CN109715136A - 永久花精油用于提高或恢复皮肤触觉的用途 - Google Patents
永久花精油用于提高或恢复皮肤触觉的用途 Download PDFInfo
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- CN109715136A CN109715136A CN201780040737.8A CN201780040737A CN109715136A CN 109715136 A CN109715136 A CN 109715136A CN 201780040737 A CN201780040737 A CN 201780040737A CN 109715136 A CN109715136 A CN 109715136A
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Abstract
本发明涉及永久花精油的用途，其被局部施用到皮肤以提高或恢复触觉感知。所述永久花精油可用于在人类中产生皮肤感觉神经的神经元突起。
Description
技术领域
本发明涉及永久花精油的用途，其被局部施用到皮肤以提高或恢复皮肤触觉。所述永久花精油可以在人类中产生皮肤感觉神经的神经元突起。
背景技术
皮肤构成主要的感觉器官，因为它与外部环境直接接触。它持续不断地接收多种多样的热、机械或化学刺激。
在皮肤中已鉴定到几种类型的感觉感受器。除了传递热和冷敏感性的温度感受器、作为疼痛感受器的伤害感受器和作为瘙痒特异性感受器的痒觉感受器之外，还已鉴定到各种不同类型的机械感受器。后者传递压力和振动敏感性和精细觉或触觉敏感性(其对于与皮肤的轻微接触做出响应)，由位于表皮基底层中的梅克尔触盘、位于乳突真皮层中的迈斯纳小体、位于真皮深部的帕西尼小体和位于真皮中的罗菲尼小体的游离末梢构成。在无毛皮肤和有毛皮肤中，这些感受器的分布是不同的。它们的密度也随着区域而变；因此，手掌具有特别好的供应，并且面部皮肤也含有大量感受器。
这些机械感受器由对无害机械刺激做出反应的被称为低阈值机械感受器(LTMR)的感觉神经元神经支配。它们根据细胞体大小、轴突直径、髓鞘化程度和轴突传导速度被分类为各种不同类型。感觉神经元向中枢神经系统提供信息，中枢神经系统反过来产生恰当的应答。因此可以识别物体并特别是辨别质地。
这些感觉神经元包含细胞体，神经突(轴突和树突)从所述细胞体出现。所述神经突通常被上面提到的感受器、特别是梅克尔细胞包围或者与它们接触。
然而，随着衰老以及在某些病理状态下，特别是由例如糖尿病、化疗或饮酒造成的周围神经病或其他神经退行性疾病例如多发性硬化症的状况下，观察到触觉降低或感觉迟钝。因此认为，触觉缺陷在法国影响几十万个体。然而，对它们的关注仍处于边缘。
因此应该理解，获得能够恢复皮肤触觉或提高皮肤触觉的手段，将是有用的。
已经提出，某些植物的某些提取物的口服给药(EP 2 438 916，US 2002/040052)或局部给药(KR 2013 0107982)可以引起神经突伸长。然而，这种效应仅被用于治疗某些神经退行性疾病或用于改善学习、专注或记忆能力的目的。
发明内容
本发明旨在提供可以促进神经突伸长的另一种植物提取物。本发明的另一个目的是提供一种能够特别是在施用美容产品期间恢复或提高皮肤触觉的植物提取物。
在这种背景下，本发明的主题是永久花精油的美容用途，也就是说非治疗性用途，其被局部施用到皮肤，用于提高或恢复皮肤触觉，特别是用于对抗由衰老造成的皮肤触觉降低。
本发明的另一个主题是一种用于提高或恢复皮肤触觉、特别是用于对抗由衰老造成的皮肤触觉降低的美容方法，也就是说非治疗性方法，所述方法包括向所述皮肤局部施用永久花精油。
本发明的一个主题还是一种永久花精油，其用于通过施用到患有周围神经病、神经退行性疾病、或创伤例如烧伤后神经末梢破坏的个体的皮肤，而在旨在提高或恢复皮肤触觉的治疗中局部使用。
详细描述
本发明使用永久花精油。在可以按照本发明使用的永久花物种中，将提到所有的蜡菊属(Helichrysum)植物，特别是被称为咖喱草的意大利腊菊(Helichrysum italicum)(或白叶蜡菊(Helichrysum angustifolium D.C.))、被称为沙地永久花的沙生蜡菊(Helichrysum arenarium)和法国腊菊(Helichrysum stoechas)或普通永久花，但不限于此。优选地使用意大利腊菊(Helichrysum italicum)的精油，不论所讨论的亚种如何。
在本说明书中，术语“精油”意指存在于永久花的任何部分或完整植物中，更特别是其地上部分例如它的花或头状花序中的挥发性有机化合物的水蒸馏或汽提的产物。
所述永久花精油可以包含在美容组合物中，并且在这种情况下，相对于按照本发明使用的组合物的总重量，它有利地占0.001重量％至5重量％，优选地占0.01重量％至2重量％。
正如从后文的实施例看出的，已证实所述永久花精油能够在人类中促进神经突生成，更具体来说产生皮肤感觉神经的神经元突起，使得它可用于恢复或提高皮肤触觉。通过原样或在用于局部使用的美容组合物中，在皮肤护理产品下使用所述永久花精油，可以利用这种性质。作为变化形式，含有所述永久花精油的美容组合物本身可以构成皮肤护理产品。在施用所述产品期间，所述永久花精油能够提高施用这种护理产品的个体感受到的触觉感受，特别是对其质地或滑动性有更好的感觉。所述永久花精油或包含它的组合物可以施用到身体的任何部位，优选地施用到作为最高度神经支配的区域的面部和/或手部的皮肤。具体来说，它可以被施用到患有触觉丧失的个体、特别是老年个体(通常为更年期女性)，或罹患病理状况特别是周围神经病、尤其是由糖尿病或化疗造成的周围神经病、神经退行性疾病例如多发性硬化症、或创伤例如烧伤后神经末梢破坏的个体的皮肤。
这种组合物通常含有生理上可接受的、特别是美容上可接受的介质，也就是说不引起与美容用途不相容的麻刺感或发红的介质。这种介质优选地含有水相以及油相。所述组合物优选地为水包油或油包水乳液的形式。
具体来说，所述水相除了水之外，还可以含有选自水性胶凝剂和亲水性活性剂例如保湿剂的至少一种组成成分。
术语“水性胶凝剂”是指在变得水合时能够固定水分子并因此能够提高所述水相的粘度的聚合化合物。这种胶凝剂可以选自：多糖，例如纤维素及其衍生物、改性淀粉、卡拉胶、琼脂、黄原胶和植物树胶例如瓜尔胶或刺槐豆胶；合成聚合物，特别是在有利情况下交联的丙烯酸钠的均聚物，以及丙烯酸类共聚物，特别是丙烯酸钠和/或(甲基)丙烯酸烷基酯和/或(甲基)丙烯酸羟基烷基酯和/或(甲基)丙烯酸(聚乙氧基)烷基酯与至少一种其他单体、有利地是2-丙烯酰胺基-2-甲基丙磺酸(AMPS)的共聚物，这些共聚物优选是交联的；以及它们的混合物。
就其部分而言，除了永久花精油之外，所述脂肪相还可以包含一种或多种挥发性和/或非挥发性油。挥发性油的实例是支链C10-C13烷烃例如异十二烷和直链C10-C13烷烃。作为非挥发性油，具体来说可以提到的是：
-酸和一元醇的酯，其选自：饱和直链C2-C10(优选为C6-C10)酸和饱和直链C10-C18(优选为C10-C14)一元醇的单酯和聚酯，饱和直链C10-C20酸和支链或不饱和C3-C20(优选为C3-C10)一元醇的单酯和聚酯，支链或不饱和C5-C20酸和支链或不饱和C5-C20一元醇的单酯和聚酯，支链或不饱和C5-C20酸和直链C2-C4一元醇的单酯和聚酯；
-C6-C12脂肪酸甘油三酯，例如辛酸和癸酸甘油三酯和三庚酸甘油脂；
-支链和/或不饱和C10-C20脂肪酸(例如亚油酸、月桂酸和肉豆蔻酸)；
-支链和/或不饱和C10-C20脂肪醇(例如辛基十二烷醇和油醇)；
-烃类例如角鲨烷(C30)、特别是从橄榄油提取的植物角鲨烷，和半角鲨烷(C15)；
-碳酸二烷基酯，例如碳酸二辛基酯和碳酸二乙基己基酯；
-二烷基醚，例如二辛基醚；以及
-它们的混合物。
还可以提到的是含有一种或多种上面提到的组成成分的植物油。
作为酸和一元醇的酯，可以具体提到的是单酯，例如癸酸可可酯和辛酸可可酯的混合物、澳洲坚果油酸乙酯、乳木果油乙酯、异硬脂酸异硬脂酯、异壬酸异壬酯、异壬酸乙基己基酯、新戊酸己酯、新戊酸乙基己基酯、新戊酸异硬脂酯、新戊酸异癸基酯、肉豆蔻酸异丙酯、肉豆蔻酸辛基十二烷基酯、棕榈酸异丙酯、棕榈酸乙基己基酯、月桂酸己酯、月桂酸异戊酯、壬酸鲸蜡基硬脂基酯、辛酸丙基庚基酯，及其混合物。可以使用的其他酯类是酸和一元醇的二酯，例如己二酸二异丙酯、己二酸二乙基己基酯、癸二酸二异丙酯和癸二酸二异戊酯。
植物油的实例具体来说是小麦胚芽油、葵花油、摩洛哥坚果油、木槿油、芫荽油、葡萄籽油、芝麻油、玉米油、杏仁油、蓖麻油、乳木果油、鳄梨油、橄榄油和大豆油、甜杏仁油、棕榈油、菜籽油、棉籽油、榛果油、澳洲坚果油、霍霍巴油、紫花苜蓿油、罂粟油、南瓜籽油、芝麻油、西葫芦油、黑加仑油、月见草油、薰衣草油、琉璃苣油、小米油、大麦油、藜麦油、黑麦油、红花油、烛果油、西番莲油、麝香玫瑰油、蓝蓟油、亚麻荠油或山茶油。
所述脂肪相还可以包含至少一种脂肪相构建剂。
术语“脂肪相构建剂”意指能够使所述组合物中包含的油类增稠的化合物，具体来说选自蜡、脂肪相胶凝剂和糊状脂肪性物质以及它们的混合物。
在本说明书的上下文中，术语“蜡”是指在25℃下为固体，具有可逆的固/液状态变化，当通过DSC测量时具有通常在30至160℃之间、优选地在50至90℃之间的熔点的脂肪性物质。蜡的实例尤其是动物或植物来源的蜡，例如蜂蜡、小烛树蜡、巴西棕榈蜡或金合欢树蜡；任选地用异硬脂酸改性的氢化植物油，特别是氢化菜籽油、大豆油、葵花油、霍霍巴油、椰子油和蓖麻油；饱和直链C14-C30脂肪酸和饱和直链C16-C36脂肪醇的酯；直链和饱和C10-C30酸；直链和饱和C8-C30醇；以及它们的混合物。这些蜡可以为微粉化形式，也就是说其中粒子的数均尺寸小于或等于50μm、特别是在0.5至50μm的范围内、优选地在1至30μm的范围内或甚至在3至20μm范围内的粉末的形式，其中所述“数均尺寸”对应于通过统计学粒径分布给出的将群体分为两半的尺寸，被称为D50。
术语“脂肪相胶凝剂”是指通过形成三维网络改变脂肪相的流变学的化合物。作为这种类型的化合物，可以具体提到的是被疏水改性、特别是用二硬脂基二甲基氯化铵疏水改性的粘土(特别是膨润土和锂皂石)，疏水改性的煅制二氧化硅，糊精棕榈酸酯和肉豆蔻酸酯，聚酰胺、烯烃/苯乙烯共聚物、聚丙烯酸烷基酯，C16-C26(优选为直链和饱和的)脂肪酸甘油酯例如化合物 HKG，纤维素衍生物和含有它们的混合物，以及它们的混合物。某些氢化植物油也可被当作脂肪相胶凝剂。
最后，可以用作脂肪相构建剂的糊状脂肪性物质被定义为具有可逆的液/固状态变化，在固体状态下表现出各向异性结晶组织化并且在23℃的温度下包含液体级分和固体级分的脂肪性物质。优选地使用植物奶油。乳木果脂、可可脂和芒果脂构成了这种糊状脂肪性物质的实例。
此外，按照本发明使用的组合物可以包含一种或多种乳化剂、香料、防腐剂、螯合剂、抗氧化剂、pH调节剂、UV隔离剂、粉状填充剂、颜料、染料及其混合物。
根据一个优选实施方式，这种组合物还含有至少一种抗衰老活性剂，特别是适合于预防和/或治疗皱纹、皮肤松垂和/或色素斑形成的活性剂，其具体来说可以选自自由基清除剂，刺激角化细胞和/或成纤维细胞分化和/或增殖的药剂，刺激糖胺聚糖和/或胶原蛋白和/或真表皮锚定原纤维的合成的药剂，防止胶原蛋白和/或糖胺聚糖和/或真表皮锚定原纤维的降解的药剂，抗糖化剂，去色素剂和/或黑素原形成抑制剂，以及它们的混合物。作为变化形式和/或另外地，符合本发明的组合物可以包含至少一种具有神经元效应的活性药剂，例如舒缓和/或抑制神经源性炎症的药剂、防止神经衰老的药剂、调节神经元的乙酰胆碱释放的药剂、降低神经元的胞吐作用的药剂及其混合物。
具体来说，这些抗衰老活性剂和/或具有神经元效应的药剂的实例是：抗坏血酸及其盐、醚和酯类，特别是抗坏血酸葡萄糖苷；腺苷；核糖；蜂蜜提取物；蛋白质和糖蛋白，特别是从甜杏仁提取的；水解植物蛋白，特别是来自于水稻、木槿籽或羽扇豆的；多肽和假二肽，例如carcinine盐酸盐、尤其由Sederma分别以商品名3000和Synthe'6销售的棕榈酰基五肽-4(Pal-Lys-Thr-Thr-Lys-Ser)和棕榈酰基三肽-38、由Lucas Meyer公司以商品名销售的棕榈酰基三肽-8、由Lipotec公司以商品名 Solution销售的五肽-18、由Sandream公司以商品名销售的sh-十肽-9和由Infinitec公司以商品名X50 Powder销售的棕榈酰基六肽-52；硅烷类，例如甘露糖醛酸甲基硅醇酯；阿拉伯木聚糖，特别是从舌状花(ryeflower)提取的，和半乳阿拉伯聚糖，特别是来自于落叶松的；透明质酸及其盐；多酚化合物，特别是从含羞草提取的；α-羟基酸，包括从柠檬提取的；植物的水性提取物，所述植物例如睡菜、野生三色堇、野生问荆、苏格兰蓟(大刺蓟(Onopordum acanthium))、蓍草(欧蓍草(Achilleamillefolium)，特别是包含在来自于BASF公司的产品中)、酸藤子(Embeliaconcinna，如由Seppic公司销售的)、梨果仙人掌(Opuntia ficus indica，特别是由Mibelle AG Biochemistry以商品名销售的)、鼠尾草(Salviaofficinalis，特别是由Provital Group销售的)、黄荆(Vitex negundo)(特别是由Laboratoires Expanscience以商品名销售的)、甜栗、番木瓜、摩洛哥坚果树、燕麦、向日葵、雏菊、牡丹或莳萝；藻类、特别是珊瑚藻、叉珊藻(Jania rubens)、裙带菜(Ungaria pinnatifada)、翅菜(Alaria esculenta)或Nannochlorosis oculata的水性提取物；精油，特别是桃金娘的精油；葡萄糖酸锌和/或葡萄糖酸铜；以及它们的混合物。
作为变化形式或另外地，按照本发明使用的组合物可以包含至少一种调节张力的聚合物，也就是说能够通过机械作用调节皮肤张力并因此能够减少皱纹和细纹外观的聚合物。它可以是合成或天然聚合物，特别是多糖，特别是海洋藻类或浮游生物提取物或植物树胶。
这种组合物可以为适合于局部施用到皮肤的任何形式，特别是乳液、霜剂、洗剂、凝胶或面膜的形式。它通常是免洗型组合物。
实施例
在阅读了下面的实施例后，本发明将被更清楚地理解，给出所述实施例纯粹是为了说明，其目的不是限制由随附的权利要求书所定义的本发明的范围。
实施例1：在人类感觉神经元和角化细胞的共培养物上的体外试验
1.材料和方法
1.1.hiPS培养和分化
感觉神经元源自于本身从人类成纤维细胞获得的iPS细胞(诱导多能干细胞)。将iPS以每孔250 000个细胞的比例接种在包被有薄层的6孔板(Corning)中的分化培养基中，所述培养基由增补有10％Knockout血清替代物(KSR，Life technologies)、5μM CHIR 99021(Tocris)、0.1μM视黄酸(Sigma)、1μg/ml EPO(红细胞生成素；Peprotech)、中心分化途径抑制剂混合物和1％PS抗生素(青霉素-链霉素；Panbiotech)的DMEM-F12(Panbiotech)构成。将所述细胞在37℃和5％CO2下在培养物中维持6天。每2天更换培养基。在这些培养条件下，所述iPS分化成人类感觉神经元。
在这个阶段，使用accutase(Sigma Aldrich)将细胞在37℃下解离10分钟。通过添加培养基终止反应。将细胞悬液以1200rpm离心5分钟。通过使用锥虫蓝的细胞计数确立细胞存活率，并将所述细胞以每孔20 000个细胞的比例接种在包被有薄层的96孔板中的分化培养基中。
将来自于成年供体的角化细胞(Lonza)在角化细胞生长培养基(Lonza)中预扩增一个循环的过程，然后通过胰蛋白酶处理进行解离，并冷冻。将这些角化细胞融化并在角化细胞生长培养基中再次扩增一个循环的过程。
在所述神经元在96孔板中粘附24小时后，通过胰蛋白酶处理解离所述角化细胞。通过细胞计数确立细胞存活率，并将角化细胞以每孔30 000个细胞的比例接种在所述神经元上方的由2/3的感觉神经元成熟培养基和1/3的角化细胞生长培养基构成的培养基中。所述成熟培养基由增补有1％N2(Life technologies)、1％PS、10ng/ml NGF(神经生长因子；Sigma Aldrich)、10ng/ml BDNF(脑源性神经营养因子；PanBiotech)、10ng/ml NT3(神经营养因子-3；PanBiotech)和10ng/ml GDNF(神经胶质细胞源性神经营养因子；PanBiotech)的DMEM-F12构成。
1.2.永久花精油的细胞毒性
在第一次培养中，在共培养24小时后，将培养基更换为由2/3的无生长因子的人类感觉神经元成熟培养基和1/3的角化细胞生长培养基构成的培养基，其中存在或不存在0.001％至0.01％范围内的各种不同浓度下的所试验的化合物。对于每种浓度来说，使用6个孔来进行培养。
在温浴48小时后，将细胞固定在终浓度为2％的聚甲醛(Sigma)的培养基溶液中，然后将细胞用磷酸盐缓冲液(PBS，PanBiotech)清洗两次。用含有0.1％皂苷(Sigma)、5％山羊血清(GS；PanBiotech)和1％BSA(牛血清白蛋白；Panbiotech)的PBS溶液在环境温度下，阻断非特异性位点15分钟。随后将所述细胞在以1/400在含有5％GS和0.1％皂苷的PBS中稀释的抗β-微管蛋白小鼠单克隆抗体(Sigma)存在下，在4℃温浴2小时。所述抗β-微管蛋白抗体标记细胞体和人类感觉神经元突起。这种抗体用以1/400在含有5％GS、0.1％皂苷和1％BSA的PBS溶液中稀释的山羊抗小鼠IgG抗体Alexa Fluor 488(Molecular Probe)，在环境温度下和暗处反应1小时来揭示。细胞核用以1/10 000在与第二抗体相同的溶液中稀释的作为核荧光标志物的Hoechst(Sigma)的溶液染色。
使用自动显微镜(InCell 2000；GE Healthcare)，以x20的放大倍数获取每个培养孔的20张照片。
1.3.永久花精油对神经突生长的影响的评估
在第二次培养中，在共培养24小时后，将培养基更换为由2/3的无生长因子的人类感觉神经元成熟培养基和1/3的角化细胞生长培养基构成的培养基，其中存在或不存在各种不同浓度的所试验的化合物或由50ng/ml NGF构成的参比分子。天然存在于表皮中的NGF或神经生长因子已知在体外刺激神经突伸长。每个试验的浓度使用6个孔进行培养。
将所述培养维持6天，并在3天后更换含有所述研究的化合物的培养基。
在培养6天后，除去培养基，并将细胞用终浓度为2％的聚甲醛在培养基中的溶液固定，然后将细胞用PBS清洗两次。用含有0.1％皂苷、5％山羊血清和1％BSA的PBS溶液在环境温度下，阻断非特异性位点15分钟。随后将所述细胞在以1/400在含有5％GS和0.1％皂苷的PBS中稀释的抗β-微管蛋白小鼠单克隆抗体存在下，在4℃温浴2小时。所述抗β-微管蛋白抗体标记细胞体和人类感觉神经元突起。这种抗体用以1/400在含有5％GS、0.1％皂苷和1％BSA的PBS溶液中稀释的山羊抗小鼠IgG抗体Alexa Fluor 488，在环境温度下和暗处反应1小时来揭示。细胞核用以1/10 000在与第二抗体相同的溶液中稀释的作为核荧光标记物的Hoechst(Sigma)的溶液染色。
使用自动显微镜(InCell 2000；GE Healthcare)，以x20的放大倍数获取每个培养孔的20张照片，并对感觉神经元的细胞体进行计数。也测量突起的长度并针对标记的神经元细胞体的数目进行标准化。将在使用待评估的化合物和NGF的处理条件下获得的结果与对照培养基进行比较。
1.4.统计研究
统计研究使用单向ANOVA检验来进行。
2.结果
2.1.永久花精油的细胞毒性
所述永久花精油在评估的浓度下对人类感觉神经元没有毒性。
2.2.永久花精油对神经突生长的影响的评估
所述永久花精油在评估的浓度下不引起人类感觉神经元数目的任何调整。这与在细胞毒性研究期间获得的结果相符。
50ng/ml的NGF引起人类感觉神经元的突起长度的增加(+22.8％，p<0.05)。这一结果验证了所述实验。
所述永久花精油在0.01％、0.005％和0.001％的浓度下引起感觉神经元的突起长度的显著增加(分别增加35.8％p<0.001、30.8％p<0.001和40.3％p<0.001)。
3.结论
所述永久花精油通过在与角化细胞的共培养物中增加人类感觉神经元的突起长度，而提高神经分布的密度。
实施例2：美容组合物
下述组合物以对于本领域技术人员来说常规的方式，通过将下述成分以指定的重量比例混合来制备：
Claims (8)
1.永久花精油的美容用途，其被局部施用到皮肤，用于提高或恢复皮肤触觉，特别是用于对抗由衰老造成的皮肤触觉降低。
2.权利要求1的用途，其特征在于所述永久花选自以下物种：意大利腊菊(Helichrysumitalicum)、沙生蜡菊(Helichrysum arenarium)和法国腊菊(Helichrysum stoechas)，优选为意大利腊菊。
3.权利要求1或2的用途，其特征在于所述精油被施用到面部和/或手部的皮肤。
4.权利要求1至3任一项的用途，其特征在于所述精油被施用到老年个体的皮肤。
5.权利要求1至4任一项的用途，其特征在于所述精油被包含在水包油或油包水乳液形式的组合物中。
6.权利要求5的用途，其特征在于所述组合物含有相对于所述组合物的总重量，0.001重量％至5重量％、优选地0.01重量％至2重量％的永久花精油。
7.一种用于提高或恢复皮肤触觉、特别是用于对抗由衰老造成的皮肤触觉降低的美容方法，所述方法包括向皮肤局部施用永久花精油。
8.一种永久花精油，其用于通过施用到患有周围神经病、神经退行性疾病、或创伤例如烧伤后神经末梢破坏的个体的皮肤，而在旨在提高或恢复皮肤触觉的治疗中局部使用。
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| Application Number | Priority Date | Filing Date | Title |
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| FR1656292A FR3053250B1 (fr) | 2016-07-01 | 2016-07-01 | Utilisation d'une huile essentielle d'immortelle pour augmenter ou restaurer la perception tactile cutanee |
| FR1656292 | 2016-07-01 | ||
| PCT/FR2017/051610 WO2018002475A1 (fr) | 2016-07-01 | 2017-06-20 | Utilisation d'une huile essentielle d'immortelle pour augmenter ou restaurer la perception tactile cutanée |
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| CN109715136A true CN109715136A (zh) | 2019-05-03 |
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| US (1) | US20190151229A1 (zh) |
| EP (1) | EP3478262A1 (zh) |
| JP (1) | JP7125354B2 (zh) |
| CN (1) | CN109715136A (zh) |
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| FR3079144B1 (fr) * | 2018-03-20 | 2020-12-25 | Laboratoires M&L | Composition cosmetique comprenant une huile essentielle d'immortelle et un extrait huileux de dreches d'immortelle |
| FR3130556A1 (fr) | 2021-12-16 | 2023-06-23 | L'oreal | Utilisation d’acide salicylique et/ou de ses dérivés et/ou de leurs sels, pour augmenter ou restaurer la perception tactile cutanée |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012066097A1 (en) * | 2010-11-17 | 2012-05-24 | L'oreal | Cosmetic composition for caring for and / or make up for the face and eyes |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4633897B2 (ja) | 2000-08-17 | 2011-02-16 | 長瀬産業株式会社 | 神経突起伸長剤 |
| FR2829145B1 (fr) | 2001-08-29 | 2004-12-03 | Occitane L | Huile essentielle extraite helichrysum italicum, sa preparation et les compositions cosmetiques et dermatologiques la contenant |
| KR100465971B1 (ko) | 2001-12-07 | 2005-01-13 | 주식회사 태평양 | 항염효과를 갖는 커리플랜트로부터 추출한 헤리크리섬오일 및 그를 함유한 화장료 조성물 |
| FR2903014B1 (fr) | 2006-06-30 | 2008-09-26 | Occitane L | Composition cosmetique a base d'acide gras polyinsatures et ses utilisations |
| JP2008101129A (ja) | 2006-10-19 | 2008-05-01 | Shiono Koryo Kk | 香料組成物およびそれが配合された化粧料 |
| FR2935610B1 (fr) | 2008-09-05 | 2010-10-29 | Lvmh Rech | Composition cosmetique ou dermatologique contenant un melange d'huiles essentielles et son utilisation, notamment pour le soin des peaux sensibles ou sensibilisees |
| JP5667358B2 (ja) | 2009-06-03 | 2015-02-12 | 富士産業株式会社 | 柑橘類果皮の麹菌発酵組成物 |
| EP2532355A1 (en) * | 2011-06-06 | 2012-12-12 | Nestec S.A. | Chicory for prevention and treatment of neurodegeneration |
| KR20130107982A (ko) | 2012-03-23 | 2013-10-02 | 경희대학교 산학협력단 | 붉은 동충하초 추출물을 포함하는 신경돌기 성장 촉진제 |
| CN103385818A (zh) | 2012-05-11 | 2013-11-13 | 苏州纳特苏生物科技有限公司 | 一种晒后美白的复方精油 |
-
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-
2017
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012066097A1 (en) * | 2010-11-17 | 2012-05-24 | L'oreal | Cosmetic composition for caring for and / or make up for the face and eyes |
| US20130315650A1 (en) * | 2010-11-17 | 2013-11-28 | L'oreal | Cosmetic composition for face and the area around the eyes |
Non-Patent Citations (5)
| Title |
|---|
| D. ANTUNES VIEGAS ，等: "Helichrysum italicum: From traditional use to scientific data", 《JOURNAL OF ETHNOPHARMACOLOGY》 * |
| FATEMEH MOOSAVI，等: "Modulation of neurotrophic signaling pathways by polyphenols", 《DRUG DESIGN, DEVELOPMENT AND THERAPY》 * |
| SANDEEP VASANT MORE等: "《The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth》", 《MOLECULES》 * |
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
| 马永兴等: "《现代衰老学》", 30 September 2008 * |
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| US20190151229A1 (en) | 2019-05-23 |
| EP3478262A1 (fr) | 2019-05-08 |
| JP7125354B2 (ja) | 2022-08-24 |
| JP2019520386A (ja) | 2019-07-18 |
| FR3053250B1 (fr) | 2020-11-27 |
| WO2018002475A1 (fr) | 2018-01-04 |
| FR3053250A1 (fr) | 2018-01-05 |
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