CN114588211A - 用于治疗外阴慢性单纯性苔藓的中药洗剂配方及制备方法 - Google Patents
用于治疗外阴慢性单纯性苔藓的中药洗剂配方及制备方法 Download PDFInfo
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Abstract
本发明涉及外阴慢性单纯性苔藓治疗技术领域,具体涉及一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方及制备方法,由如下的原料制备而成:黄柏、苦参、双花、蛇床子、白藓皮、川椒、当归、红花、三七、旱莲草,为了确保有效成分被充分提取,采用水提法提取;组方充分考虑到各组份的药效学特点,黄柏、苦参、双花、蛇床子、白癣皮、川椒配伍可清热利湿止痒的功效;当归、红花、三七、旱莲草活血化瘀,通络之作用;所用药物具有良好的止痒、抑制和祛除皮肤苔藓化的功效,同时兼具有止痒、消炎、调节免疫力、除湿、活血化瘀、解毒等功效,诸药相用,直达病变部位,可充分发挥疗效。
Description
技术领域
本发明涉及外阴慢性单纯性苔藓治疗技术领域,具体涉及用于治疗外阴慢性单纯性苔藓的中药洗剂配方及制备方法。
背景技术
外阴慢性单纯性苔藓(LSC),是一种以持续瘙痒和抓痒为特征的外阴非肿瘤性疾病,约占外阴瘙痒性疾病的10%~35%。其临床表现不一,患者常以瘙痒难耐就诊,其典型体征为患处多有皮肤暗红色或粉红色皮损,大小阴唇部皮肤变白、粗糙增厚、或萎缩褶皱,甚至皲裂、破溃等。该病的发病原因尚不清晰,近年来相关研究认为LSC可能与长期阴道分泌物、化学物质刺激、特异体质、精神因素、遗传因素和局部环境潮湿等因素有关。
由于本病的发病原因不明确,故临床治疗有一定的难度。西医常用糖皮质激素缓解瘙痒难耐的症状,临床指南推荐应用中效糖皮质激素如0.1%丁酸氢化可的松乳膏治疗,但可能出现局部红肿、灼热等不良反应,长期应用会出现萎缩变薄、纹理增厚、色素沉着等不良反应。中医认为外阴慢性单纯性苔藓属于“阴痒”“阴疮”的范畴,其病因主要感受风、湿、燥、热、毒、虫邪,涉及肝、脾、肾三脏。近年来中医药在该病治疗上发挥了很好的优势。
因此发明人针对西药治疗外阴慢性单纯性苔藓具有副作用的问题提出一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,有效缓解患者症状,避免发生治疗的同时产生不良反应,弥补了激素类外用搽剂的缺陷。
发明内容
本发明的目的在于提供能够有效缓解患者症状,避免治疗时出现的局部红肿、灼热等不良反应,避免西药长期治疗时产生的萎缩变薄、纹理增厚、色素沉着等不良反应,疗效好、治愈率高、局限性小、无不良反应等优点,有着优良有效性、实用性、安全性的用于治疗外阴慢性单纯性苔藓的中药洗剂配方。
为实现上述技术目的,达到上述技术效果,本发明是通过以下技术方案实现:
一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,其特征在于,由如下重量份的原料制备而成:黄柏2-5份、苦参2-5份、双花2-5份、蛇床子2-5份、白藓皮1-4份、川椒1-4份、当归2-5份、红花1-2份、三七1-2份、旱莲草1-4份。
作为优选,由如下重量份的原料制备而成:黄柏2.5-3.5份、苦参2.5-3.5份、双花2.5-3.5份、蛇床子2.5-3.5份、白藓皮1.5-2.5份、川椒1.5-2.5份、当归2.5-3.5份、红花1.0-1.5份、三七1.0-1.5份、旱莲草1.5-2.5份。
作为优选,由如下重量份的原料制备而成:黄柏3.5份、苦参3.5份、双花3.5份、蛇床子3.5份、白藓皮2.5份、川椒2.5份、当归3.5份、红花1.5份、三七1.5份、旱莲草2.5份。
作为优选,由如下重量份的原料制备而成:黄柏2.5份、苦参2.5份、双花2.5份、蛇床子2.5份、白藓皮1.5份、川椒1.5份、当归2.5份、红花1.0份、三七1.0份、旱莲草1.5份。
本发明中药复方洗剂原料药的最佳重量份为:黄柏3.0份、苦参3.0份、双花3.0份、蛇床子3.0份、白藓皮2.0份、川椒2.0份、当归3.0份、红花1.0份、三七1.0份、旱莲草2.0份。
一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方的制备方法,其特征在于,如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤1-3次;
S2:冷水浸泡8-15h;
S3:添加药材重量8-12倍的水,煎煮2-2.5h;
S4:添加药材重量8-12倍的水,煎煮1-1.5h;
S5:合并煎液,取上清液浓缩液600-1500ml,即得本发明的中药洗剂。
作为优选,如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤2次;
S2:冷水浸泡12h;
S3:添加药材重量10倍的水,煎煮2h;
S4:添加药材重量10倍的水,煎煮1.5h;
S5:合并煎液,取上清液浓缩液1000ml,即得本发明的中药洗剂。
作为优选,如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤2次;
S2:冷水浸泡10h;
S3:添加药材重量12倍的水,煎煮2h;
S4:添加药材重量12倍的水,煎煮1h;
S5:合并煎液,取上清液浓缩液1200ml,即得本发明的中药洗剂。
作为优选,如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤2次;
S2:冷水浸泡14h;
S3:添加药材重量8倍的水,煎煮2h;
S4:添加药材重量8倍的水,煎煮1.5h;
S5:合并煎液,取上清液浓缩液800ml,即得本发明的中药洗剂。
本发明的中药洗剂采用本领域常规的中药提取方法制备得到。为了确保有效成分被充分提取,本发明优选采用水提法在常压、60~100℃条件下进行提取。使用本发明中药洗剂前先进行热熏蒸,温度适宜后坐浴约30min,2次/d。
本发明所述的中药洗剂采用坐浴疗法,坐浴时通过水的热效应使人体毛孔充分打开,并使具有通经活络之效的佐药成分完全地渗透到人体当中,参与血液循环,促进人体患处对君药、臣药成分的吸收,清热利湿,止痒杀虫,保证对外阴慢性单纯性苔藓良好的治疗效果。
本发明提供的中药组合物中黄柏、苦参、白藓皮,大苦大寒、清热燥湿,为君药;双花、蛇床子、川椒杀虫、止痛止痒、疏散风热,散寒除湿,为臣药,并且蛇床子性温,可防黄柏、苦参太过苦寒,益阳补益;当归、红花、三七、旱莲草补血活血、散瘀止痛、通络止血,为佐药;多味中药配伍制备而成,具有清热燥湿、泻火解毒、抗炎止痒作用,尤其是对外阴慢性单纯性苔藓具有良好的治疗作用;保证治疗效果的前提下,降低对患者身体的不良影响,治疗的同时起到调理的作用。
黄柏具有清热燥湿,泻火除蒸,解毒疗疮的功效。归肾、膀胱经。用于湿热泻痢,带下阴痒,热淋涩痛,疮疡肿毒,湿疹湿疮。《临床常用中药手册》阐述:黄柏苦寒沉降,清热燥湿,泻火解毒力强,归肾、膀胱经,长于清下焦湿热。
苦参功效清热燥湿,杀虫,利尿。归心、肝、胃、大肠、膀胱经。用于阴肿阴痒,湿疹,湿疮,皮肤瘙痒,疥癣麻风。《滇南本草》阐述:凉血,解热毒,疥癞,脓窠疮毒。疗皮肤瘙痒,血风癣疮,顽皮白屑,肠风下血,便血。消风,消肿毒,痰毒。
双花(金银花)清热解毒,疏散风热。归肺、心、胃、大肠经。用于外感风热,温病发热,痈肿疮疡,咽喉肿痛,热毒痢疾。《本草纲目》阐述:金银花,善于化毒,故治痈疽、肿毒、疮癣。
蛇床子燥湿祛风,杀虫止痒,温肾壮阳。味辛、苦,性温。归肾经。用于阴痒带下,湿疹瘙痒,湿痹腰痛,肾虚阳痿,宫冷不孕。《本草经疏》阐述:蛇床子,味苦平,《别录》辛甘无毒。今详其气味,当必兼温燥,阳也。故主妇人阴中肿痛,男子阴痿湿痒,除痹气,利关节,恶疮。《别录》温中下气,令妇人子脏热,男子阴强,久服轻身,令人有子。盖以苦能除湿,温能散寒,辛能润肾,甘能益脾,故能除妇人男子一切虚寒湿所生病。寒湿既除,则病去身轻,性能益阳,故能已疾,而又有补益也。
白藓皮清热燥湿,解毒止痒,苦、寒。入脾、胃经。主治祛风,燥湿,清热,解毒。治风热疮毒,疥癣,皮肤痒疹,风湿痹痛,黄疸。《本草原始》阐述:治一切疥癞、恶风、疥癣、杨梅、诸疮热毒。
川椒(四川麻椒)温中止痛,杀虫止痒。归脾、胃、肾经。性味辛、麻,温。用于脘腹冷痛,呕吐泄泻,虫积腹痛;外治湿疹,阴痒。《本草纲目》阐述:椒,纯阳之物,其味辛而麻,其气温以热。入肺散寒,治咳嗽;入脾除湿,治风寒湿痹,水肿泻痢;入右肾补火,治阳衰溲数,足弱,久痢诸证。
当归补血活血,调经止痛,润肠通便。味甘、辛,性温。归肝、心、脾经。用于血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,风湿痹痛,跌扑损伤,痈疽疮疡,肠燥便秘。酒当归活血通经。用于经闭痛经,风湿痹痛,跌扑损伤。《本草正》阐述:当归,其味甘而重,故专能补血,其气轻而辛,故又能行血,补中有动,行中有补,诚血中之气药,亦血中之圣药也。”“大约佐之以补则补,故能养荣养血,补气生精,安五脏,强形体,益神志,凡有形虚损之病,无所不宜。佐之以攻则通,故能祛痛通便,利筋骨,治拘挛、瘫痪、燥、涩等证。
红花活血通经,散瘀止痛。味辛,性温。归心、肝经。用于经闭,痛经,恶露不行,症瘕痞块,胸痹心痛,瘀滞腹痛,胸胁刺痛,跌扑损伤,疮疡肿痛。《本草纲目》阐述:活血润燥,止痛散肿,通经。
三七散瘀止血,消肿定痛。味甘、微苦,温。归肝、胃经。用于咯血,吐血,衄血,便血,崩漏,外伤出血,胸腹刺痛,跌扑肿痛。《本草纲目》阐述:止血散血定痛,金刃箭伤、跌扑杖疮、血出不止者,嚼烂涂,或为末掺之,其血即止。亦主吐血衄血,下血血痢,崩中经水不止,产后恶血不下,血运血痛,赤目痈肿,虎咬蛇伤诸病。
旱莲草(墨旱莲)凉血,止血,补肾,益阴。性味甘酸,凉。入肝、肾经。主治:治吐血,咳血,衄血,尿血,便血,血痢,刀伤出血,须发早白,白喉,淋浊、带下,阴部湿痒。《日华子本草》阐述:排脓,止血,通小肠,敷一切疮并蚕。
本发明的有益效果:
本发明提供的用于治疗外阴慢性单纯性苔藓的中药洗剂配方中,各组分之间进行合理配伍,并发挥协同作用,具有清热燥湿、泻火解毒、抗炎止痒作用,尤其是对外阴慢性单纯性苔藓具有良好的治疗作用;与治疗外阴慢性单纯性苔藓常用的糖皮质激素类药物相比,不易反弹、复发或产生耐药性等副作用,避免出现局部红肿、灼热等不良反应,防止长期应用出现的萎缩变薄、纹理增厚、色素沉着等副作用问题,保证使用者的用药安全。
本发明提供的用于治疗外阴慢性单纯性苔藓的中药洗剂配方中,组方充分考虑到各组份的药效学特点,中医认为,此病的主要发病机理是病邪浸渍外阴,可因肝郁伐脾,肝热脾湿,湿热浸渍,冲任受损,阴部为湿热阻遏而出现此证。其中黄柏有清热燥湿,泻火解毒的作用;苦参清热除湿,解毒杀虫,阴痒阴肿;双花具有抑菌、抗病毒、抗炎、解毒、调节免疫等作用;蛇床子有燥湿杀虫止痒的功效;川椒可以杀虫止痒,温中止痛,散寒除湿,杀虫;则黄柏、苦参、双花、蛇床子、白癣皮、川椒配伍可清热利湿止痒的功效。当归、红花、三七、旱莲草活血化瘀,通络之作用。
本发明提供的用于治疗外阴慢性单纯性苔藓的中药洗剂配方中,所用药物具有良好的止痒、抑制和祛除皮肤苔藓化的功效,同时兼具有止痒、消炎、调节免疫力、除湿、活血化瘀、解毒等功效,诸药相用,直达病变部位,可充分发挥疗效。
当然,实施本发明的任一产品并不一定需要同时达到以上所述的所有优点。
具体实施方式
下面对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例,都属于本发明保护的范围。
实施例1
一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,由如下重量份的原料制备而成:黄柏30g、苦参30g、双花30g、蛇床子30g、白藓皮20g、川椒20g、当归30g、红花10g、三七10g、旱莲草20g。
一种用于治疗外阴慢性单纯性苔藓的中药洗剂的制备方法:如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤2次;
S2:冷水浸泡12h;
S3:添加药材重量10倍的水,煎煮2h;
S4:添加药材重量10倍的水,煎煮1.5h;
S5:合并煎液,取上清液浓缩液1000ml,即得本发明的中药洗剂。
使用前进行热熏蒸,温度适宜后坐浴约30min,2次/d,8周为一疗程。月经期禁用,用药期间注意外阴清洁,勤换内裤,忌食辛辣刺激食物。
此方为标准用量,适用于一般患者,改善患者外阴慢性单纯性苔藓的症状,且疗效稳定,方中黄柏、苦参、蛇床子等均可改善微循环,方中当归、红花、三七、旱莲草活血化瘀通络,减轻局部皮肤弹性差、颜色变浅的症状。方中黄柏、苦参、白藓皮等均可清热、燥湿,去除湿热之邪而痒止,改善患者阴痒、阴痛的症状,另外可改善患者皮肤粗糙增厚、皮肤破溃等。
实施例2
一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,由如下重量份的原料制备而成:黄柏25g、苦参25g、双花25g、蛇床子25g、白藓皮15g、川椒15g、当归25g、红花10g、三七10g、旱莲草15g。
一种用于治疗外阴慢性单纯性苔藓的中药洗剂的制备方法:如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤2次;
S2:冷水浸泡10h;
S3:添加药材重量12倍的水,煎煮2h;
S4:添加药材重量12倍的水,煎煮1h;
S5:合并煎液,取上清液浓缩液1200ml,即得本发明的中药洗剂。
使用前进行热熏蒸,温度适宜后坐浴约30min,2次/d,8周为一疗程。月经期禁用,用药期间注意外阴清洁,勤换内裤,忌食辛辣刺激食物。
此方为低水平用量,适用于症状较轻患者与幼儿老弱,减少各味原药材用量,降低浸泡时间,并且增加溶液用量稀释洗剂浓度,降低中药洗剂中的中药成分含量,根据患者年龄体制与病情调整用量,使该中药洗剂药方适用于不同患者,改善患者瘙痒的症状,川椒可以杀虫止痒,温中止痛,散寒除湿,杀虫;则黄柏、苦参、双花、蛇床子、白癣皮、川椒配伍可清热利湿止痒的功效;当归、红花、三七、旱莲草活血化瘀,通络之作用,药量降低进一步避免对患者产生毒副作用,保证使用者的用药安全。
实施例3
一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,由如下重量份的原料制备而成:黄柏35g、苦参35g、双花35g、蛇床子35g、白藓皮25g、川椒25g、当归35g、红花15g、三七15g、旱莲草25g。
一种用于治疗外阴慢性单纯性苔藓的中药洗剂的制备方法:如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤2次;
S2:冷水浸泡14h;
S3:添加药材重量8倍的水,煎煮2h;
S4:添加药材重量8倍的水,煎煮1.5h;
S5:合并煎液,取上清液浓缩液800ml,即得本发明的中药洗剂。
使用前进行热熏蒸,温度适宜后坐浴约30min,2次/d,8周为一疗程。月经期禁用,用药期间注意外阴清洁,勤换内裤,忌食辛辣刺激食物。
此方为高水平用量,适用于症状较重患者,病情重、病势急、病程短者用量宜大,增加各味原药材用量,提高浸泡时间,并且减少溶液用量提高洗剂浓度,增加中药洗剂中的中药成分含量,黄柏清热燥湿,泻火解毒;苦参清热除湿,解毒杀虫,阴痒阴肿;双花抑菌、抗病毒、抗炎、解毒、调节免疫;蛇床子燥湿、杀虫、止痒;川椒杀虫止痒、温中止痛、散寒除湿、杀虫;黄柏、苦参、双花、蛇床子、白癣皮、川椒配伍清热利湿止痒,当归、红花、三七、旱莲草活血通络,诸药相用,直达病变部位,可充分发挥疗效。
实施例4
本发明的临床治疗观察如下:
(一)选取我院门诊诊断外阴慢性单纯性苔藓患者124例,发病年限0.5-10年,年龄25-65岁,平均年龄(50.43±8.27),符合标准的患者随机分成两组,本发明组和对照组(西药治疗)组,分别是62例。
(二)诊断标准:参考《中药新药临床研究指导原则》和《第九版妇产科学》制定诊断标准。
(三)治疗方法:每晚睡觉前先用温水清洗外阴,用本发明先热熏蒸,温度适宜后坐浴约30min,2次/d,8为周一疗程。月经期禁用,用药期间注意外阴清洁,勤换内裤,忌食辛辣刺激食物。
治疗开始后每2周返院复查一次,观察询问患者症状及不良反应,观察局部病灶变化情况并记录,治疗一疗程后,病灶再次局部病理活检观察组织变化情况。
(四)疗效评定标准:皮肤弹性恢复、颜色恢复正常和瘙痒症状完全消失为治愈;原病变区皮肤弹性基本恢复、大部分颜色恢复正常和瘙痒症状基本消失为显效;皮肤弹性有所改善、部分颜色恢复和瘙痒症状部分减轻为有效;皮肤弹性、颜色和瘙痒症状均无明显变化为无效。
(五)本发明组标准用量组方与对照组(西药治疗)比较:
本发明组,例数39例,临床痊愈8人,显效9人,有效17人,无效7人,总有效率为82.5%;对照组,例数39例,临床痊愈3人,显效6人,有效13人无效18例,总有效率为55%;两者具有显著地差异,说明本发明组标准方明显优于对照组。
(六)本发明组低水平用量组方与对照组(西药治疗)比较:
本发明组,例数14例,临床痊愈7人,显效2人,有效3人,无效2人,总有效率为85.71%;对照组,例数14例,临床痊愈4人,显效1人,有效3人,无效6例,总有效率为57.14%;两者具有显著地差异,说明本发明组标准方明显优于对照组。
(七)本发明组高水平用量组方与对照组(西药治疗)比较:
本发明组,例数9例,临床痊愈4人,显效2人,有效2人,无效1人,总有效率为88.89%;对照组,例数9例,临床痊愈1人,显效2人,有效2人,无效4例,总有效率为55.56%;两者具有显著地差异,说明本发明组标准方明显优于对照组。
实施例5
典型病例
病例1:苗某某,女,50岁,已婚,围绝经期。患有外阴单纯性硬化性苔藓5年,小阴唇及阴蒂包皮可见局灶性病变颜色减退,皮肤弹性可,瘙痒严重,患病期间使用过糖皮质激素外用,瘙痒减轻但局部病灶未见好转。使用本发明2个月,瘙痒症状明显减轻,局部病灶颜色逐渐变浅,皮肤弹性正常,继续使用3个月,瘙痒症状消失,颜恢复正常。后随访3个月未见复发。
病例2:胡某某,女41岁,阴唇后联合瘙痒6个月,近期发现阴唇后联合存在孤立病灶皮肤呈粉红色,皮肤弹性良好。使用本发明3个月,瘙痒症状消失,病灶局部颜色恢复正常。随访半年未见复发。
病例3:陈某某,女,32岁。发现阴唇间沟颜色暗红伴局部间断瘙痒1年,皮肤弹性良好。使用本发明4个月,瘙痒症状消失,局部颜色正常。随访半年未见复发。
以上说明本发明所提供的用于治疗外阴慢性单纯性苔藓的中药洗剂配方,各组分之间进行合理配伍,并发挥协同作用,具有清热燥湿、泻火解毒、抗炎止痒作用,有效缓解瘙痒症状,治疗周期短,复发率低,对外阴慢性单纯性苔藓具有良好的治疗作用。
在本说明书的描述中,参考术语“一个实施例”、“示例”、“具体示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本发明的至少一个实施例或示例中。在本说明书中,对上述术语的示意性表述不一定指的是相同的实施例或示例。而且,描述的具体特征、结构、材料或者特点可以在任何的一个或多个实施例或示例中以合适的方式结合。
以上公开的本发明优选实施例只是用于帮助阐述本发明。优选实施例并没有详尽叙述所有的细节,也不限制该发明仅为所述的具体实施方式。显然,根据本说明书的内容,可作很多的修改和变化。本说明书选取并具体描述这些实施例,是为了更好地解释本发明的原理和实际应用,从而使所属技术领域技术人员能很好地理解和利用本发明。本发明仅受权利要求书及其全部范围和等效物的限制。
Claims (10)
1.一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,其特征在于,由如下重量份的原料制备而成:黄柏2-5份、苦参2-5份、双花2-5份、蛇床子2-5份、白藓皮1-4份、川椒1-4份、当归2-5份、红花1-2份、三七1-2份、旱莲草1-4份。
2.如权利要求1所述的一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,其特征在于:由如下重量份的原料制备而成:黄柏2.5-3.5份、苦参2.5-3.5份、双花2.5-3.5份、蛇床子2.5-3.5份、白藓皮1.5-2.5份、川椒1.5-2.5份、当归2.5-3.5份、红花1.0-1.5份、三七1.0-1.5份、旱莲草1.5-2.5份。
3.如权利要求2所述的一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,其特征在于:由如下重量份的原料制备而成:黄柏3.0份、苦参3.0份、双花3.0份、蛇床子3.0份、白藓皮2.0份、川椒2.0份、当归3.0份、红花1.0份、三七1.0份、旱莲草2.0份。
4.如权利要求2所述的一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,其特征在于:由如下重量份的原料制备而成:黄柏2.5份、苦参2.5份、双花2.5份、蛇床子2.5份、白藓皮1.5份、川椒1.5份、当归2.5份、红花1.0份、三七1.0份、旱莲草1.5份。
5.如权利要求2所述的一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方,其特征在于:由如下重量份的原料制备而成:黄柏3.5份、苦参3.5份、双花3.5份、蛇床子3.5份、白藓皮2.5份、川椒2.5份、当归3.5份、红花1.5份、三七1.5份、旱莲草2.5份。
6.一种制备权利要求1-5任一项所述用于治疗外阴慢性单纯性苔藓的中药洗剂的方法,其特征在于,如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤1-3次;
S2:冷水浸泡8-15h;
S3:添加药材重量8-12倍的水,煎煮2-2.5h;
S4:添加药材重量8-12倍的水,煎煮1-1.5h;
S5:合并煎液,取上清液浓缩液600-1500ml,即得本发明的中药洗剂。
7.如权利要求6所述的一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方的制备方法,其特征在于,如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤2次;
S2:冷水浸泡12h;
S3:添加药材重量10倍的水,煎煮2h;
S4:添加药材重量10倍的水,煎煮1.5h;
S5:合并煎液,取上清液浓缩液1000ml,即得本发明的中药洗剂。
8.如权利要求6所述的一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方的制备方法,其特征在于,如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤2次;
S2:冷水浸泡10h;
S3:添加药材重量12倍的水,煎煮2h;
S4:添加药材重量12倍的水,煎煮1h;
S5:合并煎液,取上清液浓缩液1200ml,即得本发明的中药洗剂。
9.如权利要求6所述的一种用于治疗外阴慢性单纯性苔藓的中药洗剂配方的制备方法,其特征在于,如下步骤的方法制备而得:
S1:取中药配方原材料常水洗涤2次;
S2:冷水浸泡14h;
S3:添加药材重量8倍的水,煎煮2h;
S4:添加药材重量8倍的水,煎煮1.5h;
S5:合并煎液,取上清液浓缩液800ml,即得本发明的中药洗剂。
10.如权利要求6-9所述方法制备的中药洗剂配方在制备治疗外阴慢性单纯性苔藓药物中的应用。
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