CN109692273A - 一种用于治疗皮肤真菌感染的外用药物 - Google Patents

一种用于治疗皮肤真菌感染的外用药物 Download PDF

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CN109692273A
CN109692273A CN201910029603.7A CN201910029603A CN109692273A CN 109692273 A CN109692273 A CN 109692273A CN 201910029603 A CN201910029603 A CN 201910029603A CN 109692273 A CN109692273 A CN 109692273A
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周东伟
陈国忠
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Yiyukang Traditional Chinese Medicine Health Care (jiangsu) Co Ltd
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Abstract

本发明公开了一种用于治疗皮肤真菌感染的外用药物，外用药物含有如下组成成分：蛇床子30‑100份，苦楝皮30‑100份，明矾50‑150份，花椒30‑120份，金银花粉末30‑100份，补骨脂30‑100份，玉竹30‑100份，龙衣20‑80份，蝉蜕30‑120份，蛇舌草50‑200份，黄芩30‑100份,黄连50‑150份，黄柏30‑120份，蒲公英粉末50‑150份，连翘30‑120份，蜂房40‑120份。本发明采用传统中药为原料加以制备，成本低，制备工艺简单，对由真菌感染引起的皮肤病具有显著的治疗作用，能够清热解毒、化湿杀虫、行气活血、解表散热、凉血止血、消肿生肌、化瘀止痛、祛风止痒，且降低毒副作用，效果好，同时毒副作用少，具有很高的推广价值。

Description

一种用于治疗皮肤真菌感染的外用药物
技术领域
本发明涉及真菌感染药物相关领域，具体为一种用于治疗皮肤真菌感染的外用药物。
背景技术
皮肤是人体最大的器官，作为人体的第一道生理防线主要承担着保护身体、排汗、感觉冷热和压力等功能。皮肤覆盖全身，它使体内各种组织和器官免受物理性、机械性、化学性和病原微生物性的侵袭。皮肤病是严重影响人民健康的常见病、多发病之一，其病因有很多，其中真菌感染类型居多。但是，目前抗菌素类药物被广泛、大量地使用，导致致病菌的耐药性不断提高，继发性感染和混合感染不断发生。
皮肤受到真菌感染时就会产生相应的疾病，如手癣、脚癣、股癣、花斑癣等，局部红、肿、热、痒、甚至出现水疱、皮肤角化、糜烂，临床上主要采用抗真菌药膏涂抹治疗，这样毒副作用大、治疗效果不佳、且灭菌不彻底，容易复发，给医务人员增加了极大的工作难度，同时对于疾病患者来说，在耗费了大量时间和金钱后仍然无法取得理想的疗效。
发明内容
本发明的目的在于提供一种用于治疗皮肤真菌感染的外用药物，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：一种用于治疗皮肤真菌感染的外用药物，外用药物含有如下组成成分：蛇床子30-100份，苦楝皮30-100份，明矾50-150份，花椒30-120份，金银花粉末30-100份，补骨脂30-100份，玉竹30-100份，龙衣20-80份，蝉蜕30-120份，蛇舌草50-200份，黄芩30-100份,黄连50-150份，黄柏30-120份，蒲公英粉末50-150份，连翘30-120份，蜂房40-120份。
优选的，所述外用药物含有如下组成成分和含量：蛇床子50份，苦楝皮30份，明矾50份，花椒40份，金银花粉末30份，补骨脂30份，玉竹30份，龙衣40份，蝉蜕25份，蛇舌草50份，黄芩30份，黄连50份，黄柏40份，蒲公英粉末50份，连翘30份，蜂房60份。
优选的，所述蒲公英粉末由如下方法制得：称取干燥蒲公英药材并置于中药磨粉机中研磨10~20min，过筛网备用。
优选的，所述金银花粉末由如下方法制得：称取干燥金银花药材，清洗，干燥并置于中药磨粉机中研磨5~10min，过筛网备用。
本发明还提供了上述外用药物的制备方法，包括以下步骤：
S1：按如下质量百分比分别称量下述各组分：蛇床子50份，苦楝皮30份，明矾50份，花椒40份，金银花粉末30份，补骨脂30份，玉竹30份，龙衣40份，蝉蜕25份，蛇舌草50份，黄芩30份，黄连50份，黄柏40份，蒲公英粉末50份，连翘30份，蜂房60份；
S2：将S1中蛇床子、苦楝皮、花椒、补骨脂、玉竹、龙衣、蝉蜕、黄芩、蛇舌草、黄连、黄柏、连翘洗净并放入干燥机中干燥；
S3：将S2中干燥后的各药材加入粉碎机内进行混合粉碎，将S1中明矾、蜂房加入粉碎机进行混合粉碎得混合物一；
S4：将S1中金银花粉末及蒲公英粉末置于粉碎机内与S3中制得的混合物一进行混合搅打，得到混合物二；
S5：将S4中得到的混合物二加入灭菌容器中，向灭菌容器中加入清水浸泡得混合液一；
S6：将S5中制得的混合液一加入煮锅中煮沸浓缩，并得浓缩液一。
优选的，将S6制得的浓缩液一进行冷却、过滤，二次高温消毒后装瓶待用。
与现有技术相比，本发明的有益效果是：
本发明采用传统中药为原料加以制备，成本低，制备工艺简单，对由真菌感染引起的皮肤病具有显著的治疗作用，能够清热解毒、化湿杀虫、行气活血、解表散热、凉血止血、消肿生肌、化瘀止痛、祛风止痒，且降低毒副作用，效果好，同时毒副作用少，具有很高的推广价值。
具体实施方式
下面对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1：本发明提供一种用于治疗皮肤真菌感染的外用药物，外用药物含有如下组成成分：蛇床子30-100份，苦楝皮30-100份，明矾50-150份，花椒30-120份，金银花粉末30-100份，补骨脂30-100份，玉竹30-100份，龙衣20-80份，蝉蜕30-120份，蛇舌草50-200份，黄芩30-100份,黄连50-150份，黄柏30-120份，蒲公英粉末50-150份，连翘30-120份，蜂房40-120份。
上述外用药物的制备方法，包括以下步骤：
S1：按如下质量百分比分别称量下述各组分：蛇床子50份，苦楝皮30份，明矾50份，花椒40份，金银花粉末30份，补骨脂30份，玉竹30份，龙衣40份，蝉蜕25份，蛇舌草50份，黄芩30份，黄连50份，黄柏40份，蒲公英粉末50份，连翘30份，蜂房60份；
S2：将S1中蛇床子、苦楝皮、花椒、补骨脂、玉竹、龙衣、蝉蜕、黄芩、蛇舌草、黄连、黄柏、连翘洗净并放入干燥机中干燥；
S3：将S2中干燥后的各药材加入粉碎机内进行混合粉碎，将S1中明矾、蜂房加入粉碎机进行混合粉碎得混合物一；
S4：将S1中金银花粉末及蒲公英粉末置于粉碎机内与S3中制得的混合物一进行混合搅打，得到混合物二；
S5：将S4中得到的混合物二加入灭菌容器中，向灭菌容器中加入清水浸泡得混合液一；
S6：将S5中制得的混合液一加入煮锅中煮沸浓缩，并得浓缩液一。
实施例2：
实施例2与上述实施例材料、加工步骤相同，不同之处在于两者的配比不同。
S1：按如下质量百分比分别称量下述各组分：蛇床子70份，苦楝皮30份，明矾50份，花椒60份，金银花粉末30份，补骨脂50份，玉竹30份，龙衣20份，蝉蜕50份，蛇舌草80份，黄芩30份,黄连70份，黄柏30份，蒲公英粉末50份，连翘70份，蜂房40份；
S2：将S1中蛇床子、苦楝皮、花椒、补骨脂、玉竹、龙衣、蝉蜕、黄芩、蛇舌草、黄连、黄柏、连翘洗净并放入干燥机中干燥；
S3：将S2中干燥后的各药材加入粉碎机内进行混合粉碎，将S1中明矾、蜂房加入粉碎机进行混合粉碎得混合物一；
S4：将S1中金银花粉末及蒲公英粉末置于粉碎机内与S3中制得的混合物一进行混合搅打，得到混合物二；
S5：将S4中得到的混合物二加入灭菌容器中，向灭菌容器中加入清水浸泡得混合液一；
S6：将S5中制得的混合液一加入煮锅中煮沸浓缩，并得浓缩液一。
实施例3：
实施例3与上述实施例材料、加工步骤相同，不同之处在于两者的配比不同。
S1：按如下质量百分比分别称量下述各组分：蛇床子50份，苦楝皮60份，明矾70份，花椒30份，金银花粉末60份，补骨脂30份，玉竹50份，龙衣40份，蝉蜕60份，蛇舌草50份，黄芩50份,黄连70份，黄柏50份，蒲公英粉末100份，连翘50份，蜂房70份。
S2：将S1中蛇床子、苦楝皮、花椒、补骨脂、玉竹、龙衣、蝉蜕、黄芩、蛇舌草、黄连、黄柏、连翘洗净并放入干燥机中干燥；
S3：将S2中干燥后的各药材加入粉碎机内进行混合粉碎，将S1中明矾、蜂房加入粉碎机进行混合粉碎得混合物一；
S4：将S1中金银花粉末及蒲公英粉末置于粉碎机内与S3中制得的混合物一进行混合搅打，得到混合物二；
S5：将S4中得到的混合物二加入灭菌容器中，向灭菌容器中加入清水浸泡得混合液一；
S6：将S5中制得的混合液一加入煮锅中煮沸浓缩，并得浓缩液一。
按实施例1-3中所述配比与制备方法所制得的外用药物，对其菌落生长情况和菌落抑制率等方面进行测试，结果通过A、B、C、D进行评定，如下表所示：
样品 菌落生长情况 菌落抑制率
实施例1 A B
实施例2 A A
实施例3 A C
由表中可以看出，按照实施例2中所述配比与制备方法所制得的外用药物，在其菌落生长情况和菌落抑制率方面效果较好。
本发明采用传统中药为原料加以制备，成本低，制备工艺简单，对由真菌感染引起的皮肤病具有显著的治疗作用，能够清热解毒、化湿杀虫、行气活血、解表散热、凉血止血、消肿生肌、化瘀止痛、祛风止痒，且降低毒副作用，效果好，同时毒副作用少，具有很高的推广价值。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。

Claims (6)

1.一种用于治疗皮肤真菌感染的外用药物，其特征在于，所述外用药物含有如下组成成分：蛇床子30-100份，苦楝皮30-100份，明矾50-150份，花椒30-120份，金银花粉末30-100份，补骨脂30-100份，玉竹30-100份，龙衣20-80份，蝉蜕30-120份，蛇舌草50-200份，黄芩30-100份,黄连50-150份，黄柏30-120份，蒲公英粉末50-150份，连翘30-120份，蜂房40-120份。
2.根据权利要求1所述的一种用于治疗皮肤真菌感染的外用药物，其特征在于，所述外用药物含有如下组成成分和含量：蛇床子50份，苦楝皮30份，明矾50份，花椒40份，金银花粉末30份，补骨脂30份，玉竹30份，龙衣40份，蝉蜕25份，蛇舌草50份，黄芩30份，黄连50份，黄柏40份，蒲公英粉末50份，连翘30份，蜂房60份。
3.根据权利要求1所述的一种用于治疗皮肤真菌感染的外用药物，其特征在于，所述蒲公英粉末由如下方法制得：称取干燥蒲公英药材并置于中药磨粉机中研磨10~20min，过筛网备用。
4.根据权利要求1所述的一种用于治疗皮肤真菌感染的外用药物，其特征在于，所述金银花粉末由如下方法制得：称取干燥金银花药材，清洗，干燥并置于中药磨粉机中研磨5~10min，过筛网备用。
5.根据权利要求1-4任一所述的一种用于治疗皮肤真菌感染的外用药物的制备方法，其特征在于，包括以下步骤：
S1：按如下质量百分比分别称量下述各组分：蛇床子50份，苦楝皮30份，明矾50份，花椒40份，金银花粉末30份，补骨脂30份，玉竹30份，龙衣40份，蝉蜕25份，蛇舌草50份，黄芩30份，黄连50份，黄柏40份，蒲公英粉末50份，连翘30份，蜂房60份；
S2：将S1中蛇床子、苦楝皮、花椒、补骨脂、玉竹、龙衣、蝉蜕、黄芩、蛇舌草、黄连、黄柏、连翘洗净并放入干燥机中干燥；
S3：将S2中干燥后的各药材加入粉碎机内进行混合粉碎，将S1中明矾、蜂房加入粉碎机进行混合粉碎得混合物一；
S4：将S1中金银花粉末及蒲公英粉末置于粉碎机内与S3中制得的混合物一进行混合搅打，得到混合物二；
S5：将S4中得到的混合物二加入灭菌容器中，向灭菌容器中加入清水浸泡得混合液一；
S6：将S5中制得的混合液一加入煮锅中煮沸浓缩，并得浓缩液一。
6.根据权利要求5所述的一种用于治疗皮肤真菌感染的外用药物的制备方法，其特征在于，将S6制得的浓缩液一进行冷却、过滤，二次高温消毒后装瓶待用。
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