CN109662900A - A kind of phosphatide package nano emulsion composition and its preparation method and application - Google Patents
A kind of phosphatide package nano emulsion composition and its preparation method and application Download PDFInfo
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- CN109662900A CN109662900A CN201910138023.1A CN201910138023A CN109662900A CN 109662900 A CN109662900 A CN 109662900A CN 201910138023 A CN201910138023 A CN 201910138023A CN 109662900 A CN109662900 A CN 109662900A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Abstract
The invention discloses a kind of phosphatide to wrap up nano emulsion composition, includes: (1) at least one oil, preferably vegetable oil；(2) at least one phosphatide, preferably soya lecithin；(3) at least one assistant for emulsifying agent, preferably nonionic emulsifier；(4) at least one solubilized stabilizer, preferably serine, arginine or niacinamide；(5) the freeze proof stabilizer of at least one polyalcohol；(6) water.The nano emulsion composition, a kind of oil-in-water nanometer cream composition with single layer lipid membrane structures that system is formed by lecithin, assistant for emulsifying agent embedding grease, oil droplet size can be effectively reduced, the stability of nano emulsion composition is increased, improves the transparency of nano emulsion composition.The present invention also provides the preparation method of phosphatide package nano emulsion composition and the applications in personal care articles.
Description
Technical field
The invention belongs to field of daily chemicals, are related to a kind of phosphatide package nano emulsion composition, specifically a kind of
A kind of oil-in-water nanometer cream composition with single layer lipid membrane structures is formed by lecithin, assistant for emulsifying agent embedding grease, the present invention
The preparation method for further relating to the phosphatide package nano emulsion composition and its application in personal care articles.
Background technique
In personal care articles field, grease includes crude vegetal, animal oil, dormant oil and the oily matter of some synthesis
Such as esters, long chain alkane class are the skin conditioners being commonly used, and play cutin-softening layer, to skin supplement ester rouge, moisturizing, are moistened
And other effects；Using having lubrication hair on hair, the effect of scalp is moistened.But grease type product is in water prescription, especially
It is that use is restricted in transparent, translucent formula, because oily matter is difficult to dissolve and formed in water prescription
Stable aqua.
In personal care articles field, oil-in-water emulsion is that one kind by emulsifier reduces oil water interfacial tension, by oily matter
Tiny oil droplets are dispersed into, and oil droplet is wrapped up and is distributed to the common dosage form of one of water.In general, oil-in-water emulsion
Oil droplet size arrive several microns of sizes 1, a kind of semifluid that milky is opaque is presented in appearance.This dosage form does not have heat
Mechanics rock-steady structure can only achieve a kind of dynamic equilibrium, keep the stabilization of certain time, and be difficult in transparent, translucent body
It is added in system and keeps the original transparent or semitransparent state of system, and be difficult to reach in system new dynamic equilibrium and protect
Certain stability is held, in general, can be layered quickly, be demulsified etc..
Nano-emulsion is a kind of with small emulsion droplet size (50-250nm) lotion, and appearance presents translucent to blueing light cream
White state has more stable property, and preferably skin sense, and addition is more prone to produce stable in aqua form formula
Transparent, translucent.CN201380070516.7 discloses a kind of nanoemulsion or microemulsion cosmetic composition, has saturating
Bright to sub-translucent appearance, uses polyglyceryl fatty acid ester as emulsifier.CN201610535667.0 discloses a kind of water enzyme
The method that method extracts soybean nanometer emulsion；Nano-emulsion can also be obtained by phase transition temperature method, such as CN106963657A public affairs
A kind of nanoemulsions prepared using phase transition temperature method are opened；CN201611249652.4 discloses vitamin A phase transition
Temperature method prepares nanoemulsions.Nano-emulsion can also be obtained by high-energy input method, as CN201310123795.0 uses height
Pressure microjet prepares Water-In-Oil nano-emulsion.CN106753747A prepares soybean nanoemulsions using enzyme process and high pressure microjet method,
The emulsifiers such as sucrose ester are used.
Phosphatide (Phospholipid), also referred to as Phospholipids, refer to the lipid containing phosphoric acid, belong to complex liped.Phosphatide is group
At the main component of biomembrane, it is divided into glycerophosphatide and sphingomyelins two major classes, is made of respectively glycerol and sphingol.Phosphatide is two
Property molecule, the hydrophilic head (hydrophilic head) that there is the substituent group (containing ammonia alkali or alcohols) being connected by phosphoric acid to constitute and
The hydrophobic tail (hydrophobic tail) being made of fatty acid chain.Phospholipid molecule water-wet side is close to each other as a result, hydrophobic side phase
It is mutually close, often lipid bilayer, the i.e. structure of cell membrane are collectively formed with other molecules such as protein, glycolipid, cholesterol.Phosphatide
It is important amphiphilic substance or a kind of naturally occurring emulsifying agent and surfactant.CN201810219473.9 discloses a kind of phosphorus
The method that rouge dissolution in low temperature-micro jetting technology prepares compound grease nano-emulsion, has used phosphatide as emulsifier.
CN101686924 discloses a kind of cozymase Q 10 nano emulsion compositions, has used phosphatide and assistant for emulsifying agent；
CN201210007433.0 discloses a kind of preparation method of compound fish oil nano-emulsion, has used phosphatide and assistant for emulsifying agent；
CN201410025948.2 discloses a kind of preparation method of palm oil nano-emulsion, has used phosphatide and assistant for emulsifying agent；
CN201110087892.X discloses a kind of corn germ oil nano emulsion and preparation method thereof, has used PC content >'s 70%
Phosphatide and assistant for emulsifying agent.
Summary of the invention
The object of the present invention is to provide a kind of phosphatide wrap up nano emulsion composition, the nano emulsion composition by
A kind of oil-in-water nanometer cream composition with single layer lipid membrane structures that phosphatide, assistant for emulsifying agent embedding grease are formed, described receives
Rice milk composition effectively reduces the oil droplet size of monofilm package, and transparency is high, and stability is good, can be applied to water prescription and works as
In, in especially transparent, translucent personal care product.
Another object of the present invention, which also resides in, provides the preparation method and applications of the nano emulsion composition.
Purpose to realize the present invention, the technical solution of the present invention is as follows:
A kind of phosphatide package nano emulsion composition, which is characterized in that include following components:
(1) at least one oil；
(2) at least one phosphatide；
(3) at least one assistant for emulsifying agent selected from anion emulsifier or nonionic emulsifier；
(4) at least one solubilized stabilizer；
(5) at least one freeze proof stabilizer selected from polyalcohol；
(6) water.
The oil is selected from natural oil, Synthetic Oil, silicone oil and/or hydrocarbon ils.The natural oil includes various room temperatures
It is down the plant of liquid form or the natural oil of animal origin；The Synthetic Oil includes the alkane oil, ester, ether of various synthesis
And glyceride etc.；The silicone oil includes straight chain or cyclic annular organopolysiloxane and its modifier；The hydrocarbon ils includes room temperature
It is down the lower paraffin hydrocarbon of the linear chain or branched chain of liquid or linear chain or branched chain hydrocarbon, such as atoleine, saualane of C16 or more etc..
The oily preferably vegetable oil, including but not limited to soybean oil, jojoba oil, sunflower oil, linseed oil, castor oil, peanut oil,
Rapeseed oil, Rice oil, rice bran oil, olive oil, palm oil, corn oil, sun flower seed oil, perilla herb oil, evening primrose oil, camellia seed
Oil, tea oil etc..
The composition, wherein the ratio that oil accounts for phosphatide package nano emulsion composition total weight is 0.1-50wt%, preferably
0.5-45wt%, and more preferable 1-40wt%.
The phosphatide includes phosphoglyceride and sphingomyelins, the preferably lecithin in phosphoglyceride, more preferably
Soybean lecithin or modified soybean lecithin.Particularly, in nano emulsion composition of the invention phosphatide using PC content it is lower (≤
70%) phosphatide remains to obtain the high stabilization nanoemulsions of transparency, for example, PC content is 65%, 60%, 55%, 50%,
45%, 40%, 35%, 30%, the various lecithin lower than 30%, wherein soybean lecithin includes that PC content is lower containing oil liquid
The powder phospholipid of body lecithin and not oil-containing.
The composition, wherein the amount of phosphatide is 0.1-20wt%, preferably 0.5-15wt%, more preferable 1-10wt%.
The assistant for emulsifying agent includes at least one anion emulsifier or nonionic emulsifier, preferably non-ionic emulsifier
Agent.The anion emulsifier can be selected from rhamnolipid, alkyl phosphate salt etc..The nonionic emulsifier includes but unlimited
In poly alkyl alcohol ethers nonionic emulsifier, sorbitan fatty ester class nonionic emulsifier, polyoxyethylene sorbitan mountain
Pears sugar alcohol fatty acid esters nonionic emulsifier and mono-fatty acid glyceride class, polyglyceryl fatty acid ester class non-ionic emulsifier
Agent.
The assistant for emulsifying agent is more preferably aliphatic alcohol polyether and sorbitan fatty ester or polyoxyethylene sorbitan
The mixture of sorbitan fatty acid ester.
The HLB value of the assistant for emulsifying agent is 8-15, and preferably HLB value is 9-14.5, more preferably 10-14.
Further, the poly alkyl alcohol ethers nonionic emulsifier can be selected from fatty alcohol polyoxyethylene ether, such as poly-
Ethylene oxide tristearin alcohol ether -2, polyoxyethylene lauryl ether -4, steareth -10, steareth -20,
Steareth -21, polyoxyethylene lauryl ether -23, steareth -100, cetanol polyoxyethylene
Ether -2, cetanol polyoxyethylene ether -20, Brij -2, Brij -10, Brij -20
One or more of Deng.
The sorbitan fatty ester class nonionic emulsifier can selected from sorbitan laurate,
Sorbitan palmitate, sorbitan stearate, sorbitan oleate, three oil of anhydrosorbitol
Acid esters etc..
The polyoxyethylene sorbitan aliphatic ester can selected from polyoxyethylene sorbitan oleate,
Polyoxyethylene sorbitan laurate, polyoxyethylene sorbitan palmitate, polyoxyethylene sorbitan
Alcohol stearate etc..
The mono-fatty acid glyceride class nonionic emulsifier can be selected from glycerin monostearate, single oleic
Ester, monopalmitin, glyceryl monolaurate etc..
The polyglyceryl fatty acid ester class nonionic emulsifier can be selected from the polyglycereol comprising 3-10 glycerol unit
Laurate, the polyglycerol stearate comprising 3-10 glycerol unit, the Unigly GO 102S comprising 3-10 glycerol unit
Deng.
In the composition, the amount of assistant for emulsifying agent is 0.1-20wt%, preferably 0.5-15wt%, more preferable 1-10wt%.
The freeze proof stabilizer includes at least one polyalcohol, including but not limited to glycerine, 1,2-PD, 1,3- fourth
Glycol etc..
In the composition, the amount of freeze proof stabilizer is 0.1-20wt%, preferably 0.5-15wt%, more preferable 1-
10wt%.
The solubilized stabilizer, including but not limited to azone, serine, arginine, glutamic acid, lysine, alanine,
Glycine, sarcosine, leucine, isoleucine, tryptophan, methionine, phenylalanine, cysteine, threonine, tyrosine,
Proline, histidine, aspartic acid, glutamine, asparagine, four sodium of diethyl glutamatic acid, dicarboxyl methylalanine trisodium,
Poly-D-lysine, lauroyl arginine ethyl ester hydrochloride, polyglutamic acid, glucan, glycosylglycerol, dipotassium glycyrrhizinate, nicotinoyl
Amine, Vc ethylether, ascorbic acid glucoside, ascorbic acid lactoside, Ve acetate, mulberry bark extract or purslane are extracted
Object；Preferably serine, arginine or niacinamide.
In the composition, wherein the amount of solubilized stabilizer is 0.1-30wt%, preferably 0.5-20wt%, more preferable 1-
15wt%.
It can also include optional one or more additives in phosphatide package nano emulsion composition of the present invention,
Including additives such as thickener, pH adjusting agent, preservative, essence.
Phosphatide package nano emulsion composition of the invention is oil-in-water type, is by lecithin, assistant for emulsifying agent embedding grease shape
There is single layer ester lipid membrane structures oil droplet at one kind, the composition can reduce the oil droplet size of monofilm package, increase phosphatide
The stability of nano emulsion composition is wrapped up, the transparency of phosphatide package nano emulsion composition is improved.
Phosphatide package nano emulsion composition according to the present invention has 250 nanometers or smaller liquid droplet size, preferably 10-
100 nanometers of liquid droplet size.
Phosphatide package nano emulsion composition according to the present invention has the light transmittance greater than 50%, preferably greater than 60% light transmission
Rate, more preferably greater than 70% light transmittance.
The invention further relates to the preparation methods of phosphatide package nano emulsion composition, include the following steps:
(1) oil, phosphatide, oil-soluble assistant for emulsifying agent are mixed and heated to 70-80 DEG C, stirred evenly, oil phase is made；
(2) water, polyalcohol antifreeze, water-soluble assistant for emulsifying agent, solubilized stabilizer are mixed, is heated to 70-80 DEG C, stirring
Uniformly, water phase is made；
(3) the oil phase is added to the aqueous phase, and thick lotion is made in stirring or shearing homogeneous after emulsification；
(4) microjet processing is carried out by high pressure High shear device after thick lotion being cooled to 30-40 DEG C, is made described
Nanoemulsions.
In the method, one or more additives are optionally added in above-mentioned steps.
In the method, step (3) is emulsified using homogenizer, and mixing speed is preferably 10000-20000rpm/
min。
In the method, the pressure of step (4) mesohigh high shear is 10000-15000psi.
The invention further relates to application of the phosphatide package nano emulsion composition in personal-care supplies.
The phosphatide wraps up nano emulsion composition, can be applied in personal care product, and including but not limited to hair is fragrant
The products such as wave, hair conditioner, hair growth liquor；It further include the products such as skin care cream, lotion, facial mask, aqua, Essence.
The utility model has the advantages that phosphatide of the invention wraps up nano emulsion composition, one is formed by lecithin, assistant for emulsifying agent embedding grease
Kind has the oil-in-water nanometer cream composition of single layer ester lipid membrane structures, and the addition of solubilized stabilizer can effectively reduce monofilm package
Oil droplet size, increase phosphatide package nano emulsion composition stability, improve phosphatide package nano emulsion composition transparency.
Particularly, transparent phosphatide can be obtained using low PC content phosphatide in the formula of phosphatide of the invention package nano emulsion composition
Nano emulsion composition is wrapped up, production cost is effectively reduced.Phosphatide package nano emulsion composition of the invention is answered in which can be convenient
In water prescription, obtain be more favored have transparent, translucent appearance personal care product.
Detailed description of the invention
Fig. 1, figure is compared using the foam volume of the transparent shampoo of lecithin package soybean oil nanometer emulsion preparation of the invention；
The dynamic cardability ratio of Fig. 2, the transparent shampoo prepared using lecithin package soybean oil nanometer emulsion of the invention
Compared with figure.
Specific embodiment
Detailed description of the preferred embodiments below, it should be noted however that protection of the invention
Range is not limited to these specific embodiments, but is determined by claims.
Embodiment 1
A kind of nano-emulsion of lecithin package soybean oil, is prepared via a method which:
(1) 40g soybean oil, 8g soybean lecithin (PC content 30%), 4.0g polyoxyethylene stearyl alcohol ether -21,3g is poly-
Ethylene oxide tristearin alcohol ether -2,0.1g antioxidant 2,6- di-tert-butyl hydroxy toluene are put into beaker, in 75 DEG C or so water-baths
Heating stirring is until be completely dissolved acquisition liquid oil phase；
(2) by 32.9g deionized water, 4g niacinamide, 2g polyoxyethylene (20) sorbitan monooleate, 6g propylene glycol is made
For water phase, the heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin package soybean oil oil-in-water nanometer cream.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, average particle size particle size are as follows: 97.3nm.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 69.8%.
Carrying out -18 degrees Celsius to above-mentioned nanoemulsions, respectively three times, room temperature can answer Frozen-thawed cycled after melting for 24 hours to room temperature
Original is not in demulsification, is layered, returns thick phenomenon, still keeps stable state.
Embodiment 2
A kind of nano-emulsion of lecithin package soybean oil, is prepared via a method which:
(1) 30g soybean oil, 8g soybean lecithin (PC content 30%), 4.0g polyoxyethylene stearyl alcohol ether -21,3g is poly-
Ethylene oxide tristearin alcohol ether -2,0.1g antioxidant 2,6- di-tert-butyl hydroxy toluene are put into beaker, in 75 DEG C or so water-baths
Heating stirring is until be completely dissolved acquisition liquid oil phase；
(2) by 38.9g deionized water, 8g niacinamide, 2g polyoxyethylene (20) sorbitan monooleate, 6g glycerine is made
For water phase, the heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin package soybean oil oil-in-water nanometer cream.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, average particle size particle size are as follows: 85.2.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 74.3%.
Carrying out -18 degrees Celsius to above-mentioned nanoemulsions, respectively three times, room temperature can answer Frozen-thawed cycled after melting for 24 hours to room temperature
Original is not in demulsification, is layered, returns thick phenomenon, still keeps stable state.
Embodiment 3
A kind of nano-emulsion of lecithin package jojoba oil, is prepared via a method which:
(1) by 30g jojoba oil, 8g soybean lecithin (PC content 30%), 4.0g polyoxyethylene stearyl alcohol ether -21,3g
Polyoxyethylene stearyl alcohol ether -2,0.1g antioxidant 2,6- di-tert-butyl hydroxy toluene are put into beaker, in 75 DEG C or so water-baths
Middle heating stirring is until be completely dissolved acquisition liquid oil phase；
(2) by 38.9g deionized water, 8g niacinamide, 2g polyoxyethylene (20) sorbitan monooleate, 6g propylene glycol is made
For water phase, the heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin package jojoba oil oil-in-water nanometer cream.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, particle size are as follows: 88.5.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 72.6%.
Carrying out -18 degrees Celsius to above-mentioned nanoemulsions, respectively three times, room temperature can answer Frozen-thawed cycled after melting for 24 hours to room temperature
Original is not in demulsification, is layered, returns thick phenomenon, still keeps stable state.
Embodiment 4
A kind of nano-emulsion of lecithin package jojoba oil, is prepared via a method which:
(1) by 30g jojoba oil, 8g soybean lecithin (PC content 30%), 4.0g polyoxyethylene stearyl alcohol ether -21,3g
Polyoxyethylene stearyl alcohol ether -2,0.1g antioxidant 2,6- di-tert-butyl hydroxy toluene are put into beaker, in 75 DEG C or so water-baths
Middle heating stirring is until be completely dissolved acquisition liquid oil phase；
(2) by 38.9g deionized water, 8g serine, 2g polyoxyethylene (20) sorbitan monooleate, 6g propylene glycol is made
For water phase, the heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin package jojoba oil oil-in-water nanometer cream.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, particle size are as follows: 119.4nm.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 57.2%.
Carrying out -18 degrees Celsius to above-mentioned nanoemulsions, respectively three times, room temperature can answer Frozen-thawed cycled after melting for 24 hours to room temperature
Original is not in demulsification, is layered, returns thick phenomenon, still keeps stable state.
Embodiment 5
A kind of nano-emulsion of lecithin package jojoba oil, is prepared via a method which:
(1) by 30g jojoba oil, 6g soybean lecithin (PC content 30%), 4.0g polyoxyethylene stearyl alcohol ether -21,3g
Polyoxyethylene stearyl alcohol ether -2,0.1g antioxidant 2,6- di-tert-butyl hydroxy toluene are put into beaker, in 75 DEG C or so water-baths
Middle heating stirring is until be completely dissolved acquisition liquid oil phase；
(2) by 38.9g deionized water, 8g serine, 2g L-arginine, 2g polyoxyethylene (20) anhydrous sorbitol oleic acid
Ester, for 6g propylene glycol as water phase, the heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin package jojoba oil oil-in-water nanometer cream.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, particle size are as follows: 101.5nm.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 63.8%.
Carrying out -18 degrees Celsius to above-mentioned nanoemulsions, respectively three times, room temperature can answer Frozen-thawed cycled after melting for 24 hours to room temperature
Original is not in demulsification, is layered, returns thick phenomenon, still keeps stable state.
Embodiment 6
A kind of nano-emulsion of lecithin package sun flower seed oil, is prepared via a method which:
(1) by 30g sun flower seed oil, 8g soybean lecithin (PC content 30%), 4.0g polyoxyethylene stearyl alcohol ether -21,
2g polyoxyethylene stearyl alcohol ether -2,0.1g antioxidant 2,6- di-tert-butyl hydroxy toluene are put into beaker, in 75 DEG C or so water
Heating stirring in bath is until be completely dissolved acquisition liquid oil phase；
(2) by 36.9g deionized water, 8g niacinamide, 2g serine, 3g polyoxyethylene (20) sorbitan monooleate,
For 6g propylene glycol as water phase, the heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin package sun flower seed oil oil-in-water nanometer cream.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, average particle size particle size are as follows: 75.2nm.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 78.6%.
Carrying out -18 degrees Celsius to above-mentioned nanoemulsions, respectively three times, room temperature can answer Frozen-thawed cycled after melting for 24 hours to room temperature
Original is not in demulsification, is layered, returns thick phenomenon, still keeps stable state.
Embodiment 7
A kind of nano-emulsion of lecithin package sunflower oil, is prepared via a method which:
(1) by 30g sunflower oil, 5g soybean lecithin (PC content 30%), 2g sorbitan monooleate, 0.1g antioxygen
Agent 2,6- di-tert-butyl hydroxy toluene are put into beaker, and the heating stirring in 75 DEG C or so water-baths is until be completely dissolved acquisition liquid
State oil phase；
(2) by 40.9g deionized water, 8g serine, 6g polyoxyethylene (20) sorbitan monooleate, 8g glycerine is made
For water phase, the heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin package sunflower oil oil-in-water nanometer cream.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, average particle size particle size are as follows: 90.5nm.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 70.4%.
Carrying out -18 degrees Celsius to above-mentioned nanoemulsions, respectively three times, room temperature can answer Frozen-thawed cycled after melting for 24 hours to room temperature
Original is not in demulsification, is layered, returns thick phenomenon, still keeps stable state.
Embodiment 8
A kind of nano-emulsion of lecithin package olive oil, is prepared via a method which:
(1) by 30g olive oil, 8g soybean lecithin (PC content 30%), 2.0g Brij92-2,4g polyoxy second
Alkene oleyl alcohol ether -20,0.1g antioxidant 2,6- di-tert-butyl hydroxy toluene are put into beaker, are heated and are stirred in 75 DEG C or so water-baths
It mixes until being completely dissolved acquisition liquid oil phase；
(2) by 41.9g deionized water, 8g serine, 2g polyoxyethylene (20) sorbitan monopalmitate, 8g 1,
For 3- butanediol as water phase, the heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin package olive oil oil-in-water nanometer cream.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, average particle size particle size are as follows: 115.2nm.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 54.1%.
Carrying out -18 degrees Celsius to above-mentioned nanoemulsions, respectively three times, room temperature can answer Frozen-thawed cycled after melting for 24 hours to room temperature
Original is not in demulsification, is layered, returns thick phenomenon, still keeps stable state.
Comparative example 1
A kind of soybean oil lotion, is prepared via a method which:
(1) by 40g soybean oil, 4.0g polyoxyethylene stearyl alcohol ether -21,3g polyoxyethylene stearyl alcohol ether -2,0.1g antioxygen
Agent 2,6- di-tert-butyl hydroxy toluene are put into beaker, and the heating stirring in 75 DEG C or so water-baths is until be completely dissolved acquisition liquid
State oil phase；
(2) by 40.9g deionized water, 4g niacinamide, 2g polyoxyethylene (20) sorbitan monooleate, 6g propylene glycol is made
For water phase, the heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get soybean oil lotion.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, average particle size particle size are as follows: 850nm.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 0%.
Carrying out -18 degrees Celsius to above-mentioned emulsion, respectively three times, room temperature can restore Frozen-thawed cycled after melting, no for 24 hours to room temperature
It will appear demulsification, be layered, return thick phenomenon, still keep stable state, but light transmittance is lower.
Comparative example 2
A kind of miniemulsion of lecithin package jojoba oil, is prepared via a method which:
(1) by 30g jojoba oil, 8g soybean lecithin (PC content 30%), 4.0g polyoxyethylene stearyl alcohol ether -21,3g
Polyoxyethylene stearyl alcohol ether -2,0.1g antioxidant 2,6- di-tert-butyl hydroxy toluene are put into beaker, in 75 DEG C or so water-baths
Middle heating stirring is until be completely dissolved acquisition liquid oil phase；
(2) by 46.9g deionized water, 2g polyoxyethylene (20) sorbitan monooleate, 6g propylene glycol as water phase,
Heating stirring in 75 DEG C or so water-baths obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin package jojoba oil oil-in-water miniemulsions.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, particle size are as follows: 281.5nm.
It is tested under 600nm wavelength by INESA N4 ultraviolet-uisible spectrophotometer, the light transmission of thickness 2mm cuvette chamber
Rate are as follows: 16.6%.
Carrying out -18 degrees Celsius to above-mentioned emulsion, respectively three times, room temperature can restore Frozen-thawed cycled after melting, no for 24 hours to room temperature
It will appear demulsification, be layered, return thick phenomenon, still keep stable state.Lotion light transmittance is lower, blueing light, between ordinary emulsion with
Between nano-emulsion.
Comparative example 3
A kind of lecithin package jojoba oil miniemulsion, is prepared via a method which:
(1) by 30g jojoba oil, 8g soybean lecithin, 4.0g polyoxyethylene stearyl alcohol ether -21,3g polyoxyethylene stearyl
Alcohol ether -2,0.1g antioxidant 2,6- di-tert-butyl hydroxy toluene are put into beaker, and heating stirring is straight in 75 DEG C or so water-baths
To being completely dissolved acquisition liquid oil phase；
(2) by 44.9g deionized water, 8g niacinamide, anhydrous sorbitol APEO -80 2g, as water phase, at 75 DEG C
Heating stirring in the water-bath of left and right obtains liquid water phase until being completely dissolved.
(3) in homogenizer, step (1) resulting oil is added in step (2) resulting water phase, while being opened equal
Matter machine, mixing speed 10000-20000rpm/min carry out emulsification 5min, obtain thick lotion.
(4) then under the conditions of cold bath, by thick lotion by microfluidizer, in 10000-15000psi high pressure high shear
Under the conditions of handle 3 times to get lecithin wrap up jojoba oil miniemulsion.
Not diluted sample is tested by Horiba Nano Partica SZ-100 dynamic nano laser particle size analyzer
Granularity, average particle size particle size are as follows: 350nm.
Transparency, under 600nm wavelength, thickness 2mm cuvette are tested by INESA N4 ultraviolet-uisible spectrophotometer
The light transmittance of chamber are as follows: 6.6%.
Carrying out -18 degrees Celsius to above-mentioned miniemulsion, respectively three times, room temperature cannot restore Frozen-thawed cycled after melting for 24 hours to room temperature,
There is layering, return thick phenomenon, is not able to maintain stable state.
Embodiment 9
A kind of transparent shampoo of the nano-emulsion containing lecithin package soybean oil, is calculated by mass percentage, forms
It is as follows:
The nano-emulsion 1% of lecithin package soybean oil；
Cocounut oil acyl Sodium L-alaninate 9%；
Cocoamidopropyl betaine 5.4%；
Polyquaternium -6 0.6%；
Hamposyl L isopropyl ester 0.6%；
Preservative 0.3%；
Chelating agent 0.1%
Appropriate citric acid
Appropriate essence
Deionized water is to 100%；
It is transparent shampoo before above-mentioned shampoo addition lecithin package soybean oil nanometer emulsion, lecithin package soybean oil is received
Rice milk is still able to maintain its transparent appearance after being added, and does not influence the transparency of shampoo.It is divided by INESA N4 UV, visible light
Photometer test, under 600nm wavelength, the light transmittance of thickness 10mm cuvette chamber are as follows: 99.7%.And add lecithin package
Light transmittance before soybean oil nanometer emulsion is 99.8%, and the two is almost without difference.
The foam volume (Fig. 1) of the shampoo of the present embodiment is tested by Roche foam meter, and is washed with certain well-known commercially available brand
Shampoo is compareed, and the foam of the present embodiment shampoo will be far better than commercially available brand.
| Sample | 30S foam volume (ml) | 3mins foam volume (ml) | 5mins foam volume (ml) |
| Embodiment 9 | 360 | 350 | 340 |
| Certain well-known commercial shampoos | 230 | 220 | 210 |
With dynamic cardability (Fig. 2) of the dynamic carding force instrument testing example 9 during hair washing, standard shampoo is used
And shampoo described in embodiment 9 cleans topknot, tests carding force, combing using dynamic carding force instrument to topknot in the process of cleaning
Power is smaller, illustrates that the hair conditioning of shampoo is better.From the point of view of data in figure, shampoo described in embodiment 9 is in blistering, before flushing
All well below commercially available to mark product, the carding force after drying also produces mark with commercially available carding force after section, flushing back segment, flushing
Condition is worked as.On the whole, combing type will be far better than to mark product.
| Test sample | To mark product | When spuming | Rinse leading portion | Rinse back segment | After flushing | After drying |
| To mark product | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Embodiment 9 | 1.00 | 0.73 | 0.83 | 0.71 | 0.61 | 1.03 |
Claims (12)
1. a kind of phosphatide wraps up nano emulsion composition, which is characterized in that include following components:
(1) at least one oil；
(2) at least one phosphatide；
(3) at least one assistant for emulsifying agent selected from anion emulsifier or nonionic emulsifier；
(4) at least one solubilized stabilizer；
(5) the freeze proof stabilizer of at least one polyalcohol；
(6) water.
2. phosphatide according to claim 1 wraps up nano emulsion composition, which is characterized in that the oil is selected from natural oil
Rouge, Synthetic Oil, silicone oil and/or hydrocarbon ils；The oil accounts for the 0.1-50wt% of nano emulsion composition.
3. phosphatide according to claim 1 wraps up nano emulsion composition, which is characterized in that the phosphatide is lecithin,
Phosphatide accounts for the 0.1-20wt% of nano emulsion composition.
4. phosphatide according to claim 4 wraps up nano emulsion composition, which is characterized in that the lecithin is soybean ovum
Phosphatide or modified soybean lecithin, PC content≤70wt%.
5. phosphatide according to claim 1 wraps up nano emulsion composition, which is characterized in that the assistant for emulsifying agent be it is non-from
Sub- emulsifier is selected from aliphatic alcohol polyether, sorbitan fatty ester, polyoxyethylene sorbitan aliphatic ester, list
Fatty acid glyceride or polyglyceryl fatty acid ester；The amount of assistant for emulsifying agent accounts for the 0.1-20wt% of nano emulsion composition.
6. phosphatide according to claim 5 wraps up nano emulsion composition, which is characterized in that the assistant for emulsifying agent is fat
The mixture of alcohol polyethers and sorbitan fatty ester or polyoxyethylene sorbitan aliphatic ester.
7. phosphatide according to claim 1 or 6 wraps up nano emulsion composition, which is characterized in that the assistant for emulsifying agent
HLB value is 8-15.
8. phosphatide according to claim 1 wraps up nano emulsion composition, which is characterized in that the polyalcohol is selected from the third three
Alcohol, 1,2-PD or 1,3-BDO, dosage are the 0.1-20wt% of nano emulsion composition.
9. phosphatide according to claim 1 wraps up nano emulsion composition, which is characterized in that the solubilized stabilizer is selected from
Azone, serine, arginine, glutamic acid, lysine, alanine, glycine, sarcosine, leucine, isoleucine, tryptophan,
Methionine, phenylalanine, cysteine, threonine, tyrosine, proline, histidine, aspartic acid, glutamine, asparagus fern acyl
Amine, four sodium of diethyl glutamatic acid, dicarboxyl methylalanine trisodium, poly-D-lysine, lauroyl arginine ethyl ester hydrochloride, poly- paddy
Propylhomoserin, glucan, glycosylglycerol, dipotassium glycyrrhizinate, niacinamide, Vc ethylether, ascorbic acid glucoside, ascorbic acid lactose
Glycosides, Ve acetate, mulberry bark extract or purslane extract；The amount of the solubilized stabilizer is nano emulsion composition
0.1-30wt%.
10. phosphatide according to claim 1 wraps up nano emulsion composition, which is characterized in that the phosphatide wraps up nanometer
Liquid droplet size≤250 nanometer of newborn composition, light transmittance >=50%.
11. a kind of preparation method of phosphatide package nano emulsion composition described in claim 1, includes the following steps:
(1) oil, phosphatide, oil-soluble assistant for emulsifying agent are mixed and heated to 70-80 DEG C, stirred evenly, oil phase is made；
(2) water, polyalcohol antifreeze, water-soluble assistant for emulsifying agent, emulsion stabilizer are mixed and heated to 70-80 DEG C, stirring is equal
It is even, water phase is made；
(3) the oil phase is added to the aqueous phase, and thick lotion is made in stirring or shearing homogeneous after emulsification；
(4) microjet processing is carried out with high pressure High shear device after thick lotion being cooled to 30-40 DEG C, the nano-emulsion is made
Liquid.
12. application of the phosphatide package nano emulsion composition described in claim 1 in personal-care supplies.
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