CN109805222A - A kind of health drink of patients with diabetes mellitus and preparation method thereof - Google Patents
A kind of health drink of patients with diabetes mellitus and preparation method thereof Download PDFInfo
- Publication number
- CN109805222A CN109805222A CN201711169463.0A CN201711169463A CN109805222A CN 109805222 A CN109805222 A CN 109805222A CN 201711169463 A CN201711169463 A CN 201711169463A CN 109805222 A CN109805222 A CN 109805222A
- Authority
- CN
- China
- Prior art keywords
- alkali
- fluffy
- extracting solution
- patients
- diabetes mellitus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
A kind of patients with diabetes mellitus health drink and preparation method thereof, it is related to a kind of health drink, it is combined by ultrasonic wave with dynamic countercurrent circulation, ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination greatly remain alkali it is fluffy in water-soluble functional components, the fluffy middle polyphenols recovery rate of alkali improves 30%-70% compared to traditional extraction process recovery rate, the fluffy middle polyphenols of alkali has anti-mutation, it is anti-oxidant, blood pressure lowering, reduce the content of cholesterol and triglycerides in blood plasma and liver, it is hardened with prevention of arterial, it reduces blood pressure and blood lipid, the effects of preventing and treating thrombus, suitable diabetic takes and to diabetic complication such as hypertension, hyperlipidemia, artery sclerosis is protected, in conjunction with hawthorn, balsam pear, corn stigma, good seed extracting solution, pumpkin extracting solution etc. has hypoglycemic, reduce animal Fat mitigates the effect of artery sclerosis in the deposition of vascular wall, and suitable for patients with diabetes mellitus has significant health-care effect to diabetic.
Description
[technical field]
The present invention relates to a kind of health drinks, more particularly, to the health drink and its preparation of a kind of patients with diabetes mellitus
Method.
[background technique]
Diabetes are a kind of common endocrine metabolism diseases, it is the third-largest serious after tumour, vascular lesion
The disease of human health is threatened, there is high lethality rate, the feature of high disability rate and high health care costs, become each Kuomintang-Communist of our times
With the public health problem faced.The statistical data of International Diabetes Federation is shown, is turned within diabetes mellitus in China illness rate nearly 10 years
Twice.2010, Chinese Adult diabetes prevalence was 9.7%, and patient populations become the first in the world glycosuria more than 90,000,000
Sick big country.Meanwhile the impaired glucose tolerance of prediabetes has reached 1.48 hundred million people, illness rate 15.5%.It is wherein main
It is 2 type patients.The above true explanation, with the raising of people's social and economic activities, diabetes (especially 2 types) patient has rapidly
The increased impetus can not be ignored.
Diabetic's complication pathomechanism is atherosclerosis, hyperglycemia, hypertension, high cholesterol, low-density
Lipoprotein increases, high-density lipoprotein declines, and the course of disease is reachable in the incidence of diabetic's cerebral arteriovenous malformation in 5 years or more
70%, it is mainly shown as the neurasthenia symptoms such as headache, giddy, insomnia, amnesia, absent minded, emotional instability.Nerve
The how no positive sign of system physical examination.Acute cerebrovascular disease is mainly shown as cerebral thrombosis, with arteriolar infarct and more
It is common to send out venereal disease stove, clinical symptoms are often relatively light, but normal recurrent exerbation, and progressive aggravates, and restore difficult.
Suaeda salsa is annual herb salification plant, and the fluffy middle nutritional ingredient of alkali is complete and enriches, the fluffy stem leaf protein matter of alkali,
Fat, carbohydrate three nutritious elements content are higher, and seed fat content accounts for the 36.5% of dry matter, are higher than soybean,
The protein content of fresh and tender cauline leaf accounts for the 40% of dry matter, measures 16 kinds of amino acid in Suaeda salsa altogether, wherein there is 8 kinds of human bodies must
Amino acid is needed, and content is higher, there is expansion blood vessel, enhance human immunity, be depressured, the function of hypoglycemic, prevention and cure of cardiovascular disease
Effect；The essential trace elements of the human body and vitamin abundant there are many also containing during alkali is fluffy, wherein calcium, magnesium, zinc, iron, nickel content are rich
Richness, calcium, phosphorus, iron and core yellow cellulose content are higher than or quite much higher than the vegetables such as spinach, tomato and carrot, Vitamin C content
In general vegetables, vitamin B content is 5-8 times of general vegetables, is much higher than spirulina；Invention Announce number is CN106578918A
Patent document disclose a kind of fluffy healthy and nutritious noodle of selenium-rich alkali and its production technology, it is fluffy that patent document research demonstrates alkali
Middle high 10 times of the more general food of Se content or so, and selenium is referred to as " king of anti-cancer " in body trace element by scientist, tool
There is the effect of anticancer, pre- preventing tumor, the generation of hepatopathy, raising body immunity；Invention Announce number are as follows: CN103027962A's
Patent document discloses a kind of Suaeda salsa extracting flavonoids and content assaying method, and patent document research demonstrates Suaeda salsa
(S.salsa) leaf flavonoids content is higher, and has stronger antioxidant activity, and plant flavone has anti-oxidant, antitumor, anti-dynamic
The multiple efficacies such as pulse atherosclerosis, anti-inflammatory.
Pigment during alkali is fluffy is the valuable source of natural pigment, which is researched and analysed as water-soluble anthocyan color
Element.Anthocyanidin has anti-mutation, anti-oxidant, blood pressure lowering, protection liver as natural pigment, security performance with higher
Dirty equal healthcare functions, belong to functional food additives.Polyphenols is referred to as " the 7th class nutrient ".Polyphenol can promote rouge
Class and bile acid exclude external, the content of cholesterol and triglycerides in reduction blood plasma and liver, with prevention of arterial hardening, drop
The effects of low blood pressure and blood lipid, prevention and treatment thrombus.
In conclusion the fluffy middle polyphenols of alkali has remarkable efficacy for the defence of diabetic's complication, currently
There are no a kind of methods of energy fluffy middle polyphenol substance of high efficiency extraction alkali, also without a kind of that alkali is fluffy applied to patients with diabetes mellitus
Health drink.
[summary of the invention]
In order to overcome the shortcomings in the background art, the present invention develops a kind of health drink of patients with diabetes mellitus, leads to
Cross ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination greatly remain alkali it is fluffy in it is water-soluble it is functional at
Point, the fluffy middle polyphenols recovery rate of alkali improves 30%-70% compared to traditional extraction process recovery rate, passes through sonde-type number
Aobvious refractometer can solution index of refraction, can quantitatively analyze the ingredient in the fluffy liquid of measurement alkali and mixed liquid B, test solution it is pure
Whether degree, the auxiliary fluffy liquid of allotment alkali and mixed liquid B reach required CONCENTRATION STATE, the fluffy middle polyphenols of alkali have anti-mutation,
Anti-oxidant, blood pressure lowering reduces the content of cholesterol and triglycerides in blood plasma and liver, has prevention of arterial hardening, reduces blood
The effects of pressure and blood lipid, prevention and treatment thrombus, suitable diabetic take and to diabetic complication such as hypertension, hyperlipidemia, dynamic
Arteries and veins hardening is protected, and has hypoglycemic, drop in conjunction with hawthorn, balsam pear, corn stigma, good seed extracting solution, pumpkin extracting solution etc.
Low animal fat mitigates the effect of artery sclerosis in the deposition of vascular wall, and suitable for patients with diabetes mellitus has diabetic
There is significant health-care effect.
For achieving the above object, the present invention adopts the following technical scheme:
A kind of patients with diabetes mellitus health drink and preparation method thereof, includes the following steps:
Step 1, fresh Leaves of Suaeda Salsa is acquired, food purifying machine is put into and cleans 1 time~3 times, killed using vegetable drying
The drying of bacterium machine, temperature are 30 DEG C~50 DEG C, and fruits and vegetables pulverizer crushes, and it is spare to cross 20~40 meshes；
Step 2, smashed material is put into ultrasonic wave dynamic countercurrent circulation extracting concentrating equipment, by feed liquid mass ratio 1:
50 add deionized water, add 3% (w/w) cellulase, and 0.05% vitamin C, enzymolysis time 20min~30min, enzymatic hydrolysis is added
30 DEG C~50 DEG C of temperature, ultrasonic power 125w, extraction time is 1~2 time, and merging leaching liquor, to obtain the fluffy liquid of alkali spare, passes through spy
It is 1.5456 that hair style digital display refractometer, which measures the fluffy liquid refractive index of alkali,；
Step 3, take hawthorn, balsam pear, corn stigma clean plus appropriate amount of water decoction to obtain extracting solution A spare, take good seed to crush, add
Water impregnates 30 minutes, and heating is boiled 20-40 minutes, and seed extracting solution must be praised by pouring out supernatant；It takes pumpkin to crush, soaks in water
20 minutes, heating was boiled 30 minutes, is poured out supernatant and is obtained pumpkin extracting solution；
Step 4, by the fluffy liquid of alkali made from step 2 and step 3, extracting solution A praises seed extracting solution, and pumpkin extracting solution is pressed
It is mixed to prepare mixed liquid B according to the ratio of 1:2.5:0.2:0.6, mixed liquid B refractive index is measured to obtain by sonde-type digital display refractometer
It is 1.6012；
Step 5, xylitol is added in mixed liquid B；
Step 6, mixed liquid B carries out coarse filtration, ultrafiltration by reverse osmosis unit, and sterile filling to obtain the final product.
Described patients with diabetes mellitus health drink and preparation method thereof, its mineral composition of the fluffy liquid of the alkali and contains
It measures as follows: Ca2+2985 μ g/L~5200 μ g/L, the μ g/L of Mg2+1743 μ g/L~2791, μ g/L of Fe2+162 μ g/L~185, Mn2
+ 5.11 μ g/L of μ g/L~8.03, the μ g/L of Zn+5.27 μ g/L~8.51, the μ g/L of K+0.8 μ g/L~3.0, Na+1746 μ g/L~
6899 μ g/L, 200 μ of μ g/L~400 g/L of total dissolved solid.
Described patients with diabetes mellitus health drink and preparation method thereof, reverse osmosis unit system described in step 6 are matched
It is set to: pretreatment system, smart filtration system, corollary system；Pretreatment system by mechanical filter, adsorption filter, ensured public security
Filter composition；Smart filtration system is made of hollow-fibre ultrafiltration device；Corollary system is made of water purification pot, electrical control system；
Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution, after through adsorption filter filtering can remove suspension
Object, however the impurity such as algae can be removed through mechanical filter filtering.
Described patients with diabetes mellitus health drink and preparation method thereof, ultrafiltration described in step 6 are super for hollow-fibre membrane
Filter is to remove the microorganisms such as bacterium in extracting solution, mould.
Described patients with diabetes mellitus health drink and preparation method thereof, the hollow-fibre membrane diameter be 0.01 μm~
0.001 μm, feed rate be 900L/h~1500L/h, pressure 0.045Mpa~0.18Mpa, feed concentration be 200 μ g/L~
400 μ g/L, ultrafiltration time 100min~400min, backwash cycle 10min~40min, backwash time 20min~120min, on
Run 10min~40min, upper backwash 20s~120s, lower operation 10min~40min, lower backwash 20s~120s.
Due to the adoption of the technical scheme as described above, the invention has the following beneficial effects:
1, the present invention is directed to patients with diabetes mellitus health drink, selects balsam pear that can mend gallbladder profit liver in ingredient, and diuresis disappears
Heat solves spirits, and aid digestion, anti-flu can also control laryngitis and cough due to wind-heat evil, and the Charantin in balsam pear is known as " fatty killer ",
The Fresh sap of balsam pear, the substance containing Charantin and similar insulin, has good hypoglycemic effect, can make intake fat
It being reduced with polysaccharide, the alkaloid in balsam pear has good blood sugar reducing function, and it is especially significant to diabetes, it is known as plant pancreas islet
Element；Hawthorn, sour sweet, slightly warm in nature belong to liver and gallbladder the spleen channel, it contains ursolic acid, can reduce animal tallow in the deposition of vascular wall,
Mitigate artery sclerosis to a certain extent；Corn stigma tea, corn stigma is also known as " Dracaena ", sweet in flavor mild-natured, has appetizing in adjusting, beneficial lung
The functions such as calming heart, clearing away damp-heat, sharp liver and gallbladder；Good seed is rich in antioxidant, healthy fat, fiber, magnesium, zinc, iron, calcium, only 1 big belly
The good seed of department's (29.3495 grams) can provide 10 grams of fibers, this amount has reached daily for the women more than 50 years old
The half of recommended dose；Pumpkin, in content of magnesium it is high, two ladle pumpkins contain 74 milligrams of magnesium, are equivalent to daily
The a quarter of recommended intake, some researches show that be required to comprising 300 multinomial physiology courses including decomposition food energy
Magnesium, lacking magnesium will lead to insulin resistance, and every increases of magnesium intake 100mg/ days, diabetes B risk declines about 15%；Alkali
Fluffy middle polyphenols has anti-mutation, anti-oxidant, blood pressure lowering, reduces containing for cholesterol and triglycerides in blood plasma and liver
Amount has the effects that prevention of arterial hardening, reduces blood pressure and take with blood lipid, prevention and treatment thrombus, suitable diabetic and to glycosuria
Sick complication such as hypertension, hyperlipidemia, artery sclerosis are protected, at the same alkali it is fluffy in also rich in calcium, magnesium, iron, manganese, zinc, copper,
The mineral elements such as strontium, sodium, and contain abundant amino acid classes, up to 18 kinds, including necessary amino acid: threonine, figured silk fabrics
Propylhomoserin, isoleucine, methionine, leucine, phenylalanine, lysine, tryptophan.Nonessential amino acid: asparatate, silk
Propylhomoserin, glutamic acid, glycine, alanine, cystine, tyrosine, histidine, arginine, proline.Wherein essential amino acid contains
Amount accounts for total amino acid content difference 35.2%, the reference model (36%) proposed close to FAO, it is necessary to amino acid and nonessential amino acid
Ratio be 55%, close to FAO propose reference model (0.56), comprehensive and abundant battalion can be provided for liver and gallbladder patient
It supports.
2, the fluffy middle polyphenol recovery rate of alkali of the present invention improves 30%-70% compared to traditional extraction process recovery rate, passes through
Ultrasonic wave is combined with dynamic countercurrent circulation, so that the fluffy middle polyphenol recovery rate of alkali greatly improves, is played a multiplier effect；It is logical
Cross ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination greatly remain alkali it is fluffy in it is water-soluble it is functional at
Point, the fluffy middle polyphenols recovery rate of alkali, aqueous enzymatic method combination ultrasonic wave physical process, using the very big acceleration of its generation, by force
The properties such as strong cavitation effect, high vibration are reduced and are asked when extracting, and temperature is avoided to change the activity change to effective component；This
The ultrasonic wave dynamic countercurrent auxiliary enzymes and ultrafiltration technology of invention combine the method production work for extracting the fluffy middle polyphenols of alkali
Skill is simple, the consuming time is few, reduces production work intensity, has product effective component high, and it is unfavorable to reduce temperature change bring
The advantages that influence.
3, the present invention using coarse filtration and ultrafiltration effectively eliminate the impurity such as body refuse, suspended matter, algae in extracting solution and
The microorganisms such as bacterium, mould in extracting solution, high degree remain the fluffy extracting solution of alkali, hawthorn, balsam pear, corn stigma, good seed
Extracting solution, the various nutritional ingredients of pumpkin extracting solution and microelement, it is easy to operate, it is suitable for industrialized production, compared to biography
The filter method of system, hyperfiltration technique are a kind of purifications for being widely used in water, and pollution-free, low energy consumption, and separator is simple, process
Short, easy to operate, easily controllable and maintenance, installation area are small.Carry out at normal temperature, mild condition without component damage, because
And the separation and enrichment of the particularly suitable substance to this product (thermo-responsive), have very much to the recycling of the micro constitutent in this product
Effect.Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution in ultrafiltration technology pretreatment system, after through adsorbing
Filter filtering can remove the impurity such as oil removal and algae, and then pass through the hollow-fibre membrane of ultrafiltration technology essence filtration system
Ultrafiltration is to remove the microorganisms such as bacterium in extracting solution, mould.
4, the fluffy polyphenols recovery rate of alkali may be up to 5.9% in the present invention, and polyphenols is referred to as " the 7th class nutrition
Element ", polyphenols have anti-mutation, anti-oxidant, blood pressure lowering, reduce containing for cholesterol and triglycerides in blood plasma and liver
Amount has the effects that prevention of arterial hardening, reduces blood pressure and take with blood lipid, prevention and treatment thrombus, suitable diabetic and to glycosuria
Sick complication such as hypertension, hyperlipidemia, artery sclerosis have significant health-care effect, help health.
5, the present invention by sonde-type digital display refractometer can solution index of refraction, can quantitatively analyze the fluffy liquid of measurement alkali and
Whether the ingredient in mixed liquid B, the purity of test solution, the fluffy liquid of auxiliary allotment alkali and mixed liquid B reach required CONCENTRATION STATE,
So that the present invention prepares the unification of patients with diabetes mellitus health drink standard, it is conducive to industrialization control standard and production.
6, the fluffy raw material of alkali chooses alkali fluffy plant of the growth cycle within 45 days in the present invention, and the fluffy cauline leaf of alkali at this time is fresh
It is tender, rich in nutritional ingredients such as functional pigmented, vitamin, protein and alkaloids, in addition, the fluffy raw material of alkali selected by the present invention
For artificial cultivation, wild suaeda glauce raw material heavy metals exceeding standard problem that may be present, artificial cultivation, good growing environment are avoided
It ensure that the safety of raw material.
7, sucrose, pure plant extracting solution, using xylose are free of in the health drink of patients with diabetes mellitus of the present invention
Alcohol, it is green safe.
8, physical and chemical index detection, every main indicator are carried out to the health drink of patients with diabetes mellitus provided by the invention
It is all satisfied requirements of the national standard.
[Detailed description of the invention]
Fig. 1 is influence of the liquid-solid ratio to the fluffy pigment extraction effect of alkali；
Fig. 2 is the response surface that solid-liquid ratio, cellulase, vitamin C and ultrasonic power influence polyphenol content；
Fig. 3 is the overall structure diagram of sonde-type digital display refractometer；
Fig. 4 is that sonde-type digital display refractometer optical signal issues side schematic diagram of internal structure；
Fig. 5 is sonde-type digital display refractometer optical signal receiving side schematic diagram of internal structure；
Fig. 6 is sonde-type digital display refractometer probe schematic diagram of internal structure；
Fig. 7 is the schematic diagram of the section structure when sonde-type digital display refractometer probe is connect with optical fiber interface；
Fig. 8 is sonde-type digital display refractometer electrical block diagram.
In figure: 1. hosts；2. display screen；3. on & off switch；4. tuning up key；5. locking key；6. optical fiber interface；7. probe；
8. optical fiber；9. fibre-optical splice；10. signal processing circuit board；11. laser light source control circuit board；12. laser light source A；13. swashing
Radiant B；14. laser light source C；15. reflecting mirror A；16. battery；17. light intensity sensor；18. reflecting mirror B；19. prism A；20.
Trimming groove；21. probing shell；22. prism B；23. reflecting mirror C；24. naked fibre hole A；25. naked fibre hole B；26. optical fiber A；27.
Optical fiber B；28. tapered lens.
[specific embodiment]
The present invention can be explained in more detail by the following examples, the open purpose of the present invention is intended to protect the present invention
All changes and improvements in range, the invention is not limited to the following examples；
A kind of patients with diabetes mellitus health drink and preparation method thereof, includes the following steps:
Step 1, fresh Leaves of Suaeda Salsa is acquired, food purifying machine is put into and cleans 1 time~3 times, killed using vegetable drying
The drying of bacterium machine, temperature are 30 DEG C~50 DEG C, and fruits and vegetables pulverizer crushes, and it is spare to cross 20~40 meshes；
Step 2, smashed material is put into ultrasonic wave dynamic countercurrent circulation extracting concentrating equipment, by feed liquid mass ratio 1:
50 add deionized water, add 3% (w/w) cellulase, and 0.05% vitamin C, enzymolysis time 20min~30min, enzymatic hydrolysis is added
30 DEG C~50 DEG C of temperature, ultrasonic power 125w, extraction time is 1~2 time, and merging leaching liquor, to obtain the fluffy liquid of alkali spare, passes through spy
It is 1.5456 that hair style digital display refractometer, which measures the fluffy liquid refractive index of alkali,；
Step 3, take hawthorn, balsam pear, corn stigma clean plus appropriate amount of water decoction to obtain extracting solution A spare, take good seed to crush, add
Water impregnates 30 minutes, and heating is boiled 20-40 minutes, and seed extracting solution must be praised by pouring out supernatant；It takes pumpkin to crush, soaks in water
20 minutes, heating was boiled 30 minutes, is poured out supernatant and is obtained pumpkin extracting solution；
Step 4, by the fluffy liquid of alkali made from step 2 and step 3, extracting solution A praises seed extracting solution, and pumpkin extracting solution is pressed
It is mixed to prepare mixed liquid B according to the ratio of 1:2.5:0.2:0.6, mixed liquid B refractive index is measured to obtain by sonde-type digital display refractometer
It is 1.6012；
Step 5, xylitol is added in mixed liquid B；
Step 6, mixed liquid B carries out coarse filtration, ultrafiltration by reverse osmosis unit, and sterile filling to obtain the final product.
Described patients with diabetes mellitus health drink and preparation method thereof, its mineral composition of the fluffy liquid of the alkali and contains
It measures as follows: Ca2+2985 μ g/L~5200 μ g/L, the μ g/L of Mg2+1743 μ g/L~2791, μ g/L of Fe2+162 μ g/L~185, Mn2
+ 5.11 μ g/L of μ g/L~8.03, the μ g/L of Zn+5.27 μ g/L~8.51, the μ g/L of K+0.8 μ g/L~3.0, Na+1746 μ g/L~
6899 μ g/L, 200 μ of μ g/L~400 g/L of total dissolved solid.
Described patients with diabetes mellitus health drink and preparation method thereof, reverse osmosis unit system described in step 6 are matched
It is set to: pretreatment system, smart filtration system, corollary system.Pretreatment system by mechanical filter, adsorption filter, ensured public security
Filter composition；Smart filtration system is made of hollow-fibre ultrafiltration device；Corollary system is made of water purification pot, electrical control system.
Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution, after through adsorption filter filtering can remove suspension
Object, however the impurity such as algae can be removed through mechanical filter filtering.
Described patients with diabetes mellitus health drink and preparation method thereof, ultrafiltration described in step 6 are super for hollow-fibre membrane
Filter is to remove the microorganisms such as bacterium in extracting solution, mould.
Described patients with diabetes mellitus health drink and preparation method thereof, the hollow-fibre membrane diameter be 0.01 μm~
0.001 μm, feed rate be 900L/h~1500L/h, pressure 0.045Mpa~0.18Mpa, feed concentration be 200 μ g/L~
400 μ g/L, ultrafiltration time 100min~400min, backwash cycle 10min~40min, backwash time 20min~120min, on
Run 10min~40min, upper backwash 20s~120s, lower operation 10min~40min, lower backwash 20s~120s.
Wherein, water used in step 1-step 4 is deionized water, and the minerals in water have been filtered out in deionized water,
Avoid the interference of calcium in water, magnesium plasma.
Addition vitamin C can play the color protection fluffy to alkali, anti-oxidation efficacy in step 2, while also can be realized battalion
Support the purpose strengthened.
Wherein, sonde-type digital display refractometer used in the refractive index of the fluffy liquid of measurement alkali and mixed liquid B are as follows:
A kind of sonde-type digital display refractometer in conjunction with described in Figure of description 3-8, including host 1 and probe 7, in host 1
Part is upper layer and lower layer, and 1 inside upper layer of host is that optical signal issues side, and 1 inside lower layer of host is optical signal receiving side, described
It includes signal processing circuit board 10 and laser light source control circuit board 11,10 He of signal processing circuit board that optical signal, which issues side,
It is electrically connected between laser light source control circuit board 11, is equipped with tapered lens 28 in 1 inside upper layer optical fiber interface of host, 6 exit,
Reflecting mirror A15, the reflecting mirror A15 and level side are equipped at the 1 inside upper layer upper right corner of end hosts of tapered lens 28
Be 45 ° to angle, at the 1 inside upper layer lower right corner of the opposite side reflecting mirror A15 host be equipped with laser light source A12, laser light source B13,
Laser light source C14, angle is 4 ° between the laser light source A12 and laser light source B13, the laser light source B13 and swash
Angle is 4 ° between radiant C14, the laser light source A12, laser light source B13, in laser light source C14 laser diode rule
Lattice are respectively ML101J25 Mitsubishi 650nm 100mw, the Europe Si Lang 450nm 80mw and PL520A, the Europe PL450B Si Lang 520nm
120mw；The optical signal receiving side includes battery 16 and prism A19, and the battery 16 is detachable rechargeable battery, for letter
Number processing circuit plate 10, laser light source control circuit board 11, light intensity sensor 17 are powered, in 1 inside lower layer optical fiber interface 6 of host
Exit is equipped with prism A19, is equipped with trimming groove 20 in the side of prism A19, right in the 1 inside lower layer of diagonal host of prism A19
Reflecting mirror B18 is equipped at inferior horn, the angle of the reflecting mirror B18 and vertical direction is 29 °, the host 1 on the opposite reflecting mirror B18
Internal lower layer's lower right-hand corner is equipped with light intensity sensor 17, and the light intensity sensor 17 is electrically connected with signal processing circuit board 10；?
The one side wall of host 1 is equipped with optical fiber interface 6, and fibre-optical splice 9 is connected with optical fiber interface 6, the fibre-optical splice 9 and probe
It is connected between 7 by optical fiber 8, includes optical fiber A26 and optical fiber B27 in optical fiber 8, be internally provided in probe 7 naked
Fine hole A24 and naked fibre hole B25 is equipped with probing shell 21 outside probe 7, is equipped with prism B22 in 7 head sides of popping one's head in, described
Prism B22 be made of the glass of ZF7 material, pop one's head in the 7 head other sides be equipped with reflecting mirror C23, on the upper surface of host 1
It is respectively equipped with display screen 2, display screen 2 is 12846 Liquid Crystal Modules, and on & off switch 3 tunes up key 4, tunes up key 4 and uses before measuring
In correction, reduce error, locking key 5, locking key 5 is read for lock-screen.
Wherein, 4 ° of angles, laser light source B13 and laser light source C14 are set between laser light source A12 and laser light source B13
Between setting 4 ° of angles be it is a branch of in order to merge into three beams of laser, according to the specific size of the present apparatus and requirement setting folder
Angle is 4 °；It is in order to enable reflected light back is to designated position, 29 ° of folders that the angle that reflecting mirror B18 and vertical direction is arranged, which is 29,
Angle is calculated according to this refractometer overall dimensions；Signal processing circuit board 10 and laser light source control circuit board 11 are used for
The calculating of reading.
When measuring the refractive index of the fluffy liquid of alkali and mixed liquid B, the probe 7 of sonde-type digital display refractometer is put into prepare liquid
After in vivo, after pressing the booting of on & off switch 3 on sonde-type digital display refractometer host, signal processing circuit board 10 and laser light source control
Circuit board 11 processed, which is powered, starts to work, and laser light source control circuit board 11 drives laser light source A12, laser light source B13, laser light
C14 work in source issues laser, directive reflecting mirror A15, laser warp by laser light source A12, laser light source B13, laser light source C14
Directive tapered lens 28 after reflecting mirror A15 reflection, laser light tapered lens 28 enter optical fiber A26, after the transmission of optical fiber 8
It is projected by the other end of optical fiber A26, laser enters naked fibre hole A24, enters back into prism B22, laser is after prism B22 injection
Directive testing liquid, laser a part can be reflected by testing liquid, and a part can inject testing liquid, be reflected by testing liquid
Laser directive reflecting mirror C23, laser enter naked fibre hole B25 after reflecting mirror C23 reflection, optical fiber B27 are entered back into, by light
Laser is projected by the other end of optical fiber B27 after 8 transmission of fibre, laser directive reflecting mirror B18, reflection after prism A19 refraction
Laser directive light intensity sensor 17 after mirror B18 reflection, light intensity sensor 17 send data to signal processing after detecting luminous intensity
Circuit board 10, signal processing circuit board 10 calculate and measure return luminous intensity, obtain the refraction of prepare liquid by calculating intensity value
Rate finally shows that measurement result, circuit structure connection figure are as shown in Figure 6 in display screen 2.
Refractive index is one of important physical constant of substance, and refractive index is closely related with solution concentration, and many pure materials are all
With certain refractive index, refractive index will change if wherein containing impurity, deviation occur, impurity is more, and deviation is got over
Greatly.Therefore, by the measurement of refractive index, the purity of substance can be measured.Sonde-type digital display refractometer is the total reflection according to light
The instrument of principle design, it can quantitatively be analyzed using the index of refraction of the measuring method measurement unknown materials for body critical angle of being all-trans
The ingredient in the fluffy liquid of alkali and mixed liquid B, the purity of test solution are measured, whether the fluffy liquid of auxiliary allotment alkali and mixed liquid B reach
To required CONCENTRATION STATE, table 1 is that the fluffy liquid of measurement alkali and mixed liquid B refractive index situation are tested by sonde-type digital display refractometer:
The refractive index of the fluffy liquid of 1 alkali of table and mixed liquid B
| Pendulous frequency | 1 | 2 | 3 | 4 | 5 | Average value |
| The fluffy liquid of alkali | 1.5415 | 1.5437 | 1.5485 | 1.5469 | 1.5472 | 1.5456 |
| Mixed liquid B | 1.6028 | 1.5987 | 1.6014 | 1.6025 | 1.6004 | 1.6012 |
It is by the refractive index average value that can be seen that the fluffy liquid of alkali to five the fluffy liquid of alkali, mixed liquid B measurement results
1.5456, the refractive index average value of mixed liquid B is 1.6012, by the fluffy liquid of measurement alkali, the refractive index of mixed liquid B, can be examined
Whether the mixed liquid B concentration matched complies with standard, to guarantee the mixed liquid B constant concentration matched, and then guarantees mixing
Liquid B is rich in the nutrition composition of different proportion.
The detection of every physical and chemical index:
Preparation method described in Example preparation patients with diabetes mellitus health drink, by GB/T12143.1,
GB8537-1995, GB4789 examination criteria compare indices, the results are shown in Table 2.
The health drink indices of 2 patients with diabetes mellitus of table
It is visible full according to the health drink items main indicator of patients with diabetes mellitus prepared by the present invention by 2 result of table
Sufficient requirements of the national standard.
Fluffy leaching liquor Mineral Elements in Jadeite Shellfish content such as the following table 3 of alkali in the present invention:
The fluffy leaching liquor Mineral Elements in Jadeite Shellfish content of 3 alkali of table
In order to determine the fluffy solid-liquid ratio with water of alkali, the present invention carries out experimental study for the fluffy solid-liquid ratio with water of alkali, obtains
Liquid-solid ratio is to the influence diagram of the fluffy pigment extraction effect of alkali, as shown in Figure 1, as shown in Figure 1, with the increase of liquid-solid ratio, pigment is molten
The absorbance of liquid gradually rises, and when liquid-solid ratio is 40:1, light absorption value is significantly increased, and show that the fluffy pigment recovery rate of alkali also significantly rises
Height, when liquid-solid ratio is greater than 40:1, curve tends towards stability, and absorbance changes less, comprehensively considers energy-saving and emission-reduction, selects liquid-solid ratio
For 40:1 (mL/g).
On the basis of above-mentioned single factor experiment, solid-liquid ratio, 4 cellulase, vitamin C and ultrasonic power factors are chosen
Box-Behnken design is carried out, the results are shown in Table 4:
4 Box-Behnken experimental design scheme of table and result
Regression fit is carried out to 4 test data of table using 8.0 design software of Design-Expert, obtains polyphenol content pair
Solid-liquid ratio, cellulase, 4 factors of vitamin C and ultrasonic power secondary multinomial regression model:
Polyphenol content=5.55+0.13A+0.19B+0.32C+0.19D-0.33A2-0.39B2-0.28C2-0.96D2
5 response surface design quadratic regression equation model the results of analysis of variance of table
Note: * significant difference p < 0.05；The extremely significant p < 0.01 of * difference.
Make response surface figure according to regression equation, investigate the shape of be fitted response surface, analysis solid-liquid ratio, cellulase,
Fig. 2 is met personally in the influence of vitamin C and ultrasonic power to polyphenol content, response.As shown in Table 5, mutation model p value < 0.0001,
Reach extremely significant level, illustrates that the models fitting degree is fine.It as shown in Figure 2, is 1:50, cellulase 3%, dimension in solid-liquid ratio
Raw element C 0.05%, ultrasonic power 125w, polyphenol content reach peak, and the result and experiment of single factor result one
It causes.
It is above-mentioned the experimental results showed that, the present invention passes through ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination pole
It is big remain alkali it is fluffy in water-soluble functional components, the fluffy middle polyphenols recovery rate of alkali mentions compared to traditional extraction process
Rate is taken to improve 30%-70%, the fluffy polyphenol recovery rate of alkali of the invention may be up to 5.9%, and the fluffy middle polyphenols of alkali has anti-
Mutation, anti-oxidant, blood pressure lowering reduce the content of cholesterol and triglycerides in blood plasma and liver, have prevention of arterial hardening, drop
The effects of low blood pressure and blood lipid, prevention and treatment thrombus, suitable diabetic takes and to diabetic complication such as hypertension, high blood
Rouge, artery sclerosis are protected, and have drop blood in conjunction with hawthorn, balsam pear, corn stigma, good seed extracting solution, pumpkin extracting solution etc.
Sugar reduces animal tallow in the deposition of vascular wall, mitigates the effect of artery sclerosis, suitable for patients with diabetes mellitus, to diabetes
Patient has significant health-care effect.
Patients with diabetes mellitus health drink clinical observation data produced by the present invention is as follows:
1, general information
The observation subject age that the present invention is included in is 35-70 years old, average age 49 years old.127 people of male, 116 people of women see
It examines object and makees physical examination, the diabetic without serious organ disease.
2, case standard is tested
Diabetic's clinical symptoms are mostly tired, often have hunger, perspiration, out of strength, palpitaition, tremble, hypoglycemia, thirsty
More drinks, mostly food gluttony, urinary micturition, body is thin, serious concurrent dizziness, tuberculosis, thoracic obstruction, apoplexy, night blindness etc..
3, instructions of taking
It is treated using patients with diabetes mellitus health drink of the invention, it is 3 times a day, 220 milliliters oral every time.l
Patients with type Ⅰ DM (insulin-dependent) is persistently drunk one month, and diabetes B (non-insulin-depending type) is persistently drunk 2 months.
Obtain following statistical table.It is significantly wherein that symptom all disappears or is obviously improved: is effectively that symptom is changed
It is kind；It is in vain symptom without improvement.
4, observation method
Cardinal symptom: often have hunger, perspiration, it is out of strength, polydipsia, mostly food gluttony, urinary micturition
Minor symptom: palpitaition is trembled, hypoglycemia, dizziness, tuberculosis, thoracic obstruction, apoplexy
Safety: some cases are selected to carry out blood, urine, feces routine test.
5, evaluation criterion
Recovery from illness: cardinal symptom and minor symptom are all eliminated.
Significant: cardinal symptom and minor symptom have clear improvement.
Effective: cardinal symptom and minor symptom have improvement.
Invalid: cardinal symptom and minor symptom are without improvement.
6, treatment results
| Number of cases | Recovery from illness | Significantly | Effectively | In vain | Efficient % | |
| L patients with type Ⅰ DM | 74 | 12 | 30 | 28 | 4 | 94.6 |
| Diabetes B | 126 | 16 | 55 | 48 | 5 | 96.0 |
Part not in the detailed description of the invention is the prior art.
Claims (5)
1. a kind of patients with diabetes mellitus health drink and preparation method thereof, it is characterized in that: including the following steps:
Step 1, fresh Leaves of Suaeda Salsa is acquired, food purifying machine is put into and cleans 1 time~3 times, utilize vegetable drying sterilization machine
Drying, temperature are 30 DEG C~50 DEG C, and fruits and vegetables pulverizer crushes, and it is spare to cross 20~40 meshes；
Step 2, smashed material is put into ultrasonic wave dynamic countercurrent circulation extracting concentrating equipment, added by feed liquid mass ratio 1:50
Deionized water adds 3%(w/w) cellulase, 0.05% vitamin C, the enzymolysis time min of 20 min~30, hydrolysis temperature is added
30 DEG C~50 DEG C, 125 w of ultrasonic power, extraction time is 1~2 time, and merging leaching liquor, to obtain the fluffy liquid of alkali spare, passes through sonde-type
It is 1.5456 that digital display refractometer, which measures the fluffy liquid refractive index of alkali,；
Step 3, take hawthorn, balsam pear, corn stigma clean plus appropriate amount of water decoction to obtain extracting solution A spare, take good seed to crush, add water logging
Bubble 30 minutes, heating are boiled 20-40 minutes, and seed extracting solution must be praised by pouring out supernatant；It takes pumpkin to crush, soaks in water 20
Minute, heating is boiled 30 minutes, is poured out supernatant and is obtained pumpkin extracting solution；
Step 4, by the fluffy liquid of alkali made from step 2 and step 3, extracting solution A praises seed extracting solution, and pumpkin extracting solution is according to 1:
The ratio of 2.5:0.2:0.6 is mixed to prepare mixed liquid B, by sonde-type digital display refractometer measure mixed liquid B refractive index is
1.6012；
Step 5, xylitol is added in mixed liquid B；
Step 6, mixed liquid B carries out coarse filtration, ultrafiltration by reverse osmosis unit, and sterile filling to obtain the final product.
2. patients with diabetes mellitus health drink according to claim 1 and preparation method thereof, it is characterized in that: the alkali
Its mineral composition of fluffy liquid and content are as follows: the 2985 μ g/L of μ g/L~5200 of Ca2+, 1743 the Mg2+ μ of μ g/L~2791 g/
L, the 162 μ g/L of μ g/L~185 of Fe2+, 5.11 the Mn2+ μ g/L of μ g/L~8.03,5.27 Zn+ μ g/L of μ g/L~8.51,
The 0.8 μ g/L of μ g/L~3.0 of K+, 1746 Na+ μ g/L of μ g/L~6899,200 μ of μ g/L~400 g/ of total dissolved solid
L。
3. patients with diabetes mellitus health drink according to claim 1 and preparation method thereof, it is characterized in that: step 6 institute
The reverse osmosis unit system configuration stated are as follows: pretreatment system, smart filtration system, corollary system；Pretreatment system is by mechanical filter
Device, adsorption filter, cartridge filter composition；Smart filtration system is made of hollow-fibre ultrafiltration device；Corollary system is by water purification
Tank, electrical control system composition；Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution, after through absorbing and filter
Device filtering can remove oil removal, however can remove the impurity such as algae through mechanical filter filtering.
4. patients with diabetes mellitus health drink according to claim 3 and preparation method thereof, it is characterized in that: step 6 institute
Stating ultrafiltration is hollow-fibre membrane ultrafiltration to remove the microorganisms such as bacterium in extracting solution, mould.
5. patients with diabetes mellitus health drink according to claim 3 or 4 and preparation method thereof, it is characterized in that: described
Hollow-fibre membrane diameter be 0.01 μm~0.001 μm, feed rate be the L/h of 900 L/h~1500,0.045 Mpa of pressure~
0.18 Mpa, feed concentration are the 200 μ g/L of μ g/L~400, ultrafiltration time 100 min~400 min, 10 min of backwash cycle
~40 min, backwash time 20 min~120 min, upper operation 10 min~40 min, upper backwash 20 s~120 s, lower fortune
Row 10 min~40 min, lower backwash 20 s~120 s.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711169463.0A CN109805222A (en) | 2017-11-22 | 2017-11-22 | A kind of health drink of patients with diabetes mellitus and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711169463.0A CN109805222A (en) | 2017-11-22 | 2017-11-22 | A kind of health drink of patients with diabetes mellitus and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109805222A true CN109805222A (en) | 2019-05-28 |
Family
ID=66600866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711169463.0A Pending CN109805222A (en) | 2017-11-22 | 2017-11-22 | A kind of health drink of patients with diabetes mellitus and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109805222A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048218A (en) * | 2009-10-30 | 2011-05-11 | 常堡同 | Beverage for reducing blood sugar, blood pressure and blood fat and production method thereof |
| CN102987490A (en) * | 2012-12-18 | 2013-03-27 | 山东绿洲醇食品有限公司 | Suaeda glauca wild vegetable juice and production method and application thereof |
| KR101261029B1 (en) * | 2011-11-11 | 2013-05-06 | 목포대학교산학협력단 | Composition for preventing or improving the diabete containing suaeda japonica |
| CN103610187A (en) * | 2013-12-04 | 2014-03-05 | 大连润扬科技发展有限公司 | Beverage suitable for diabetics to drink and preparation method thereof |
-
2017
- 2017-11-22 CN CN201711169463.0A patent/CN109805222A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048218A (en) * | 2009-10-30 | 2011-05-11 | 常堡同 | Beverage for reducing blood sugar, blood pressure and blood fat and production method thereof |
| KR101261029B1 (en) * | 2011-11-11 | 2013-05-06 | 목포대학교산학협력단 | Composition for preventing or improving the diabete containing suaeda japonica |
| CN102987490A (en) * | 2012-12-18 | 2013-03-27 | 山东绿洲醇食品有限公司 | Suaeda glauca wild vegetable juice and production method and application thereof |
| CN103610187A (en) * | 2013-12-04 | 2014-03-05 | 大连润扬科技发展有限公司 | Beverage suitable for diabetics to drink and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 盛显良等: "《有机化学实验》", pages: 68 - 71 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104004813B (en) | A kind of preparation of mushroom biologically active peptide | |
| CN102302210A (en) | Beverage with anti-fatigue effect | |
| CN105063139A (en) | Preparation method of sea-buckthorn seed polypeptide used for sobering up from drunkenness | |
| CN106084087A (en) | A kind of preparation method of Fructus Trichosanthis polysaccharide | |
| CN109805403A (en) | A kind of fluffy extract of saline-alkali land and preparation method thereof | |
| CN103284148A (en) | Processing method of persimmon leaf concentrated powder rich in natural vitamin C | |
| CN103342755B (en) | Equal one-level part IV of lycium barbarum polysaccharide and its preparation method and application | |
| CN109805214A (en) | A kind of health drink of patients with diabetes mellitus and preparation method thereof | |
| CN109805222A (en) | A kind of health drink of patients with diabetes mellitus and preparation method thereof | |
| CN101336935B (en) | Sea cucumber extract and preparation method thereof | |
| CN105558896A (en) | Composition containing effective components of sea cucumber and cordyceps sinensis, preparation method and application thereof | |
| CN109628265A (en) | A kind of liver-protection health-care molecule wine and preparation method thereof containing general flavone | |
| CN109354601A (en) | The extracting method of selenoprotein in a kind of pear fruit | |
| CN108048504A (en) | A kind of extracting method of Moringa polysaccharide | |
| CN105520847B (en) | A kind of heal-care essential oil and preparation method thereof containing JINHUAKUIZI oil | |
| CN107927500A (en) | A kind of method that ultrasound wave auxiliary enzyme method prepares the fluffy beverage of alkali | |
| CN109805221A (en) | A kind of health drink and preparation method thereof with preventing hypertension function | |
| CN109805228A (en) | A kind of health drink and preparation method thereof with prevention hyperlipidemia function | |
| CN109805226A (en) | A kind of health drink and preparation method thereof with anti-aging skin-care functional | |
| CN109805223A (en) | A kind of health drink of patients with diabetes mellitus and preparation method thereof | |
| CN106360189A (en) | Lycium ruthenicum juice and preparing method thereof | |
| CN109805227A (en) | A kind of health drink and preparation method thereof with anti-cancer function | |
| CN109805216A (en) | A kind of health drink and preparation method thereof with prevention liver and bladder disease function | |
| CN111249317A (en) | Preparation method of myxomycete fermentation liquor, myxomycete fermentation liquor and application | |
| CN109805230A (en) | A kind of health drink and preparation method thereof with anti-aging skin-care functional |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |