CN103893731A - Traditional Chinese medicine for treating esophagus cancer, gastric cancer, liver cancer and brain tumor and preparation method thereof - Google Patents
Traditional Chinese medicine for treating esophagus cancer, gastric cancer, liver cancer and brain tumor and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine for treating esophagus cancer, gastric cancer, liver cancer and brain tumor. The traditional Chinese medicine is characterized by being prepared from the following Chinese medicinal materials in parts by weight: 35-150 parts of common monkshood root, 8-35 parts of tatarian aster root, 8-35 parts of Chinese thorowax root, 8-35 parts of grassleaf sweelflag rhizome, 8-35 parts of officinal magnolia bark, 8-35 parts of platycodon root, 8-35 parts of Chinese honey locust fruit, 8-35 parts of medicinal evodia fruit, 8-35 parts of dried ginger, 8-35 parts of coptis root, 8-35 parts of ginseng, 8-35 parts of white poria, 8-35 parts of cassia bark, 8-35 parts of croton seed and 8-35 parts of fructus zanthoxyli. The invention further discloses a preparation method of the traditional Chinese medicine. The method comprises the following steps: preparing weighted Chinese medicinal materials into mixed Chinese medicinal powder; mixing the mixed Chinese medicinal powder with honey to obtain pills. The Chinese medicinal composition has the characteristics of small side effects and prevention of relapse after healing.
Description
Technical field
The invention belongs to Chinese medicine composition and preparation method thereof technical field, relate to a kind of Chinese medicine for the treatment of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor, the invention still further relates to the preparation method of above-mentioned Chinese medicine.
Background technology
The esophageal carcinoma is the malignant tumor that is primary in mucous membrane of esophagus epithelium or body of gland, is positioned at hypopharynx between esophagus-stomach joint portion.The esophageal carcinoma belongs to the cardiac spasm disease category of Chinese medicine.Dysphagic is with dysphagia, and diet is hampered by esophagus, inappetence, or eat the disease of telling as primary symptom.Choking is dysphagia, refers to swallow not smooth or difficult.Diaphragm is that lattice are refused, and refers to inappetence, or eats and tell.Choke and can occur separately, also can be before diaphragm and drive, but clinical how dysphagic and see.How becoming estranged because of feelings will, injury due to diet, gets old and weak, zang-fu disharmony, so that Tianjin blood depletion is withered, and QI and blood phlegm accumulating with stagnant blood filling chest and diaphragm, hinders in esophagus and forms.China is Incidence of esophageal cancer and the highest country of mortality rate in the world, and approximately there is 53.8% patient with esophageal carcinoma in the whole world in China according to estimates, and the esophageal carcinoma accounts for 22.4% of malignant tumor, is only second to gastric cancer.Gastric cancer refers to the malignant tumor that is primary in gastric epithelial.The traditional Chinese medical science thinks that gastric cancer belongs to regurgitation, and regurgitation is dysphagic, and gastric abscess, gathers, the sick category such as fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times.Choke and be equivalent to esophagus, diaphragm is equivalent to stomach.Ming Dynasty Zhang Zhongjing is thought yang deficiency, and depressed is the main pathogenesis of gastric cancer, and yang deficiency refers to Deficiency and coldness of spleen and stomach, and transporting is lost strong, raw in phlegm-damp, the depressed qi depression to blood stasis that refers to, and the expectorant resistance network that becomes silted up, is into tumor piece then.Gastric cancer is one of modal tumor in the world, occupies the second of global cancer mortality reason, and the sickness rate of China is Hesperian several times.China's gastric cancer accounts for 42% of whole world patients with gastric cancer number, is the second country occurred frequently in the world.In China, the sickness rate of gastric cancer and mortality rate all occupy first of various malignant tumor, and sickness rate accounts for 10.5% of whole tumors, occupy first of digestive tract tumor, have every year 170000 people to die from gastric cancer.Primary hepatocarcinoma is the malignant tumor that is primary in hepatocyte or stones in intrahepatic bile duct cell.Hepatocarcinoma is equivalent to the liver rump of Chinese medicine, and jaundice is gathered, hypochondriac pain, the sick category such as tympanites.Hepatocarcinoma is one of common malignant tumor of the mankind, and sickness rate occupies the 6th, the whole world, and annual neopathy rate is 500,000～1,000,000.China's hepatocarcinoma accounts for the over half of whole world hepatocarcinoma, is mainly that the case that forms with hepatitis B development is in the majority.China is hepatitis B and primary hepatocarcinoma big country, approximately has 1.2 hundred million people's hepatitis b virus infections, and hepatitis b surface antigen positive, wherein approximately has 3,000 ten thousand for chronic hepatitis B patient.China's primary hepatocarcinoma accounts for 45%～55% of global patient's total number of persons, and annual 32.2 ten thousand～34.7 ten thousand people are ill, serious threat people ' s health and life.The cerebral tumor refers to the tumor that is primary in cerebral tissue.Whole world sickness rate is male 3.7 ten thousand～100,000, women 2.6 ten thousand～100,000, and the sickness rate of nearly 20 years is in rising trend, and primary brain tumors accounts for 1.5%～3% of general tumour sickness rate, and this disease coincidence in child is higher, is only second to leukemia and occupies second.In the cerebral tumor, 60% is cerebral glioma, annual neopathy 100,000 example left and right.
Also be used for the treatment of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor without specific drug at present, early stage patient adopts operative treatment, and expense is higher, and the survival rate of postoperative 5 years is lower, easily morbidity repeatedly, symptom further increases the weight of after being ill, and even a large amount of cancer cell metastasis are to the heart, liver, spleen, lung, the organs such as kidney.
Can treat in the market Chinese patent medicine and the Western medicine few of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor, clothes after poor effect, the object that not reaching effects a permanent cure takes stopgap measures, thus still taking operation and chemotherapy as main, early operation can also be controlled symptom, and middle and advanced stage Surgical Significance is little; In addition, after operation, cancerous cell also can continued growth, can not thoroughly kill cancerous cell, and operation has its limitation and adaptability.Chemotherapy also can only temporarily allow the state of an illness take a favorable turn, and can not nurse one's health the vital organs of the human body, from radical cure.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine for the treatment of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor, there is side effect little and control the feature of rear difficult recurrence.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine.
The first technical scheme of the present invention is that the Chinese medicine of the treatment esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor, is made up of following Chinese crude drug:
35 parts～150 parts of Radix Aconitis, 8 parts～35 parts of Radix Asteriss, 8 parts～35 parts of Radix Bupleuri, 8 parts～35 parts of Rhizoma Acori Graminei, 8 parts～35 parts of Cortex Magnoliae Officinalis, 8 parts～35 parts of Radix Platycodoniss, 8 parts～35 parts of Fructus Gleditsia, 8 parts～35 parts of Fructus Evodiaes, 8 parts～35 parts of Rhizoma Zingiberiss, 8 parts～35 parts of Rhizoma Coptidis, 8 parts～35 parts of Radix Ginsengs, 8 parts～35 parts of Porias, 8 parts～35 parts of Cortex Cinnamomis, 8 parts～35 parts of Fructus Crotonis, 8 parts～35 parts of Pericarpium Zanthoxylis.
The second technical scheme of the present invention is, the preparation method of the Chinese medicine of the treatment esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor is specifically implemented according to following steps:
Step 1, take medical material:
35 parts～150 parts of Radix Aconitis, 8 parts～35 parts of Radix Asteriss, 8 parts～35 parts of Radix Bupleuri, 8 parts～35 parts of Rhizoma Acori Graminei, 8 parts～35 parts of Cortex Magnoliae Officinalis, 8 parts～35 parts of Radix Platycodoniss, 8 parts～35 parts of Fructus Gleditsia, 8 parts～35 parts of Fructus Evodiaes, 8 parts～35 parts of Rhizoma Zingiberiss, 8 parts～35 parts of Rhizoma Coptidis, 8 parts～35 parts of Radix Ginsengs, 8 parts～35 parts of Porias, 8 parts～35 parts of Cortex Cinnamomis, 8 parts～35 parts of Fructus Crotonis, 8 parts～35 parts of Pericarpium Zanthoxylis;
Step 2, respectively the Radix Aconiti taking in step 1, Radix Asteris, Radix Bupleuri, Cortex Magnoliae Officinalis, Fructus Gleditsia, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Fructus Evodiae and Fructus Crotonis are concocted;
Step 3, prepare the Chinese medicine of the treatment esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor.
The feature of the second technical scheme of the present invention is also:
Step 2 is specifically implemented according to following steps:
The Fructus Crotonis taking in step 1 is removed the peel to film, the heart successively, then the Fructus Crotonis of peeling film, the heart is stirred fry in oil, obtain the Fructus Crotonis after stirring fry in oil, after then the Fructus Crotonis after stirring fry in oil being dried, pulverize, obtain Fructus Crotonis fine powder;
The Radix Aconiti taking in step 1 is immersed in water, removes the skin umbilicus of Radix Aconiti;
The Radix Asteris taking in step 1 is removed to reed head and leaf;
The Radix Bupleuri taking in step 1 is removed to reed head;
By the Cortex Magnoliae Officinalis peeling, the processed with Rhizoma Zingiberis Recens that take in step 1;
By the Fructus Gleditsia peeling, son, the stir-fry that take in step 1;
The Cortex Cinnamomi taking in step 1 is removed to rough bark;
The Pericarpium Zanthoxyli taking in step 1 is removed to Semen zanthoxyli, and the person of remaining silent, micro-stir-fry, removes antiperspirant;
The Rhizoma Zingiberis taking in step 1 is soaked;
The Fructus Evodiae taking in step 1 is first put into hot water and wash, and then fish for out parch.
In step 2, the size of Fructus Crotonis fine powder is 125um～180um.
Step 3 is specifically implemented according to following steps:
Step 3.1, the Rhizoma Acori Graminei taking in the Radix Aconiti after step 2 is concocted, Radix Asteris, Radix Bupleuri, Cortex Magnoliae Officinalis, Fructus Gleditsia, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Fructus Evodiae and step 1, Radix Platycodonis, Rhizoma Coptidis, Radix Ginseng, Poria are amounted to 14 taste medical materials independent oven dry respectively, pulverize respectively again, obtain 14 kinds of independently Chinese medicine fine powders;
Step 3.2, the Fructus Crotonis fine powder obtaining in step 2 and 14 kinds of Chinese medicine fine powders obtaining through step 3.1 are mixed, after stirring, form and mix Chinese medicine powder;
Step 3.3, in mass ratio for 1:(0.36～1.3) take respectively mixing Chinese medicine powder, refined honey that step 3.2 obtains;
Step 3.4, make pellet after the mixing Chinese medicine powder taking in step 3.3 is mixed with refined honey, then the pellet of making is dried to the Chinese medicine of the esophageal carcinoma that obtains medical treatment, gastric cancer, hepatocarcinoma and the cerebral tumor.
14 kinds of Chinese medicine fine powders that obtain through step 3.1, the particle diameter of every kind of Chinese medicine fine powder is 125um～180um.
The invention has the beneficial effects as follows:
(1) Chinese medicine of the present invention by clinical verification repeatedly, has determined curative effect, effective, rapid-action, side effect is little, taking convenience, do not perform an operation, treating both the principal and secondary aspects of a disease and control after the feature such as do not recur.
(2) Chinese medicine of the present invention is through clinical verification for many years, can treating the poisonous disease with poisonous drugs, and hard masses softening and resolving, strengthening vital QI to eliminate pathogenic factors, blood circulation promoting and blood stasis dispelling, soothing liver and strengthening spleen, regulates the flow of vital energy that it is stagnant to disappear, and reduces phlegm except drink, and promoting diuresis to clear away damp pathogen, reaches the conditioning vital organs of the human body, equilibrium between yin and yang, the effect that having effects a permanent cure takes stopgap measures.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in detail.
The present invention treats the Chinese medicine of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor, is made up of following Chinese crude drug:
35 parts～150 parts of Radix Aconitis, 8 parts～35 parts of Radix Asteriss, 8 parts～35 parts of Radix Bupleuri, 8 parts～35 parts of Rhizoma Acori Graminei, 8 parts～35 parts of Cortex Magnoliae Officinalis, 8 parts～35 parts of Radix Platycodoniss, 8 parts～35 parts of Fructus Gleditsia, 8 parts～35 parts of Fructus Evodiaes, 8 parts～35 parts of Rhizoma Zingiberiss, 8 parts～35 parts of Rhizoma Coptidis, 8 parts～35 parts of Radix Ginsengs, 8 parts～35 parts of Porias, 8 parts～35 parts of Cortex Cinnamomis, 8 parts～35 parts of Fructus Crotonis, 8 parts～35 parts of Pericarpium Zanthoxylis.
The present invention treats each medical material in the Chinese medicine of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor and is preferably:
75 parts of Radix Aconitis, 15 parts of Radix Asteriss, 15 parts of Radix Bupleuri, 15 parts of Rhizoma Acori Graminei, 15 parts of Cortex Magnoliae Officinalis, 15 parts of Radix Platycodoniss, 15 parts of Fructus Gleditsia, 15 parts of Fructus Evodiaes, 15 parts of Rhizoma Zingiberiss, 15 parts of Rhizoma Coptidis, 15 parts of Radix Ginsengs, 15 parts of Porias, 15 parts of Cortex Cinnamomis, 15 parts of Fructus Crotonis, 15 parts of Pericarpium Zanthoxylis.
The property of medicine and the function of the each Chinese crude drug one, adopting in the present invention cure mainly:
Radix Aconiti: belong to medicine for rheumatism; Hot in nature; Acrid in the mouth, hardship; Very toxic, GUIXIN, liver,kidney,spleen warp; Eliminating cold-damp, loose ailment said due to cold or exposure, inducing menstruation to relieve menalgia; Being used for the treatment of anemofrigid-damp arthralgia, joint pain, spasm of the limbs, hemiplegia, wind syndrome of head headache, trusted subordinate's cold type of pain and carbuncle of yin nature swells and ache.
Radix Asteris: belong to medicine for the treatment of cough and asthma; Warm in nature; Acrid in the mouth, hardship; Return lung meridian; Can nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm, ehrlich carcinoma is had to antitumaous effect.
Radix Bupleuri: belong to pungent and cold medicine for relieving the exterior syndrome; Cold nature; Bitter in the mouth; Return liver and gall warp; Can dispelling wind bring down a fever, soothing liver-QI yang invigorating, saikoside has adjusting immunologic function, can suppress generation, the development of tumor, has stronger anti-tumor activity.
Cortex Magnoliae Officinalis: belong to aromatic damp resolving drug; Warm in nature; Bitter in the mouth, pungent; Return spleen, stomach, lung, large intestine channel, dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full; Can be used in removing dampness intestinal stasis relieving, row warm in nature loose, can be except the stagnation of QI, dry spleen damp in stomach, controlling the wet gastral cavity of QI stagnating in middle-JIAO due to unfavorable of consolidating and having one's mind filled with the diseases such as swollen stomachache.
Rhizoma Acori Graminei: belong to reduce phlegm, softening the hard mass, eliminating stagnation medicine; Warm in nature; Acrid in the mouth, hardship, GUIXIN, stomach warp; Energy waking up the patient from unconsciousness by dissipating phlegm, allay excitement beneficial will, removing dampness to restore normal function of the stomach; Clinically for nervous system neoplasms, malignant lymphoma, digestive tract tumor and the cerebral tumor etc.; Confirm through experiment in vitro: have the effect of killing ascitic type cancerous cell; Zoopery also proves that it has active anticancer.
Radix Platycodonis: belong to medicine for the treatment of cough and asthma; Property is put down; Acrid in the mouth, hardship, return spleen channel, lung qi dispersing; There is sore-throat relieving, eliminate the phlegm and evacuation of pus effect; For cough, abundant expectoration, not smooth and pharyngalgia uncomfortable in chest, there are gastric acid secretion inhibiting and antiulcer action, also have antiinflammatory, antitumaous effect, to hepatocarcinoma, Growth of Gastric has obvious inhibitory action.
Fructus Gleditsia: warm in nature; Acrid in the mouth, salty, returns lung meridian, and large intestine channel is slightly poisonous; Dispel the wind expectorant, except noxious dampness, have one's ideas straightened out logical close, parasite killing eliminating stagnation; Be used for the treatment of apoplexy locked mouth, expectorant prolong stop up contain, coma in silence, waist foot wind pain, wind syndrome of head, headache and apoplexy facial hemiparalysis; The total extractum of Fructus Gleditsia has effect anticancer and inhibition tumor.
Fructus Evodiae: belong to medicine for warming up the interior and relieving the cold; Acrid in the mouth, hardship; Slightly poisonous, enter liver, stomach, spleen, kidney channel; Stopping nausea and vomiting by lowering the adverse flow of QI, warming middle-JIAO to relieve pain, parasite killing; At the clinical Deficiency and coldness of spleen and stomach for gastroenteric tumor, phlegm resistance disease and headache due to JUE YIN disorder etc.; The alkaloid extracting in Fructus Evodiae has obvious anti-invasion and metastasis effect, and melanoma cell, human leukemia cell, cervical cancer cell and prostate gland cancer cell are all had to inhibitory action.
Rhizoma Coptidis: belong to heat clearing and fire purging medicine; Cold in nature; Bitter in the mouth; GUIXIN, spleen, stomach, liver, gallbladder, energy heat clearing and damp drying, eliminating fire and detoxication; Be usually used in malignant tumor of mouth, digestive system tumor, as: the evil type tumors such as the esophageal carcinoma, gastric cancer, hepatocarcinoma and colon cancer; Also be usually used in the diseases such as the heating, infection, diarrhoea of tumor patient; Rhizoma Coptidis can anticancer nucleic acid synthetic, berberine can the growth to tumor by number of mechanisms, propagation produces inhibitory action, and promotes the apoptosis of tumor cell, performance antitumor action.
Radix Ginseng: belong to tonic; Warm in nature; Sweet in the mouth, micro-hardship; Return spleen, lung, heart channel, strongly invigorating primordial QI; Can answer that arteries and veins is admittedly de-, invigorating the spleen and replenishing QI, promote the production of body fluid, calm the nerves; For the empty gas weak person of cancer body, the internal organs infringements such as treatment tumor patient is hemorrhage, bone marrow depression, cardiopulmonary Liver and kidney; Be widely used in the kinds of tumors such as hepatocarcinoma, gastric cancer, the esophageal carcinoma, pulmonary carcinoma; Treat large hemoptysis, bone marrow depression, leukopenia, hepatocarcinoma; Energy enhancing human body immunity power, has inhibitory action to some transplanted tumor.
Poria: belong to eliminating dampness and diuresis medicine; Property is put down; Sweet in the mouth; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; The clinical kinds of tumors that is used for the treatment of, as: digestive tract, respiratory tract, urinary tract, gynecological tumor and lymphoma, the deficiency-weakness of spleen-QI such as leukemia, the edema of water damp-phlegm Sheng is had loose bowels, and nervous insomnias etc. also can be for conditioning after being ill; Carboxymethyl pachyman has therapeutical effect to malignant tumor such as gastric cancer; Pachyman and other cancer therapy drugs have share potentiation.
Cortex Cinnamomi: belong to medicine for warming up the interior and relieving the cold; Extremely hot in nature; Acrid in the mouth, sweet; Mend fire supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation; Clinical in bone tumor, melanoma, uterus carcinoma etc., also can be used for that bone marrow transplantation after chemotherapy, bone shift and cancerous pain etc.
Fructus Crotonis: belong to purgatives medicine, treating the poisonous disease with poisonous drugs medicine; Hot in nature; Acrid in the mouth; Very toxic, return stomach, large intestine channel; The cold eliminating stagnation of temperature, by the capable water of expectorant; Clinical in the esophageal carcinoma, gastric cancer, hepatocarcinoma, intestinal cancer, advanced carcinoma lymphatic metastasis and cancer ascites etc.; Fructus Crotonis extract, to liver ascites, has obvious inhibitory action, can kill the effect of liver ascites and ehrlich ascites cell; The contained crotonoside of Fructus Crotonis has stronger cancer suppressing action, can tumoricidal microtubule, thus cause the change of plasma membrane popularity and cytoplasmic structure, play antitumaous effect.
Pericarpium Zanthoxyli: belong to medicine for warming up the interior and relieving the cold; Warm in nature; Acrid in the mouth; Return spleen, stomach, kidney channel; Energy warming middle-JIAO to relieve pain and killing parasites for relieving itching; Treatment aversion to wind, extremity insensitive impediment, dispelling cold and removing dampness, stagnation resolving, the dyspepsia that disappears, logical three warmers and warming the spleen stomach; Modern study has strong antibacterial and analgesic activity.
Rhizoma Zingiberis: belong to pungent and warm medicine for relieving the exterior syndrome; Return spleen, stomach, lung, the heart, kidney channel; Induce sweat cold expelling, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, for coldness and pain in the epigastrium, vomiting have loose bowels, cold extremities faint pulse, phlegm retention breath with cough; Gingerol has stimulation to gastric mucosa, and the secretion of energy facilitating digestion liquid, increases appetite, has the enteral abnormal fermentation of inhibition and promotes gas to discharge, and has town to tell effect.
Two, the effect of playing after the each Chinese crude drug adopting in the present invention cooperatively interacts is as follows:
(1) according to theory of Chinese medical science, monarch drug: the medicine that plays therapeutical effect for main disease or primary symptom; Ministerial drug: the medicine that plays primary treatment effect for hold concurrently disease or double disease; Adjuvant drug: implication has three: one, is used for the treatment of the medicine of less important double disease, and the 2nd, eliminate and alleviate the monarch and his subjects' toxicity or strong medicine, the 3rd, need to select the medicine that can work again the effect of coordinating contrary to monarch drug nature and flavor according to the state of an illness; Make medicine: implication has two: one, the through sick institute of the efficacy of a drug that can guiding side's Chinese medicine, the 2nd, interaction that can coordinating the actions of various ingredients in a prescription.In Chinese medicine of the present invention, monarch drug is: Radix Ginseng, Fructus Crotonis; Ministerial drug is: Radix Aconiti, Rhizoma Acori Graminei, Fructus Evodiae, Radix Platycodonis, Poria, Cortex Cinnamomi, Pericarpium Zanthoxyli and Fructus Gleditsia; Adjuvant drug is: Cortex Magnoliae Officinalis, Radix Asteris and Radix Bupleuri; Make medicine be: Rhizoma Coptidis and Rhizoma Zingiberis.
(2) in Chinese medicine of the present invention, by Radix Aconiti dispelling pathogenic wind and eliminating phlegm, the Radix Asteris lung moistening of reducing phlegm, Radix Bupleuri regulates immunologic function, Cortex Magnoliae Officinalis removing dampness intestinal stasis relieving, Rhizoma Acori Graminei resolving phlegm and softening hard masses and eliminating stagnation, the Radix Platycodonis lung qi dispersing that eliminates the phlegm, dispel the wind expectorant and except noxious dampness, Fructus Evodiae warming the interior cold relieving of Fructus Gleditsia, Rhizoma Coptidis clearing away heat-fire, Radix Ginseng invigorating the spleen and replenishing QI, Poria eliminating dampness and diuresis, Cortex Cinnamomi warming the interior cold relieving, Fructus Crotonis rushes down lower treating the poisonous disease with poisonous drugs, Pericarpium Zanthoxyli warming the interior cold relieving, Rhizoma Zingiberis relieving the exterior syndrome with drugs of pungent in flavor and warm in nature.
(3), in Chinese medicine of the present invention, people participates in Poria compatibility can treat the esophageal carcinoma, gastric cancer, hepatocarcinoma and upper gastrointestinal hemorrhage; People participates in Poria, Rhizoma Zingiberis compatibility energy antitumor, strengthens immunologic function.Poria and Cortex Magnoliae Officinalis, the Radix Platycodonis compatibility treatment esophageal carcinoma; Poria and Rhizoma Zingiberis compatibility treatment gastric cancer; Poria and Radix Ginseng, Fructus Gleditsia compatibility treatment gastric cancer, breast carcinoma; Poria and Radix Platycodonis compatibility treatment pulmonary carcinoma.The pain that Cortex Cinnamomi and Rhizoma Zingiberis compatibility treatment neoplasm metastasis cause; Cortex Cinnamomi and Poria compatibility treatment ovarian cancer are suffered from a deficiency of the kidney.Fructus Evodiae and Rhizoma Coptidis, Rhizoma Zingiberis compatibility treatment gastric cancer acid regurgitation; Fructus Evodiae and Radix Ginseng, Poria compatibility treatment gastric cancer.Rhizoma Coptidis and Radix Bupleuri compatibility Hepatoma therapy.Coma epilepsy due to Rhizoma Acori Graminei and Poria compatibility treatment heat attacking the pericardium, gastral cavity painful abdominal mass is not hungry, suppresses digestive tract abnormalities fermentation, alleviates spasm, can kill ascites cells.Fructus Crotonis and Rhizoma Zingiberis compatibility treatment cancerous protuberance are cold long-pending, sphincter disturbance; The effect of Fructus Crotonis and ginseng compatibility's energy eliminating pathogenic factor for supporting vital QI.Radix Bupleuri and Radix Ginseng, Poria, Rhizoma Zingiberis compatibility are used for the treatment of simple gastritis, alternate attack of chill and fever, and costa sternales is bitter full, and vexed vomiting, has antiinflammatory, choleretic effect.Cortex Magnoliae Officinalis and Radix Ginseng, Rhizoma Zingiberis compatibility are for removing dampness intestinal stasis relieving, and Cortex Magnoliae Officinalis row warm in nature is loose can be except the stagnation of QI in stomach, and dry spleen damp is controlled the gastral cavity of wet QI stagnating in middle-JIAO admittedly due to unfavorable and had one's mind filled with the diseases such as swollen, stomachache.Cortex Magnoliae Officinalis and Rhizoma Coptidis compatibility are not healed for a long time for undigested diarrhea, have antiinflammatory, hepatoprotective effect.Pericarpium Zanthoxyli and Rhizoma Zingiberis compatibility are for stomach abdomen cold type of pain, and vomiting is had loose bowels.By the compatibility of scientific and precise, can play treating the poisonous disease with poisonous drugs, hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors, soothing liver and strengthening spleen, regulates the flow of vital energy that it is stagnant to disappear, and reduces phlegm except drink, promoting diuresis to clear away damp pathogen.
After above-mentioned 15 taste Chinese crude drug compatibilities, the collaborative superposition of each taste Chinese crude drug manifests completely, make medicine give full play to greatest treatment efficacy, play treating the poisonous disease with poisonous drugs, hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors, soothing liver and strengthening spleen, regulate the flow of vital energy disappear stagnant, reduce phlegm except drink and promoting diuresis to clear away damp pathogen; The cancerous cell that can thoroughly kill the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor, has and does not perform an operation, treating both the principal and secondary aspects of a disease, and side effect is little, the feature such as after controlling, does not recur.
The present invention treats the preparation method of the Chinese medicine of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor, specifically implements according to following steps:
Step 1, take medical material:
Take respectively by mass percentage following medical material:
35 parts～150 parts of Radix Aconitis, 8 parts～35 parts of Radix Asteriss, 8 parts～35 parts of Radix Bupleuri, 8 parts～35 parts of Rhizoma Acori Graminei, 8 parts～35 parts of Cortex Magnoliae Officinalis, 8 parts～35 parts of Radix Platycodoniss, 8 parts～35 parts of Fructus Gleditsia, 8 parts～35 parts of Fructus Evodiaes, 8 parts～35 parts of Rhizoma Zingiberiss, 8 parts～35 parts of Rhizoma Coptidis, 8 parts～35 parts of Radix Ginsengs, 8 parts～35 parts of Porias, 8 parts～35 parts of Cortex Cinnamomis, 8 parts～35 parts of Fructus Crotonis, 8 parts～35 parts of Pericarpium Zanthoxylis.
Step 2, respectively the Radix Aconiti taking in step 1, Radix Asteris, Radix Bupleuri, Cortex Magnoliae Officinalis, Fructus Gleditsia, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Fructus Evodiae, Fructus Crotonis are concocted, concrete processing procedure is as follows:
The Fructus Crotonis taking in step 1 is removed the peel to film, the heart successively, can reduce toxicity and strengthen antitumor curative effect, the Fructus Crotonis of peeling film, the heart is stirred fry in oil, obtain the Fructus Crotonis after stirring fry in oil, then after the Fructus Crotonis after stirring fry in oil being dried, pulverize, sieve, obtaining size is the Fructus Crotonis fine powder of 125um～180um;
The Radix Aconiti taking in step 1 is immersed in water, removes the skin umbilicus of Radix Aconiti;
The Radix Asteris taking in step 1 is removed to reed head and leaf;
The Radix Bupleuri taking in step 1 is removed to reed head;
By the Cortex Magnoliae Officinalis peeling, the processed with Rhizoma Zingiberis Recens that take in step 1;
By the Fructus Gleditsia peeling, son, the stir-fry that take in step 1;
The Cortex Cinnamomi taking in step 1 is removed to rough bark;
The Pericarpium Zanthoxyli taking in step 1 is removed to Semen zanthoxyli, remove the seed in Pericarpium Zanthoxyli shell, the person of remaining silent, micro-stir-fry, removes antiperspirant (referring to fry out moisture or oil content), can reduce like this its toxicity and strengthen active anticancer;
The Rhizoma Zingiberis taking in step 1 is soaked;
The Fructus Evodiae taking in step 1 is first put into hot water and wash, and then fish for out stir-fry.
Step 3, prepare the Chinese medicine of the treatment esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor:
Step 3.1, the Rhizoma Acori Graminei taking in the Radix Aconiti after step 2 is concocted, Radix Asteris, Radix Bupleuri, Cortex Magnoliae Officinalis, Fructus Gleditsia, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Fructus Evodiae and step 1, Radix Platycodonis, Rhizoma Coptidis, Radix Ginseng, Poria are amounted to 14 taste medical materials independent oven dry respectively, pulverize respectively again, obtain 14 kinds of independently Chinese medicine fine powders, the particle diameter of each Chinese medicine fine powder is 125um～180um(and the Chinese medicine powder of pulverizing can be sieved);
Step 3.2, the Fructus Crotonis fine powder obtaining in step 2 and 14 kinds of Chinese medicine fine powders obtaining through step 3.1 are mixed, after stirring, form and mix Chinese medicine powder;
Step 3.3, take respectively for 1:0.36～1.43 mixing Chinese medicine powder, the refined honey that step 3.2 obtains in mass ratio;
Step 3.4, the mixing Chinese medicine powder taking in step 3.3 is mixed with refined honey after, make pellet, then the pellet made dried, obtain the present invention and treat the Chinese medicine of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor.
The present invention treats the Chinese medicine of the esophageal carcinoma, gastric cancer, hepatocarcinoma, the cerebral tumor except being prepared into pill, can also be prepared into according to the actual requirements powder, decoction, capsule, tablet, sublimed preparation, oral liquid, syrup, sucks agent, granule, electuary, solution, eye drop, injection, cold compress agent, suppository, lozenge, water preparation, after unguentum or spray, pack in bottle packaging warehouse-in into.
The present invention treats in the preparation method of Chinese medicine of the esophageal carcinoma, gastric cancer, hepatocarcinoma, the cerebral tumor, and the object of concocting Part of Chinese Medicinal is as follows:
In order to give full play to the effect of Chinese crude drug treatment disease, and overcome some toxic reaction, ensure safety, reach greatest treatment efficacy, need to be carefully dished up various Chinese crude drugs, although some drugs has good curative effect, but also exist certain Side effect, can reduce or eliminate Side effect by concocting, make to reach after taking set curative effect, be unlikely to have side effects, therefore Chinese medicine composition of the present invention has added the step of concocting in the process of preparation, Radix Aconiti is removed the peel, umbilicus, Radix Asteris removing LU, leaf, Radix Bupleuri removing LU, Cortex Cinnamomi removes rough bark, Cortex Magnoliae Officinalis peeling processed with Rhizoma Zingiberis Recens, Fructus Gleditsia peeling, son, parch, Fructus Crotonis peeling film, the heart, Pericarpium Zanthoxyli removes Semen zanthoxyli, the micro-stir-fry of the person of remaining silent, these are all in order to remove its invalid components or toxic component, retain effective ingredient, thereby make medicine reach greatest treatment efficacy, make in Chinese medicine composition the ratio of each medical material accurate, the main concocting method that uses clean system, Chinese crude drug will be through steeping, wash, process, stir-fry, processed with Rhizoma Zingiberis Recens, dry etc. and to concoct and process after, make the physicochemical property of some drugs produce variation in various degree, some compositions are out dissolved, some compositions are decomposed or change into new composition, all these all can the centering medicine property of medicine and curative effect produce impact in various degree.
Because the Chinese medicine that forms Chinese patent medicine is usually to multiple internal organs, meridians have effect, play a role in order to make medicine concentrate on diseased region, often add the method for adjuvant to concoct, strengthen its effect to diseased region, weaken the effect to irrelevant position, the therapeutical effect of outstanding Chinese patent medicine to main dirty main internal organs.
After Rhizoma Zingiberis in Chinese medicine composition of the present invention is brewed, less pungent and hardship is many, subtract its dry loose it, can walk, can fall apart, can enter blood system, to assist Radix Ginseng tonic to bring into play maximum anti-tumor activity.After Radix Aconiti is brewed, can strengthen the effect of cold-dispelling arthralgia chiefly caused by damp pathogen.After Cortex Magnoliae Officinalis processed with Rhizoma Zingiberis Recens, can reduce dry property, strengthen warming spleen and stomach for dispelling cold, the effect of dampness preventing or arresting vomiting.Fructus Gleditsia makes effective ingredient easily fried after frying, and has strengthened antineoplastic curative effect.After Fructus Crotonis stirs fry in oil, reduce toxicity, strengthen antitumor action.Pericarpium Zanthoxyli reduces its toxicity and zest after frying, and strengthens effect for the treatment of cancer.Fructus Evodiae hot water wash, after stir-fry, reduces its toxicity, relaxes dry property, makes effective ingredient fried, strengthens anticancer therapeutic.Due to a normally medicine multiple-effect of Chinese medicine, in different Chinese patent medicines, the effect that same medicine is required is also different, must concoct medicine wherein, adjusts its property of medicine, brings into play it and is good at.Thereby the process of preparing Chinese medicine can change the lifting of medicine and change the property of medicine.Lifting sink-float is to show the trend of drug effect in the time of body.
Chinese medicine of the present invention is to examine machine at Chinese medical discrimination, establish on the basis of Therapeutic Method, according to side's principle processed of ancient prescription, by selecting suitable medicine, decide suitable dosage, specify the suitable a series of process such as dosage form and usage, last completed treatment trusted subordinate gathers, large as cup, jaundice dyspepsia, vigor vomiting, the full flatulence of limb, constantly abdominal distention, hardness in the epigastrium knot, superiorly rob the heart, be close to and attack both sides of the chest, ten kinds of diseases caused by retention of the body fluids, eight kinds of painful abdominal mass plugs, regurgitation of food from the stomach and tell contrary, diet dysphagia, five kinds of pouring expectorant, nine types of precordial pain, eat the diseases such as indigestion, headache and dizzy and all Zhu Feng for many years.
Chinese medicine of the present invention is also after distinguishing disease, under Therapeutic Principle's guidance, and the therapeutic scheme of drafting for the etiology and pathogenesis of disease.According to theory of Chinese medical science, method for the treatment of is the foundation of use side or prescription, and prescription is the means that embody and verify method for the treatment of.Prescription uses multi-flavor medicine to some disease simultaneously, wherein certainly exists the problem of a compatibility, comprises the whether suitable of flavour of a drug, the number of figure place, the weight of component etc., the curative effect that all directly impact is brought into play the treatment of disease.One, each taste Chinese crude drug combines taking disease as basis, and having is to demonstrate,prove system side; So-called gas has how many, and disease has prosperity and decline, treatments can be classified into mildness and intenseness according to their therapeutic speeds, and there is size side; Its two, the compatibility of concrete each taste Chinese crude drug, is decided by the establishment of method for the treatment of; Its three, system side whether suitable, mainly sees that whether the compatibility of the five tastes appropriate to the property of medicine four gas, as anxious intense nature and taste, slow thin nature and taste, fever and chills and warm and cool, instead from its disease.Traditional Chinese medical science prescription compatibility is particular about mutually collaborative, interacts, and changes the property of medicine thereby counteract each other, and heightens the effect of a treatment and makes it to reach the object for the treatment of Cancerous disease.Medicine only has single effect simply, and after compatibility, the property of medicine changes, and effect changes, and curative effect also changes, and can produce mutual synergism, strengthens therapeutic effect, expands therapeutic domain, adapts to the complicated state of an illness, reduces toxicity.The different concocting methods of medicine and different amounts, also can make curative effect that very large change occurs.
Embodiment 1
35 parts of Radix Aconitis, 8 parts of Radix Asteriss, 8 parts of Radix Bupleuri, 8 parts of Rhizoma Acori Graminei, 8 parts of Cortex Magnoliae Officinalis, 8 parts of Radix Platycodoniss, 8 parts of Fructus Gleditsia, 8 parts of Fructus Evodiaes, 8 parts of Rhizoma Zingiberiss, 8 parts of Rhizoma Coptidis, 8 parts of Radix Ginsengs, 8 parts of Porias, 8 parts of Cortex Cinnamomis, 8 parts of Fructus Crotonis, Pericarpium Zanthoxyli 8.
The Fructus Crotonis taking is removed the peel to film, the heart successively, stir fry in oil, obtain the Fructus Crotonis after stirring fry in oil, after then the Fructus Crotonis after stirring fry in oil being dried, pulverize, obtaining size is the Fructus Crotonis fine powder of 125um; The Radix Aconiti taking is immersed in water, removes the skin umbilicus of Radix Aconiti; The Radix Asteris taking is removed to reed head and leaf; The Radix Bupleuri taking is removed to reed head; By the Cortex Magnoliae Officinalis peeling, the processed with Rhizoma Zingiberis Recens that take; By Fructus Gleditsia peeling, son, stir-fry; The Cortex Cinnamomi taking is removed to rough bark; The Pericarpium Zanthoxyli taking is removed to Semen zanthoxyli, remove the seed in Pericarpium Zanthoxyli shell, the person of remaining silent, micro-stir-fry, removes antiperspirant; The Rhizoma Zingiberis taking is soaked; The Fructus Evodiae taking is first put into hot water and wash, and then fish for out stir-fry;
Radix Aconiti, Radix Asteris, Radix Bupleuri, Cortex Magnoliae Officinalis, Fructus Gleditsia, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Fructus Evodiae after concocting and the Rhizoma Acori Graminei taking, Radix Platycodonis, Rhizoma Coptidis, Radix Ginseng, Poria are amounted to ten four Chinese medicine materials dries respectively, pulverize respectively again, obtain 14 kinds of Chinese medicine fine powders, the particle diameter of each Chinese medicine fine powder is 125um; Fructus Crotonis fine powder and 14 kinds of Chinese medicine fine powders are mixed, after stirring, form and mix Chinese medicine powder; For taking respectively, 1:0.36 mixes Chinese medicine powder, refined honey in mass ratio; After the mixing Chinese medicine powder taking is mixed with refined honey, make pellet, then the pellet made is dried, obtain the present invention and treat the Chinese medicine of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor.
Embodiment 2
75 parts of Radix Aconitis, 15 parts of Radix Asteriss, 15 parts of Radix Bupleuri, 15 parts of Rhizoma Acori Graminei, 15 parts of Cortex Magnoliae Officinalis, 15 parts of Radix Platycodoniss, 15 parts of Fructus Gleditsia, 15 parts of Fructus Evodiaes, 15 parts of Rhizoma Zingiberiss, 15 parts of Rhizoma Coptidis, 15 parts of Radix Ginsengs, 15 parts of Porias, 15 parts of Cortex Cinnamomis, 15 parts of Fructus Crotonis, 15 parts of Pericarpium Zanthoxylis.
The Fructus Crotonis taking is removed the peel to film, the heart successively, stir fry in oil, obtain the Fructus Crotonis after stirring fry in oil, after then the Fructus Crotonis after stirring fry in oil being dried, pulverize, obtaining size is the Fructus Crotonis fine powder of 150um; The Radix Aconiti taking is immersed in water, removes the skin umbilicus of Radix Aconiti; The Radix Asteris taking is removed to reed head and leaf; The Radix Bupleuri taking is removed to reed head; By the Cortex Magnoliae Officinalis peeling, the processed with Rhizoma Zingiberis Recens that take; By Fructus Gleditsia peeling, son, stir-fry; The Cortex Cinnamomi taking is removed to rough bark; The Pericarpium Zanthoxyli taking is removed to Semen zanthoxyli, remove the seed in Pericarpium Zanthoxyli shell, the person of remaining silent, micro-stir-fry, removes antiperspirant; The Rhizoma Zingiberis taking is soaked; The Fructus Evodiae taking is first put into hot water and wash, and then fish for out stir-fry;
Radix Aconiti, Radix Asteris, Radix Bupleuri, Cortex Magnoliae Officinalis, Fructus Gleditsia, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Fructus Evodiae after concocting and the Rhizoma Acori Graminei taking, Radix Platycodonis, Rhizoma Coptidis, Radix Ginseng, Poria are amounted to ten four Chinese medicine materials dries respectively, pulverize respectively again, obtain 14 kinds of Chinese medicine fine powders, the particle diameter of each Chinese medicine fine powder is 150um; Fructus Crotonis fine powder and 14 kinds of Chinese medicine fine powders are mixed, after stirring, form and mix Chinese medicine powder; For taking respectively, 1:1 mixes Chinese medicine powder, refined honey in mass ratio; After the mixing Chinese medicine powder taking is mixed with refined honey, make pellet, then the pellet made is dried, obtain the present invention and treat the Chinese medicine of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor.
Embodiment 3
150 parts of Radix Aconitis, 35 parts of Radix Asteriss, 35 parts of Radix Bupleuri, 35 parts of Rhizoma Acori Graminei, 35 parts of Cortex Magnoliae Officinalis, 35 parts of Radix Platycodoniss, 35 parts of Fructus Gleditsia, 35 parts of Fructus Evodiaes, 35 parts of Rhizoma Zingiberiss, 35 parts of Rhizoma Coptidis, 35 parts of Radix Ginsengs, 35 parts of Porias, 35 parts of Cortex Cinnamomis, 35 parts of Fructus Crotonis, 35 parts of Pericarpium Zanthoxylis.
The Fructus Crotonis taking is removed the peel to film, the heart successively, stir fry in oil, obtain the Fructus Crotonis after stirring fry in oil, after then the Fructus Crotonis after stirring fry in oil being dried, pulverize, obtaining size is the Fructus Crotonis fine powder of 180um; The Radix Aconiti taking is immersed in water, removes the skin umbilicus of Radix Aconiti; The Radix Asteris taking is removed to reed head and leaf; The Radix Bupleuri taking is removed to reed head; By the Cortex Magnoliae Officinalis peeling, the processed with Rhizoma Zingiberis Recens that take; By Fructus Gleditsia peeling, son, stir-fry; The Cortex Cinnamomi taking is removed to rough bark; The Pericarpium Zanthoxyli taking is removed to Semen zanthoxyli, remove the seed in Pericarpium Zanthoxyli shell, the person of remaining silent, micro-stir-fry, removes antiperspirant; The Rhizoma Zingiberis taking is soaked; The Fructus Evodiae taking is first put into hot water and wash, and then fish for out stir-fry;
Radix Aconiti, Radix Asteris, Radix Bupleuri, Cortex Magnoliae Officinalis, Fructus Gleditsia, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Fructus Evodiae after concocting and the Rhizoma Acori Graminei taking, Radix Platycodonis, Rhizoma Coptidis, Radix Ginseng, Poria are amounted to ten four Chinese medicine materials dries respectively, pulverize respectively again, obtain 14 kinds of Chinese medicine fine powders, the particle diameter of each Chinese medicine fine powder is 180um; Fructus Crotonis fine powder and 14 kinds of Chinese medicine fine powders are mixed, after stirring, form and mix Chinese medicine powder; For taking respectively, 1:1.3 mixes Chinese medicine powder, refined honey in mass ratio; After the mixing Chinese medicine powder taking is mixed with refined honey, make pellet, then the pellet made is dried, obtain the present invention and treat the Chinese medicine of the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor.
The Chinese medicine that the present invention treats the esophageal carcinoma, gastric cancer, hepatocarcinoma, the cerebral tumor has wide, strange, strong three large outstanding features compared with similar drugs, can treat the esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor that any reason causes; Take rear instant effect, curative effect is high, and side effect is little, treating both the principal and secondary aspects of a disease, the feature of taking convenience.
1. wide---so-called wide, select exactly famous and precious Chinese herbal medicine, as: people participates in after the mutual compatibility of other Chinese crude drug, can treating the poisonous disease with poisonous drugs, hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors, soothing liver and strengthening spleen, regulate the flow of vital energy disappear stagnant, reduce phlegm except the effect of drink and promoting diuresis to clear away damp pathogen, give prominence in Chinese medicine composition, monarch, minister, help, make ingenious compatibility, make it to give full play to greatest treatment efficacy; In compositions of the present invention, monarch drug is: Radix Ginseng, Fructus Crotonis, and ministerial drug is: Radix Aconiti, Rhizoma Acori Graminei, Fructus Evodiae, Radix Platycodonis, Poria, Cortex Cinnamomi, Pericarpium Zanthoxyli and Fructus Gleditsia, adjuvant drug is: Cortex Magnoliae Officinalis, Radix Asteris and Radix Bupleuri, make medicine be: Rhizoma Coptidis and Rhizoma Zingiberis.
2. strange---be exactly the multiple poisonous Chinese herbal medicine of selecting, through concocting, mutually after compatibility, changed the property of medicine, strengthened the method for the treatment of for the treatment of the poisonous disease with poisonous drugs, medicine can be given full play to greatest treatment efficacy; As: Fructus Crotonis is very toxic, and removes the peel film, the heart, stirs fry in oil, and can reduce toxicity, strengthens treating the poisonous disease with poisonous drugs, antineoplastic curative effect; Fructus Gleditsia is slightly poisonous, through peeling, son, after frying, strengthens the anticancer function of tumor inhibition of the total extractum of Fructus Gleditsia; Radix Aconiti is very toxic through bubble, after peeling, umbilicus, reduces toxicity, strengthens the effect of expelling wind and removing dampness; Fructus Evodiae is slightly poisonous, with strengthening melanocytoma after hot water wash, stir-fry, and human leukemia cell, the inhibitory action of tumor cell.
3. strong---so-called is exactly function and the effect of concentrating medicine by force, completely according to theory of Chinese medical science monarch, minister, assistant, the senior combination principle making, with monarch, minister is main, assistant, it is auxiliary making, and makes it reach maximum, best curative effect.
The Chinese medicine that the present invention treats the esophageal carcinoma, gastric cancer, hepatocarcinoma, the cerebral tumor is by ten Chinese medicine of the five flavours material science compatibilities, use after two courses for the treatment of to esophageal carcinoma effective percentage 97% gastric cancer effective percentage 96%, hepatocarcinoma 95%, cerebral tumor effective percentage 95% is below concrete clinical case:
One, case 600 examples, wherein: the esophageal carcinoma 180 examples, gastric cancer 120 examples, hepatocarcinoma 160 examples, the cerebral tumor 140 examples.
Two, symptom:
The esophageal carcinoma: dysphagia, vomiting, chest and back pain, malaise.
Gastric cancer: stomachache, gastral cavity abdomen enclosed mass, melena, malaise.
Hepatocarcinoma: hepatalgia, abdominal distention, jaundice, nausea and vomiting, loss of appetite, malaise.
The cerebral tumor: headache, dizziness, vomiting, visual deterioration, malaise.
Three, instructions of taking:
Make honeyed pill by proportioning.As large in Semen Firmianae (one is 0.2g～0.3g), evening every day administered before bed time three balls, ginger decoction send down; Gradually add to five balls or seven balls, stool tonneau stops increasing, then reduces back clothes to three balls or four balls or five balls; It within three months, is a course for the treatment of.
Four, criterion of therapeutical effect:
(1) criterion of cure:
The esophageal carcinoma: dysphagia disappears, vomiting disappears, and chest and back pain disappears, and malaise disappears.
Gastric cancer: stomachache disappears, gastral cavity abdomen enclosed mass disappears, and melena disappears, and malaise disappears.
Hepatocarcinoma: liver pain disappears, abdominal distention disappears, and jaundice disappears, and nausea and vomiting disappears, and appetite is normal, and malaise disappears.
The cerebral tumor: headache and dizzy disappears, vomiting disappears, and vision restoration is normal, and malaise disappears.
(2) effective standard:
The esophageal carcinoma: swallow to some extent and take a turn for the better, vomiting reduces, and chest and back pain alleviates, and malaise lightens.Gastric cancer: stomachache alleviates, and gastral cavity abdomen enclosed mass diminishes, and melena tails off, and malaise lightens.
Hepatocarcinoma: liver pain alleviates, abdominal distention takes a turn for the better, and jaundice reduces, and nausea and vomiting alleviates, and appetite increases, and malaise lightens.
The cerebral tumor: headache and dizzy alleviates, vomiting reduces, and vision is recovered to some extent, and malaise lightens.
Four, therapeutic outcome (in table 1)
Table 1
Case 1:
Guo, female, 65 years old, feel in the recent period dysphagia, also with vomiting, chest pain, does endoscopy of esophagus to local hospital, is diagnosed as the esophageal carcinoma.
Through hospitalization, improvement is left hospital, after have lasting radiotherapy and chemotherapy effect not clearly, after half a year, symptom increases the weight of.
Take a course for the treatment of of this Chinese medicine, sb.'s illness took a favorable turn, can have a meal, vomiting is basic to disappear, chest pain obviously alleviates, and adheres to taking 3 courses for the treatment of, and diet is normal, chest pain disappears, vomiting disappears, and does endoscopy of esophagus at local hospital, and lump disappears, continue to take 2 courses for the treatment of in case recur, so far without recurrence.
Case 2:
Zhu, man, 62 years old, suffering from gastropathy had more than 10 year, has in the recent period gastralgia, and abdominal distention, indistinctly has enclosed mass, loss of appetite, the Of-thin that disappears, weak.Do gastroscopy in safe and comfortable hospital, be diagnosed as gastric cancer.
Not good at local hospital therapeutic effect.
Take one course for the treatment of of this Chinese medicine, gastral cavilty is pain a little a little, and abdominal distention disappears, and appetite increases, weak disappearance; Adhere to taking 2 courses for the treatment of, gastral cavilty portion pain disappears again, and diet is normal, and abdominal distention disappears, and does gastroscopy lump disappear at local hospital; In case recurrence continues to take 2 courses for the treatment of, so far without recurrence.
Case 3:
Liu, female, 68 years old, do magnetic resonance examination at local hospital, be diagnosed as hepatocarcinoma.
Nearly two weeks hepatalgia increases the weight of, abdominal distention, and facial jaundice ， Xiao Of-thin, weak, not bery desirable in a month effect of hospitalize.
Take a course for the treatment of of this Chinese medicine, hepatalgia obviously alleviates, and appetite increases, and facial jaundice reduces; Continue to take 2 courses for the treatment of, hepatalgia disappears completely, and facial jaundice disappears, and diet is normal, can go to work in the fields, and does magnetic resonance examination lump disappear at local hospital; In case 2 courses for the treatment of have been taken again in recurrence, so far without recurrence.
Case 4:
Liu, man, 52 years old, had headache nearly January, dizziness, vomiting, visual deterioration, not bery takes notice of; Recently increase the weight of, do magnetic resonance examination to local hospital, be diagnosed as the cerebral tumor, and in brain, shift.
Hospital's suggestion can not be performed an operation, suggestion expectant treatment, and a month effect of hospitalization is unsatisfactory.
Take a course for the treatment of of this Chinese medicine, headache and dizzy obviously alleviates, and vomiting disappears, and vision is recovered to some extent, continues to take 2 courses for the treatment of of this medicine, and mental restoration is normal, and headache and dizzy disappears, and vision restoration is normal, can do down farm work; Doing magnetic resonance examination tumor disappears; For preventing recurrence, continue to take 2 courses for the treatment of, so far without recurrence.
Claims (6)
1. the Chinese medicine of the treatment esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor, is characterized in that, is made up of following Chinese crude drug:
35 parts～150 parts of Radix Aconitis, 8 parts～35 parts of Radix Asteriss, 8 parts～35 parts of Radix Bupleuri, 8 parts～35 parts of Rhizoma Acori Graminei, 8 parts～35 parts of Cortex Magnoliae Officinalis, 8 parts～35 parts of Radix Platycodoniss, 8 parts～35 parts of Fructus Gleditsia, 8 parts～35 parts of Fructus Evodiaes, 8 parts～35 parts of Rhizoma Zingiberiss, 8 parts～35 parts of Rhizoma Coptidis, 8 parts～35 parts of Radix Ginsengs, 8 parts～35 parts of Porias, 8 parts～35 parts of Cortex Cinnamomis, 8 parts～35 parts of Fructus Crotonis, 8 parts～35 parts of Pericarpium Zanthoxylis.
2. a preparation method for the Chinese medicine of the treatment esophageal carcinoma claimed in claim 1, gastric cancer, hepatocarcinoma and the cerebral tumor, is characterized in that, specifically implements according to following steps:
Step 1, take medical material:
35 parts～150 parts of Radix Aconitis, 8 parts～35 parts of Radix Asteriss, 8 parts～35 parts of Radix Bupleuri, 8 parts～35 parts of Rhizoma Acori Graminei, 8 parts～35 parts of Cortex Magnoliae Officinalis, 8 parts～35 parts of Radix Platycodoniss, 8 parts～35 parts of Fructus Gleditsia, 8 parts～35 parts of Fructus Evodiaes, 8 parts～35 parts of Rhizoma Zingiberiss, 8 parts～35 parts of Rhizoma Coptidis, 8 parts～35 parts of Radix Ginsengs, 8 parts～35 parts of Porias, 8 parts～35 parts of Cortex Cinnamomis, 8 parts～35 parts of Fructus Crotonis, 8 parts～35 parts of Pericarpium Zanthoxylis;
Step 2, respectively the Radix Aconiti taking in step 1, Radix Asteris, Radix Bupleuri, Cortex Magnoliae Officinalis, Fructus Gleditsia, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Fructus Evodiae and Fructus Crotonis are concocted;
Step 3, prepare the Chinese medicine of the treatment esophageal carcinoma, gastric cancer, hepatocarcinoma and the cerebral tumor.
3. the preparation method of the Chinese medicine of the treatment esophageal carcinoma according to claim 2, gastric cancer, hepatocarcinoma and the cerebral tumor, is characterized in that, described step 2 is specifically implemented according to following steps:
The Fructus Crotonis taking in step 1 is removed the peel to film, the heart successively, the Fructus Crotonis of peeling film, the heart is stirred fry in oil, obtain the Fructus Crotonis after stirring fry in oil, after then the Fructus Crotonis after stirring fry in oil being dried, pulverize, obtain Fructus Crotonis fine powder;
The Radix Aconiti taking in step 1 is immersed in water, removes the skin umbilicus of Radix Aconiti;
The Radix Asteris taking in step 1 is removed to reed head and leaf;
The Radix Bupleuri taking in step 1 is removed to reed head;
By the Cortex Magnoliae Officinalis peeling, the processed with Rhizoma Zingiberis Recens that take in step 1;
By the Fructus Gleditsia peeling, son, the stir-fry that take in step 1;
The Cortex Cinnamomi taking in step 1 is removed to rough bark;
The Pericarpium Zanthoxyli taking in step 1 is removed to Semen zanthoxyli, and the person of remaining silent, micro-stir-fry, removes antiperspirant;
The Rhizoma Zingiberis taking in step 1 is soaked;
The Fructus Evodiae taking in step 1 is first put into hot water and wash, and then fish for out parch.
4. the preparation method of the Chinese medicine of the treatment esophageal carcinoma according to claim 3, gastric cancer, hepatocarcinoma and the cerebral tumor, is characterized in that, in described step 2, the size of Fructus Crotonis fine powder is 125um～180um.
5. the preparation method of the Chinese medicine of the treatment esophageal carcinoma according to claim 2, gastric cancer, hepatocarcinoma and the cerebral tumor, is characterized in that, described step 3 is specifically implemented according to following steps:
Step 3.1, the Rhizoma Acori Graminei taking in the Radix Aconiti after step 2 is concocted, Radix Asteris, Radix Bupleuri, Cortex Magnoliae Officinalis, Fructus Gleditsia, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Fructus Evodiae and step 1, Radix Platycodonis, Rhizoma Coptidis, Radix Ginseng, Poria are amounted to 14 taste medical materials independent oven dry respectively, pulverize respectively again, obtain respectively 14 kinds of independently Chinese medicine fine powders;
Step 3.2, the Fructus Crotonis fine powder obtaining in step 2 and 14 kinds of Chinese medicine fine powders obtaining through step 3.1 are mixed, after stirring, form and mix Chinese medicine powder;
Step 3.3, in mass ratio for 1:(0.36～1.3) take respectively mixing Chinese medicine powder, refined honey that step 3.2 obtains;
Step 3.4, make pellet after the mixing Chinese medicine powder taking in step 3.3 is mixed with refined honey, then the pellet of making is dried to the Chinese medicine of the esophageal carcinoma that obtains medical treatment, gastric cancer, hepatocarcinoma and the cerebral tumor.
6. the preparation method of Chinese medicine composition according to claim 5, is characterized in that, in described 14 kinds of Chinese medicine fine powders that obtain through step 3.1, the particle diameter of every kind of Chinese medicine fine powder is 125um～180um.
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| CN108338985A (en) * | 2017-01-22 | 2018-07-31 | 成都中医药大学 | The new application of crotonoside |
| CN111346125A (en) * | 2020-03-18 | 2020-06-30 | 李永伟 | Chinese medicinal monomer compound mainly prepared from gleditsia sinensis extract freeze-dried powder, and preparation method and application thereof |
| CN111920874A (en) * | 2020-09-29 | 2020-11-13 | 河南中医药大学 | A Chinese medicinal buccal pill for treating middle and late stage esophageal cancer |
| CN111991548A (en) * | 2020-09-23 | 2020-11-27 | 王海军 | Anti-tumor traditional Chinese medicine composition and preparation method thereof |
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| CN104367943A (en) * | 2014-11-04 | 2015-02-25 | 宋秀香 | Formula and preparation method of traditional Chinese medicine for treating liver cancer |
| CN108338985A (en) * | 2017-01-22 | 2018-07-31 | 成都中医药大学 | The new application of crotonoside |
| CN108338985B (en) * | 2017-01-22 | 2020-06-19 | 成都中医药大学 | Application of crotonoside |
| CN111346125A (en) * | 2020-03-18 | 2020-06-30 | 李永伟 | Chinese medicinal monomer compound mainly prepared from gleditsia sinensis extract freeze-dried powder, and preparation method and application thereof |
| CN111991548A (en) * | 2020-09-23 | 2020-11-27 | 王海军 | Anti-tumor traditional Chinese medicine composition and preparation method thereof |
| CN111920874A (en) * | 2020-09-29 | 2020-11-13 | 河南中医药大学 | A Chinese medicinal buccal pill for treating middle and late stage esophageal cancer |
| CN111920874B (en) * | 2020-09-29 | 2021-09-24 | 河南中医药大学 | A Chinese medicinal buccal pill for treating middle and late stage esophageal cancer |
| CN112618687A (en) * | 2020-12-22 | 2021-04-09 | 中国中医科学院西苑医院 | Traditional Chinese medicine composition and yin-yang attacking accumulation pill for treating colorectal cancer |
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