CN109770078A - A kind of feed addictive preventing nursing period calf diarrhea and its application method - Google Patents
A kind of feed addictive preventing nursing period calf diarrhea and its application method Download PDFInfo
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Abstract
The invention discloses a kind of feed addictive for preventing nursing period calf diarrhea and its application methods.The present invention is with natural astaxanthin, sodium humate, beta-hydroxy-Beta-methyl butyric acid, glutamine, xylo-oligosaccharide and Chinese herb feed additive (hairyvein agrimony, honeysuckle, the Chinese bulbul, hawthorn, granatum, talcum, Radix Glycyrrhizae) carry out prescription, improve nursing period calf gastrointestinal bacterial flora balance, promote gastrointestinal tract mucous development, cause of disease and unfavorable factor are reduced to its damage effect, have additional nutrients the digestion and absorption of ingredient, improve immunity of organisms, alleviate the oxidative stress and oxidative damage being subjected to, improve anti-stress ability, to accomplish to prevent the generation of nursing period calf diarrhea, feed nutrition substance is promoted to absorb, improve the purpose of the calf general level of the health and production performance.
Description
Technical field
The present invention relates to a kind of feed addictive for preventing nursing period calf diarrhea and its application methods, belong to feed technology
Field.
Background technique
Calf diarrhea refers to disease of the nursing period calf characterized by diarrhea as caused by many reasons, shows as having loose bowels
Just, soft stool or watery stool and vomiting, dehydration and weight loss etc..This disease can occur throughout the year, 3 week old after being especially born
Within newborn calf occur it is more.In jumpbogroup raising, calf diarrhea incidence often reaches 90%-100%, and death rate highest can
It is to cause one of calf retarded growth and dead principal disease up to 50% or more.Although current calf management, animal house are built
If, vaccine inoculation work be constantly progressive and perfect, but calf diarrhea is still the common disease in vaccary, and diarrhea occurred
Calf goes back easy infection respiratory disease in later growth course, this causes serious economic loss to cattle-raising.Therefore, such as
What prevention nursing period calf diarrhea is the most important thing in cowboying production.
The generation of calf diarrhea is summed up and is mainly caused by the reason of following several respects: (1) calf body after birth
Structure and function also incomplete development, especially gastrointestinal disturbances system poor for environment-adapting ability, if at this moment temperature change is big, ring
Border difference and feeding feed it is stale or rotten and mildew feed, it is easy to lead to digestive system disorder, disappear
Change bad, diarrhea situation；(2) the environmental sanitation condition of colony house is poor, and pathogenic bacteria and virus are easily bred in this ambient growth, and
Just the calf resistance of birth soon is weaker, easily infection germs and viruses, causes the symptoms such as loss of appetite, diarrhea；(3) big
The farming site of scale, the germ and microorganism of colony house sharply increase, and calf easily infects helminth, such as common roundworm,
Nematode etc. shows as the symptoms such as diarrhea, blood stool, loss of appetite, dehydration.
Antibiotic is added in daily ration can play the role of certain prevention calf diarrhea, but feed antibiotic milk or
Antibiotic daily ration can have a negative impact to the health of calf, therefore research and develop and a kind of can prevent calf with the preparation of substitute antibiotics
Ox diarrhea is current urgent problem to be solved.
Summary of the invention
In view of the above-mentioned problems, the present invention provides a kind of feed addictives for preventing nursing period calf diarrhea.The feed adds
Add agent to promote calf gastrointestinal development, reduce cause of disease to its damage effect, the digestion and absorption for the ingredient that has additional nutrients is alleviated and is subjected to
Oxidative stress and oxidative damage improve anti-stress ability, improve the cellular immunity and humoral immunity ability of calf, alternative daily ration
In antibiotic, effectively prevent nursing period calf diarrhea generation.
The technical scheme is that a kind of feed addictive for preventing nursing period calf diarrhea, characterized in that by following
The group of weight percent is grouped as: natural astaxanthin 10-15%, sodium humate 10-15%, beta-hydroxy-Beta-methyl butyric acid 20-
25%, glutamine 10-12%, xylo-oligosaccharide 30-35%, Chinese herb feed additive 12-14%.Above-mentioned raw materials are that granularity is less than
The dry powder of 0.5mm.
The component and its parts by weight of said herbal medicine additive are as follows: hairyvein agrimony 20-25, honeysuckle 15-20, Chinese bulbul 10-
12, hawthorn 10-12, granatum 10-12, talcum 10-15, Radix Glycyrrhizae 10-15, are ground into the dry powder of 40-200 mesh after mixing.
Feed addictive optimum ratio (weight ratio): natural astaxanthin 12%, sodium humate 12%, beta-hydroxy-Beta-methyl
Butyric acid 22%, glutamine 10%, xylo-oligosaccharide 32%, Chinese herb feed additive 12%.
Application method: being added directly into cream, takes together when breast-feeding, additive amount 1.0-1.5%；Feeding period be from
Terminate to after weaning within the 1st day after calf birth.
Each raw material effect:
Natural astaxanthin: being one of most strong, the most efficient natural having now been found that, antioxidant activity
It is 10 times of beta carotene, 1000 times of vitamin E, can effectively clear the oxygen radical in body cell, enhancing body is anti-
Oxidative stress ability protects body from the influence of unfavorable factor.
Beta-hydroxy-Beta-methyl butyric acid: it is that gut epithelium grows important energy source, promotes epithelial cell proliferation and mucous membrane
Growth increases mesenteric blood flow and gastrointestinal hormone secretion, promotes the proliferation of Bifidobacterium and Bacillus acidi lactici in enteron aisle, inhibits large intestine
The effect of bacillus plays good effect in terms of maintaining intestinal environment stable and prevention.
Sodium humate: there is colloid property and adsorption capacity, form good ion exchange and catalytic action, make in feed
Various nutritional ingredients sufficiently decompose and carry out good organic assembling, increase gastrointestinal function, promote the assimilation of protein.
Suction-operated makes feed nutrient relatively pass through slowly enteron aisle, enhances and assimilates the time, improves the absorptivity of nutritional ingredient.
Improve gastrointestinal function, promote gastric secretion, increases appetite, the growth of beneficial bacterium, inhibits the breeding of spoilage organisms in stimulating gastrointestinal.
Glutamine: being nutriment necessary to intestinal mucosa cell metabolism, to the complete of maintenance intestinal mucosal epithelial structure
Whole property plays a very important role.Glutamine can be effectively prevented intestinal mucosa atrophy, keep normal bowel mucous membrane weight,
Structure and protein content, enhancing intestinal cell activity, improve intestinal immunity, reduce enteric bacteria and it is endotoxic easily
Position, to promote calf to the digestion and absorption of nutritional ingredient in daily ration, improves the general level of the health and growth performance of calf.
Xylo-oligosaccharide: the inductive formation panimmunity factor promotes interferon to generate, and activating macrophage and T, B lymph are thin
Born of the same parents improve the activity of natural killer cells, promote antibody to generate, enhance the immune function of body.
Chinese herb feed additive: by hairyvein agrimony, honeysuckle, the Chinese bulbul, hawthorn, granatum, talcum, Radix Glycyrrhizae prescription, wherein celestial
Crane grass astringing to arrest bleeding, stop dysentery desinsection are monarch drug in a prescription；Honeysuckle and the Chinese bulbul are clearing heat and detoxicating, remove heat from the blood and relieve diarrhea as ministerial drug；Hawthorn promoting blood circulationization
Silt, convergence and dysentery, food digesting stomach fortifying, granatum relieving diarrhea with astringents, astringing to arrest bleeding, talcum clearing away summerheat, diuresis antidiarrheal, bactericidal antiphlogistic are
Adjutant, Radix Glycyrrhizae coordinating the drug actions of a prescription are to make medicine.Above-mentioned raw materials collective effect has the function of convergence and dysentery, antibacterial anti-inflammatory, coordinating intestines and stomach,
Calf diarrhea can be prevented and treated, immunity of organism and digestive function are enhanced, also there is antagonism to various bacteria and virus and is killed
Wound effect, improves resisting stress capability.
Beneficial effects of the present invention: the present invention is with natural astaxanthin, sodium humate, beta-hydroxy-Beta-methyl butyric acid, glutamy
Amine, xylo-oligosaccharide and Chinese herb feed additive carry out prescription, from promoting function of intestinal canal, enhance nutrition in enteron aisle when assimilating
Between, improve immunity of organism and the multi-angles such as anti-oxidant, resisting stress and anti-virus ability, stop dysentery and start with, wherein beta-hydroxy-β-first
Base butyric acid promotes epithelial cell proliferation and mucous membrane growth, and gastrointestinal bacterial flora is maintained to stablize；Glutamine supplements intestinal mucosa metabolism
Nutriment promotes the reparation and regeneration of mucous membrane structure, improves intestinal immunity；Sodium humate promotes the assimilation of protein,
Enhance enteron aisle assimilates the time；Natural astaxanthin has stronger oxidation resistance；Xylo-oligosaccharide improves exempting from for body
Epidemic disease, resisting stress and antibacterial, anti-virus ability；Chinese herb feed additive has the function of the treatment of convergence and dysentery, antibacterial anti-inflammatory.Each raw material
Collective effect, conditioning nursing period calf gastrointestinal bacterial flora balance, promotes gastrointestinal tract mucous development, reduces cause of disease and unfavorable factor pair
Its damage effect, the digestion and absorption for the ingredient that has additional nutrients improve immunity of organisms, alleviate the oxidative stress being subjected to and oxidation damage
Wound improves anti-stress ability, to accomplish the generation of prevention nursing period calf diarrhea, feed nutrition substance is promoted to absorb, improved
The purpose of the calf general level of the health and production performance.Also improve antibacterial, anti-virus ability, the antibiotic in alternative daily ration.
Specific embodiment
In the present embodiment, the manufacturer of natural astaxanthin is Yunnan Ai Erfa astaxanthin biological Technology Co., Ltd., is had
Effective component content is 5%.The manufacturer of xylo-oligosaccharide be Shandong Longli Biology Science and Technology Co., Ltd, active constituent content be >=
35%.Sodium humate is feed grade, it is desirable that fulvo acid content (butt) >=65%.
Embodiment 1:
It matches (weight ratio): natural astaxanthin 12%, sodium humate 12%, beta-hydroxy-Beta-methyl butyric acid 22%, glutamy
Amine 10%, xylo-oligosaccharide 32%, Chinese herb feed additive 12%.Above-mentioned raw materials granularity is the dry powder less than 0.5mm.
Chinese herb feed additive (parts by weight): hairyvein agrimony 23, honeysuckle 17, the Chinese bulbul 10, hawthorn 10, granatum 10, talcum
15, Radix Glycyrrhizae 15 are ground into the dry powder of 100 mesh after mixing.
Experimental design:
Feeding experiment was carried out in Shandong oaks herding Zhong Ye Co., Ltd in the 10-12 month in 2017.The rigid birth lotus of selection
This smooth calf 20, is divided into test group and control group, and every group 10.The original body mass difference of two groups of calves it is not significant (P >
0.05), 30 ages in days wean, and the environment such as illumination ventilation are consistent with feeding and management condition.Wherein control group does not add any additive,
Test group adds the feed addictive that 1.2% present invention prepares in milk.The identical concentrate supplement (opened guideway) of every group of feeding
And coarse fodder, it being freely eaten, free water, feeding to wean terminates, and experimental period 30 days.The present invention is prepared before feeding daily
Feed addictive is dissolved in milk, point early, middle and late 3 times uniformly feedings.Daily observation calf discharge feces situation, record diarrhea individual and
Duration, the head number of days that diarrhea finally occurs with every group of calf calculates Scours index divided by total raising head number of days, with evaluation
The influence of feed addictive of the invention to nursing period calf diarrhea.Vena cava anterior is taken a blood sample at the end of experimental period, detects serum
Immune indexes, to evaluate the influence of feed addictive of the invention to calf immune function；Detect serum oxidative stress index, with
Evaluate the influence of feed addictive of the invention to calf anti-stress ability.Test result is as shown in table 1-3.
Influence of 1 compound additive of table to calf diarrhea index
| Group | Head number | Scours index (%) |
| Control group | 10 | 7.4a |
| Test group | 10 | 0.3b |
Note: same column shoulder mark lowercase difference person, significant difference (p < 0.05), similarly hereinafter.
Influence (g/L) of 2 compound additive of table to calf immune function
| Group | IgA | IgG | IgM | Complement C_3 | Complement C4 |
| Control group | 2.12±0.05a | 1.43±0.07a | 8.62±0.09a | 0.38±0.02a | 0.37±0.01a |
| Test group | 3.25±0.03b | 2.18±0.04b | 11.51±0.11b | 0.44±0.01b | 0.43±0.02b |
Influence of 3 compound additive of table to calf anti-stress ability
| Group | MDA(nmol/Ml) | SOD(U/mL) | GSH-Px(U/mL) |
| Control group | 4.73±0.03a | 139.62±8.45a | 271.36±10.73b |
| Test group | 3.94±0.08b | 167.20±1.68b | 368.07±8.73a |
The result shows that nursing period calf diarrhea can not only effectively be prevented by adding 1.2% compound additive in cream, and improve
Calf entirety immune level and anti-stress ability.Seen from table 1,1.2% compound additive, calf diarrhea are added in test group cream
Index is 0.3, significantly reduces 7.1 compared with control group.As can be seen from Table 2, adding 1.2% compound additive, nursing period in test group cream
Calf entirety immune level significantly improves, compared with the control group, IgA, IgG, IgM, Complement C_3, Complement C4 level points in blood
Indescribably high 53.3%, 52.4%, 33.5%, 15.8% and 16.2%.Seen from table 3,1.2% compound additive is added in cream,
MDA level in blood reduces by 16.7%, SOD and 19.8% and 35.6% is respectively increased in GSH-Px activity.
It can be seen that natural astaxanthin, sodium humate, beta-hydroxy-Beta-methyl butyric acid, glutamine, xylo-oligosaccharide and in
Chinese herbal medicine additive agent carries out compatibility, can not only give full play to respective advantage, and have synergistic effect, to prevention nursing period calf
The diarrhea effect of being significantly improved, calf entirety immune level and anti-stress ability significantly improve.
Embodiment 2:
It matches (weight ratio): natural astaxanthin 13%, sodium humate 13%, beta-hydroxy-Beta-methyl butyric acid 24%, glutamy
Amine 10%, xylo-oligosaccharide 30%, Chinese herb feed additive 10%.Above-mentioned raw materials granularity is the dry powder less than 0.5mm.
Chinese herb feed additive (parts by weight): hairyvein agrimony 25, honeysuckle 20, the Chinese bulbul 12, hawthorn 12, granatum 12, talcum
12, Radix Glycyrrhizae 10 are ground into the dry powder of 80 mesh after mixing.
Application method: being added directly into cream, takes together when breast-feeding, additive amount 1.0-1.5%；Feeding period be from
Terminate to after weaning within the 1st day after calf birth.
Embodiment 3:
It matches (weight ratio): natural astaxanthin 11%, sodium humate 11%, beta-hydroxy-Beta-methyl butyric acid 21%, glutamy
Amine 12%, xylo-oligosaccharide 35%, Chinese herb feed additive 10%.Above-mentioned raw materials granularity is the dry powder less than 0.5mm.
Chinese herb feed additive (parts by weight): hairyvein agrimony 20, honeysuckle 15, the Chinese bulbul 10, hawthorn 10, granatum 10, talcum
15, Radix Glycyrrhizae 10 are ground into the dry powder of 200 mesh after mixing.
Application method: being added directly into cream, takes together when breast-feeding, additive amount 1.0-1.5%；Feeding period be from
Terminate to after weaning within the 1st day after calf birth.
Claims (6)
1. a kind of feed addictive for preventing nursing period calf diarrhea, characterized in that be grouped as by the group of following weight percentage:
It is natural astaxanthin 10-15%, sodium humate 10-15%, beta-hydroxy-Beta-methyl butyric acid 20-25%, glutamine 10-12%, low
Xylan 30-35%, Chinese herb feed additive 12-14%.
2. a kind of feed addictive for preventing nursing period calf diarrhea as described in claim 1, characterized in that the Chinese herbal medicine
The component and its parts by weight of additive are as follows: hairyvein agrimony 20-25, honeysuckle 15-20, Chinese bulbul 10-12, hawthorn 10-12, granatum
10-12, talcum 10-15, Radix Glycyrrhizae 10-15.
3. a kind of feed addictive for preventing nursing period calf diarrhea as claimed in claim 2, characterized in that by following weight
The group of percentage is grouped as: natural astaxanthin 12%, sodium humate 12%, beta-hydroxy-Beta-methyl butyric acid 22%, glutamine
10%, xylo-oligosaccharide 32%, Chinese herb feed additive 12%.
4. a kind of feed addictive for preventing nursing period calf diarrhea as described in any one of claim 1-3, feature
It is that the component is the dry powder that granularity is less than 0.5mm.
5. prevent the application method of the feed addictive of nursing period calf diarrhea described in any one of claim 1-3,
It is characterized in, is added directly into cream, is taken together when breast-feeding, additive amount 1.0-1.5%.
6. application method as claimed in claim 5, characterized in that feeding period is from the 1st day after calf birth to after wean
Terminate.
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| CN110973380A (en) * | 2019-12-27 | 2020-04-10 | 广州美瑞泰科生物工程技术有限公司 | Feed additive for preventing calf diarrhea and preparation method and application thereof |
| CN110973376A (en) * | 2019-11-13 | 2020-04-10 | 中国农业科学院北京畜牧兽医研究所 | Feed additive for reducing calf diarrhea rate and preparation method thereof |
| CN111280316A (en) * | 2020-02-13 | 2020-06-16 | 黑龙江省三禾饲料有限公司 | Concentrate supplement feed for preventing early weaning calf diarrhea and preparation method thereof |
| CN111387356A (en) * | 2020-04-26 | 2020-07-10 | 贵州省畜牧兽医研究所 | Chinese herbal medicine feed additive for preventing diarrhea of young ruminants and preparation method and application thereof |
| CN114041533A (en) * | 2021-11-12 | 2022-02-15 | 哈尔滨金绿达农牧科技有限公司 | Antibiotic-free feed additive for preventing and controlling calf diarrhea and preparation method and using method thereof |
| CN115176903A (en) * | 2022-07-21 | 2022-10-14 | 延边大学 | Antibiotic-free feed additive for preventing calf diarrhea |
| CN115209886A (en) * | 2020-03-12 | 2022-10-18 | 雅培制药有限公司 | Methods of treating diarrhea or intestinal inflammatory conditions |
| CN116326689A (en) * | 2023-03-27 | 2023-06-27 | 宁夏博瑞饲料有限公司 | Feed additive for preventing calf diarrhea by combining mother and child and application thereof |
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| CN114041533A (en) * | 2021-11-12 | 2022-02-15 | 哈尔滨金绿达农牧科技有限公司 | Antibiotic-free feed additive for preventing and controlling calf diarrhea and preparation method and using method thereof |
| CN115176903A (en) * | 2022-07-21 | 2022-10-14 | 延边大学 | Antibiotic-free feed additive for preventing calf diarrhea |
| CN116326689A (en) * | 2023-03-27 | 2023-06-27 | 宁夏博瑞饲料有限公司 | Feed additive for preventing calf diarrhea by combining mother and child and application thereof |
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