CN109689692A - 用于肿瘤治疗的双特异性抗体和抗体偶联物及其应用 - Google Patents

用于肿瘤治疗的双特异性抗体和抗体偶联物及其应用 Download PDF

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CN109689692A
CN109689692A CN201780038865.9A CN201780038865A CN109689692A CN 109689692 A CN109689692 A CN 109689692A CN 201780038865 A CN201780038865 A CN 201780038865A CN 109689692 A CN109689692 A CN 109689692A
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antibody
cell
vhh
muc1
bispecific antibody
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CN109689692B (zh
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于浩洋
王�忠
李正成
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Benhealth Biopharmaceutic Shenzhen Co ltd
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Benhealth Biopharmaceutic Shenzhen Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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Abstract

本发明提供一种双特异性抗体，其包含抗MUC1 VHH的抗体片段和抗CD16 VHH的抗体片段。本发明使用的抗体片段为来自骆驼重链抗体的可变区序列，与抗原具有高结合亲和性。本发明将识别MUC1和识别CD16的抗体片段构建在同一抗体分子中，可以特异性结合MUC1和CD16分子，促进NK细胞对MUC1阳性表达细胞的杀伤作用，对MUC1阳性肿瘤的生长起到抑制的作用。本发明还提供所述双特异性抗体的偶联物、相关的药物组合物和应用。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201780038865.9A 2016-06-22 2017-06-21 用于肿瘤治疗的双特异性抗体和抗体偶联物及其应用 Active CN109689692B (zh)

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CN2016104567918 2016-06-22
CN201610456791 2016-06-22
CN201710052692 2017-01-24
CN2017100526928 2017-01-24
PCT/CN2017/089307 WO2017219974A1 (zh) 2016-06-22 2017-06-21 用于肿瘤治疗的双特异性抗体和抗体偶联物及其应用

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US11000603B2 (en) 2015-04-14 2021-05-11 Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. Multi-specific binding conjugate, related pharmaceutical compositions and use
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EP3450460B1 (en) * 2016-04-29 2023-07-12 Benhealth Biopharmaceutic (Shenzhen) Co. Ltd. Multi-specific binding conjugate, related pharmaceutical compositions and use
WO2017219974A1 (zh) 2016-06-22 2017-12-28 本康生物制药（深圳）有限公司 用于肿瘤治疗的双特异性抗体和抗体偶联物及其应用
CN110382550A (zh) * 2017-01-24 2019-10-25 本康生物制药（深圳）有限公司 抗体偶联物、相关的药物组合物及应用
US20230340157A1 (en) * 2019-09-27 2023-10-26 Beijing Starmab Biomed Technology Ltd Monospecific and multi-specific antibodies

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CN105431378A (zh) * 2014-06-25 2016-03-23 生物辐射实验室股份有限公司 纳米粒子-抗体偶联物的纯化
CN104800838A (zh) * 2015-04-14 2015-07-29 苏静 MUC1-Fc多肽疫苗及其制备方法和应用
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