CN109789152A - 双组分组合物 - Google Patents

双组分组合物 Download PDF

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Publication number
CN109789152A
CN109789152A CN201780039928.2A CN201780039928A CN109789152A CN 109789152 A CN109789152 A CN 109789152A CN 201780039928 A CN201780039928 A CN 201780039928A CN 109789152 A CN109789152 A CN 109789152A
Authority
CN
China
Prior art keywords
component
aqueous solution
acid
salt
asa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780039928.2A
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English (en)
Chinese (zh)
Inventor
约翰·比约恩·弗雷德里克松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asamedic AS
Original Assignee
Asamedic AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asamedic AS filed Critical Asamedic AS
Priority to CN202410125479.5A priority Critical patent/CN117982446A/zh
Publication of CN109789152A publication Critical patent/CN109789152A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
CN201780039928.2A 2016-06-28 2017-06-28 双组分组合物 Pending CN109789152A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202410125479.5A CN117982446A (zh) 2016-06-28 2017-06-28 双组分组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20161073 2016-06-28
NO20161073 2016-06-28
PCT/EP2017/065970 WO2018002124A1 (en) 2016-06-28 2017-06-28 Two-component composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202410125479.5A Division CN117982446A (zh) 2016-06-28 2017-06-28 双组分组合物

Publications (1)

Publication Number Publication Date
CN109789152A true CN109789152A (zh) 2019-05-21

Family

ID=59285173

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780039928.2A Pending CN109789152A (zh) 2016-06-28 2017-06-28 双组分组合物
CN202410125479.5A Pending CN117982446A (zh) 2016-06-28 2017-06-28 双组分组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202410125479.5A Pending CN117982446A (zh) 2016-06-28 2017-06-28 双组分组合物

Country Status (25)

Country Link
US (3) US11918554B2 (enExample)
EP (2) EP3871677A1 (enExample)
JP (2) JP2019520377A (enExample)
KR (1) KR102397334B1 (enExample)
CN (2) CN109789152A (enExample)
AU (1) AU2017288465B2 (enExample)
BR (1) BR112018076553A2 (enExample)
CA (1) CA3027462A1 (enExample)
CY (1) CY1124724T1 (enExample)
DK (1) DK3474858T3 (enExample)
EA (1) EA201990093A1 (enExample)
ES (1) ES2897981T3 (enExample)
HR (1) HRP20211761T1 (enExample)
HU (1) HUE056659T2 (enExample)
IL (1) IL263982B (enExample)
LT (1) LT3474858T (enExample)
MX (1) MX388400B (enExample)
MY (1) MY195384A (enExample)
NZ (1) NZ749230A (enExample)
PL (1) PL3474858T3 (enExample)
PT (1) PT3474858T (enExample)
RS (1) RS62574B1 (enExample)
SI (1) SI3474858T1 (enExample)
SM (1) SMT202100645T1 (enExample)
WO (1) WO2018002124A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3474858T (lt) 2016-06-28 2021-12-27 Asamedic As Dviejų komponentų kompozicija, apimanti acetilsalicilo rūgštį
EP3501522A1 (en) 2017-12-22 2019-06-26 Asamedic AS Compositions comprising acetylsalicylic acid and a phosphate salt
EP3501523A1 (en) 2017-12-22 2019-06-26 Asamedic AS Two-component compositions comprising acetyl salicylic acid and a carbonate salt
WO2020150460A1 (en) * 2019-01-18 2020-07-23 Milne Iii Donald A Micronized aspirin formulation

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GB912894A (en) * 1959-11-02 1962-12-12 Guy Leopold Van Moorleghem Method for the preparing a solution of aspirin for injection and product obtained thereby
WO2002009666A1 (en) * 2000-07-27 2002-02-07 The Boots Company Plc Pharmaceutical extemporary compositions
CN1418635A (zh) * 2002-12-19 2003-05-21 王登之 治疗感冒发热的阿司匹林口腔崩解片及其制备方法
CN101632647A (zh) * 2008-07-21 2010-01-27 北京迈劲医药科技有限公司 阿司匹林与碱性药物组成的复方制剂的制备方法

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FR304M (fr) * 1960-08-19 1961-03-20 Guy Soluté injectable d'aspirine et son procédé de fabrication.
FR2320759A1 (fr) 1975-08-11 1977-03-11 Union Pharma Scient Appl Solution d'acide acetylsalicylique extemporanee injectable
AU632602B2 (en) 1989-08-02 1993-01-07 John David Arnold Method and preparation for reducing risk of myocardial infarction
US5157030A (en) 1989-08-25 1992-10-20 Alexander Galat Rapidly soluble aspirin compositions and method
FR2712809B1 (fr) 1993-11-26 1996-04-12 Union Pharma Scient Appl Nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide.
JPH07157432A (ja) * 1993-12-07 1995-06-20 Daikyo Yakuhin Kogyo Kk 貼付剤
GB9701160D0 (en) * 1997-01-21 1997-03-12 Parkinson Sidney Medicament dispenser
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US5776431A (en) 1997-03-26 1998-07-07 Galat; Alexander Water-soluble aspirin composition
JP4126405B2 (ja) * 1998-02-02 2008-07-30 甲陽ケミカル株式会社 芳香族カルボン酸類の溶解度向上化水溶液
NO309761B1 (no) * 1999-05-03 2001-03-26 Anders Aelveborn Beholder eller kapsel for adskilt oppbevaring av to- komponents blandbare materialer
US7029701B2 (en) 2000-09-11 2006-04-18 Andrx Pharmaceuticals, Llc Composition for the treatment and prevention of ischemic events
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ITMI20022619A1 (it) 2002-12-11 2004-06-12 Ind Italiana Integratori Trei S P A Preparazioni farmaceutiche ad uso veterinario contenenti acido acetilsalicilico in forma di polvere solubile tamponata.
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HUE039878T2 (hu) * 2012-09-25 2019-02-28 Bayer Pharma AG Regorafenib és acetilszalicilsav kombinációja kolorektális rák kezelésére
PT3060203T (pt) 2013-10-23 2017-10-27 Bayer Healthcare Llc Comprimido efervescente que contém um teor elevado de aspirina
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WO2017001468A1 (en) * 2015-07-02 2017-01-05 Asamedic As Two-component composition
LT3474858T (lt) 2016-06-28 2021-12-27 Asamedic As Dviejų komponentų kompozicija, apimanti acetilsalicilo rūgštį
EP3501523A1 (en) 2017-12-22 2019-06-26 Asamedic AS Two-component compositions comprising acetyl salicylic acid and a carbonate salt
EP3501522A1 (en) 2017-12-22 2019-06-26 Asamedic AS Compositions comprising acetylsalicylic acid and a phosphate salt

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB912894A (en) * 1959-11-02 1962-12-12 Guy Leopold Van Moorleghem Method for the preparing a solution of aspirin for injection and product obtained thereby
WO2002009666A1 (en) * 2000-07-27 2002-02-07 The Boots Company Plc Pharmaceutical extemporary compositions
CN1418635A (zh) * 2002-12-19 2003-05-21 王登之 治疗感冒发热的阿司匹林口腔崩解片及其制备方法
CN101632647A (zh) * 2008-07-21 2010-01-27 北京迈劲医药科技有限公司 阿司匹林与碱性药物组成的复方制剂的制备方法

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鲜于云艳等: "《临床常见疾病健康教育处方》", 30 April 2015, 湖北科学技术出版社 *

Also Published As

Publication number Publication date
MY195384A (en) 2023-01-18
DK3474858T3 (da) 2021-11-22
HUE056659T2 (hu) 2022-03-28
ES2897981T3 (es) 2022-03-03
BR112018076553A2 (pt) 2019-04-02
US11369581B2 (en) 2022-06-28
IL263982A (en) 2019-01-31
PL3474858T3 (pl) 2022-01-17
WO2018002124A1 (en) 2018-01-04
CA3027462A1 (en) 2018-01-04
MX388400B (es) 2025-03-20
CY1124724T1 (el) 2022-07-22
IL263982B (en) 2022-03-01
PT3474858T (pt) 2021-11-22
EA201990093A1 (ru) 2019-07-31
KR102397334B1 (ko) 2022-05-11
CN117982446A (zh) 2024-05-07
JP2019520377A (ja) 2019-07-18
JP2023027071A (ja) 2023-03-01
KR20190040184A (ko) 2019-04-17
MX2018015965A (es) 2019-05-22
HRP20211761T1 (hr) 2022-02-18
AU2017288465A1 (en) 2019-01-17
US11918554B2 (en) 2024-03-05
NZ749230A (en) 2023-05-26
US20220218724A1 (en) 2022-07-14
SI3474858T1 (sl) 2022-01-31
US20210212976A1 (en) 2021-07-15
EP3871677A1 (en) 2021-09-01
JP7520941B2 (ja) 2024-07-23
SMT202100645T1 (it) 2022-01-10
US20240216318A1 (en) 2024-07-04
AU2017288465B2 (en) 2019-10-10
EP3474858B1 (en) 2021-08-18
EP3474858A1 (en) 2019-05-01
LT3474858T (lt) 2021-12-27
RS62574B1 (sr) 2021-12-31

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Application publication date: 20190521