CN109715215A - 眼用组合物 - Google Patents
眼用组合物 Download PDFInfo
- Publication number
- CN109715215A CN109715215A CN201780041866.9A CN201780041866A CN109715215A CN 109715215 A CN109715215 A CN 109715215A CN 201780041866 A CN201780041866 A CN 201780041866A CN 109715215 A CN109715215 A CN 109715215A
- Authority
- CN
- China
- Prior art keywords
- ophthalmic composition
- chlorhexidine
- agent
- inflammatory agent
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 136
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 83
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 73
- 238000000034 method Methods 0.000 claims abstract description 43
- 229940121363 anti-inflammatory agent Drugs 0.000 claims abstract description 42
- 239000002260 anti-inflammatory agent Substances 0.000 claims abstract description 42
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 30
- 239000002904 solvent Substances 0.000 claims abstract description 30
- 208000015181 infectious disease Diseases 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 28
- 239000013543 active substance Substances 0.000 claims abstract description 16
- -1 diflurprednate Chemical compound 0.000 claims description 22
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- 230000002335 preservative effect Effects 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
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- LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 claims description 13
- 229960002800 prednisolone acetate Drugs 0.000 claims description 13
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims description 11
- 206010010741 Conjunctivitis Diseases 0.000 claims description 10
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 10
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- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims description 8
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 claims description 8
- 208000001860 Eye Infections Diseases 0.000 claims description 7
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 7
- 229960000590 celecoxib Drugs 0.000 claims description 7
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 7
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- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 claims description 6
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- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims description 6
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- 229960004384 ketorolac tromethamine Drugs 0.000 claims description 6
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 claims description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 6
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims description 6
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 5
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 5
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 3
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims description 3
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- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- OGPIIGMUPMPMNT-UHFFFAOYSA-M sodium meclofenamate (anhydrous) Chemical compound [Na+].CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C([O-])=O)=C1Cl OGPIIGMUPMPMNT-UHFFFAOYSA-M 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- APSWQQYXFMUODF-UHFFFAOYSA-M sodium;5-(2-methylpropyl)-4,6-dioxo-5-prop-2-enyl-1h-pyrimidine-2-thiolate Chemical compound [Na+].CC(C)CC1(CC=C)C(=O)NC(=S)N=C1[O-] APSWQQYXFMUODF-UHFFFAOYSA-M 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 239000006228 supernatant Substances 0.000 description 1
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- IDELNEDBPWKHGK-UHFFFAOYSA-N thiobutabarbital Chemical compound CCC(C)C1(CC)C(=O)NC(=S)NC1=O IDELNEDBPWKHGK-UHFFFAOYSA-N 0.000 description 1
- 229940035274 tobradex Drugs 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- QGUALMNFRILWRA-UHFFFAOYSA-M tolmetin sodium Chemical compound [Na+].C1=CC(C)=CC=C1C(=O)C1=CC=C(CC([O-])=O)N1C QGUALMNFRILWRA-UHFFFAOYSA-M 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- IALIDHPAWNTXOK-UHFFFAOYSA-N tricosanal Chemical compound CCCCCCCCCCCCCCCCCCCCCCC=O IALIDHPAWNTXOK-UHFFFAOYSA-N 0.000 description 1
- 229940078279 trilisate Drugs 0.000 description 1
- GOZBHBFUQHMKQB-UHFFFAOYSA-N trimecaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=C(C)C=C1C GOZBHBFUQHMKQB-UHFFFAOYSA-N 0.000 description 1
- 229950002569 trimecaine Drugs 0.000 description 1
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- 241000701161 unidentified adenovirus Species 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 229940087652 vioxx Drugs 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/10—Antimycotics
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US201662332789P | 2016-05-06 | 2016-05-06 | |
| US62/332789 | 2016-05-06 | ||
| US201662337571P | 2016-05-17 | 2016-05-17 | |
| US62/337571 | 2016-05-17 | ||
| PCT/US2017/031211 WO2017192944A1 (en) | 2016-05-06 | 2017-05-05 | Ophthalmic compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109715215A true CN109715215A (zh) | 2019-05-03 |
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| CN201780041866.9A Pending CN109715215A (zh) | 2016-05-06 | 2017-05-05 | 眼用组合物 |
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| US (2) | US10610499B2 (enExample) |
| EP (1) | EP3452093B1 (enExample) |
| JP (1) | JP6941157B2 (enExample) |
| CN (1) | CN109715215A (enExample) |
| AU (1) | AU2017261303B9 (enExample) |
| BR (1) | BR122024001664A2 (enExample) |
| CA (1) | CA3022983C (enExample) |
| DK (1) | DK3452093T3 (enExample) |
| TW (1) | TWI738774B (enExample) |
| WO (1) | WO2017192944A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114746098A (zh) * | 2019-12-03 | 2022-07-12 | Ntc有限公司 | 用于眼科的包含布地奈德的组合物 |
| CN119792261A (zh) * | 2025-03-14 | 2025-04-11 | 华中科技大学同济医学院附属同济医院 | 治疗泌尿系感染的抗菌剂及其制备方法和应用 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3022983C (en) | 2016-05-06 | 2024-05-07 | SaCSh Corp. | Ophthalmic compositions comprising chlorhexidine and an anti-inflammatory agent |
| KR102340804B1 (ko) * | 2019-07-22 | 2021-12-17 | 주식회사 휴온스메디케어 | 클로르헥시딘 또는 이의 유도체를 포함하는 항균 지속성이 개선된 수용성 소독용 조성물 및 이를 포함하는 섬유형 소독제 |
| US12357594B1 (en) | 2021-06-30 | 2025-07-15 | Sage Products, Llc | Antimicrobial solution for pre-operative preparation |
| US11951087B2 (en) * | 2021-07-27 | 2024-04-09 | Lanny Leo Johnson | Eye wash compositions and methods |
| WO2025176750A1 (en) | 2024-02-23 | 2025-08-28 | Heinrich-Heine-Universität Düsseldorf | Dual targeting in a new class of active ingredients |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1122225A (zh) * | 1993-12-27 | 1996-05-15 | 千寿制药株式会社 | 含有二氟泼尼松龙酯的眼悬浮液 |
| EP0807434A4 (en) * | 1995-01-20 | 1998-04-22 | Wakamoto Pharma Co Ltd | ANTI-INFLAMMATORY EYE DROPS |
| US20050234018A1 (en) * | 2004-04-15 | 2005-10-20 | Allergan, Inc. | Drug delivery to the back of the eye |
| US20100240624A1 (en) * | 2009-03-17 | 2010-09-23 | Aciex Therapeutics, Inc. | Ophthalmic Formulations of Ketotifen and Methods of Use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO59572A2 (enExample) | 1972-01-29 | 1976-03-15 | ||
| JP3781792B2 (ja) * | 1993-12-27 | 2006-05-31 | 千寿製薬株式会社 | ジフルプレドナート含有点眼用懸濁液剤 |
| GB9616208D0 (en) * | 1996-08-01 | 1996-09-11 | Smithkline Beecham Plc | Novel Compounds |
| US6218428B1 (en) | 2000-04-28 | 2001-04-17 | Emil Chynn | Ophthalmic composition |
| US6872705B2 (en) | 2001-07-13 | 2005-03-29 | Allergan, Inc. | Use of antimicrobial peptides as preservatives in ophthalmic preparations, including solutions, emulsions, and suspensions |
| DE102005046769A1 (de) * | 2005-09-29 | 2007-04-05 | Berlin-Chemie Ag | Lichtstabile, brivudinhaltige pharmazeutische Formulierung zur Behandlung von Augenherpes (Herpes Ophthalmicus) |
| WO2009006130A2 (en) | 2007-06-28 | 2009-01-08 | Bausch & Lomb Incorporated | Salt free hyaluronate ophthalmic solution |
| US9017725B2 (en) | 2009-06-09 | 2015-04-28 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| US20130165419A1 (en) | 2011-12-21 | 2013-06-27 | Insite Vision Incorporated | Combination anti-inflammatory ophthalmic compositions |
| CN102973925A (zh) * | 2012-11-27 | 2013-03-20 | 顾月燕 | 一种促进伤口愈合的组合物的制备方法 |
| CN105979940A (zh) * | 2013-12-12 | 2016-09-28 | 创新技术股份有限公司 | 控制感染的材料和方法 |
| CA3022983C (en) | 2016-05-06 | 2024-05-07 | SaCSh Corp. | Ophthalmic compositions comprising chlorhexidine and an anti-inflammatory agent |
-
2017
- 2017-05-05 CA CA3022983A patent/CA3022983C/en active Active
- 2017-05-05 US US15/587,764 patent/US10610499B2/en active Active
- 2017-05-05 JP JP2019510569A patent/JP6941157B2/ja active Active
- 2017-05-05 EP EP17723886.2A patent/EP3452093B1/en active Active
- 2017-05-05 BR BR122024001664-8A patent/BR122024001664A2/pt not_active Application Discontinuation
- 2017-05-05 WO PCT/US2017/031211 patent/WO2017192944A1/en not_active Ceased
- 2017-05-05 TW TW106114962A patent/TWI738774B/zh active
- 2017-05-05 AU AU2017261303A patent/AU2017261303B9/en active Active
- 2017-05-05 CN CN201780041866.9A patent/CN109715215A/zh active Pending
- 2017-05-05 DK DK17723886.2T patent/DK3452093T3/da active
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2018
- 2018-01-24 US US15/878,767 patent/US10632083B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1122225A (zh) * | 1993-12-27 | 1996-05-15 | 千寿制药株式会社 | 含有二氟泼尼松龙酯的眼悬浮液 |
| EP0807434A4 (en) * | 1995-01-20 | 1998-04-22 | Wakamoto Pharma Co Ltd | ANTI-INFLAMMATORY EYE DROPS |
| US20050234018A1 (en) * | 2004-04-15 | 2005-10-20 | Allergan, Inc. | Drug delivery to the back of the eye |
| US20100240624A1 (en) * | 2009-03-17 | 2010-09-23 | Aciex Therapeutics, Inc. | Ophthalmic Formulations of Ketotifen and Methods of Use |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114746098A (zh) * | 2019-12-03 | 2022-07-12 | Ntc有限公司 | 用于眼科的包含布地奈德的组合物 |
| CN119792261A (zh) * | 2025-03-14 | 2025-04-11 | 华中科技大学同济医学院附属同济医院 | 治疗泌尿系感染的抗菌剂及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3452093A1 (en) | 2019-03-13 |
| AU2017261303A1 (en) | 2018-11-22 |
| DK3452093T3 (da) | 2021-06-28 |
| CA3022983C (en) | 2024-05-07 |
| AU2017261303B9 (en) | 2021-09-23 |
| AU2017261303B2 (en) | 2021-09-16 |
| WO2017192944A1 (en) | 2017-11-09 |
| TWI738774B (zh) | 2021-09-11 |
| JP2019515040A (ja) | 2019-06-06 |
| BR122024001664A2 (pt) | 2024-02-27 |
| EP3452093B1 (en) | 2021-04-28 |
| US20170319515A1 (en) | 2017-11-09 |
| US20180147162A1 (en) | 2018-05-31 |
| CA3022983A1 (en) | 2017-11-09 |
| TW201740928A (zh) | 2017-12-01 |
| US10632083B2 (en) | 2020-04-28 |
| JP6941157B2 (ja) | 2021-09-29 |
| BR112018072647A2 (pt) | 2019-02-19 |
| US10610499B2 (en) | 2020-04-07 |
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| CB02 | Change of applicant information |
Country or region after: U.S.A. Address after: New York, United States Applicant after: Shachi Co.,Ltd. Address before: New York, United States Applicant before: SaCSh Corp. Country or region before: U.S.A. |
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| CB02 | Change of applicant information |