.
The medicine cake that the present invention is made is pasted on SHENQUE acupoint, ZHONGWAN acupoint 6-8 hours, once a day, is used in conjunction 3-5 days.
Embodiment 2
A, weigh 12 grams of evodia rutaecarpa, 12 grams of Chinese cassia tree, 15 grams in one's early teens, finish pull out 13 grams, 13 grams of the root of Dahurain angelica, 10 grams of the root of herbaceous peony, pepper
14 grams, 14 grams of fennel seeds, 13 grams of the dried immature fruit of citron orange, 13 grams of nutmeg, 6 grams of the bark of official magnolia, 6 grams of honey-fried licorice root, 5 grams of ginseng, 10 grams of cloves, rhizoma zingiberis 8
It is gram standby；Remaining step is same as Example 1.
Embodiment 3
A, weigh 15 grams of evodia rutaecarpa, 15 grams of Chinese cassia tree, 10 grams in one's early teens, finish pull out 10 grams, 15 grams of the root of Dahurain angelica, 12 grams of the root of herbaceous peony, pepper
10 grams, 15 grams of fennel seeds, 15 grams of the dried immature fruit of citron orange, 10 grams of nutmeg, 10 grams of the bark of official magnolia, 3 grams of honey-fried licorice root, 3 grams of ginseng, 9 grams of cloves, rhizoma zingiberis 9
It is gram standby；Remaining step is same as Example 1.
Claims (4)
1. a kind of medicine for treating infantile abdominal distension abdomen pain, it is characterized in that, the raw material matched by following portions by weight is made：Evodia rutaecarpa
10-15, Chinese cassia tree 10-15, in one's early teens 10-20, finish pull out 10-15, root of Dahurain angelica 10-15, it is root of herbaceous peony 10-12, pepper 10-15, small
It is fennel 10-15, the dried immature fruit of citron orange 10-15, nutmeg 10-15, the bark of official magnolia 5-10, honey-fried licorice root 3-9, ginseng 3-6, cloves 9-12, dry
Ginger 6-9.
2. a kind of according to claim 1 treat the medicine that infantile abdominal distension abdomen aches, it is characterized in that, matched by following portions by weight
Raw material be made：Evodia rutaecarpa 12, Chinese cassia tree 12, in one's early teens 15, finish and pull out the 13, root of Dahurain angelica 13, the root of herbaceous peony 10, pepper 14, fennel seeds 14, the dried immature fruit of citron orange
13rd, nutmeg 13, the bark of official magnolia 6, honey-fried licorice root 6, ginseng 5, cloves 10, rhizoma zingiberis 8.
3. a kind of medicine for treating infantile abdominal distension abdomen pain according to claim 1 or 2, it is characterised in that：The medicine
Preparation formulation is patch.
4. a kind of preparation method of medicine for treating infantile abdominal distension abdomen pain as claimed in claim 3, it is characterized in that：The patch
Preparation method, comprise the steps：
A, by above-mentioned raw materials medicine parts by weight proportioning weigh respectively：Evodia rutaecarpa, Chinese cassia tree, in one's early teens, finish pull out, the root of Dahurain angelica, the root of herbaceous peony, Hu
Green pepper, fennel seeds, the dried immature fruit of citron orange, nutmeg, the bark of official magnolia, honey-fried licorice root, ginseng, cloves, rhizoma zingiberis are standby；
B, each bulk drug mixing that step A is prepared fried with slow fire to micro- Jiao, it is cool after to smash 100 mesh sieves standby；
C, the medicinal powder 4-5g for taking step B to cross 100 mesh sieves every time when using, and reconciled with vinegar or ginger juice and be made as medicine cake.
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| CN109481654A (en) * | 2018-11-09 | 2019-03-19 | 刘中利 | A kind of preparation method of navel-warming plaster patch |
| CN110314185A (en) * | 2019-08-12 | 2019-10-11 | 含山县中医医院 | A kind of preparation method of warm nature abdominal pain in children navel paster |
| CN111529672B (en) * | 2020-05-26 | 2022-03-04 | 驻马店市淘儿宁药械有限公司 | A Chinese medicinal navel patch for treating infantile diseases via navel part, and its preparation method |
| CN116509824B (en) * | 2023-06-28 | 2023-09-15 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine gel and preparation process thereof |
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