CN109846774B - Antibacterial mouth wash and preparation method thereof - Google Patents
Antibacterial mouth wash and preparation method thereof Download PDFInfo
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- CN109846774B CN109846774B CN201910058677.3A CN201910058677A CN109846774B CN 109846774 B CN109846774 B CN 109846774B CN 201910058677 A CN201910058677 A CN 201910058677A CN 109846774 B CN109846774 B CN 109846774B
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Abstract
The invention aims to provide bacteriostatic mouth wash with better bacteriostatic effect and low irritation, which is characterized by comprising the following components in percentage by mass: 1.2 to 2.0 percent of phellodendron ketone, 1.5 to 2.2 percent of white atractylodes rhizome essential oil, 1.0 to 2.0 percent of angelica essential oil, 0.1 to 0.2 percent of preservative, 0.1 to 0.3 percent of solubilizer, 3 to 5 percent of humectant, 1.0 to 3.0 percent of flavoring agent and the balance of deionized water. The phellodendron ketone can promote the bacteriostatic action of the bighead atractylodes rhizome essential oil and the angelica essential oil, so that the bacteriostatic effect is improved when the phellodendron ketone, the bighead atractylodes rhizome essential oil and the angelica essential oil are used together, and therefore the bacteriostatic mouth wash disclosed by the invention has a good bacteriostatic effect. In addition, the bacteriostatic mouth wash disclosed by the invention is free of irritation, toxic and side effects and good in taste, so that the bacteriostatic mouth wash is suitable for daily use.
Description
Technical Field
The invention belongs to the field of daily necessities, relates to mouthwash and a preparation method thereof, and particularly relates to antibacterial mouthwash and a preparation method thereof.
Background
The mouthwash is a common daily article and is used for cleaning the oral cavity to achieve the effects of maintaining the health of the oral cavity, reducing halitosis and the like.
In general, the number and the kind of the foreign bacteria in the oral cavity are large and complicated, and these foreign bacteria are also very serious in the occurrence of diseases such as dental caries and periodontitis. In order to remove the bacteria more thoroughly when rinsing the mouth, some bacteriostatic mouthwashes have been developed in the prior art, in which a certain amount of bacteriostatic agent is added.
At present, the common bacteriostatic agents or bacteriostatic agents in daily necessities mainly comprise phenols, boric acids and the like, and common preservatives such as parabens and traditional bactericides such as sulfur and the like are also used as bacteriostatic agents in the field of daily necessities. However, these ingredients are often chemically synthesized or natural ingredients having strong irritation, and when used in the oral cavity, they tend to irritate the oral mucosa of the user, thereby reducing the feeling of use and possibly causing allergy. In addition, if the user has an oral ulcer or oral mucosal lesion in the mouth, such irritating ingredients may also over-irritate the wound and aggravate the condition.
Therefore, in recent years, researchers in the field of daily necessities have paid more attention to the development of natural and low-irritation antibacterial components, such as essential oil antibacterial components extracted from various traditional Chinese medicines. However, the extracted essential oils generally have low bacteriostatic activity, and it is difficult to achieve the desired bacteriostatic effect.
Disclosure of Invention
In order to solve the problems, the inventor of the invention researches different types of traditional Chinese medicine essential oil, combination and effects of the traditional Chinese medicine essential oil and the combination, and finds that when phellodendron ketone is used together with bighead atractylodes rhizome essential oil and angelica essential oil, the bacteriostatic effect of the two types of essential oil is promoted, so that the three components can generate better bacteriostatic effect after being mixed.
Based on the above findings, the inventors propose bacteriostatic mouth wash containing obacunone, white atractylodes rhizome essential oil and dahurian angelica root essential oil. Specifically, the invention provides bacteriostatic mouth wash which is characterized by comprising the following components in percentage by mass: 1.2 to 2.0 percent of phellodendron ketone, 1.5 to 2.2 percent of white atractylodes rhizome essential oil, 1.0 to 2.0 percent of angelica essential oil, 0.1 to 0.2 percent of preservative, 0.1 to 0.3 percent of solubilizer, 3 to 5 percent of humectant, 1.0 to 3.0 percent of flavoring agent and the balance of deionized water.
The bacteriostatic mouth wash provided by the invention also has the technical characteristics that the preservative is sorbic acid, the solubilizer is polysorbate 80, and the flavoring agent comprises menthol and acesulfame potassium.
The bacteriostatic mouth wash provided by the invention also has the technical characteristics that the mass percent of menthol is 0.5-1.5%, and the mass percent of acesulfame potassium is 0.5-1.5%.
The bacteriostatic mouth wash provided by the invention also has the technical characteristics that the bacteriostatic mouth wash also contains caramel pigment 0.4-1.0%.
The bacteriostatic mouth wash provided by the invention also has the technical characteristics that the mass percent of phellodendron ketone is 1.6%, the mass percent of bighead atractylodes rhizome essential oil is 1.9%, and the mass percent of angelica dahurica essential oil is 1.7%.
The invention also provides a preparation method of the antibacterial mouthwash, which is characterized by comprising the following steps:
step S1, putting deionized water into a clean container, adding the preservative, the solubilizer, the humectant and the flavoring agent while stirring at room temperature until the preservative, the solubilizer, the humectant and the flavoring agent are completely dissolved and uniformly dispersed to prepare phase A; step S2, adding phellodendron ketone, bighead atractylodes rhizome essential oil and angelica essential oil into the phase A, and uniformly stirring at room temperature until a stable clear solution system is formed; and step S3, standing at room temperature for a preset time, and filtering to obtain the bacteriostatic mouth wash.
The preparation method of the bacteriostatic mouth wash provided by the invention also has the technical characteristics that the stirring rotation speed in the step S1 and the stirring rotation speed in the step S2 are 800 revolutions per minute.
The preparation method of the bacteriostatic mouth wash provided by the invention also has the technical characteristics that the preparation process of the bighead atractylodes rhizome essential oil is as follows: weighing Atractylodis rhizoma powder, placing in a drying container, adding ethyl acetate at a liquid-solid ratio of 6:1, shaking, sealing, placing in the shade, soaking at 22-24 deg.C for 3 times with 12h ultrasound for 20min each time to obtain leachate; filtering the leaching solution, recovering ethyl acetate by adopting a rotary film decompression method, adding a small amount of anhydrous sodium sulfate into the residual liquid to remove water and dry, and filtering to obtain the white atractylodes rhizome essential oil.
The preparation method of the bacteriostatic mouth wash provided by the invention also has the technical characteristics that the preparation process of the angelica essential oil is as follows: weighing radix Angelicae Dahuricae powder, placing in a drying container, adding ethyl acetate according to a liquid-solid ratio of 8:1, shaking, sealing, placing in indoor shade, soaking at 22-24 deg.C for 3 times, and ultrasonically treating for 20min every 3 hr to obtain leachate; and (3) filtering the leaching solution, continuously distilling for a preset time by using a steam distillation device, adding 95% ethanol into the residual liquid until the final concentration of the ethanol in the system is 65%, standing overnight, filtering to remove precipitates, adding a small amount of anhydrous sodium sulfate to remove water and dry, filtering, and performing rotary distillation and concentration to obtain the angelica essential oil.
Action and Effect of the invention
According to the bacteriostatic mouth wash provided by the invention, 1.2-2.0% of phellodendron ketone, 1.5-2.2% of white atractylodes rhizome essential oil and 1.0-2.0% of angelica essential oil are contained in percentage by mass, wherein the phellodendron ketone can promote the bacteriostatic action of the white atractylodes rhizome essential oil and the angelica essential oil, so that the bacteriostatic effect is improved when the phellodendron ketone, the white atractylodes rhizome essential oil and the angelica essential oil are used together, and therefore, the bacteriostatic mouth wash provided by the invention has a better bacteriostatic effect than that of the conventional bacteriostatic mouth wash containing traditional Chinese medicine essential oil. In addition, the bacteriostatic mouth wash disclosed by the invention is free of irritation, toxic and side effects and good in taste, so that the bacteriostatic mouth wash is suitable for daily use.
Detailed Description
The following examples are given to illustrate specific embodiments of the present invention.
In the following examples, bacteriostatic mouth washes were prepared by the following steps:
step S1, putting deionized water into a clean container, adding sorbic acid (as a preservative), polysorbate 80 (as a solubilizer, hereinafter referred to as polysorbate), glycerin (as a humectant), caramel pigment (as a pigment for adjusting the color of a finished product), menthol and acesulfame potassium (all as flavoring agents) while stirring (600 revolutions per minute) at room temperature until the components are completely dissolved and uniformly dispersed to prepare phase A;
step S2, adding phellodendron ketone, bighead atractylodes rhizome essential oil and angelica essential oil into phase A, and uniformly stirring (600 revolutions per minute) at room temperature until a stable clear solution system is formed;
and step S3, standing at room temperature for 24h, and filtering (sterilizing or filtering and then adding other aseptic treatment) to obtain the bacteriostatic mouth wash.
The essential oil of the white atractylodes rhizome and the essential oil of the dahurian angelica root used in the process are both prepared by the laboratory of the inventor, and the obacunone and other reagents are purchased by common commercial approaches.
The preparation process of the white atractylodes rhizome essential oil is as follows: weighing 30g of 20-mesh bighead atractylodes rhizome powder, placing the powder into a dry 500L conical flask, adding 180mL of ethyl acetate according to the liquid-solid ratio of 6:1, shaking up, sealing, placing the flask in the shade at the ambient temperature of 22-24 ℃, soaking for 12h every time, and carrying out ultrasonic treatment for 20min for 3 times to obtain a leaching solution. Filtering the leaching solution, recovering ethyl acetate by adopting a rotary film decompression method, adding a small amount of anhydrous sodium sulfate into the residual liquid to remove water and dry, and filtering to obtain golden yellow oily liquid, namely the white atractylodes rhizome essential oil.
Through a process parameter comparison experiment, the inventor of the invention determines that the optimal process conditions of the white atractylodes rhizome essential oil are as follows: the solvent adopts ethyl acetate, the liquid-solid ratio is 6:1, and the leaching process is that ultrasonic treatment is carried out for 3 times every 12 hours under the condition of the environmental temperature of 24 ℃; under the condition, the yield of the white atractylodes rhizome essential oil is the highest and is 2.83 percent.
The preparation process of the angelica essential oil comprises the following steps: weighing 30g of radix angelicae dahuricae powder with a 20-mesh sieve, placing the powder in a dry 500L conical flask, adding 160mL of distilled water according to a liquid-solid ratio of 8:1, shaking up, sealing, placing the flask in the shade at an ambient temperature of 22-24 ℃, soaking for 3h every time, and performing ultrasonic treatment for 20min for 3 times to obtain a leaching solution. Filtering the leachate, continuously distilling for 5h by using a water vapor distillation device, adding 95% ethanol into the residual liquid until the final concentration of the ethanol in the system is 65%, standing overnight (namely, ethanol extraction), filtering to remove precipitates, adding a small amount of anhydrous sodium sulfate to remove water and dry, filtering, and performing rotary evaporation and concentration to obtain brown yellow oily liquid, namely the angelica essential oil.
Through a process parameter comparison experiment, the inventor of the invention determines that the optimal process conditions of the angelica essential oil are as follows: the environmental temperature is 24 ℃, the soaking time is 3h, the ultrasonic treatment is carried out for 20min for 3 times, the ethanol concentration in the ethanol extraction is 65%, and the yield of the angelica essential oil is the highest and is 2.46% under the condition.
In addition, the preparation process of the bacteriostatic mouth wash is mainly a physical mixing process, so that the content ratio of each component in the finally obtained solution is equal to the addition amount of the components. In the following description, the addition amounts of the respective components are expressed by percentage contents, and these percentage contents are all referred to as mass percentage contents. Obviously, these contents also correspond to the contents of the ingredients in the finished mouthwash solution in percentages by mass.
< example 1>
Example 1 is a preparation experiment of the bacteriostatic mouth wash of the invention.
In example 1, the addition amounts of the respective components were: 1.6% of phellodendron ketone, 1.9% of bighead atractylodes rhizome essential oil, 1.7% of angelica essential oil, 0.15% of sorbic acid, 0.18% of polysorbate, 3.6% of glycerol, 0.58% of caramel pigment, 1.4% of menthol, 1.2% of acesulfame potassium and the balance of deionized water.
< example 2>
Example 2 is a preparation experiment of the bacteriostatic mouth wash of the invention.
In example 2, the addition amounts of the respective components were: 1.3% of phellodendron ketone, 1.7% of bighead atractylodes rhizome essential oil, 1.9% of angelica essential oil, 0.2% of sorbic acid, 0.12% of polysorbate, 4% of glycerol, 0.7% of caramel pigment, 1.5% of menthol, 1.5% of acesulfame and the balance of deionized water.
< example 3>
Example 3 is a preparation experiment of the bacteriostatic mouth wash of the invention.
In example 3, the addition amounts of the respective components were: : 2.0% of phellodendron ketone, 1.6% of white atractylodes rhizome essential oil, 1.2% of angelica essential oil, 0.10% of sorbic acid, 0.22% of polysorbate, 3.0% of glycerol, 0.4% of caramel pigment, 1.0% of menthol, 1.0% of acesulfame potassium and the balance of deionized water.
The following comparative example is a comparative experiment of bacteriostatic mouth wash. In the following comparative examples, the bacteriostatic mouth wash was prepared in the same manner as in the above examples, by mixing the ingredients other than the bacteriostatic component (essential oil or chemically synthesized bacteriostatic agent) to prepare phase a, adding the bacteriostatic component to phase a, stirring, standing, and filtering to obtain the bacteriostatic mouth wash.
< comparative example 1>
The bacteriostatic mouth wash of comparative example 1 of the invention is prepared from the following components: 1.9% of bighead atractylodes rhizome essential oil, 1.7% of angelica essential oil, 0.15% of sorbic acid, 0.18% of polysorbate, 3.6% of glycerin, 0.58% of caramel pigment, 1.4% of menthol, 1.2% of acesulfame potassium and the balance of deionized water.
< comparative example 2>
The bacteriostatic mouth wash of comparative example 2 of the invention is prepared from the following components: 1.6% of phellodendron ketone, 1.7% of angelica essential oil, 0.15% of sorbic acid, 0.18% of polysorbate, 3.6% of glycerol, 0.58% of caramel pigment, 1.4% of menthol, 1.2% of acesulfame potassium and the balance of deionized water.
< comparative example 3>
The bacteriostatic mouth wash of comparative example 3 of the invention is prepared from the following components: 1.6% of phellodendron ketone, 1.9% of bighead atractylodes rhizome essential oil, 0.15% of sorbic acid, 0.18% of polysorbate, 3.6% of glycerin, 0.58% of caramel pigment, 1.4% of menthol, 1.2% of acesulfame potassium and the balance of deionized water.
< comparative example 4>
The bacteriostatic mouth wash of comparative example 4 of the invention is prepared from the following components: 1.6% of phellodendron ketone, 0.15% of sorbic acid, 0.18% of polysorbate, 3.6% of glycerol, 0.58% of caramel pigment, 1.4% of menthol, 1.2% of acesulfame potassium and the balance of deionized water.
< comparative example 5>
The bacteriostatic mouth wash of comparative example 5 of the invention is prepared from the following components: 0.02% of benzyl alcohol, 0.15% of sorbic acid, 0.18% of polysorbate, 3.6% of glycerol, 0.58% of caramel pigment, 1.4% of menthol, 1.2% of acesulfame potassium and the balance of deionized water.
< comparative example 6>
The bacteriostatic mouth wash of comparative example 6 of the invention is prepared from the following components: 0.02% of benzyl alcohol, 1.6% of phellodendron ketone, 0.15% of sorbic acid, 0.18% of polysorbate, 3.6% of glycerol, 0.58% of caramel pigment, 1.4% of menthol, 1.2% of acesulfame potassium and the balance of deionized water.
< comparative example 7>
The bacteriostatic mouth wash of comparative example 7 of the invention is prepared from the following components: 0.02% of benzyl alcohol, 1.9% of white atractylodes rhizome essential oil, 1.7% of angelica essential oil, 0.15% of sorbic acid, 0.18% of polysorbate, 3.6% of glycerol, 0.58% of caramel pigment, 1.4% of menthol, 1.2% of acesulfame potassium and the balance of deionized water.
Effects and effects of the embodiments
The effect and effect of the bacteriostatic mouth wash prepared by the embodiment of the invention are described in the following by combining the performance test results of the above embodiments and comparative examples.
1. Experiment for inhibiting bacteria
According to appendix C4 of GB15797-2002 sanitation Standard for Disposable sanitary articles, the bacteriostatic performance test method of the dissolution antibacterial (bacteriostatic) product is adopted to detect the bacteriostatic level of the bacteriostatic mouthwash prepared by the invention by a suspension quantitative method so as to measure the bacteriostatic ability of the bacteriostatic mouthwash. The bacteria to be detected are three types of bacteria, namely staphylococcus aureus (ATCC6538), escherichia coli (ATCC 25922) and candida albicans (ATCC 10231), the detection concentration is 1:1, the action time is 20min, and the result is shown in the following table 1.
Table 1 results of tests on bacteriostatic properties of bacteriostatic mouth rinses of examples and comparative examples
| Group of | Staphylococcus aureus inhibition (%) | Escherichia coli inhibition (%) | Candida albicans inhibition (%) |
| Example 1 | 99.54 | 99.38 | 98.96 |
| Example 2 | 97.25 | 97.46 | 98.02 |
| Example 3 | 98.47 | 99.51 | 99.04 |
| Comparative example 1 | 56.27 | 50.33 | 58.78 |
| Comparative example 2 | 91.39 | 92.73 | 89.73 |
| Comparative example 3 | 90.78 | 91.54 | 90.02 |
| Comparative example 4 | 82.08 | 85.67 | 80.16 |
| Comparative example 5 | 80.49 | 78.36 | 80.21 |
| Comparative example 6 | 85.28 | 86.11 | 84.47 |
| Comparative example 7 | 81.93 | 79.16 | 82.39 |
As can be seen directly from table 1, the bacteriostatic mouth washes of examples 1 to 3 all have good bacteriostatic effects, and the inhibitory rates on three common bacteria, namely staphylococcus aureus, escherichia coli and candida albicans, are all more than 97%.
When example 1 is compared with comparative example 1, it can be seen that when phellodendron ketone is not used, the bacteriostatic effect of the combination of the white atractylodes rhizome essential oil and the dahurian angelica root essential oil is poor.
Comparing the example 1 with the comparative example 1, the comparative example 2 and the comparative example 3 respectively, it can be seen that when the bighead atractylodes rhizome essential oil and the obacunone are mixed or the angelica dahurica essential oil and the obacunone are mixed, the inhibition rate of the three bacteria can reach about 90%, and the inhibition effect of the obacunone on the two essential oils is promoted.
Comparing comparative example 4 and comparative example 5, it can be seen that 1.6% of obacunone and 0.02% of benzyl alcohol have almost the same bacteriostatic effect; further, comparing example 1 with comparative example 7, it can be seen that the bacteriostatic rate of the mixture of 1.6% obacunone, the white atractylodes rhizome essential oil and the radix angelicae dahuricae essential oil is significantly higher than that of the mixture of 0.02% benzyl alcohol and the two essential oils, which indicates that the promoting effect of obacunone on the bacteriostatic effect of the white atractylodes rhizome essential oil and the radix angelicae dahuricae essential oil is not due to the simple superposition of the bacteriostatic effect of obacunone and the bacteriostatic effect of the essential oils. In addition, comparing comparative example 4, comparative example 5 and comparative example 6, it can be seen that the bacteriostatic rate is slightly improved after the obacunone and the phenol are mixed, which indicates that the bacteriostatic effect is superimposed after the two bacteriostatic substances are mixed, but the apparent bacteriostatic effect generated by the superposition of the effect is lower than the apparent bacteriostatic effect generated after the obacunone promotes the atractylodes macrocephala koidz essential oil and the angelica dahurica essential oil, and further indicates that the obacunone actually has a promoting effect on the two essential oils. The phenomenon is probably related to the components with bacteriostatic activity contained in the two essential oils, the obacunone has certain bacteriostatic action and can generate synergistic action with the active components, so that the bacteriostatic ability of the two essential oils is greatly improved, and the common bacteriostatic agent cannot play a role.
Combining the results of the above examples and comparative examples, the following conclusions can be drawn: the phellodendron ketone has a promoting effect on the bacteriostatic effect of the bighead atractylodes rhizome essential oil and the angelica essential oil, and the promoting effect is not generated by simple superposition of the bacteriostatic effect. Therefore, the bacteriostatic effect of the bacteriostatic mouth wash product can be greatly improved by mixing the obacunone, the white atractylodes rhizome essential oil and the angelica dahurica essential oil, so that the bacteriostatic requirement in daily use is met.
2. Irritation test
A total of 90 healthy, oral disease-free college students (18-26 years old) were recruited as volunteers and randomized into 3 groups of 30 persons each. The mouthwashes prepared in examples 1 to 3 were used for 14 days, once a day, morning and evening, respectively. The results are shown in Table 2 below.
TABLE 2 acute toxicity test results
| Group of | Irritation of mucous membrane | Health state of teeth | Sense organ after use |
| EXAMPLE 1 group | Is free of | Good effect | Fresh breath and has a certain deodorizing effect |
| EXAMPLE 2 group | Is free of | Good effect | Fresh breath and has a certain deodorizing effect |
| EXAMPLE 3 group | Is free of | Good effect | Fresh breath and has a certain deodorizing effect |
The results of irritation tests of all groups of examples are combined, so that the mouth wash of all the examples is free of irritation, toxic and side effects and good in taste after being used, and has the certain effects of removing bad breath and refreshing breath.
From the results of the performance tests, it can be known that the bacteriostatic mouth wash of the embodiment contains, by mass, 1.2% -2.0% of obacunone, 1.5% -2.2% of white atractylodes rhizome essential oil and 1.0% -2.0% of dahurian angelica root essential oil, wherein the obacunone can promote the bacteriostatic action of the white atractylodes rhizome essential oil and the dahurian angelica root essential oil, so that the bacteriostatic effect is improved when the obacunone, the white atractylodes rhizome essential oil and the dahurian angelica root essential oil are used together, and therefore, the bacteriostatic mouth wash of the embodiment has a better bacteriostatic effect than a conventional bacteriostatic mouth wash containing traditional Chinese medicine essential oil. In addition, the bacteriostatic mouth wash of the embodiment has no irritation, no toxic or side effect and good taste, thereby being suitable for daily use.
Claims (6)
1. The bacteriostatic mouth wash is characterized by comprising the following components in percentage by mass:
1.2 to 2.0 percent of phellodendron ketone, 1.5 to 2.2 percent of white atractylodes rhizome essential oil, 1.0 to 2.0 percent of angelica essential oil, 0.1 to 0.2 percent of preservative, 0.1 to 0.3 percent of solubilizer, 3 to 5 percent of humectant, 1.0 to 3.0 percent of flavoring agent and the balance of deionized water,
wherein the preservative is sorbic acid, the solubilizer is polysorbate 80, the flavoring agent is a composition of menthol and acesulfame potassium,
the preparation process of the bighead atractylodes rhizome essential oil is as follows:
weighing Atractylodis rhizoma powder, placing in a drying container, adding ethyl acetate at a liquid-solid ratio of 6:1, shaking, sealing, placing in the shade, soaking at 22-24 deg.C for 3 times with 12h ultrasound for 20min each time to obtain leachate;
filtering the leachate, recovering ethyl acetate by a rotary film decompression method, adding a small amount of anhydrous sodium sulfate into the residual liquid to remove water and dry, filtering to obtain the white atractylodes rhizome essential oil,
the preparation process of the angelica essential oil is as follows:
weighing radix Angelicae Dahuricae powder, placing in a drying container, adding ethyl acetate according to a liquid-solid ratio of 8:1, shaking, sealing, placing in indoor shade, soaking at 22-24 deg.C for 3 times, and ultrasonically treating for 20min every 3 hr to obtain leachate;
and (3) filtering the leachate, continuously distilling for a preset time by using a steam distillation device, adding 95% ethanol into the residual liquid until the final concentration of the ethanol in the system is 65%, standing overnight, filtering to remove precipitates, adding a small amount of anhydrous sodium sulfate to remove water and dry, filtering, and performing rotary distillation and concentration to obtain the angelica essential oil.
2. Bacteriostatic mouth wash according to claim 1 characterized in that:
wherein the mass percent of the menthol is 0.5-1.5%,
the mass percent of the acesulfame-K is 0.5-1.5%.
3. A bacteriostatic mouth wash according to claim 1, characterized by further comprising:
0.4 to 1.0 percent of caramel pigment.
4. Bacteriostatic mouth wash according to claim 1 characterized in that:
wherein the mass percent of the obacunone is 1.6 percent,
the mass percentage of the white atractylodes rhizome essential oil is 1.9 percent,
the radix angelicae essential oil accounts for 1.7% by mass.
5. The preparation method of the bacteriostatic mouth wash according to claim 1, which comprises the following steps:
step S1, putting deionized water into a clean container, adding the preservative, the solubilizer, the humectant and the flavoring agent while stirring at room temperature until the preservative, the solubilizer, the humectant and the flavoring agent are completely dissolved and uniformly dispersed to prepare phase A;
step S2, adding the phellodendron ketone, the bighead atractylodes rhizome essential oil and the angelica essential oil into the phase A, and uniformly stirring at room temperature until a stable clear solution system is formed;
and step S3, standing at room temperature for a preset time, and filtering to obtain the bacteriostatic mouthwash.
6. A method for preparing bacteriostatic mouth wash according to claim 5, characterized in that:
wherein the rotation speed of the stirring in the steps S1 and S2 is 800 revolutions per minute.
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