CN109820743A - A kind of water solubility licoflavone composition and its preparation method and application - Google Patents
A kind of water solubility licoflavone composition and its preparation method and application Download PDFInfo
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- CN109820743A CN109820743A CN201910191564.0A CN201910191564A CN109820743A CN 109820743 A CN109820743 A CN 109820743A CN 201910191564 A CN201910191564 A CN 201910191564A CN 109820743 A CN109820743 A CN 109820743A
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- licoflavone
- water solubility
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Abstract
The invention discloses a kind of water-soluble licoflavone compositions, including following components in percentage by weight: licoflavone 5~20%, cosolvent 40~60%, solubilizer 8~15%, preservative 0.1~1% and surplus solvent.The present invention has synergy synergistic effect by arranging in pairs or groups licoflavone and solvent, cosolvent, solubilizer according to specific ratio in terms of licoflavone water solubility.The cosmetic formulations system for realizing various dosage forms can be used and not be precipitated, and particularly with transparence cosmetic system, still be able to maintain transparent appearance；And it is big to overcome prior art preparation water solubility licoflavone technical difficulty, time-consuming for operation, energy consumption is high.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of water solubility licoflavone composition and preparation method thereof
And application.
Background technique
With society's rapid development now, people never halt the serious hope of beauty, and daily skin nursing is essential, this is just
All kinds of skin protection cosmetics are needed to accommodate.And the trend of skin care item is that source is natural and safe without toxic side effect now.
Licoflavone is extracted by Radix Glycyrrhizae through multiple working procedure, and source is natural, has whitening, anti-inflammatory, oxidation resistant effect
With being known as " whitening gold " because it has the function of inhibiting TYR enzyme activity to inhibiting melanin production.Licoflavone
Though there are many cosmetology effects, it is not widely used.Structural property is closely related with itself for reason, and licoflavone is not
It is dissolved in water, insoluble in most greases, is dissolved in the polyalcohols such as ethyl alcohol, propylene glycol.Oily, water-insoluble characteristic is cosmetic formulations
Exploitation brings very big difficulty, and handling bad problems of dissolution will lead to the precipitation of storage process, influence product appearance, effect, skin
Sense and stability, especially exploitation transparency liquid, gel-like product, it is particularly evident.
In the prior art, have and licoflavone is added in formula, such as patent CN105168055A, formula system is impermeable
Bright creams class, its own is with certain suspending power, and opaque appearance is but also the licoflavone that may be precipitated has one
Determine covering effect.Also there is technology such as patent CN102274145A using cyclodextrin cladding processing licoflavone, propose its water solubility
Height, but treatment process time consumption and energy consumption is high, and technical difficulty of operation is big, and because of cyclodextrin physical property itself, is applied to
Semi-transparent or opaque state can be presented in bright aqua product, still can not be applied in transparent aqua class cosmetic formulations.
Summary of the invention
A kind of water-soluble licoflavone group is provided it is an object of the invention to overcome above-mentioned the deficiencies in the prior art place
Close object and preparation method.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of water solubility licoflavone composition, including with
The component of lower weight percent: licoflavone 5~20%, cosolvent 40~60%, solubilizer 8~15%, preservative 0.1~
1% and surplus solvent.
Due to licoflavone grease not soluble in water and most, oily, water-insoluble characteristic is that cosmetic formulations develop band
Carry out very big difficulty, handling bad problems of dissolution will lead to the precipitation of storage process, influence product appearance, effect, skin sense and steady
Qualitative, the present invention is by arranging in pairs or groups licoflavone and solvent, cosolvent, solubilizer according to specific ratio, in licoflavone water
There is synergy synergistic effect in terms of dissolubility.The cosmetic formulations system for realizing various dosage forms can be used and not be precipitated, especially
For transparence cosmetic system (such as facial mask, Essence, moisture retention water), it is still able to maintain transparent appearance；And it overcomes existing
The water-soluble licoflavone technical difficulty of technology preparation is big, and time-consuming for operation, energy consumption is high.
As the preferred embodiment of water-soluble licoflavone composition of the invention, the natural Radix Glycyrrhizae in licoflavone source
It extracts, purity >=98%, the licoflavone is 10wt%.
As the preferred embodiment of water-soluble licoflavone composition of the invention, the solvent is glycerol, propylene glycol, fourth
At least one of glycol, pentanediol.
As the preferred embodiment of water-soluble licoflavone composition of the invention, the cosolvent is that liquid moors Lip river sand
Nurse.
As the preferred embodiment of water-soluble licoflavone composition of the invention, the liquid poloxamer is that pool Lip river is husky
At least one of nurse 184, PLURONICS F87.
As the preferred embodiment of water-soluble licoflavone composition of the invention, the solubilizer is that PEG-40 hydrogenates castor
Sesame oil, PEG-60 rilanit special, in coceth -7/PPG-1-PEG-9 laurel glycol ethers/Cremophor RH40
It is at least one.
As the preferred embodiment of licoflavone composition of the invention water-soluble, the preservative is Phenoxyethanol, fragrant
At least one of fresh ketone.
The water-soluble licoflavone composition of the invention is preparing the application in skin care item.
The present invention also provides the skin care item containing water-soluble licoflavone composition.
Further provide the preparation method of the water-soluble licoflavone composition, which is characterized in that including following
Step:
(1) licoflavone and solvent, cosolvent mixing are warming up to 55-60 DEG C, are kept stirring 30min；
(2) solubilizer is added, continues insulated and stirred 30min；
(3) stirring is cooled to 40-45 DEG C, and preservative is added, and continues stirring and is cooled to 30-35 DEG C, can discharge.
Compared with prior art, the invention has the benefit that
1, solubility problem of the licoflavone in cosmetic formulations use is solved, is added using composition of the present invention
Using more convenient.
2, transparent appearance can be achieved in transparent aqua cosmetic formulations, do not whiten, be not precipitated.
3, strong operability, easy to operate, more save the cost.
Specific embodiment
Purposes, technical schemes and advantages in order to better illustrate the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
In following embodiments and comparative example, the substance being not specifically noted commercially is obtained.
The natural Radix Glycyrrhizae in licoflavone source is extracted, purity >=98%.
Examples 1 to 4 and comparative example 1~5
The weight percentage component of the licoflavone composition of Examples 1 to 4 and comparative example 1~5 is as shown in table 1, real
Apply the preparation side of the licoflavone composition of example 1~4 and comparative example 1~5 are as follows:
(1) licoflavone and solvent, cosolvent mixing are warming up to 55-60 DEG C, are kept stirring 30min.
(2) solubilizer is added, continues insulated and stirred 30min.
(3) stirring is cooled to 40-45 DEG C, and preservative is added, and continues stirring and is cooled to 30-35 DEG C, can discharge.
Table 1
Embodiment 5
Water-soluble and stability is carried out to the licoflavone composition that Examples 1 to 4 and comparative example 1~5 are prepared
Experimental test.
(1) water-soluble experiment
Using the licoflavone composition of above-described embodiment 1-4 and comparative example 1-5 prepare weight percentage be 0.05%,
0.1%, 0.15%, 0.2%, 0.25% aqueous solution observes appearance transparence and whether has Precipitation.Test result such as table
Shown in 2:
Table 2
As can be seen from Table 2, licoflavone composition of the invention prepare 0.05%, 0.1%, 0.15%, 0.2%,
0.25% aqueous solution, appearance transparent solve the prior art because handling bad problems of dissolution without Precipitation, high water solubility
The precipitation that will lead to storage process influences product appearance, effect, skin sense and stability, especially exploitation transparency liquid, gel-like
Product, particularly evident technical problem, compared with the present invention, difference is comparative example 1~3, has lacked solvent, cosolvent, increasing
At least one of solvent ingredient, and can be seen that from result, when licoflavone composition is prepared more than 0.2wt% concentration,
There are whiting or Precipitation, the state of transparent no Precipitation cannot be reached；Comparative example 4~5 helps compared with the present invention
Solvent, solubilizer content not within content range of the invention, and when its effect 0.2wt% concentration, have whiting or
Precipitation cannot reach the state of transparent no Precipitation.The result shows that licoflavone solvent of the invention, cosolvent,
Under the combination of solubilizer, the water solubility of licoflavone can be effectively improved.
(2) stability experiment
Respectively in -15 DEG C, 45 DEG C of detection embodiment 1-4, the cold-resistant of comparative example 1-5 product, heat resistance, and it is detected cold
At thermal cycle (45 DEG C are placed 24 hours, are transferred to -15 DEG C and are placed 24 hours, are so a circulation, constantly circulation places test)
Stability under reason.The results are shown in Table 3:
Table 3
As known from Table 3, the licoflavone composition that the embodiment of the present invention 1~4 obtains is surveyed in -15 DEG C of cold-resistant 45 DEG C of heat resistances
Test result is 3 months without significant change, and cold cycling 4 circulations have good cold-resistant, heat resistance, stablize without significant change
Property is good；There is a small amount of Precipitation under its cold resistance of comparative example 2~5 shortcoming, cold cycling, stability shows not as good as the present invention
, in the case where specific proportional region combines, the stability of licoflavone of the present invention can be promoted with solvent in cosolvent, solubilizer.
Embodiment 6
It is with weight percent by the licoflavone composition that the embodiment of the present invention 1~4 and comparative example 1~5 are prepared
0.25% is added in moisturiser and moisture retention water formula, and moisturiser and moisture retention water specific formula are as shown in table 4 by weight percentage,
And finished appearance is observed, and hot and cold, cold cycling equistability is carried out to finished product and is tested, test result such as table 5, table 6,7 institute of table
Show:
Table 4
Table 5
The stability test result of 6 moisturiser of table
Table 7
From table 5 to table 7 it is found that the licoflavone composition that the embodiment of the present invention 1~4 is prepared can be used for moisturiser,
In the skin care item such as moisture retention water, the cosmetic formulations system of various dosage forms can be used and not be precipitated, good stability, and comparative example 1
With moisturiser or moisture retention water, appearance has the precipitation of brown little particle, opaque, use heat-resisting, cold resistance equistability for~5 uses
It is bad, it is water-soluble bad, it is impossible to be used in transparent cosmetics series.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of water solubility licoflavone composition, which is characterized in that including following components in percentage by weight: licoflavone 5
~20%, the solvent of cosolvent 40~60%, solubilizer 8~15%, preservative 0.1~1% and surplus.
2. water solubility licoflavone composition according to claim 1, which is characterized in that the licoflavone source is natural
Radix Glycyrrhizae is extracted, purity >=98%, and the licoflavone is 10wt%.
3. water solubility licoflavone composition according to claim 1, which is characterized in that the solvent is glycerol, the third two
At least one of alcohol, butanediol, pentanediol.
4. water solubility licoflavone composition according to claim 1, which is characterized in that the cosolvent is that liquid moors Lip river
Sha Mu.
5. water solubility licoflavone composition according to claim 4, which is characterized in that the liquid poloxamer is pool
At least one of Luo Shamu 184, PLURONICS F87.
6. water solubility licoflavone composition according to claim 1, which is characterized in that the solubilizer is PEG-40 hydrogen
Change castor oil, PEG-60 rilanit special, coceth -7/PPG-1-PEG-9 laurel glycol ethers/Cremophor RH40
At least one of.
7. water solubility licoflavone composition according to claim 1, which is characterized in that the preservative is benzene oxygen second
At least one of alcohol, fragrant fresh ketone.
8. any one water-soluble licoflavone composition is preparing the application in skin care item according to claim 1~7.
9. a kind of skin care item containing licoflavone composition water-soluble as described in any one of claim 1~7.
10. a kind of preparation method of water-soluble licoflavone composition as described in any one of claims 1 to 7, feature exist
In, comprising the following steps:
(1) licoflavone and solvent, cosolvent mixing are warming up to 55-60 DEG C, are kept stirring 30min；
(2) solubilizer is added, continues insulated and stirred 30min；
(3) stirring is cooled to 40-45 DEG C, and preservative is added, and continues stirring and is cooled to 30-35 DEG C, can discharge.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111803393A (en) * | 2020-08-03 | 2020-10-23 | 上海奥利实业有限公司 | Transparent aqueous solution of water-oil insoluble licoflavone, and preparation method and application thereof |
| CN113520892A (en) * | 2020-04-17 | 2021-10-22 | 华熙生物科技股份有限公司 | Aqueous composition of glabridin and preparation method thereof |
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| JPH02204417A (en) * | 1989-02-02 | 1990-08-14 | Maruzen Kasei Co Ltd | Hydrophobic licorice flavonoid preparation |
| CN102140144A (en) * | 2011-01-07 | 2011-08-03 | 上海奥利实业有限公司 | Production method of water-soluble licoflavone |
| CN104337859A (en) * | 2014-09-12 | 2015-02-11 | 宁夏医科大学 | Licoflavone self-microemulsion composition and preparation method thereof |
| CN104586689A (en) * | 2014-12-26 | 2015-05-06 | 唯美度科技（北京）有限公司 | Licorice-extract-containing emulsion and preparation method thereof |
| CN107890433A (en) * | 2017-11-08 | 2018-04-10 | 常州武城服饰有限公司 | A kind of preparation method of licoflavone composition for cosmetics |
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2019
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|---|---|---|---|---|
| JPH02204417A (en) * | 1989-02-02 | 1990-08-14 | Maruzen Kasei Co Ltd | Hydrophobic licorice flavonoid preparation |
| CN102140144A (en) * | 2011-01-07 | 2011-08-03 | 上海奥利实业有限公司 | Production method of water-soluble licoflavone |
| CN104337859A (en) * | 2014-09-12 | 2015-02-11 | 宁夏医科大学 | Licoflavone self-microemulsion composition and preparation method thereof |
| CN104586689A (en) * | 2014-12-26 | 2015-05-06 | 唯美度科技（北京）有限公司 | Licorice-extract-containing emulsion and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113520892A (en) * | 2020-04-17 | 2021-10-22 | 华熙生物科技股份有限公司 | Aqueous composition of glabridin and preparation method thereof |
| CN111803393A (en) * | 2020-08-03 | 2020-10-23 | 上海奥利实业有限公司 | Transparent aqueous solution of water-oil insoluble licoflavone, and preparation method and application thereof |
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