CN104586689A - Licorice-extract-containing emulsion and preparation method thereof - Google Patents
Licorice-extract-containing emulsion and preparation method thereof Download PDFInfo
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- CN104586689A CN104586689A CN201410828711.8A CN201410828711A CN104586689A CN 104586689 A CN104586689 A CN 104586689A CN 201410828711 A CN201410828711 A CN 201410828711A CN 104586689 A CN104586689 A CN 104586689A
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Abstract
The invention relates to the field of daily chemicals, in particular to a licorice-extract-containing emulsion and a preparation method thereof. The licorice-extract-containing emulsion comprises the following components in parts by weight: 0.01-10 parts of a licorice extract, 1-20 parts of phospholipid, 5-25 parts of oil, 0.5-20 parts of a nonionic surfactant and 60-90 parts of a dispersion medium, wherein the nonionic surfactant is selected from one or more of span-60, span-80, polyglycerol-10 oleate, polyglycerol monooleate, tween-80, polyoxyethylated castor oil and caprylocaproyl macrogolglycerides. Due to the presence of keratoderma, the active ingredient molecules difficultly pass through the skin obstacle to be absorbed by the organism; according to the licorice extract-containing emulsion, the licorice extract is wrapped in lipid nanoemulsion, so that the water solubility of the licorice extract can be effectively increased, the transdermal absorption capacity of the licorice extract is improved and the application of the licorice extract in the field of skin external use is strengthened.
Description
Technical field
The present invention relates to household chemicals field, particularly a kind of Emulsion containing Radix Glycyrrhizae extract and preparation method thereof.
Background technology
Licoflavone (Glycyrrhizic Flavone) is the composition that the class biological activity that extracts from Radix Glycyrrhizae root welding technology is stronger, and the water insoluble and various grease of licoflavone, is dissolved in ethanol, propylene glycol, glycerol and part organic solvent.
Find through retrieval, publication number is the production method that the application for a patent for invention of CN102140144A also discloses a kind of water solublity licoflavone, in dehydrated alcohol and at room temperature-50 DEG C, licoflavone and cyclodextrin react 0.5 ~ 2 hour, drying, is dissolved in deionized water, filters; Described licoflavone and the weight ratio of cyclodextrin are 4-8: 1.
Publication number is that the application for a patent for invention of CN102949440A discloses a kind of licoflavone phosphatide complexes, and this licoflavone phosphatide complexes is that licoflavone and phospholipid are with the complex of mass ratio 1:0.1-10; Preparation method is according to described proportional quantity, licoflavone and phospholipid are joined in organic solvent, temperature 10 DEG C-90 DEG C, reaction 20min-8h clarifies to reactant liquor, decompression or lyophilization, removing organic solvent, add the free drug that atent solvent is separated non-compound again, removing atent solvent, dry, obtain licoflavone phosphatide complexes.This invention is embedded by the phospholipid of licoflavone, improves the physicochemical property of licoflavone hydrophilic and oleophilic, improves the solubility property of licoflavone.
Not about the report of the Emulsion containing Radix Glycyrrhizae extract in prior art.
Summary of the invention
The object of this invention is to provide a kind of Emulsion (lipid nanoemulsion) containing Radix Glycyrrhizae extract and preparation method thereof.
To achieve the object of the present invention, the technical scheme that concrete employing is following: a kind of Emulsion containing Radix Glycyrrhizae extract, its raw material by weight, comprise following component: the licoflavone of 0.01 ~ 10 part, the phospholipid of 1 ~ 20 part, the oil of 5 ~ 25 parts, the non-ionic surface active agent of 0.5 ~ 20 part, the disperse medium of 60 ~ 90 parts.
For reaching better effect, preferably, its raw material by weight, comprises following component: the licoflavone of 0.5 ~ 3 part, the phospholipid of 2 ~ 3.5 parts, the oil of 5 ~ 25 parts, the non-ionic surface active agent of 1 ~ 10 part, the disperse medium of 60 ~ 90 parts.
Concrete, described phospholipid be selected from soybean phospholipid or Ovum Gallus domesticus Flavus lecithin one or both, preferred soybean phospholipid.
Concrete, described grease separation from one or more of soybean oil, caprylic/capric triglyceride, safflower oil or olive oil, preferably octanoic acid/tricaprin and/or soybean oil.
Concrete, described non-ionic surface active agent be selected from sorbester p18, sorbester p17, Natrulon H-10 oleate, polyglycerol monooleate Tween 80, polyoxyethylene castor oil or Labraso one or more.
Concrete, described disperse medium be selected from water, glycerol or propylene glycol one or more.
Emulsion (lipid nanoemulsion) containing Radix Glycyrrhizae extract provided by the invention, by phospholipid microcapsule package action, enhances the water solublity of Radix Glycyrrhizae extract (licoflavone), and then enhances the transdermal capability of Radix Glycyrrhizae extract.This nanoemulsions good water solubility, forms suppression ratio to melanin high, can be applied to cosmetics, play the effect of delaying skin aging.
Preferably, following three kinds of modes are had containing the composition of the Emulsion of Radix Glycyrrhizae extract and content.
First kind of way, the Emulsion containing Radix Glycyrrhizae extract of the present invention, by weight, it is composed as follows:
Preferably, by weight, it is composed as follows:
The second way, the Emulsion containing Radix Glycyrrhizae extract of the present invention, by weight, it is composed as follows:
Preferably, by weight, it is composed as follows:
The third mode, the Emulsion containing Radix Glycyrrhizae extract of the present invention, by weight, it is composed as follows:
Preferably, by weight, it is composed as follows:
In the composition of the above-mentioned Emulsion containing Radix Glycyrrhizae extract, component A and B component are the relation of 1:1.
Present invention also offers the preparation method of the above-mentioned Emulsion containing Radix Glycyrrhizae extract, comprise the following steps:
(1) component A mixed, high speed shear under 8000 ~ 12000rpm condition, without the visible solid content of naked eyes to system;
(2) B component is added step (1) products therefrom, high speed shear under 8000 ~ 12000rpm condition, obtains colostrum, colostrum is through high pressure homogenizer process, pressure 800 ~ 2000bar used, cycle-index 5 ~ 10 times, obtains the Emulsion containing Radix Glycyrrhizae extract.
Due to the existence of keratodermatitis, active ingredient molecule is difficult to be absorbed by body by skin barrier.Radix Glycyrrhizae extract (licoflavone) is wrapped in lipid nanometer Ruzhong by the present invention, effectively can increase the water solublity of Radix Glycyrrhizae extract, improve the Transdermal absorption ability of Radix Glycyrrhizae extract, thus enhance the application of Radix Glycyrrhizae extract in external preparation for skin field.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
Embodiment 1:
Contain the composed as follows of the Emulsion of Radix Glycyrrhizae extract in the present embodiment:
Should be as follows containing the preparation method of the Emulsion of Radix Glycyrrhizae extract:
1) by above-mentioned licoflavone, soybean phospholipid, caprylic/capric triglyceride, sorbester p17, glycerol, mixed with propylene glycol, high speed shear under 8000rpm condition, without the visible solid content of naked eyes to system;
2) Tween 80, polyoxyethylene castor oil and water are added step 1) product, high speed shear under 12000rpm condition, obtain colostrum, colostrum is through high pressure homogenizer process, pressure 800bar used, circulate 5 times, obtain the Emulsion (licoflavone lipid nanoemulsion) of transparent clear shape containing Radix Glycyrrhizae extract.
Embodiment 2:
Contain the composed as follows of the Emulsion of Radix Glycyrrhizae extract in the present embodiment:
Should be as follows containing the preparation method of the Emulsion of Radix Glycyrrhizae extract:
1) by above-mentioned prescription, by component A high speed shear under 12000rpm condition, without the visible solid content of naked eyes to system;
2) B component is added step 1) product, high speed shear under 8000rpm condition, obtains colostrum, colostrum is through high pressure homogenizer process, pressure 1200bar used, circulates 7 times, obtains the Emulsion (licoflavone lipid nanoemulsion) of transparent clear shape containing Radix Glycyrrhizae extract.
Embodiment 3:
Contain the composed as follows of the Emulsion of Radix Glycyrrhizae extract in the present embodiment:
Should be as follows containing the preparation method of the Emulsion of Radix Glycyrrhizae extract:
1) by above-mentioned prescription, by component A, high speed shear under 10000rpm condition, without the visible solid content of naked eyes to system;
2) B component is added step 1) product, high speed shear under 10000rpm condition, obtains colostrum, colostrum is through high pressure homogenizer process, pressure 2000bar used, circulates 10 times, obtains the Emulsion (licoflavone lipid nanoemulsion) of transparent clear shape containing Radix Glycyrrhizae extract.
Embodiment 4-6
The difference of embodiment 4-6 embodiment 1 is only each component and content difference, specific as follows:
Embodiment 7-9
Embodiment 7-9 and the difference of embodiment 2 be only each component and content different, specific as follows:
Embodiment 10-12
Embodiment 10-12 and the difference of embodiment 3 be only each component and content different, specific as follows:
Experimental example 1: entrapment efficiency determination
Sample: product prepared by embodiment of the present invention 1-12 is as sample 1-12.
Experimental technique: adopt dialysis, get 1ml licoflavone lipid nanoemulsion and put into bag filter, 40ml deionized water carries out 8h dialysis.Envelop rate (encapsulating efficiency, EE) is calculated as follows:
EE=analyses rear lipid nanometer Ruzhong licoflavone content/licoflavone lipid nanometer theoretical content × 100%.
The results are shown in Table 1.
The different sample envelop rate of table 1
| Title | Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Sample 6 |
| Envelop rate (%) | 93.1 | 90.7 | 88.2 | 92.3 | 91.6 | 90.9 |
| Title | Sample 7 | Sample 8 | Sample 9 | Sample 10 | Sample 11 | Sample 12 |
| Envelop rate (%) | 89.6 | 89.2 | 90.1 | 87.3 | 85.6 | 83.2 |
As can be known from Table 1, through the dialysis test of 8h, licoflavone lipid nanoemulsion prepared by the present invention, has fabulous envelop rate.
Experimental example 2: particle size determination
Test specimen: product prepared by embodiment of the present invention 1-12 is as sample 1-12.
Particle size determination: adopt Malvern Zetasizer 3000HSA Particle Size Analyzer to detect particle diameter, before mensuration, sample 1-12 Millipore ultra-pure water is diluted 30 times, and experimental result is in table 2.
Table 2: different sample particle diameter size
| Title | Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Sample 6 |
| Mean diameter (nm) | 113 | 146 | 198 | 118 | 126 | 124 |
| Title | Sample 7 | Sample 8 | Sample 9 | Sample 10 | Sample 11 | Sample 12 |
| Mean diameter (nm) | 156 | 153 | 148 | 202 | 234 | 245 |
From table 2, the mean diameter after product emulsifying of the present invention is less than 250nm.
Experimental example 3: permeation test in vitro
Sample: product prepared by embodiment of the present invention 1-12 is as sample 1-12.Reference substance 1 is the licoflavone aqueous solution of 0.2%; Reference substance 2 is the licoflavone phosphatide complexes of CN102949440A; Reference substance 3 is the water solublity licoflavone of CN102140144A.Before test, by dilution, be 0.05% by licoflavone concentration unification in various sample.
Test method: get (25 ± 5) g male mice, with the Na of 6%
2s solution sloughs belly wool, and disconnected neck cuts skin of abdomen after putting to death immediately, rejects subcutaneous tissue and fat, repeatedly rinses by purified water.Be fixed on by skin on diffusion cell, upward, by purified water as acceptable solution, rotating speed is 180rpm to horny layer, and diffusion area is 3.3cm
2, acceptance pool cumulative volume is 18ml, 37 DEG C of water-bath circulations.Getting 1 gram of sample is put on Corium Mus, gets acceptable solution 2ml respectively in 1,2,4,6,8h, and supplements the blank acceptable solution of same volume, measures each sample content by HPLC method, and unit of account area Percutaneous permeability Q, computing formula is as follows:
Q=Σ CnV/A (wherein Cn represents the sample concentration of the n-th sub-sampling, and V represents the volume of the liquid of acceptance pool, and A represents diffusion area).
The results are shown in Table 3.
Table 3: different sample unit are Percutaneous permeability (μ g/cm
2)
| Title | Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Sample 6 | Reference substance 1 | Reference substance 2 |
| Content | 342.3 | 282.9 | 309.4 | 323.5 | 331.8 | 328.6 | 19.7 | 200.8 |
| Title | Sample 7 | Sample 8 | Sample 9 | Sample 10 | Sample 11 | Sample 12 | Reference substance 3 | -- |
| Content | 268.2 | 275.3 | 264.3 | 305.6 | 303.2 | 300.8 | 154.9 | -- |
As shown in Table 3, product of the present invention, compared with reference substance 1-3, significantly can increase the transdermal amount of licoflavone.
Experimental example 4: melanin inhibition test
By B16 melanocyte with 1 × 10
5the density of individual/mL is inoculated in 6 orifice plates.Every hole 3ml, after hatching 24h, abandons supernatant, adds medicine to be measured, after drug effect 3d, abandons supernatant, and PBS washs, and every hole adds 0.5mL trypsin digestion cell 3min, and every hole adds 2ml maintenance medium and stops digestion.After piping and druming mixing, often kind of concentration is taken out 0.5mL and is made cell counting.All the other cell suspension, with the centrifugal 5min of 2500r/min, abandon supernatant, add sodium hydroxide solution, melanin is dissolved in precipitation, select 490nm wavelength to survey absorbance on enzyme-linked immunosorbent assay instrument, calculate melanin generating suppression, the results are shown in Table 4.
Trial target is with experimental example 3.
Melanin generating suppression=[1-(medicine hole absorbance ÷ medicine porocyte density) ÷ (control wells absorbance ÷ control wells cell density] × 100%
Table 4 melanin generating suppression (%)
| Title | Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Sample 6 | Reference substance 1 | Reference substance 2 |
| Suppression ratio | 41.9 | 38.7 | 40.4 | 40.8 | 41.2 | 40.6 | 25.7 | 32.1 |
| Title | Sample 7 | Sample 8 | Sample 9 | Sample 10 | Sample 11 | Sample 12 | Reference substance 3 | -- |
| Suppression ratio | 35.6 | 37.8 | 37.2 | 40.2 | 39.8 | 39.1 | 30.2 | -- |
As shown in Table 4, compared with reference substance, licoflavone lipid nanoemulsion of the present invention greatly can strengthen melanin generating suppression.
Experimental example 5: tryrosinase vitality test
By B16 melanocyte with 1 × 10
5the density of individual/mL is inoculated in 96 orifice plates.Every hole 100 μ L, after hatching 24h, abandons supernatant, adds medicine to be measured, after drug effect 3d, abandon supernatant, PBS washing twice, and every hole adds the PBS of 90 μ L containing 1% (volume fraction) Triton X-100.Ultrasonication in ice bath, every hole adds the L-dopa of 10 μ L 10mmoL/L, hatches 60min for 37 DEG C, and in 475nm place colorimetric, blank well returns to zero, and surveys each hole absorbance, calculates inhibitory activity against tyrosinase, the results are shown in Table 5.
Trial target is with experimental example 3.
Suppression ratio=(1-medicine group mean absorbance values ÷ matched group mean absorbance values) × 100%.
Table 5 inhibitory activity against tyrosinase (%)
As shown in Table 5, compared with reference substance, licoflavone lipid nanoemulsion of the present invention, to tyrosinase activity inhibitory action, is significantly improved.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1., containing an Emulsion for Radix Glycyrrhizae extract, it is characterized in that, its raw material by weight, comprise following component: the licoflavone of 0.01 ~ 10 part, the phospholipid of 1 ~ 20 part, the oil of 5 ~ 25 parts, the non-ionic surface active agent of 0.5 ~ 20 part, the disperse medium of 60 ~ 90 parts;
Preferably, its raw material by weight, comprises following component: the licoflavone of 0.5 ~ 3 part, the phospholipid of 2 ~ 3.5 parts, the oil of 5 ~ 25 parts, the non-ionic surface active agent of 1 ~ 10 part, the disperse medium of 60 ~ 90 parts.
2. the Emulsion containing Radix Glycyrrhizae extract according to claim 1, is characterized in that: described phospholipid be selected from soybean phospholipid or Ovum Gallus domesticus Flavus lecithin one or both, preferred soybean phospholipid.
3. the Emulsion containing Radix Glycyrrhizae extract according to claim 1, is characterized in that: described grease separation from one or more of soybean oil, caprylic/capric triglyceride, safflower oil or olive oil, preferably octanoic acid/tricaprin and/or soybean oil.
4. the Emulsion containing Radix Glycyrrhizae extract according to claim 1, is characterized in that: described non-ionic surface active agent be selected from sorbester p18, sorbester p17, Natrulon H-10 oleate, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil or Labraso one or more.
5. the Emulsion containing Radix Glycyrrhizae extract according to claim 1, is characterized in that: described disperse medium be selected from water, glycerol or propylene glycol one or more.
6. the Emulsion containing Radix Glycyrrhizae extract according to any one of claim 1-5, is characterized in that: by weight, comprises component A and B component,
Described component A comprises the licoflavone of 0.5 ~ 3 part, the phospholipid of 0.5 ~ 3.5 part, the caprylic/capric triglyceride of 5 ~ 25 parts, the sorbester p17 of 0.1 ~ 1.5 part, the glycerol of 1 ~ 10 part, the propylene glycol of 1 ~ 5 part;
Described B component comprises the Tween 80 of 0.5 ~ 5 part, the polyoxyethylene castor oil of 0.1 ~ 5 part, the water of 40 ~ 85 parts.
7. the Emulsion containing Radix Glycyrrhizae extract according to claim 6, is characterized in that: percentage composition by weight, comprises component A and B component,
Described component A comprises the licoflavone of 0.5 part, the soybean phospholipid of 1.2 parts, the caprylic/capric triglyceride of 10 parts, the sorbester p17 of 0.25 part, the glycerol of 5 parts, the propylene glycol of 2 parts;
Described B component comprises the Tween 80 of 0.5 part, the polyoxyethylene castor oil of 0.5 part, the water of 80.05 parts.
8. the Emulsion containing Radix Glycyrrhizae extract according to any one of claim 1-6, is characterized in that: by weight, comprises component A and B component,
Described component A comprises the licoflavone of 0.5 ~ 3 part, the phospholipid of 0.5 ~ 3.5 part, the soybean oil of 5 ~ 25 parts, the polyglycerol monooleate of 0.5 ~ 2 part, the glycerol of 1 ~ 10 part, the propylene glycol of 1 ~ 5 part;
Described B component comprises the Tween 80 of 0.5 ~ 5 part, the polyoxyethylene castor oil of 0.1 ~ 5 part, the Labraso of 0.1 ~ 5 part, the water of 35 ~ 90 parts.
9. the Emulsion containing Radix Glycyrrhizae extract according to any one of claim 1-6, is characterized in that: percentage composition by weight, comprises component A and B component,
Described component A comprises the licoflavone of 0.5 ~ 3 part, the phospholipid of 0.5 ~ 3.5 part, the soybean oil of 5 ~ 10 parts, the caprylic/capric triglyceride of 5 ~ 20 parts, the polyglycerol monooleate of 0.5 ~ 2 part, the sorbester p17 of 0.1 ~ 1.5 part, the glycerol of 1 ~ 10 part, the propylene glycol of 1 ~ 5 part;
Described B component comprises the Tween 80 of 0.5 ~ 5 part, the polyoxyethylene castor oil of 0.1 ~ 5 part, the Labraso of 0 ~ 5 part, the water of 50 ~ 75 parts.
10. the preparation method containing Radix Glycyrrhizae extract Emulsion according to any one of claim 6 ~ 9, is characterized in that, comprise the following steps:
(1) component A mixed, high speed shear under 8000 ~ 12000rpm condition, without the visible solid content of naked eyes to system;
(2) B component is added step (1) products therefrom, high speed shear under 8000 ~ 12000rpm condition, obtains colostrum, colostrum is through high pressure homogenizer process, pressure 800 ~ 2000bar used, cycle-index 5 ~ 10 times, obtains the Emulsion containing Radix Glycyrrhizae extract.
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| CN106389168A (en) * | 2016-11-14 | 2017-02-15 | 吉林大学 | Positively-charged oil-in-water nano cream with spot whitening effect and preparation method of positively-charged oil-in-water nano cream |
| CN106691888A (en) * | 2015-11-12 | 2017-05-24 | 武汉百思凯瑞纳米科技有限公司 | High-skin-retention glabridin nano composition as well as preparation method and application thereof |
| CN109662900A (en) * | 2019-02-25 | 2019-04-23 | 南京华狮新材料有限公司 | A kind of phosphatide package nano emulsion composition and its preparation method and application |
| CN109820743A (en) * | 2019-03-13 | 2019-05-31 | 广州玮弘祺生物科技有限公司 | A kind of water solubility licoflavone composition and its preparation method and application |
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| CN106691888A (en) * | 2015-11-12 | 2017-05-24 | 武汉百思凯瑞纳米科技有限公司 | High-skin-retention glabridin nano composition as well as preparation method and application thereof |
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| CN109662900B (en) * | 2019-02-25 | 2022-03-22 | 南京华狮新材料有限公司 | Phospholipid-coated nanoemulsion composition and preparation method and application thereof |
| CN109820743A (en) * | 2019-03-13 | 2019-05-31 | 广州玮弘祺生物科技有限公司 | A kind of water solubility licoflavone composition and its preparation method and application |
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| CN110151581A (en) * | 2019-07-05 | 2019-08-23 | 华欧研创生物科技(深圳)有限公司 | A kind of lightening compositions and its nano-emulsion preparation comprising glabridin |
| CN110151581B (en) * | 2019-07-05 | 2022-09-02 | 华欧研创生物科技(深圳)有限公司 | Whitening composition containing glabridin and nanoemulsion preparation thereof |
| WO2023274654A1 (en) * | 2021-06-28 | 2023-01-05 | Firmenich Sa | Flavor nanoemulsions for beverage and personal care applications |
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