CN109908312B - 一种痔疮膏及其制备方法 - Google Patents
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Abstract
本发明提供一种痔疮膏及其制备方法,涉及药膏技术领域。一种痔疮膏,包括按重量份数计的以下原料:黄柏6‑15份;煅石膏25‑35份;紫草5‑15份;当归15‑25份;莪术5‑15份;乳香15‑25份;五倍子5‑15份;煅龙骨25‑35份;白芨5‑15份;冰片1‑5份;珍珠25‑35份;炉甘石25‑35份。煅石膏、当归、乳香、煅龙骨、珍珠以及炉甘石用作君药,主要达到使痔疮快速萎缩,并能明显减轻患者痛苦的作用。其余各药共同作为臣药,主要起加强君药药效的作用,防止君药药性的流失,保障患者病灶部位能够充分吸收君药中的有效成分,从而保证了痔疮的治疗效果。以上诸药共同取到清热解毒、消肿止痛、收敛生肌的功效。
Description
技术领域
本发明涉及药膏技术领域,具体而言,涉及一种痔疮膏及其制备方法。
背景技术
痔疮是肛门直肠下端和肛管皮肤下的静脉丛发生扩张和屈曲所形成的一个或多个柔软的静脉团的一种慢性疾病,这种静脉团俗称痔核,按其生成部位不同分为内痔、外痔和混合痔三种。中药认为痔疮多因湿热内积;久坐;久立;饮食辛辣或临产用力;大便秘结等导致浊气瘀血流注肛门而患病。痔疮的并发症:1.引起脱垂;嵌顿甚至坏死,2.长期便血易致贫血,3.容易引发妇科炎症,4.导致肛周长期湿疹。患痔日久者,因年老体弱,肛门松弛,气虚不能提升,痔核尤其容易脱出,且不易自行回复,严重影响了患者的工作和生活。痔疮可通过局部用药对其进行治疗,现有的痔疮膏治疗效果还有待提高。
发明内容
本发明的目的在于提供一种痔疮膏,其具有较好的治疗效果。
本发明的另一目的在于提供一种痔疮膏的制备方法,该方法简单高效,适合批量生产。
本发明解决其技术问题是采用以下技术方案来实现的。
本发明提出一种痔疮膏,其主要包括按重量份数计的以下原料:
黄柏6-15份;煅石膏25-35份;紫草5-15份;当归15-25份;莪术5-15份;乳香15-25份;五倍子5-15份;煅龙骨25-35份;白芨5-15份;冰片1-5份;珍珠25-35份;炉甘石25-35份。
本发明提出一种痔疮膏制备方法,包括:将黄柏、煅石膏、紫草、当归、莪术、乳香、五倍子、煅龙骨、白芨、冰片、珍珠和炉甘石与凡士林、甘油混合制得痔疮膏。
本发明实施例提供的痔疮膏及其制备方法至少具有以下有益效果:
本发明实施例提供一种痔疮膏,包括按重量份数计的以下原料:黄柏6-15份;煅石膏25-35份;紫草5-15份;当归15-25份;莪术5-15份;乳香15-25份;五倍子5-15份;煅龙骨25-35份;白芨5-15份;冰片1-5份;珍珠25-35份;炉甘石25-35份。一种上述痔疮膏的制备方法:将黄柏、煅石膏、紫草、当归、莪术、乳香、五倍子、煅龙骨、白芨、冰片、珍珠和炉甘石与凡士林、甘油混合制得痔疮膏。煅石膏、当归、乳香、煅龙骨、珍珠以及炉甘石用作君药,主要达到使痔疮快速萎缩,并能明显减轻患者痛苦的作用,还具有清热解毒、抗菌消炎、破瘀止血以及收敛止痛的功效。黄柏、紫草、莪术、五倍子、白芨和冰片共同作为臣药,主要起加强君药药效的作用,防止君药药性的流失,保障患者病灶部位能够充分吸收君药中的有效成分,从而保证了痔疮的治疗效果。
具体实施方式
为使本发明实施例的目的;技术方案和优点更加清楚,下面将对本发明实施例中的技术方案进行清楚;完整地描述。实施例中未注明具体条件者,按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者,均为可以通过市售购买获得的常规产品。
下面对本发明实施例的痔疮膏和制备方法进行具体说明。
本发明实施例提供一种痔疮膏,其主要包括按重量份数计的以下原料:
黄柏6-15份;煅石膏25-35份;紫草5-15份;当归15-25份;莪术5-15份;乳香15-25份;五倍子5-15份;煅龙骨25-35份;白芨5-15份;冰片1-5份;珍珠25-35份;炉甘石25-35份。
煅石膏为白色的粉末或酥松块状物,表面透出微红色的光泽,不透明。体较轻,质软,易碎,捏之成粉。煅石膏为石膏的炮制品,可以取净石膏,在无烟炉火中或坩锅内煅至酥松,取出晾凉,打碎即得。煅石膏功能主治:收湿、生肌、敛疮、止血,外治溃疡不敛、湿疹瘙痒、水火烫伤、外伤出血。
当归,别名干归、秦哪、西当归、岷当归、金当归、当归身、涵归尾、当归曲、土当归,多年生草本。其根可入药,是最常用的中药之一,具有补血和血,调经止痛,润燥滑肠、抗癌、抗老防老、免疫之功效。
乳香为橄榄科植物乳香树及同属植物树皮渗出的树脂。性辛、苦、温。入心、肝、脾经。具有活血、行气、止痛、抑菌等功用。可用于治疗瘀阻气滞的脘腹疼痛,风湿痹痛,跌打损伤,痛经,产后腹痛等。
龙骨为古代哺乳动物如象类、犀牛类、三趾马等的骨胳的化石。取刷净的龙骨,在无烟的炉火上或坩埚内煅红透,取出,放凉,碾碎即为煅龙骨。煅龙骨具有镇惊安神,敛汗固精,止血涩肠,生肌敛疮的作用。用治惊痫癫狂,怔忡健忘,失眠多梦,自汗盗汗,遗精淋浊,吐衄便血,崩漏带下,泻痢脱肛,溃疡久不收口。
珍珠具有安神定惊、清热滋阴、明目去翳、解毒生肌等功效,现代研究还表明珍珠在提高人体免疫力、延缓衰老、祛斑美白、补充钙质等方面都具有独特的作用。在《本草纲目》中特别记载了:“珍珠味咸甘寒无毒,镇心点目;珍珠涂面,令人润泽好颜色。涂手足,去皮肤逆胪;坠痰,除面斑,止泻;除小儿惊热,安魂魄;止遗精白浊,解痘疗毒。……令光泽洁白”等。同时,它还记载了珍珠药用的多种方法。
炉甘石为碳酸盐类矿物方解石族菱锌矿。主要成分为碳酸锌(ZnC03),尚含少量氧化钙(CaO),氧化镁(MgO),氧化铁(Fe203),氧化锰(MnO)。炉甘石为不溶于水的天然碳酸锌,广用于皮肤科,作为中度的防腐、收敛、保护、治疗皮肤炎症或表面创伤。外用可抑制局部葡萄球菌生长,能部分吸收创面分泌液,有收敛、保护作用。
煅石膏、当归、乳香、煅龙骨、珍珠以及炉甘石用作君药,主要达到使痔疮快速萎缩,并能明显减轻患者痛苦的作用,还具有清热解毒、抗菌消炎、破瘀止血以及收敛止痛的功效。
紫草是紫草科紫草属多年生草本植物,性寒,味苦。功能主治:凉血,活血,清热,解毒。治温热斑疹,湿热黄疸,紫癜,吐、衄、尿血,淋浊,热结便秘,烧伤,湿疹,丹毒,痈疡。
黄柏也称黄檗、元柏、檗木,是芸香科黄檗属落叶乔木。黄柏的树皮内层经炮制后入药。味苦,性寒。清热解毒,泻火燥湿。主治急性细菌性痢疾、急性肠炎、急性黄疸型肝炎、泌尿系统感染等炎症。外用治火烫伤、中耳炎、急性结膜炎等。
莪术,别称莪药、莪茂、青姜、黑心姜、姜黄,为多年生宿根草本。其根茎供药用,主治“气血凝滞,心腹胀痛,症瘕,积聚,宿食不消,妇女血瘀经闭,跌打损伤作痛,还有行气解郁,破瘀,止痛、抗菌、抗炎的功用。
五倍子为漆树科植物盐肤木、青麸杨和红麸杨等树上寄生倍蚜科昆虫角倍蚜或倍蛋蚜后形成的虫瘿。当然,本发明实施例中所用五倍子是能直接使用的药材(即已除去虫卵)。五倍子味酸,涩,性寒,归肺、大肠、肾经。其具有敛肺、止汗、涩肠、固精、止血、解毒等功效。主治:肺虚久咳、自汗盗汗、久痢久泻、脱肛、遗精、白浊、各种出血、痈肿疮疖。
白芨又名连及草、甘根、白及、箬兰、朱兰、紫兰、紫蕙、百笠等。白芨补肺,止血,消肿,生肌,敛疮。治肺伤咳血,衄血,金疮出血,痈疽肿毒,溃疡疼痛,汤火灼伤,手足皲裂。现代药理学也表明,白芨具有以下作用:
1、收敛止血。白芨的止血作用,是因为它能增强血小板因子活性,在较短时间内凝血,使得凝血酶快速生成,同时抑制纤维蛋白溶酶活性,可以起到局部止血的作用。白芨的收敛止血功效,可以用于咳血、吐血、外伤出血、肺结核咳血、溃疡出血等症状。白芨的止血与三七的止血不一样。白芨是收敛止血,而三七是散瘀止血。
2、消肿生肌。白芨具有消肿生肌的功效,能治疗生疮出血、溃疡、痈疽肿毒、手足皲裂、肛裂、疮疡等。
3、补肺。白芨味苦、甘而涩,性微寒,入肺经,具有补肺的功效,对治疗肺痿肺烂、肺结核有一定的效果。
4、美容。白芨含有丰富的挥发油及粘液质等成分,具有美白祛斑的功效,磨成粉外用涂擦,可以消除脸上痤疮留下的痕迹,滋润、美白肌肤,起到美容的效果。
5、抗菌。白芨对于大型结核杆菌有显著抑制作用,也能对革兰氏阳性菌起到抑制作用。
6、抗溃疡。白芨具有抗溃疡的作用,白芨具有高度的粘性,可在胃内形成胶状膜,能促使溃疡面愈合。再加上白芨中含有的有益成分,对于葡萄球菌、链球菌等有抑菌作用,能形成保护膜,从而起到防止胃部感染的作用。
冰片为从龙脑香的树脂和挥发油中取得的结晶,是近乎纯粹的右旋龙脑。龙脑香的树脂和挥发油中含有多种萜类成分。除龙脑外,尚含葎草烯、β-榄香烯、石竹烯等倍半萜,齐墩果酸、麦珠子酸、积雪草酸、龙脑香醇酮、龙脑香二醇酮、古柯二醇等三萜化合物。冰片苦辛性凉,长于通诸窍、散郁火、去翳明目;外用能清热消肿、止痒止痛。黄柏苦寒,功擅清热燥湿、泻火解毒;外用能燥湿敛疮。二者相伍外用,有清热泻火、解毒消肿、燥湿敛疮、止痛止痒之功效,用于治疗火热内郁上攻所引起的口腔糜烂、溃疡、口舌生疮、咽喉肿痛等症。
黄柏、紫草、莪术、五倍子、白芨和冰片共同作为臣药,主要起加强君药药效的作用,防止君药药性的流失,保障患者病灶部位能够充分吸收君药中的有效成分,从而保证了痔疮的治疗效果。
进一步地,痔疮膏的原料还可以是以下重量份计:
黄柏10份;煅石膏30份;紫草10份;当归20份;莪术10份;乳香20份;五倍子10份;煅龙骨30份;白芨10份;冰片3份;珍珠30份;炉甘石30份。
各原料采用上述配比,各原料能够充分发挥协同增效作用,可以达到更好的疗效,药材也不会存在浪费现象。
痔疮膏的原料还可以进一步包括按重量份计的以下原料:
马铃薯5-10份;甘草酸铵10-15份;山莨菪碱3-8份;蛤蚧4-9份;槐花12-16份;大黄3-7份;山茶花5-12份;青黛8-12份;皂角7-15份;无花果10-15份。
马铃薯,别称土豆、地蛋、洋芋等。中医认为马铃薯“性平味甘无毒,能健脾和胃,益气调中,缓急止痛,通利大便,对脾胃虚弱、消化不良、肠胃不和、脘腹作痛、大便不畅的患者效果显著”。可以用来主治胃痛、痄肋、痈肿、湿疹、烫伤,是和胃健中药和解毒消肿药。马铃薯中含有过氧化氢酶,过氧化氢酶是一种结合酶,是活细胞产生的具有催化功能的蛋白质。过氧化氢酶在酶中催化能力最强,它的活化能仅为8.4KJ/mol。过氧化氢酶的催化反应是利用过氧化氢使酚类、胺类、抗坏血酸等物质氧化,使对人体有害的酚类、胺类等排出体外,是线粒体外的生物氧化体系的一部分。过氧化氢酶同时具备生物转化作用,通过化学反应,使非营养物质的极性增加;也可以使某些非营养物质的生物活性降低或者消失,这也称为解毒作用,易于有害物质排出体外。
甘草中有效成分之一的甘草酸是非常珍贵的天然解毒剂,有显著的促进肾上腺皮质激素样作用,可用于人体抗衰老、抗炎症、降压、增强机体免疫力、提高生理机能、改善高血脂、维持水盐代谢平衡。甘草酸铵是甘草酸的特有结构,具有抗炎、抗过敏等方面的生理活性。目前,被广泛应用于临床。
槐花,味苦,性平,无毒,具有清热、凉血、止血、降压的功效。对吐血、尿血、痔疮出血、风热目赤、高血压病、高脂血症、颈淋巴结核、血管硬化、大便带血、糖尿病、视网膜炎、银屑病等有显著疗效;还可以驱虫、治咽炎。槐花能增强毛细血管的抵抗力,减少血管通透性,可使脆性血管恢复弹性的功能,从而降血脂和防止血管硬化。
青黛,为爵床科马蓝属植物马蓝、蓼科蓼属植物蓼蓝、豆科木蓝属植物木蓝、十字花科菘蓝属植物菘蓝的叶或茎叶经加工制得的干燥粉末或团块。性咸,寒;归肝、肺、胃经。用于清热,凉血,解毒。主治温毒斑疹,吐血,咯血,咽喉肿痛等;现代药理学证明其具有抗肿瘤、抗炎镇痛、抗溃疡、抗菌作用,对胸腺T淋巴细胞和脾脏T淋巴细胞有促进增殖的作用,可改善免疫系统功能。
皂角药用部分为豆科植物皂荚的果实或不育果实。其具有祛痰止咳;开窍通闭;杀虫散结的功效。主痰咳喘满;中风口噤;痰涎壅盛;神昏不语;癫痫;喉痹;二便不通;痈肿疥癣。
无花果具有清热生津;健脾开胃;解毒消肿的功效。主咽喉肿痛;燥咳声嘶;乳汁稀少;肠热便秘;食欲不振;消化不良,泄泻痢疾;痈肿;癣疾。用于咳喘,咽喉肿痛,便秘,痔疮。根、叶:肠炎,腹泻;外用治痈肿。
马铃薯、甘草酸铵、槐花、青黛、皂角以及无花果主要作为佐药,其能够使君药和臣药的药性逐步释放,使人体接受程度更好,治疗过程更加顺畅,同时对病灶部位起到更好的消炎、消肿、抗菌等作用。
山莨菪碱为阻断M胆碱受体的抗胆碱药,作用与阿托品相似或稍弱。其可使平滑肌明显松弛,并能解除血管痉挛(尤其是微血管),同时有镇痛作用,但扩瞳和抑制腺体(如唾液腺)分泌的作用较弱,且极少引起中枢兴奋症状。
蛤蚧入药部分一般为壁虎科动物蛤蚧除去内脏的全体。蛤蚧的功效与作用如下:益肾补肺;定喘止嗽,主肺肾两虚气喘咳嗽,虚劳咳嗽;咯血;肾虚阳痿;遗精;小便频数;消渴。
大黄主治:实热便秘、热结胸痞、湿热泻痢、黄疸、淋病、水肿腹满、小便不利、目赤、咽喉肿痛、口舌生疮、胃热呕吐、吐血、咯血、衄血、便血、尿血、蓄血、经闭、产后瘀滞腹痛、症瘕积聚、跌打损伤、热毒痈疡、丹毒、烫伤。
山茶花,为山茶科山茶属植物红山茶的花,性苦、辛,凉;归肝、肺、大肠经。用于凉血止血,散瘀消肿。主治吐血,咳血,便血,痔血,赤白痢,血淋,血崩等。现代药理学证明,其具有抗癌作用,叶和花瓣中含有的山茶皂苷能使真菌的分生孢子异常出芽。
山莨菪碱、蛤蚧、大黄以及山茶花主要作为使药,使痔疮膏中各个原料的有效成分按照其在配伍中所起的疗效直达病所,使痔疮膏见效更快,也使各原料更好地进行协同配合治疗,减少药物带来的不良反应,患者的治疗过程更加舒适。
还提供一种上述痔疮膏的制备方法,主要包括以下步骤:
当归和莪术分别采用炒当归和炒莪术,当然用户也可以自己将当归和莪术进行炒制处理,得到炒当归和炒莪术。炒当归和炒莪术有利于后期对当归和莪术的蒸馏提取,使有效成分提取的更加彻底,从而使得有效成分进行作用时更加容易被患者吸收,疗效更快、更好。本发明实施例中的当归和莪术均采用炒当归和炒莪术。
将紫草、当归、莪术、槐花、山茶花、无花果分别进行蒸馏提取,所得提取物混合得到挥发油。将蒸馏所得混合药渣(六种药渣的混合物)留存备用,挥发油备用。
马铃薯的处理包括以下步骤:
选用优质马铃薯,去除病残部分,然后去皮,清洗。将洗净的马铃薯切碎然后打成浆。所得浆液经过滤处理或者离心处理得到洁净浆液,备用。过滤或离心后所得固体残渣烘干、研磨成粉,得薯粉,备用。固体残渣中仍然保留了多种有效成分,对患者痔疮位置的生肌、愈合、保护(减少排泄过程对痔疮位置的摩擦,以及在痔疮位置表面形成保护膜,减少细菌对痔疮位置的侵扰)均起到有效作用。
将混合药渣、薯粉、黄柏、白芨、大黄和皂角共同熬制成浸膏,备用。
将煅石膏、煅龙骨、炉甘石、五倍子、乳香、冰片、珍珠均研磨成粉末状,备用。
将蛤蚧采用乙醇浸泡处理,浸泡20-30小时,乙醇浓度为98wt%。浸泡后将浸泡液以及通过挤压蛤蚧得到的液体混合进行浓缩,所得浓缩物备用。足够时间的浸泡,才能使蛤蚧内的有效成分充分溶出,提高蛤蚧的利用率,也提高最终膏剂中的有效成分占比。
将青黛进行煎煮,将煎煮所得煎煮液浓缩至80%-85wt%后,再向其中加入甘草酸铵和山莨菪碱,所得混合物研磨成粉,得添加粉,备用。
向熔化的凡士林中加入粉末状的煅石膏、煅龙骨、炉甘石、珍珠和五倍子,然后进行搅拌,搅拌至温度降低至60℃后再加入乳香、冰片、添加粉、薯粉以及挥发油,最后再加入浸膏。搅拌30-40分钟后,再加入浓缩物和洁净浆液,继续搅拌,最后加入甘油和苯甲酸,制得符合要求的膏剂。甘油用量需要根据具体情况而定,使产品能够达到膏剂要求的硬度即可;苯甲酸作为抑菌剂加入,使膏剂制备过程中的洁净程度有较好的保障。该过程中,搅拌总用时为1-3小时,搅拌转速为50-90转/分。发明人通过试验发现搅拌的时间和转速对于膏剂最后的药效有一定的影响,在上述搅拌时长以及搅拌转速内,所得膏剂的药效更好。
以下结合实施例对本发明的特征和性能作进一步的详细描述。
实施例1
本实施例提供一种痔疮膏,其主要采用以下过程进行制备:
该痔疮膏的原料包括:
黄柏6g;煅石膏25g;紫草5g;当归15g;莪术5g;乳香15g;五倍子5g;煅龙骨25g;白芨5g;冰片1g;珍珠25g;炉甘石25g。
该痔疮膏的制备方法包括:
所有原料均为粉末状,粉末粒径为100纳米。将所有粉末原料与凡士林、甘油混合,即制得痔疮膏。
实施例2
本实施例提供一种痔疮膏,其主要采用以下过程进行制备:
该痔疮膏的原料包括:
黄柏15g;煅石膏35g;紫草15g;当归25g;莪术15g;乳香25g;五倍子15g;煅龙骨35g;白芨15g;冰片5g;珍珠35g;炉甘石35g。
该痔疮膏的制备方法包括:
将紫草、当归、莪术分别进行蒸馏提取,所得提取物混合得到挥发油。将蒸馏所得混合药渣(三种药渣的混合物)留存备用,挥发油备用。
将挥发油、混合药渣以及其他原料与凡士林、甘油混合,即制得痔疮膏。
实施例3
本实施例提供一种痔疮膏,其主要采用以下过程进行制备:
该痔疮膏的原料包括:
黄柏10g;煅石膏30g;紫草10g;当归20g;莪术10g;乳香20g;五倍子10g;煅龙骨30g;白芨10g;冰片3g;珍珠30g;炉甘石30g。
该痔疮膏的制备方法包括:
将紫草、当归、莪术分别进行蒸馏提取,所得提取物混合得到挥发油。将蒸馏所得混合药渣(三种药渣的混合物)留存备用,挥发油备用。
将混合药渣与黄柏、白芨共同熬制成浸膏。再将浸膏、挥发油与凡士林、甘油混合,即制得痔疮膏。
实施例4
本实施例提供一种痔疮膏,其主要采用以下过程进行制备:
该痔疮膏的原料包括:
黄柏6g;煅石膏35g;紫草15g;当归15g;莪术5g;乳香25g;五倍子5g;煅龙骨28g;白芨15g;冰片5g;珍珠25g;炉甘石35g,马铃薯5g;甘草酸铵10g;山莨菪碱3g;蛤蚧4g;槐花12g;大黄3g;山茶花5g;青黛8g;皂角7g;无花果10g。
该痔疮膏的制备方法包括:
将紫草、当归、莪术、槐花、山茶花、无花果分别进行蒸馏提取,所得提取物混合得到挥发油。将蒸馏所得混合药渣(六种药渣的混合物)留存备用,挥发油备用。
马铃薯的处理包括以下步骤:
选用优质马铃薯,去除病残部分,然后去皮,清洗。将洗净的马铃薯切碎然后打成浆。所得浆液经过滤处理或者离心处理得到洁净浆液,备用。过滤或离心后所得固体残渣烘干、研磨成粉,得薯粉,备用。固体残渣中仍然保留了多种有效成分,对患者痔疮位置的生肌、愈合、保护(减少排泄过程对痔疮位置的摩擦,以及在痔疮位置表面形成保护膜,减少细菌对痔疮位置的侵扰)均起到有效作用。
将混合药渣、薯粉、黄柏、白芨、大黄和皂角共同熬制成浸膏,备用。
将煅石膏、煅龙骨、炉甘石、五倍子、乳香、冰片、珍珠均研磨成粉末状,备用。
将蛤蚧采用乙醇浸泡处理,浸泡20小时,乙醇浓度为98wt%。浸泡后将浸泡液以及通过挤压蛤蚧得到的液体混合进行浓缩,所得浓缩物备用。足够时间的浸泡,才能使蛤蚧内的有效成分充分溶出,提高蛤蚧的利用率,也提高最终膏剂中的有效成分占比。
将青黛进行煎煮,将煎煮所得煎煮液浓缩至80%wt%后,再向其中加入甘草酸铵和山莨菪碱,所得混合物研磨成粉,得添加粉,备用。
向熔化的凡士林中加入粉末状的煅石膏、煅龙骨、炉甘石、珍珠和五倍子,然后进行搅拌,搅拌至温度降低至60℃后再加入乳香、冰片、添加粉、薯粉以及挥发油,最后再加入浸膏。搅拌30分钟后,再加入浓缩物和洁净浆液,继续搅拌,最后加入甘油和苯甲酸,制得符合要求的膏剂。甘油用量需要根据具体情况而定,使产品能够达到膏剂要求的硬度即可。该过程中,搅拌总用时为1小时,搅拌转速为50转/分。
实施例5
本实施例提供一种痔疮膏,其主要采用以下过程进行制备:
该痔疮膏的原料包括:
黄柏8g;煅石膏27g;紫草9g;当归17g;莪术8g;乳香16g;五倍子6g;煅龙骨27g;白芨9g;冰片2g;珍珠26g;炉甘石28g,马铃薯10g;甘草酸铵15g;山莨菪碱8g;蛤蚧9g;槐花16g;大黄7g;山茶花12g;青黛12g;皂角15g;无花果15g。
该痔疮膏的制备方法与实施例4中提供的制备方法大致相同,不同之处在于:
蛤蚧在乙醇中浸泡的时间为:30小时;青黛煎煮液浓缩至85wt%后加入甘草酸铵和山莨菪碱;最后的混合搅拌过程中,加入浓缩物和洁净浆液之前已搅拌了40分钟,最后的混合搅拌过程总用时为3小时,搅拌转速为90转/分。
实施例6
本实施例提供一种痔疮膏,其主要采用以下过程进行制备:
该痔疮膏的原料包括:
黄柏11g;煅石膏32g;紫草12g;当归23g;莪术13g;乳香24g;五倍子13g;煅龙骨31g;白芨16g;冰片4g;珍珠34g;炉甘石31g,马铃薯7g;甘草酸铵13g;山莨菪碱5g;蛤蚧6g;槐花14g;大黄5g;山茶花9g;青黛10g;皂角11g;无花果12g。
该痔疮膏的制备方法与实施例4中提供的制备方法大致相同,不同之处在于:
蛤蚧在乙醇中浸泡的时间为:25小时;青黛煎煮液浓缩至82wt%后加入甘草酸铵和山莨菪碱;最后的混合搅拌过程中,加入浓缩物和洁净浆液之前已搅拌了35分钟,最后的混合搅拌过程总用时为2小时,搅拌转速为70转/分。
实施例7
本实施例提供一种痔疮膏,其主要采用以下过程进行制备:
该痔疮膏的原料包括:
黄柏9g;煅石膏34g;紫草7g;当归20g;莪术11g;乳香20g;五倍子11g;煅龙骨27g;白芨14g;冰片3g;珍珠33g;炉甘石29g,马铃薯6g;甘草酸铵11g;山莨菪碱7g;蛤蚧5g;槐花13g;大黄4g;山茶花6g;青黛9g;皂角8g;无花果11g。
该痔疮膏的制备方法与实施例4中提供的制备方法大致相同,不同之处在于:
蛤蚧在乙醇中浸泡的时间为:28小时;青黛煎煮液浓缩至84wt%后加入甘草酸铵和山莨菪碱;最后的混合搅拌过程中,加入浓缩物和洁净浆液之前已搅拌了38分钟,最后的混合搅拌过程总用时为2.5小时,搅拌转速为80转/分。
实施例8
本实施例提供一种痔疮膏,其主要采用以下过程进行制备:
该痔疮膏的原料包括:
黄柏10g;煅石膏30g;紫草10g;当归20g;莪术10g;乳香20g;五倍子10g;煅龙骨20g;白芨10g;冰片3g;珍珠30g;炉甘石30g,马铃薯9g;甘草酸铵14g;山莨菪碱7g;蛤蚧8g;槐花15g;大黄6g;山茶花11g;青黛11g;皂角14g;无花果14g。
该痔疮膏的制备方法与实施例4中提供的制备方法大致相同,不同之处在于:
蛤蚧在乙醇中浸泡的时间为:22小时;青黛煎煮液浓缩至81wt%后加入甘草酸铵和山莨菪碱;最后的混合搅拌过程中,加入浓缩物和洁净浆液之前已搅拌了32分钟,最后的混合搅拌过程总用时为1.5小时,搅拌转速为60转/分。
试验例1
急毒试验。对实施例1-8提供的痔疮膏进行试验。对小鼠给药熏蒸的半数致死量(LD50)进行了试验测定,但未测到LD50,因此进行了最大耐受量试验。结果:按成人单位体重临床日用剂量的500倍对小鼠肛门用药,十日内小鼠无一死亡,处死小鼠解剖观察各脏器未发现毒性反应,给药组与对照组小鼠无任何差异。
长毒试验。应用Wistar大鼠将实验药物设定为高、中、低三个剂量,分别按人单位体重用药量的80倍、40倍和20倍的给药量为实验组,另设一正常饲养的对照组。连续肛门给药90天、180天,部分动物停药10天后,观察对大鼠各项生理、生化指标的影响。实验结果表明:对大鼠的进食量和生长发育(体重增长)均无影响。对肝功能和肾功能均未发现明显毒性作用。对血常规、血生化、尿液生化及骨髓片等均未见明显影响,各组间与对照组比较无明显差异。
试验例2
临床试用病例如下:
罗某,男,40岁;痔疮为外痔,已患三年,每次大便有痛感,偶尔有少量便血。第一次使用本发明实施例4提供的痔疮膏后,大便无痛感,也无便血,大便变顺畅。坚持连续使用4天,每天晚上睡前擦拭一次,每天便后擦拭一次,大便无痛感,也无便血,无不适。连续使用10天后,经检查,痔疮已痊愈。
曾某,男,35岁;痔疮为中后期内痔,已患四年,大便痛感强烈,便血较多;用市售的马应龙痔疮膏治疗,并用中药清洗患部,疗效不稳,时好时坏;近期病情恶化,准备手术治疗。第一次使用本发明实施例5提供的痔疮膏后,大便痛感减轻很多,便血量减少;大便后再次擦拭痔疮膏。第二天大便时,痛感又稍有减轻,大便排出较为顺畅,便血减少更加明显。坚持连续使用5天,每天晚上睡前擦拭一次,每天便后擦拭一次。5天后大便几乎无痛感,几乎无便血。连续使用7天后,大便通畅,毫无痛感,无便血,经检查,痔疮已痊愈。
柯某,女,10岁;混合痔1年,大便有痛感,间歇性便血;使用本发明实施例6提供的痔疮膏后,当天大便顺畅,痛感不明显。连续使用5天,每天晚上睡前擦拭一次,每天便后擦拭一次。5天后大便无痛感,无便血,肛门处无不适,经检查,痔疮已痊愈。
以上所描述的实施例是本发明一部分实施例,而不是全部的实施例。本发明的实施例的详细描述并非旨在限制要求保护的本发明的范围,而是仅仅表示本发明的选定实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
Claims (3)
1.一种痔疮膏,其特征在于,由按重量份数计的以下原料药制成:
黄柏6-15份;煅石膏25-35份;紫草5-15份;当归15-25份;莪术5-15份;乳香15-25份;五倍子5-15份;煅龙骨25-35份;白芨5-15份;冰片1-5份;珍珠25-35份;炉甘石25-35份;马铃薯5-10份;甘草酸铵10-15份;山莨菪碱3-8份;蛤蚧4-9份;槐花12-16份;大黄3-7份;山茶花5-12份;青黛8-12份;皂角7-15份和无花果10-15份。
2.根据权利要求1所述的痔疮膏,其特征在于,
所述黄柏10份;所述煅石膏30份;所述紫草10份;所述当归20份;所述莪术10份;所述乳香20份;所述五倍子10份;所述煅龙骨30份;所述白芨10份;所述冰片3份;所述珍珠30份和所述炉甘石30份。
3.一种如权利要求1-2任一项所述的痔疮膏的制备方法,其特征在于,包括:
将紫草、当归、莪术、槐花、山茶花、无花果分别进行蒸馏提取,所得提取物混合得到挥发油,将蒸馏所得混合药渣留存备用,挥发油备用;
选用优质马铃薯,去除病残部分,然后去皮,清洗;将洗净的马铃薯切碎然后打成浆,所得浆液经过滤处理或者离心处理得到洁净浆液,备用,过滤或离心后所得固体残渣烘干、研磨成粉,得薯粉,备用;
将混合药渣、薯粉、黄柏、白芨、大黄和皂角共同熬制成浸膏,备用;
将煅石膏、煅龙骨、炉甘石、五倍子、乳香、冰片、珍珠均研磨成粉末状,备用;
将蛤蚧采用乙醇浸泡处理,浸泡20-30小时,乙醇浓度为98wt%,浸泡后将浸泡液以及通过挤压蛤蚧得到的液体混合进行浓缩,所得浓缩物备用;
将青黛进行煎煮,将煎煮所得煎煮液浓缩至80wt%-85wt%后,再向其中加入甘草酸铵和山莨菪碱,所得混合物研磨成粉,得添加粉,备用;
向熔化的凡士林中加入粉末状的煅石膏、煅龙骨、炉甘石、珍珠和五倍子,然后进行搅拌,搅拌至温度降低至60℃后再加入乳香、冰片、添加粉、薯粉以及挥发油,最后再加入浸膏,搅拌30-40分钟后,再加入浓缩物和洁净浆液,继续搅拌,最后加入甘油和苯甲酸,制得符合要求的膏剂。
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