CN109793827A - A kind of pharmaceutical composition that treating psoriasis, its preparation and preparation method - Google Patents
A kind of pharmaceutical composition that treating psoriasis, its preparation and preparation method Download PDFInfo
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- CN109793827A CN109793827A CN201910235166.4A CN201910235166A CN109793827A CN 109793827 A CN109793827 A CN 109793827A CN 201910235166 A CN201910235166 A CN 201910235166A CN 109793827 A CN109793827 A CN 109793827A
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Abstract
The invention belongs to pharmaceutical technology fields, more particularly to the pharmaceutical composition for the treatment of psoriasis of the invention, for the curing psoriasis of the phase of progress, clearing heat and cooling blood, removing toxic substances promoting blood circulation, new skin lesion can be inhibited to generate to expand with old skin lesion, mild treatment, makes the progress phase rapidly enter stationary phase, and temperature rise help over the course for the treatment of, protect liver blood-nourishing reduces damage of the medicine of bitter cold to physical function.The preparation method of the preparation of the treatment psoriasis of the invention formulates corresponding processing step according to each component nature and flavor and effect, improves water-bindered pill composition more palatable, the prominent sweet nature and flavor of each component medium temperature, and bitter taste subtracts light, and taking experience improves；Meanwhile it is fast in human body interior suction receipts decomposition rate with sweet warm nature taste component after taking the water-bindered pill, alleviate bitter cold component to the stimulation at the internal organs such as liver position, reducing in therapeutic process stimulates and damage to human body, and therapeutic effect is more mild.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of pharmaceutical composition for treating psoriasis, its preparation and system
Preparation Method.
Background technique
Psoriasis is commonly called as psoriasis, is a kind of common chronic recurrent inflammatory dermatoses, and characteristic lesions are red
Be covered with the multilayer silvery white scales of skin that peel off in papule or patch, be apt to occur in four limbs and stretch side, scalp and back, serious skin lesion can general hair whole body,
And it may occur in which that high fever, warts, erythroderma sample changes and whole body size arthropathy.This disease course of disease is long, the sustainable several years to number
It 10 years, during which can recurrent exerbation.According to the development of the state of an illness, this disease can be divided into progress phase, stationary phase and catagen.
(1) carry out the phase: for the acute attack stage, new skin lesion is continuously emerged, and old skin lesion continuous enlargement, inflammation is obvious, can have
Isomorphic effect, i.e. Koebner phenomenon, refer to normal appearance skin wound, scratch, inject or the stimulations such as needle thorn after occur with it is former
The identical skin lesion of disease property of hair property generally occurs skin lesion for 3~18 days in injury, therefore strip squama occur in scratch or operative incision
The damage of bits property should be taken into account the possibility of psoriasis.
And in general, psoriasis carries out the best period that the phase is treatment.And the body sensibility of patient increases at this time, such as
Chance wound, needle thorn, external application is compared with strong stimulation drug or being scalded with hot water can be such that skin lesion aggravates, therefore carries out controlling for phase in psoriasis
Treatment wants mild and effective.
Summary of the invention
Based on problem above, one purpose of the invention be to provide a kind of pharmaceutical composition can effectively eliminate psoriasis into
The new skin lesion that the departure date occurs inhibits old skin lesion to expand, effectively eliminates inflammation.
Another object of the present invention is to provide the preparation method of the preparation described in one kind comprising described pharmaceutical composition.
The technical solution of the present invention is as follows:
The present invention provides a kind of pharmaceutical composition for treating psoriasis, including following parts by weight of component: 100-120 portions of buffalos
Angle, 120-150 portions of dandelions, 80-100 parts of oldenlandia diffusas, 60-75 portions of Asian puccoons, 50-60 parts of radix paeoniae rubras, 60-75 parts of dittany barks,
105-120 parts of radix rehmanniae recens, 80-100 parts of Radix Salviae Miltiorrhizaes, 50-60 portions of radix scrophulariaes, 60-75 parts of polygonum cuspidates, 50-60 parts of cortex moutans, 60-75 parts of Huangs
Stilbene and 20-34 portions of Radix Glycyrrhizaes.
The above pharmaceutical composition, for treating progress phase psoriasis, clearing heat and cooling blood, removing toxic substances promoting blood circulation, ecchymose removing stagnation resolvation, Wen Tongjing
Network, benefiting qi and raising yang, temperature compensation protect liver, the formation and old skin lesion that can reduce new skin lesion expand, while the matrix of guarantor was being treated
It is not damaged by the medicine of cool blood in journey, help rising Yang.
Preferably, the pharmaceutical composition for the treatment of psoriasis of the invention, including following parts by weight of component: 112 parts of cornu bubalis,
135 portions of dandelions, 90 parts of oldenlandia diffusas, 68 portions of Asian puccoons, 54 parts of radix paeoniae rubras, 68 parts of dittany barks, 112 parts of radix rehmanniae recens, 90 parts of Radix Salviae Miltiorrhizaes,
54 portions of radix scrophulariaes, 68 parts of polygonum cuspidates, 54 parts of cortex moutans, 68 parts of Radix Astragalis and 27 portions of Radix Glycyrrhizaes.
The pharmaceutical composition for the treatment of psoriasis according to the present invention, is examined based on each component compatibility relationship and final drug effect
Consider, constituent part dosage is further limited, cornu bubali is identical as radix rehmanniae recen dosage, radix paeoniae rubra, radix scrophulariae and Radix Glycyrrhizae and dosage
Identical, Asian puccoon, Radix Salviae Miltiorrhizae, paste are identical with Radix Astragali dosage.
A kind of preparation for treating psoriasis provided by the invention, is with the water-bindered pill made of the pharmaceutical composition.
A kind of preparation method of preparation for treating psoriasis provided by the invention,
The each component of described pharmaceutical composition is ground into fine powder, adds water and edible adhesive to be uniformly mixed, the water-bindered pill is made.
The preparation method of the preparation for the treatment of psoriasis according to the present invention, the granularity of the fine powder are controlled at≤75 μm,
Can guarantee to add when making the water-bindered pill less water and edible additive make the raw material for preparing the water-bindered pill i.e. and have suitable viscosity and
Processability guarantees the effective component percentage in the water-bindered pill.
The preparation method of the preparation for the treatment of psoriasis according to the present invention, the weight for the pharmaceutical composition for including in the water-bindered pill
Amount percentage is 90-97%.
In view of in the described pharmaceutical composition in the present invention each component be mostly cool blood, heat-clearing, detoxicating functions component,
The nature and flavor of more bitter colds should not be received the direct stimulation of human body itself and taste based on bitter cold nature and flavor drug is reduced by patient,
It influences to use therapeutic effect, the preparation method of the preparation of another treatment psoriasis provided by the invention can be in former medicine group
On the basis of polymer component, improve water-bindered pill composition more palatable, the prominent sweet nature and flavor of each component medium temperature, bitter taste subtracts light, takes experience and changes
It is kind；Meanwhile it is fast in human body interior suction receipts decomposition rate with sweet warm nature taste component after taking the water-bindered pill, alleviate bitter cold component to liver etc.
The stimulation at internal organs position, reducing in therapeutic process stimulates and damages to human body, reduces side effect,
Specifically includes the following steps:
(1) 8-10 times of percentage by volume is added in dandelion, radix rehmanniae recen, Radix Astragali and the Radix Glycyrrhizae in described pharmaceutical composition is
Refluxing extraction 2-3 times in the ethanol water of 70-75%, combined extract, filtering obtain filtrate, after recycling the ethyl alcohol in filtrate,
The dry 30-40% for being concentrated into former filtrate volume, obtains bonding medical fluid；
(2) it is crushed after mixing other components, obtains mixed powder；
(3) mixed powder is mixed in the bonding medical fluid, stirs evenly, water-bindered pill raw material is made；
(4) water-bindered pill is made in the water-bindered pill raw material, it is dry, complete preparation.
The water-bindered pill preparation that method made above obtains, with the drug component of mild help
It is based in water-bindered pill preparation process, institute in step (2) according to the preparation method of the preparation of the above treatment psoriasis
The considerations of stating water-bindered pill raw material suitable viscosity and processability, the partial size of the mixed powder are 180-250 mesh.
According to the preparation method of the preparation of the above treatment psoriasis, in step (4), based on to water-bindered pill form and drug effect guarantor
The influence held, drying temperature are set as 40-45 DEG C.
To make to more fully understand the present invention, each component of the present invention is briefly described:
Cornu bubali: it is bitter in taste salty, it trembles with fear, effect heat-clearing, cool blood, removing toxic substances.
Dandelion: nature and flavor bitter sweet is trembled with fear, major function: clearing heat and detoxicating, diuresis dissipating bind.
Oldenlandia diffusa: it is bitter in taste, light, it trembles with fear, it is clearing heat and detoxicating；Enhance immune function of human body.
Asian puccoon: it is bitter in taste, it trembles with fear, major function: cool blood, promoting blood circulation, heat-clearing, removing toxic substances.
Radix paeoniae rubra: it is bitter in taste, it is slightly cold, major function: clearing heat and cooling blood, removing blood stasis and acesodyne.
Dittany bark: it is bitter in taste, it is salty, it trembles with fear, major function: heat-clearing and damp-drying drug, dispelling wind and arresting itching, removing toxic substances.
Radix rehmanniae recen: nature and flavor are sweet, slight bitter, tepor, major function: clearing heat and cooling blood is clear, heat is promoted the production of body fluid enriching yin, blood-nourishing, and protect liver is dirty.
Radix Salviae Miltiorrhizae: bitter in taste, tepor, major function: promoting blood circulation, calming heart and tranquilizing mind, apocenosis, analgesic.
Radix scrophulariae: nature and flavor are sweet, bitter, salty, slightly cold, effect: clearing heat and cooling blood, purging fire for removing toxin, enriching yin.
Polygonum cuspidate: it is bitter in taste, it puts down, promoting blood circulation to remove blood stasis, wind-dispelling, removing toxicity for detumescence, protect liver antibacterial.
Cortex moutan: nature and flavor are pungent, bitter, cool, function heat-clearing, and cool blood and blood, dispersing blood stasis is anti-inflammatory antibacterial, improves immunity.
Radix Astragali: nature and flavor are sweet, tepor, invigorating qi for consolidating superficies, torr sore myogenic, detumescence.
Radix Glycyrrhizae: nature and flavor are flat, sweet, detoxify, analgesic.
The above component, the common compatibility of cornu bubali, dandelion, oldenlandia diffusa, Asian puccoon, effect, plays clearing heat and cooling blood, purging intense heat
The effect of removing toxic substances, dittany bark antipyretic and itching-stopping；Radix Glycyrrhizae pungent-warm rising Yang；Simultaneously with cortex moutan, radix paeoniae rubra, Radix Salviae Miltiorrhizae, polygonum cuspidate clearing and activating the channels and collaterals, disappear
Stasis of blood myogenic；Radix rehmanniae recen, Radix Astragali enriching yin boost qi blood-nourishing.Phase new skin lesion hair is carried out psoriasis is effectively relieved with clearing heat and cooling blood component
Exhibition, while promoting skin lesion to repair, warm blood, liver protection reaches while treating psoriasis illness, tonifying Qi and blood,
Temperature compensation treatment, induced damage resistive body foundation, does not make psoriasis comparatively fast enter stationary phase, the fast quick-recovery of patient body function.
The invention has the benefit that
The pharmaceutical composition for the treatment of psoriasis of the invention, for the curing psoriasis of the phase of progress, clearing heat and cooling blood, removing toxic substances is lived
Blood can inhibit new skin lesion to generate and expand with old skin lesion, mild to treat, and so that the progress phase is rapidly entered stationary phase, and treating
Temperature rise help in journey, protect liver blood-nourishing reduce damage of the medicine of bitter cold to physical function.
The preparation method of the preparation of the treatment psoriasis of the invention is formulated corresponding according to each component nature and flavor and effect
Processing step, improve water-bindered pill composition more palatable, the prominent sweet nature and flavor of each component medium temperature, bitter taste subtracts light, and taking experience improves；Meanwhile
It is fast in human body interior suction receipts decomposition rate with sweet warm nature taste component after taking the water-bindered pill, alleviate bitter cold component to the internal organs such as liver position
Stimulation, reducing in therapeutic process stimulates and damages to human body, and therapeutic effect is more mild.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Following embodiment is with 1 part for 1g.
Embodiment 1
The present invention provides a kind of pharmaceutical composition for treating psoriasis, including following parts by weight of component: 100 parts of cornu bubalis,
150 portions of dandelions, 80 parts of oldenlandia diffusas, 75 portions of Asian puccoons, 50 parts of radix paeoniae rubras, 75 parts of dittany barks, 105 parts of radix rehmanniae recens, 100 parts of pellets
Ginseng, 50 portions of radix scrophulariaes, 75 parts of polygonum cuspidates, 50 parts of cortex moutans, 75 parts of Radix Astragalis and 20 portions of Radix Glycyrrhizaes.
The present invention provides a kind of preparation for treating psoriasis, and the preparation is with water made of above-mentioned pharmaceutical composition
Ball.
The preparation method of the preparation is,
The each component of described pharmaceutical composition is ground into the fine powder of granularity≤75 μm, adds water and edible adhesive to mix equal
It is even, the water-bindered pill is made, the weight percent for the pharmaceutical composition for including in the water-bindered pill is 90-97%.
Embodiment 2
The present invention provides a kind of pharmaceutical composition for treating psoriasis, including following parts by weight of component: 120 parts of cornu bubalis,
120 portions of dandelions, 100 parts of oldenlandia diffusas, 60 portions of Asian puccoons, 60 parts of radix paeoniae rubras, 60 parts of dittany barks, 120 parts of radix rehmanniae recens, 80 parts of pellets
Ginseng, 60 portions of radix scrophulariaes, 60 parts of polygonum cuspidates, 60 parts of cortex moutans, 60 parts of Radix Astragalis and 34 portions of Radix Glycyrrhizaes.
The present invention provides a kind of preparation for treating psoriasis, and the preparation is with water made of above-mentioned pharmaceutical composition
Ball, the weight percent for the pharmaceutical composition for including in the water-bindered pill are 97%.
The preparation method of the preparation, comprising the following steps:
(1) 8-10 times of percentage by volume is added in dandelion, radix rehmanniae recen, Radix Astragali and the Radix Glycyrrhizae in described pharmaceutical composition is
Refluxing extraction 2 times in 75% ethanol water, combined extract, filtering obtain filtrate, dry after recycling the ethyl alcohol in filtrate
It is concentrated into the 40% of former filtrate volume, obtains bonding medical fluid；
(2) it is crushed after mixing other components, obtains the mixed powder that partial size is 180 mesh；
(3) mixed powder is mixed in the bonding medical fluid, stirs evenly, water-bindered pill raw material is made；
(4) water-bindered pill is made in the water-bindered pill raw material, 45 DEG C of dryings are to moisture content 5% hereinafter, completing preparation.
Embodiment 3
The present invention provides a kind of pharmaceutical composition for treating psoriasis, including following parts by weight of component: 112 parts of cornu bubalis,
135 portions of dandelions, 90 parts of oldenlandia diffusas, 68 portions of Asian puccoons, 54 parts of radix paeoniae rubras, 68 parts of dittany barks, 112 parts of radix rehmanniae recens, 90 parts of Radix Salviae Miltiorrhizaes,
54 portions of radix scrophulariaes, 68 parts of polygonum cuspidates, 54 parts of cortex moutans, 68 parts of Radix Astragalis and 27 portions of Radix Glycyrrhizaes.
The present invention provides a kind of preparation for treating psoriasis, and the preparation is with water made of above-mentioned pharmaceutical composition
Ball.
The preparation method of the preparation, comprising the following steps:
(1) 8-10 times of percentage by volume is added in dandelion, radix rehmanniae recen, Radix Astragali and the Radix Glycyrrhizae in described pharmaceutical composition is
Refluxing extraction 3 times in 70% ethanol water, combined extract, filtering obtain filtrate, dry after recycling the ethyl alcohol in filtrate
It is concentrated into the 30% of former filtrate volume, obtains bonding medical fluid；
(2) it is crushed after mixing other components, obtains the mixed powder that partial size is 250 mesh；
(3) mixed powder is mixed in the bonding medical fluid, stirs evenly, water-bindered pill raw material is made；
(4) water-bindered pill is made in the water-bindered pill raw material, 40 DEG C of dryings are to moisture content 5% hereinafter, completing preparation.
Experimental example
1, experimental subjects and method
It collects and is treated in the entitled experimental group of patient 30 that psoriasis carries out the phase using preparation of the invention, clinical observation
Treatment condition.Instructions of taking is using 5g of water-bindered pill preparation about 60 of the invention, three times per day.
The patient that 30 psoriasis of control group carry out the phases uses Diying Tablet, one time 5,2 times a day.
It is as a treatment course with 3 weeks, therapeutic effect is judged after 3 courses for the treatment of of continuous use follow-up observation.
2, curative effect judging standard
Recovery from illness: skin lesion is all subsided, and skin condition restores normal or has temporary pigment deposition；
Effective: 60% or more skin lesion recession, bleeding, inflammatory symptom obviously subside；
It is effective: 50% or more skin lesion recession；
Invalid: skin lesion is not affected significantly, and the state of an illness does not develop to stationary phase.
Total effective rate=and (recovery from illness+effective+effectively)/always test number * 100%.
3, treatment results
Table 1
| Group | Recovery from illness/people | Effective/people | Effectively/people | In vain/people | Total effective rate/% |
| Treatment group | 16 | 8 | 4 | 2 | 93.3 |
| Control group | 5 | 10 | 6 | 9 | 70 |
The above result shows that water-bindered pill preparation made of the pharmaceutical composition of the application, carries out phase treatment for psoriasis, it can
To significantly improve skin lesion development, skin lesion is promoted to subside, total effective rate reaches 93.3%, much higher than using Diying Tablet treatment 70%
Total effective rate.
And the patient after recovery from illness is treated with the application, it is paid a return visit after half a year, 1 year, is showed no recurrence.
Typical case:
1, Mr. Wang, male, 19 years old, student, psoriasis vulgaris carried out the phase, and when beginning, apparent silver bits symptom occurs in loins,
New cerise skin lesion continuously emerges, and loose, the caducous silvery white scales of skin that peel off is covered in skin lesion, throughout loins, clothes in one week
With water-bindered pill preparation for treating of the invention, 10 days or so, new skin lesion no longer occurred, and red papules symptom mitigates, and inflammation mitigates；It takes
After 3 courses for the treatment of, inflammation all subsides, and skin lesion area reduces, and the silvery white scales of skin that peel off disappears, and cutaneous lesion flattens.It is paid a return visit after 1 year, nothing
Recurrence.
2, Zhao, female, 50 years old, certain chemical plant worker suffered from more than ten years of psoriasis vulgaris, and 2 months 2016, illness recurrence,
There are a large amount of red papules in foot and back part, and then papule area expands, and the silvery white scales of skin that peel off occurs in papule surface, and surprise is itched difficulty
It is resistance to.Take water-bindered pill preparation for treating of the invention, after 1 course for the treatment of, verifying mitigates, and red papules gradually subside, and pruritis is obvious
Alleviate；After 4 courses for the treatment of, silvery white scales of skin that peel off matting, inflammation all disappears, pigment deposition, continues to strengthen 1 course for the treatment of of treatment.Respectively
It was paid a return visit in 2017 and 2018, no recurrence.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of pharmaceutical composition for treating psoriasis, which is characterized in that including following parts by weight of component: 100-120 portions of buffalos
Angle, 120-150 portions of dandelions, 80-100 parts of oldenlandia diffusas, 60-75 portions of Asian puccoons, 50-60 parts of radix paeoniae rubras, 60-75 parts of dittany barks,
105-120 parts of radix rehmanniae recens, 80-100 parts of Radix Salviae Miltiorrhizaes, 50-60 portions of radix scrophulariaes, 60-75 parts of polygonum cuspidates, 50-60 parts of cortex moutans, 60-75 parts of Huangs
Stilbene and 20-34 portions of Radix Glycyrrhizaes.
2. the pharmaceutical composition for the treatment of psoriasis according to claim 1, which is characterized in that including following parts by weight group
Point: 112 parts of cornu bubalis, 135 portions of dandelions, 90 parts of oldenlandia diffusas, 68 portions of Asian puccoons, 54 parts of radix paeoniae rubras, 68 parts of dittany barks, 112 parts
Radix rehmanniae recen, 90 parts of Radix Salviae Miltiorrhizaes, 54 portions of radix scrophulariaes, 68 parts of polygonum cuspidates, 54 parts of cortex moutans, 68 parts of Radix Astragalis and 27 portions of Radix Glycyrrhizaes.
3. the pharmaceutical composition for the treatment of psoriasis according to claim 1, which is characterized in that cornu bubali and radix rehmanniae recen dosage
Identical, radix paeoniae rubra, radix scrophulariae and Radix Glycyrrhizae are identical as dosage, and Asian puccoon, Radix Salviae Miltiorrhizae, paste are identical with Radix Astragali dosage.
4. a kind of preparation for treating psoriasis, which is characterized in that the preparation is with any medicine group of claim 1-3
Close the water-bindered pill made of object.
5. the preparation method of preparation as claimed in claim 4, which is characterized in that
The each component of described pharmaceutical composition is ground into fine powder, adds water and edible adhesive to be uniformly mixed, the water-bindered pill is made.
6. preparation method according to claim 5, which is characterized in that granularity≤75 μm of the fine powder.
7. preparation method according to claim 5, which is characterized in that the weight for the pharmaceutical composition for including in the water-bindered pill
Percentage is 90-97%.
8. the preparation method of preparation as claimed in claim 4, which comprises the following steps:
(1) 8-10 times of percentage by volume is added in dandelion, radix rehmanniae recen, Radix Astragali and the Radix Glycyrrhizae in described pharmaceutical composition is 70-
Refluxing extraction 2-3 times in 75% ethanol water, combined extract, filtering obtain filtrate, after recycling the ethyl alcohol in filtrate, do
The dry 30-40% for being concentrated into former filtrate volume, obtains bonding medical fluid；
(2) it is crushed after mixing other components, obtains mixed powder；
(3) mixed powder is mixed in the bonding medical fluid, stirs evenly, water-bindered pill raw material is made；
(4) water-bindered pill is made in the water-bindered pill raw material, it is dry, complete preparation.
9. preparation method according to claim 8, which is characterized in that in step (2), the partial size of the mixed powder is
180-250 mesh.
10. preparation method according to claim 8, which is characterized in that in step (4), drying temperature is 40-45 DEG C.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815298A (en) * | 2018-09-27 | 2018-11-16 | 四川省益康源医疗器械有限公司 | A kind of blood-head poison stops up psoriasis pustulosa treatment formula and preparation method |
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2019
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815298A (en) * | 2018-09-27 | 2018-11-16 | 四川省益康源医疗器械有限公司 | A kind of blood-head poison stops up psoriasis pustulosa treatment formula and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 刘朝霞: "《当代中医皮肤科临床家丛书.第3辑》", 31 January 2017, 中国医药科技出版社 * |
| 梁尚财: "寻常型银屑病临床分型论治体会", 《吉林中医药》 * |
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Application publication date: 20190524 |