CN107890433A - A kind of preparation method of licoflavone composition for cosmetics - Google Patents
A kind of preparation method of licoflavone composition for cosmetics Download PDFInfo
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- CN107890433A CN107890433A CN201711091254.9A CN201711091254A CN107890433A CN 107890433 A CN107890433 A CN 107890433A CN 201711091254 A CN201711091254 A CN 201711091254A CN 107890433 A CN107890433 A CN 107890433A
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- licoflavone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- Birds (AREA)
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- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to field of pharmaceutical preparations, and in particular to a kind of preparation method of licoflavone composition for cosmetics.Raw material of the present invention is licoflavone, first freezed, form solid, pass through polyethylene, ethyl cellulose is that capsule material prepares licoflavone micro-capsule, microencapsulation changes material hydrophilic and oleophilic property, improve the dispersiveness of licoflavone, and ethyl cellulose is stablized, nontoxic coating material, in the preparation process of ethyl cellulose microcapsule, polyethylene is as important adjuvant, licoflavone is protected, prevent radix glycyrrhizae affected by environment and decomposed metamorphic and sustained release performance, improve concentration of the licoflavone in skin, reach slow release long-acting, strengthen the effect of licoflavone whitening spot-removing.Microencapsulation improves the water solubility of licoflavone, so as to expand application of the licoflavone in whitening, spot-removing function cosmetics.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, and in particular to a kind of preparation side of Licorice flavanone composition for cosmetics
Method.
Background technology
Radix glycyrrhizae is one of conventional herbal species in China, rich in triterpene saponin, flavonoids isoreactivity composition, has tonifying spleen
QI invigorating, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription and other effects.Content highest active component is triterpene in radix glycyrrhizae
Saponins compound --- glycyrrhizic acid.Glycyrrhizic acid is to study the most thorough, most widely used radix glycyrrhizae active component.
Medicine manufacture often only extracts the glycyrrhizic acid in radix glycyrrhizae, and remaining liquorice dregs are often treated as waste material after extraction
Discard.The glycyrrhiza extract lost easily causes the pollution of environment, and also creates the waste of resource.There are some researches show these are sweet
Careless slag is rich in Flavonoid substances；And Flavonoid substances have extensive bioactivity in radix glycyrrhizae, licoflavone is to be present in radix glycyrrhizae
In a kind of flavones ingredient, there is liver protecting, anti-oxidant, antiulcer, antitumor, anti-inflammatory antiallergic action and enzyme level
Deng pharmacological action.The enzyme inhibition that research shows licoflavone and had is mainly reflected in the activity for suppressing tyrosinase, and then
Suppress the synthesis of melanin, the effect that it suppresses tyrosinase activity is 25 times of kojic acid, is ascorbic 80 times.Radix glycyrrhizae is yellow
Ketone can also suppress the activity of dopachrome interconvertible enzyme and hinder the polymerization of 5,6- dihydroxy indoles, therefore in treatment chloasma
Product rich in licoflavone achieves good therapeutic effect.
The excellent white-skinned face function of licoflavone and security, it is set to be widely used in skin-lightening cosmetic, but because
Oil soluble material for licoflavone itself, solubility is minimum in aqueous, and the base-material of most cosmetics be it is water-based, it is sweet
The oil-soluble characteristic of straw colour ketone makes its compatibility and application in cosmetics nevertheless suffer from larger limitation.If effectively increase
Add solubility of the licoflavone in water, with regard to application of the licoflavone in skin-lightening cosmetic can be greatly increased.
In addition, the approach for obtaining licoflavone at present first crushes it, then with water or organic all using licorice as raw material
Solvent is extracted, then carries out phase partitioning, is most decolourized, is purified through large aperture resin etc. afterwards and is obtained.Idiographic flow is as follows：It is sweet
Grass roots → crushing → solvent first time extraction → filtering → concentration go water obtain the dissolving of solvent → solvent → second and phase partitioning →
Filtering → concentration → the heating dissolving → concentration of addition Diluted Alcohol → obtains product.But such licoflavone preparation method part
Technique is coarse, and extraction species are single or inferior separating effect, active ingredient are made a low multiple use, and yield is low；Although another part
Preferable separation and Extraction effect can be reached, but due to cost height, it is difficult to realize large-scale production.
Therefore, invent a kind of new licoflavone composition, solve the problems of nowadays, be adapted to market and
The demand of society, is a thing being extremely necessary.
The content of the invention
The technical problems to be solved by the invention：Itself it is oil soluble material for current licoflavone, in aqueous
Dissolubility is poor, the problem of causing to be restricted in cosmetics preparation, there is provided a kind of Licorice flavanone composition for cosmetics
Preparation method.
In order to solve the above technical problems, the present invention is using technical scheme as described below：
A kind of preparation method of licoflavone composition for cosmetics, the preparation method comprise the following steps：
（1）Licoflavone is freezed, obtains frozen material, frozen material is put into pulverizer and crushed, sieves, obtains sieving, will
Sieving, absolute ethyl alcohol are mixed, and are stirred 20 ~ 30min, obtain stirring thing,
（2）Polyethylene, ethyl cellulose, hexamethylene are put into container and mixed, and is stirred, then is heated back
Stream, until polyethylene, ethyl cellulose are completely dissolved, the stirring thing of ethyl cellulose quality 40 ~ 50% is being added into container,
Stop heating after continuing 20 ~ 30min of stirring, be cooled to room temperature, filter, obtain filter residue, filter residue is washed 2 ~ 3 times with hexamethylene, obtained
Filter residue after washing, the filter residue after washing is dried at 25 ~ 30 DEG C of temperature, thing must be dried；
（3）Count in parts by weight, take 10 ~ 15 parts of water, 2 ~ 8 parts dry thing, 2 ~ 6 parts of emulsifying agents, 0.5~2 part of polymethylacrylic acid
Glyceride, first by water, emulsifying agent, polymethyl acid glyceride in 50 ~ 60 DEG C of water-baths of temperature dissolving, it is to be dissolved completely after, then
Thing is dried in addition, and carries out stirring and dissolving, obtains lysate；
（4）Distilled water, NMF, triethanolamine are mixed, obtain mixture, add mixture to be heated to temperature 60 ~
It is stirring while adding uniform in 65 DEG C of lysate, put to room temperature, produce the licoflavone composition for cosmetics.
The step（1）The temperature of middle freezing is -2 ~ 0 DEG C.
The step（2）Middle polyethylene, ethyl cellulose, the mass ratio 2 of hexamethylene：1：4~5.
The step（2）In 70 ~ 80 DEG C of temperature being heated to reflux, 1 ~ 2h of time.
The step（3）Middle emulsifying agent be Arabic gum, sodium alkyl benzene sulfonate it is therein any one.
The step（4）Middle distilled water, NMF, the mass ratio 10 ~ 15 of triethanolamine：4~8：2~3.
The step（4）Middle NMF be sorbierite, propane diols it is therein any one.
Compared with other method, advantageous effects are the present invention：
（1）Raw material of the present invention is licoflavone, is first freezed licoflavone, so as to form solid, and passes through polyethylene, second
Base cellulose is that capsule material prepares licoflavone micro-capsule, and microencapsulation can change the properties such as material hydrophilic and oleophilic, sweet so as to improve
The dispersiveness of straw colour ketone, and ethyl cellulose is as stable, nontoxic coating material, in the preparation of ethyl cellulose microcapsule
Cheng Zhong, polyethylene, so as to be played a protective role to licoflavone, prevent that radix glycyrrhizae is affected by environment as important auxiliary additive
And decomposed metamorphic and sustained release performance, local concentration of the licoflavone in skin is improved, reaches slow release long-acting, strengthens licoflavone
The effect of whitening spot-removing.
（2）The method of the present invention, microencapsulation add solubility of the licoflavone in water, and emulsifying agent in additive
It is that the droplet for preventing dispersed phase condenses mutually, makes the emulsion to be formed more stable, NMF is to prevent oil/water type from emulsifying
The drying shrinkage of body, both additions are so as to expanding application of the licoflavone in whitening, spot-removing function cosmetics.
Brief description of the drawings
Fig. 1 is the water-soluble specific detection case of licoflavone composition.
Embodiment
Emulsifying agent be Arabic gum, sodium alkyl benzene sulfonate it is therein any one.
NMF be sorbierite, propane diols it is therein any one.
A kind of preparation method of licoflavone composition for cosmetics, the preparation method comprise the following steps：
（1）Licoflavone is freezed at temperature -2 ~ 0 DEG C, frozen material is obtained, frozen material is put into pulverizer and crushed, crosses 5
~ 10 mesh sieves, obtain sieving, in mass ratio 1：3 ~ 4, sieving, absolute ethyl alcohol are mixed, and is carried out with 200 ~ 260r/min
20 ~ 30min is stirred, obtains stirring thing,
（2）In mass ratio 2：1：4 ~ 5, polyethylene, ethyl cellulose, hexamethylene are put into container and mixed, and with 500 ~
600r/min is stirred, then is heated to reflux 1 ~ 2h at 70 ~ 80 DEG C of temperature, until polyethylene, ethyl cellulose are completely dissolved,
The stirring thing of ethyl cellulose quality 40 ~ 50% is being added into container, is stopping heating after continuing 20 ~ 30min of stirring, is cooled to
Room temperature, filtering, obtains filter residue, filter residue is washed 2 ~ 3 times with hexamethylene, the filter residue after must washing, by the filter residue after washing in temperature
Dried at 25 ~ 30 DEG C, thing must be dried；
（3）Count in parts by weight, take 10 ~ 15 parts of water, 2 ~ 8 parts dry thing, 2 ~ 6 parts of emulsifying agents, 0.5~2 part of polymethylacrylic acid
Glyceride, first by water, emulsifying agent, polymethyl acid glyceride in 50 ~ 60 DEG C of water-baths of temperature dissolving, it is to be dissolved completely after, then
Thing is dried in addition, and is stirred dissolving with 100 ~ 180r/min, obtains lysate；
（4）In mass ratio 10 ~ 15：4~8：2 ~ 3, distilled water, NMF, triethanolamine are mixed, obtain mixture, by quality
Than 2 ~ 3：1 ~ 2, add mixture to and be heated in the lysate of 60 ~ 65 DEG C of temperature, side edged is stirred with 100 ~ 120r/min
Uniformly, put to room temperature, produce the licoflavone composition for cosmetics.
Embodiment 1
Emulsifying agent is Arabic gum.
NMF is sorbierite.
A kind of preparation method of licoflavone composition for cosmetics, the preparation method comprise the following steps：
（1）Licoflavone is freezed at -2 DEG C of temperature, frozen material is obtained, frozen material is put into pulverizer and crushed, cross 5 mesh
Sieve, obtains sieving, in mass ratio 1：3, sieving, absolute ethyl alcohol are mixed, and 20min is stirred with 200r/min,
Obtain stirring thing,
（2）In mass ratio 2：1：4, polyethylene, ethyl cellulose, hexamethylene are put into container and mixed, and with 500r/
Min is stirred, then is heated to reflux 1h under temperature 70 C, until polyethylene, ethyl cellulose are completely dissolved, into container
The stirring thing of ethyl cellulose quality 40% is added, continues to stop heating after stirring 20min, is cooled to room temperature, filters, obtain filter residue,
Filter residue is washed 2 times with hexamethylene, the filter residue after must washing, the filter residue after washing is dried at 25 DEG C of temperature, thing must be dried；
（3）Count in parts by weight, take 10 parts of water, 2 parts dry thing, 2 parts of emulsifying agents, 0.5 part of polymethyl acid glyceride, first will
Water, emulsifying agent, polymethyl acid glyceride temperature 50 C water-bath dissolve, it is to be dissolved completely after, add and dry thing, and with
100r/min is stirred dissolving, obtains lysate；
（4）In mass ratio 10：4：2, distilled water, NMF, triethanolamine are mixed, obtain mixture, in mass ratio 2：1,
Add mixture to and be heated in the lysate of temperature 60 C, side edged is stirred with 100r/min, is put to room temperature, is produced
Licoflavone composition for cosmetics.
Embodiment 2
Emulsifying agent is sodium alkyl benzene sulfonate.
NMF is sorbierite.
A kind of preparation method of licoflavone composition for cosmetics, the preparation method comprise the following steps：
（1）Licoflavone is freezed at -1 DEG C of temperature, frozen material is obtained, frozen material is put into pulverizer and crushed, cross 7 mesh
Sieve, obtains sieving, in mass ratio 1：3, sieving, absolute ethyl alcohol are mixed, and 25min is stirred with 230r/min,
Obtain stirring thing,
（2）In mass ratio 2：1：4, polyethylene, ethyl cellulose, hexamethylene are put into container and mixed, and with 550r/
Min is stirred, then is heated to reflux 1h at 75 DEG C of temperature, until polyethylene, ethyl cellulose are completely dissolved, into container
The stirring thing of ethyl cellulose quality 55% is added, continues to stop heating after stirring 25min, is cooled to room temperature, filters, obtain filter residue,
Filter residue is washed 2 times with hexamethylene, the filter residue after must washing, the filter residue after washing is dried at 27 DEG C of temperature, thing must be dried；
（3）Count in parts by weight, take 13 parts of water, 6 parts dry thing, 4 parts of emulsifying agents, 1 part of polymethyl acid glyceride, first will
Water, emulsifying agent, polymethyl acid glyceride in 55 DEG C of water-baths of temperature dissolving, it is to be dissolved completely after, add and dry thing, and with
150r/min is stirred dissolving, obtains lysate；
（4）In mass ratio 13：6：2, distilled water, NMF, triethanolamine are mixed, obtain mixture, in mass ratio 2：1,
Add mixture to and be heated in the lysate of 63 DEG C of temperature, side edged is stirred with 110r/min, is put to room temperature, is produced
Licoflavone composition for cosmetics.
Embodiment 3
Emulsifying agent is sodium alkyl benzene sulfonate.
NMF is propane diols.
A kind of preparation method of licoflavone composition for cosmetics, the preparation method comprise the following steps：
（1）Licoflavone is freezed at 0 DEG C of temperature, frozen material is obtained, frozen material is put into pulverizer and crushed, cross 10 mesh
Sieve, obtains sieving, in mass ratio 1：4, sieving, absolute ethyl alcohol are mixed, and 30min is stirred with 260r/min,
Obtain stirring thing,
（2）In mass ratio 2：1：5, polyethylene, ethyl cellulose, hexamethylene are put into container and mixed, and with 600r/
Min is stirred, then is heated to reflux 2h at 80 DEG C of temperature, until polyethylene, ethyl cellulose are completely dissolved, into container
The stirring thing of ethyl cellulose quality 40 ~ 50% is added, continues to stop heating after stirring 30min, is cooled to room temperature, filters, must filter
Slag, filter residue is washed 3 times with hexamethylene, the filter residue after must washing, the filter residue after washing is dried at 30 DEG C of temperature, must be dried
Thing；
（3）Count in parts by weight, take 15 parts of water, 8 parts dry thing, 6 parts of emulsifying agents, 2 parts of polymethyl acid glycerides, first will
Water, emulsifying agent, polymethyl acid glyceride temperature 60 C water-bath dissolve, it is to be dissolved completely after, add and dry thing, and with
180r/min is stirred dissolving, obtains lysate；
（4）In mass ratio 15：8：3, distilled water, NMF, triethanolamine are mixed, obtain mixture, in mass ratio 3：2,
Add mixture to and be heated in the lysate of 65 DEG C of temperature, side edged is stirred with 120r/min, is put to room temperature, is produced
Licoflavone composition for cosmetics.
Comparative example：The licoflavone composition of Guangzhou Chemical Co., Ltd. production
Method：Embodiment and the licoflavone composition prepared by comparative example are placed in the aqueous solution of phase homogenous quantities, detect it
Dissolution rate in water, its water miscible quality is characterized with this.
The water-soluble specific detection case of licoflavone composition is shown in Figure of description Fig. 1
From the foregoing, it will be observed that the solubility property of licoflavone composition in aqueous prepared by the present invention is good, be a kind of safety and
Efficient licoflavone composition, is worthy to be popularized and uses.
Claims (7)
1. the preparation method of a kind of licoflavone composition for cosmetics, it is characterised in that the preparation method includes as follows
Step：
（1）Licoflavone is freezed, obtains frozen material, frozen material is put into pulverizer and crushed, sieves, obtains sieving, will
Sieving, absolute ethyl alcohol are mixed, and are stirred 20 ~ 30min, obtain stirring thing,
（2）Polyethylene, ethyl cellulose, hexamethylene are put into container and mixed, and is stirred, then is heated back
Stream, until polyethylene, ethyl cellulose are completely dissolved, the stirring thing of ethyl cellulose quality 40 ~ 50% is being added into container,
Stop heating after continuing 20 ~ 30min of stirring, be cooled to room temperature, filter, obtain filter residue, filter residue is washed 2 ~ 3 times with hexamethylene, obtained
Filter residue after washing, the filter residue after washing is dried at 25 ~ 30 DEG C of temperature, thing must be dried；
（3）Count in parts by weight, take 10 ~ 15 parts of water, 2 ~ 8 parts dry thing, 2 ~ 6 parts of emulsifying agents, 0.5~2 part of polymethylacrylic acid
Glyceride, first by water, emulsifying agent, polymethyl acid glyceride in 50 ~ 60 DEG C of water-baths of temperature dissolving, it is to be dissolved completely after, then
Thing is dried in addition, and carries out stirring and dissolving, obtains lysate；
（4）Distilled water, NMF, triethanolamine are mixed, obtain mixture, add mixture to be heated to temperature 60 ~
It is stirring while adding uniform in 65 DEG C of lysate, put to room temperature, produce the licoflavone composition for cosmetics.
2. it is used for the preparation method of the licoflavone composition of cosmetics according to claim 1, it is characterised in that the step
Suddenly（1）The temperature of middle freezing is -2 ~ 0 DEG C.
3. it is used for the preparation method of the licoflavone composition of cosmetics according to claim 1, it is characterised in that the step
Suddenly（2）Middle polyethylene, ethyl cellulose, the mass ratio 2 of hexamethylene：1：4~5.
4. it is used for the preparation method of the licoflavone composition of cosmetics according to claim 1, it is characterised in that the step
Suddenly（2）In 70 ~ 80 DEG C of temperature being heated to reflux, 1 ~ 2h of time.
5. it is used for the preparation method of the licoflavone composition of cosmetics according to claim 1, it is characterised in that the step
Suddenly（3）Middle emulsifying agent be Arabic gum, sodium alkyl benzene sulfonate it is therein any one.
6. it is used for the preparation method of the licoflavone composition of cosmetics according to claim 1, it is characterised in that the step
Suddenly（4）Middle distilled water, NMF, the mass ratio 10 ~ 15 of triethanolamine：4~8：2~3.
7. it is used for the preparation method of the licoflavone composition of cosmetics according to claim 1, it is characterised in that the step
Suddenly（4）Middle NMF be sorbierite, propane diols it is therein any one.
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Cited By (1)
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| CN109820743A (en) * | 2019-03-13 | 2019-05-31 | 广州玮弘祺生物科技有限公司 | A kind of water solubility licoflavone composition and its preparation method and application |
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| CN109820743A (en) * | 2019-03-13 | 2019-05-31 | 广州玮弘祺生物科技有限公司 | A kind of water solubility licoflavone composition and its preparation method and application |
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Application publication date: 20180410 |