CN109689879A - 茯苓发酵产物及其制法 - Google Patents
茯苓发酵产物及其制法 Download PDFInfo
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- CN109689879A CN109689879A CN201780055209.XA CN201780055209A CN109689879A CN 109689879 A CN109689879 A CN 109689879A CN 201780055209 A CN201780055209 A CN 201780055209A CN 109689879 A CN109689879 A CN 109689879A
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- poria cocos
- acid
- tunning
- sour
- solid state
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (5)
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US201662383864P | 2016-09-06 | 2016-09-06 | |
US62/383,864 | 2016-09-06 | ||
US201762463418P | 2017-02-24 | 2017-02-24 | |
US62/463,418 | 2017-02-24 | ||
PCT/CN2017/100537 WO2018045946A1 (fr) | 2016-09-06 | 2017-09-05 | Produit de fermentation de poria cocos et son procédé de préparation |
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CN (1) | CN109689879A (fr) |
TW (1) | TWI679983B (fr) |
WO (1) | WO2018045946A1 (fr) |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102091100A (zh) * | 2009-12-15 | 2011-06-15 | 云南云百草生物技术有限公司 | 茯苓与蛹虫草固体共发酵提高主要药用成分的方法 |
TW201404313A (zh) * | 2012-07-31 | 2014-02-01 | Su-Der Chen | 茯苓固態發酵產物及其製造方法 |
CN103864504A (zh) * | 2012-12-12 | 2014-06-18 | 四川省中医药科学院 | 培养食药用菌的固体发酵基质及其制备方法和用途 |
CN104357524A (zh) * | 2014-10-10 | 2015-02-18 | 福建农林大学 | 一种使茯苓高产三萜酸的纯小麦培养基及其制备方法 |
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CN102523922B (zh) * | 2012-01-13 | 2013-09-11 | 河南科技大学 | 一种培养茯苓子实体的培养方法 |
CN103710212A (zh) * | 2013-12-16 | 2014-04-09 | 彭聪 | 一种土茯苓酒的酿造方法 |
TWI547284B (zh) * | 2014-05-21 | 2016-09-01 | 杏輝藥品工業股份有限公司 | 茯苓萃取物及其製備方法與應用 |
CN104256831B (zh) * | 2014-10-27 | 2016-05-11 | 福建农林大学 | 一种茯苓固态发酵型饮料及其制作方法 |
CN104686202A (zh) * | 2015-03-20 | 2015-06-10 | 江南大学 | 虫草红薯 |
-
2017
- 2017-09-05 TW TW106130282A patent/TWI679983B/zh active
- 2017-09-05 CN CN201780055209.XA patent/CN109689879A/zh active Pending
- 2017-09-05 WO PCT/CN2017/100537 patent/WO2018045946A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102091100A (zh) * | 2009-12-15 | 2011-06-15 | 云南云百草生物技术有限公司 | 茯苓与蛹虫草固体共发酵提高主要药用成分的方法 |
TW201404313A (zh) * | 2012-07-31 | 2014-02-01 | Su-Der Chen | 茯苓固態發酵產物及其製造方法 |
CN103864504A (zh) * | 2012-12-12 | 2014-06-18 | 四川省中医药科学院 | 培养食药用菌的固体发酵基质及其制备方法和用途 |
CN104357524A (zh) * | 2014-10-10 | 2015-02-18 | 福建农林大学 | 一种使茯苓高产三萜酸的纯小麦培养基及其制备方法 |
Non-Patent Citations (4)
Title |
---|
RIOS, JL: "Chemical Constituents and Pharmacological Properties of Poria cocos", 《PLANTA MEDICA》 * |
余梦瑶等: "两种茯苓固体发酵菌质的制备及其主要成分含量测定", 《中国食用菌》 * |
屈直等: "茯苓菌种选育及生产技术研究进展 ", 《西南农业学报》 * |
秦晓瑜等: "固态发酵炮制中药材研究进展", 《中药材》 * |
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WO2018045946A1 (fr) | 2018-03-15 |
TWI679983B (zh) | 2019-12-21 |
TW201811351A (zh) | 2018-04-01 |
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