CN109674813A - For improving the compound formulation of buck physiological function - Google Patents
For improving the compound formulation of buck physiological function Download PDFInfo
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- CN109674813A CN109674813A CN201811518894.8A CN201811518894A CN109674813A CN 109674813 A CN109674813 A CN 109674813A CN 201811518894 A CN201811518894 A CN 201811518894A CN 109674813 A CN109674813 A CN 109674813A
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- fucose
- buck
- alginic acid
- chitosan oligosaccharide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Molecular Biology (AREA)
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- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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Abstract
The present invention discloses a kind of for adjusting the compound formulation of buck physiological function, and raw material percentage composition is as follows: alginic acid oligosaccharides 1 ~ 25%, chitosan oligosaccharide 1 ~ 25%, fucose 1 ~ 25%, surplus maize cob meal；The alginic acid oligosaccharides degree of polymerization is 2 ~ 10, and mannuronic acid and guluronic acid composition ratio are 7 ~ 3:3 ~ 2, and average molecular weight is 300 ~ 3000 Da；The chitosan oligosaccharide degree of polymerization is 2 ~ 20, deacetylation at least 95%, and average molecular weight is 300 ~ 4000 Da；The fucose is α-L-type fucose, purity at least 85%.It is bright to improve animal sperm quantity and quality (linear motion sperm quantity), increase the testis and epididymis weight of animal, enhance Reproductive Performance, extends good species buck service life, raising reproductive capacity；Effect stability is reliable, is applicable in animal range extensively and has no toxic side effect, is pollution-free, long-time using effect is more preferably.
Description
Technical field
The invention belongs to natural products development technique fields and agricultural breeding field, more particularly to one kind is for adjusting male
The compound formulation of animal physiological function.
Background technique
As the improvement of people's living standards, demand of the people to meat, eggs and milk is growing.Accelerating livestock and poultry breeding industry
During sound development, breeding is important link, is only improved animal reproduction ability, could fundamentally increase livestock and poultry quantity and
Improve quality.Therefore, how to keep buck constitution strong, enhance reproductive organs function, it is ensured that semen quality is excellent, makes hero
Property animal have vigorous breeding capacity, improve conception rate, the breeding service life for extending excellent breeding stock is current reality
Production and research work problem in the urgent need to address.
Summary of the invention
The present invention provides a kind of raw for adjusting buck to solve above-mentioned technical problem present in the prior art
Manage the compound formulation of function.
The technical solution of the invention is as follows: a kind of for adjusting the compound formulation of buck physiological function, raw material group
As follows at percentage: alginic acid oligosaccharides 1 ~ 25%, chitosan oligosaccharide 1 ~ 25%, fucose 1 ~ 25%, surplus are the corncobs as carrier
Powder；The alginic acid oligosaccharides degree of polymerization is that 2 ~ 10, wherein mannuronic acid and guluronic acid composition ratio are 7 ~ 3:3 ~ 2, is put down
Average molecular weight is 300 ~ 3000 Da；The chitosan oligosaccharide degree of polymerization be 2 ~ 20, deacetylation at least 95%, average molecular weight be 300 ~
4000 Da；The fucose is α-L-type fucose, purity at least 85%.
Raw material percentage composition are as follows: alginic acid oligosaccharides 10 ~ 15%, chitosan oligosaccharide 10 ~ 15%, fucose 10 ~ 15%, surplus are to make
For the maize cob meal of carrier.
The present invention can improve animal sperm quantity and quality (linear motion sperm quantity), increase the testis and epididymis of animal
Weight enhances Reproductive Performance, extends good species buck service life, raising reproductive capacity；Effect stability is reliable, is applicable in dynamic
Object range is wide and has no toxic side effect, is pollution-free, and long-time using effect is more preferably.
Specific embodiment
Embodiment 1:
The present invention is used to adjust the compound formulation of buck physiological function, and raw material percentage composition is as follows: alginic acid oligosaccharides
25%, chitosan oligosaccharide 1%, fucose 25%, the maize cob meal surplus 49% as carrier.The alginic acid oligosaccharides degree of polymerization used is 2 ~ 10,
Wherein mannuronic acid and guluronic acid composition ratio are 7 ~ 3:3 ~ 2, and average molecular weight is 300 ~ 3000 Da；The shell is few
The sugared degree of polymerization is 2 ~ 20, deacetylation at least 95%, and average molecular weight is 300 ~ 4000 Da；The fucose is α-L-type rock algae
Sugar, purity at least 85%.
Embodiment 2:
The present invention is used to adjust the compound formulation of buck physiological function, and raw material percentage composition is as follows: alginic acid oligosaccharides
20%, chitosan oligosaccharide 10%, fucose 2%, the maize cob meal surplus 68% as carrier.The alginic acid oligosaccharides degree of polymerization used is 2 ~ 10,
Wherein mannuronic acid and guluronic acid composition ratio are 7 ~ 3:3 ~ 2, and average molecular weight is 300 ~ 3000 Da；The shell is few
The sugared degree of polymerization is 2 ~ 20, deacetylation at least 95%, and average molecular weight is 300 ~ 4000 Da；The fucose is α-L-type rock algae
Sugar, purity at least 85%.
Embodiment 3:
The present invention is used to adjust the compound formulation of buck physiological function, and raw material percentage composition is as follows: alginic acid oligosaccharides
15%, chitosan oligosaccharide 15%, fucose 15%, the maize cob meal surplus 55% as carrier.The alginic acid oligosaccharides degree of polymerization used is 2 ~ 10,
Wherein mannuronic acid and guluronic acid composition ratio are 7 ~ 3:3 ~ 2, and average molecular weight is 300 ~ 3000 Da；The shell is few
The sugared degree of polymerization is 2 ~ 20, deacetylation at least 95%, and average molecular weight is 300 ~ 4000 Da；The fucose is α-L-type rock algae
Sugar, purity at least 85%.
Alginic acid oligosaccharides described above, chitosan oligosaccharide, fucose, the equal buyable of maize cob meal obtain.
In order to further explain effect of the invention, following test is provided:
This test takes 120 (18 ± 2 grams of weight) cleaning grade Kunming kind Healthy females, male mice (60 females, 60 heros
Property), provided by Dalian Medical Univ's Experimental Animal Center, approval number is SCXK(the Liao Dynasty) 2008-0002, the feeding of cleaning grade animal house
It supports.It is randomly divided into control group (female, 1 group of Xiong Ge), alginic acid oligosaccharides group (female, 1 group of Xiong Ge), chitosan oligosaccharide group (female, male each 1
Group) and glycoconjugate group (female, 1 group of Xiong Ge), totally 8 groups (female, 4 group of Xiong Ge), 15 mouse of every group.Control group mice
Feeding arm's length basis daily ration, formula are shown in (table 1) that alginic acid oligosaccharides group is added described in the embodiment of the present invention 1 ~ 3 in basal diet
Alginic acid oligosaccharides, chitosan oligosaccharide group add 1 ~ 3 chitosan oligosaccharide of the embodiment of the present invention in basal diet, and glycoconjugate group is in basal diet
Compound formulation prepared by the embodiment of the present invention 3 is added, each group additive amount is 300 mg/kg.Basal diet composition and nutrition at
Divide and is shown in Table 1.
1 experimental basis daily ration of table composition and nutritional ingredient
Note: every kg Basic drawing contains Fe 60, Cu 20, Mn 100, Se 0.3,10.4 mg；VA 60 mg of 10000 IU, VE,
VD 1500 IU, VK 0.5 mg, VB 15 mg, VB 220 mg, VB 63 mg, VB 120.02 mg, 20 mg of niacin, pantothenic acid
20 mg, 1.5 mg of folic acid, 0.4 mg of biotin.
Test 1:
After the feeding of each group mouse is 4 weeks full, control group, alginic acid oligosaccharides group, chitosan oligosaccharide group and glycoconjugate group each group mouse are carried out
Female, male mouse (1:1) between group mates mating breeding.Female mice records the first tire of female mice reproductive performance through the gestational period, childbirth phase
(see Table 2), from table 2 it can be seen that control group successful pregnancies 11, alginic acid oligosaccharides group, chitosan oligosaccharide group and glycoconjugate group respectively at
Function is become pregnant 12, and control group total yield coefficient is 124, and average litter size is 11.3；Alginic acid oligosaccharides group total yield coefficient is 150
Only, average litter size is 12.5, increases by 1.2 than control group, is better than control group；Chitosan oligosaccharide group total yield coefficient is 156, is put down
Equal litter size is 13, increases by 1.7 than control group, is better than control group；And compound formulation group total yield coefficient is 165, it is average
Farrowing is 13.8, increases by 2.5 than control group, hence it is evident that be better than control group, alginic acid oligosaccharides group and chitosan oligosaccharide group, it was demonstrated that addition
Compound formulation can obviously increase the reproductive performance of male mouse.
Table 2: compound formulation influences mouse propagation performance
Test example 2:
It takes every group of 12 male mice fasting 12 hours after mating successfully, after weighing, the neck that breaks puts to death mouse, cuts open pluck male mouse rapidly
Testis, epididymis claim fresh weight, calculate shoot formation, and calculation method is as follows: shoot formation=organ fresh weight (g)/empty body weight (g) ×
100.It the results are shown in Table 3, the testis of glycoconjugate group mouse and epididymis weight will be higher than other groups as can be seen from the results, it was demonstrated that multiple
The Reproductive Performance of male mice can be increased to a certain degree by closing sugar, the testis and epididymis index of glycoconjugate group also above other groups,
Its function and effect of further secondary evidence.
Influence of 3 compound formulation of table to male mice reproductive organs
Test 3:
After male mice execution will be tested, after taking its bilateral epididymal, epididymis to claim fresh weight rapidly, epididymis is placed on cleaning glass slide
On, epididymis (need not shred) is cut off with eye scissors, physiological saline is extracted with syringe and drips 1-2 drop of liquid on epididymis.It takes clean
Glass slide press lightly on, be sufficiently mixed sperm in its epididymis with liquid, then with syringe extract mixing liquid drop it is thin in blood
On born of the same parents' counter, covered is immediately placed in microscopically observation counting.Observe sperm that straight line fast forwards through just by it
A grades are denoted as, the sperm of curvilinear motion is denoted as b grades, and the sperm that original place is spinned is denoted as c grades, and motionless sperm is denoted as d grades.When every
Statistics terminates when sperm is observed to 200 sperms in male mice epididymis, and the sum of a, b, c three-level sperm numerical value is sperm motility
Rate.It the results are shown in Table 4.As can be seen from the test results, glycoconjugate group sperm motility highest can achieve 85%, wherein a grades of sperms
Vigor reaches 36%, is all apparently higher than the 68.5% and 17.5% of control group, while also above two kinds of oligosaccharides groups of independent addition.Sperm
The raising of locomitivity will greatly improve the survival rate and rate of fertilization of its sperm, increase its reproductive performance.
4 compound formulation of table influences male mice sperm motility
Claims (2)
1. a kind of for adjusting the compound formulation of buck physiological function, it is characterised in that raw material percentage composition is as follows: brown
Alginic acid oligosaccharides 1 ~ 25%, chitosan oligosaccharide 1 ~ 25%, fucose 1 ~ 25%, surplus are the maize cob meals as carrier；The alginic acid oligosaccharides
The degree of polymerization is that 2 ~ 10, wherein mannuronic acid and guluronic acid composition ratio are 7 ~ 3:3 ~ 2, and average molecular weight is 300 ~ 3000
Da；The chitosan oligosaccharide degree of polymerization is 2 ~ 20, deacetylation at least 95%, and average molecular weight is 300 ~ 4000 Da；The fucose
For α-L-type fucose, purity at least 85%.
2. according to claim 1 for adjusting the compound formulation of buck physiological function, it is characterised in that raw material composition
Percentage are as follows: alginic acid oligosaccharides 10 ~ 15%, chitosan oligosaccharide 10 ~ 15%, fucose 10 ~ 15%, surplus are the maize cob meals as carrier.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811518894.8A CN109674813A (en) | 2018-12-12 | 2018-12-12 | For improving the compound formulation of buck physiological function |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811518894.8A CN109674813A (en) | 2018-12-12 | 2018-12-12 | For improving the compound formulation of buck physiological function |
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| Publication Number | Publication Date |
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| CN109674813A true CN109674813A (en) | 2019-04-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811518894.8A Pending CN109674813A (en) | 2018-12-12 | 2018-12-12 | For improving the compound formulation of buck physiological function |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115606696A (en) * | 2022-09-08 | 2023-01-17 | 沈阳农业大学 | Feed additive for improving breeding capability and semen quality of male livestock |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562050A (en) * | 2004-03-24 | 2005-01-12 | 中国海洋大学 | Use of oligose alginate in anti-dementia and anti-diabetes |
| CN104115995A (en) * | 2013-04-26 | 2014-10-29 | 中国科学院大连化学物理研究所 | Composite carbohydrate preparation for improving animal semen vitality and application thereof |
| CN104431341A (en) * | 2013-09-13 | 2015-03-25 | 中国科学院大连化学物理研究所 | Functional glycoconjugate for improving reproductive performance of female animals and application thereof |
| CN104543416A (en) * | 2013-10-09 | 2015-04-29 | 中国科学院大连化学物理研究所 | Functional monosaccharide feed for adjusting reproductive performance of female animals and application thereof |
| CN108077590A (en) * | 2017-12-25 | 2018-05-29 | 大连海洋大学 | Promote sow mammogenesis and improve the feed addictive of milk quality |
-
2018
- 2018-12-12 CN CN201811518894.8A patent/CN109674813A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562050A (en) * | 2004-03-24 | 2005-01-12 | 中国海洋大学 | Use of oligose alginate in anti-dementia and anti-diabetes |
| CN104115995A (en) * | 2013-04-26 | 2014-10-29 | 中国科学院大连化学物理研究所 | Composite carbohydrate preparation for improving animal semen vitality and application thereof |
| CN104431341A (en) * | 2013-09-13 | 2015-03-25 | 中国科学院大连化学物理研究所 | Functional glycoconjugate for improving reproductive performance of female animals and application thereof |
| CN104543416A (en) * | 2013-10-09 | 2015-04-29 | 中国科学院大连化学物理研究所 | Functional monosaccharide feed for adjusting reproductive performance of female animals and application thereof |
| CN108077590A (en) * | 2017-12-25 | 2018-05-29 | 大连海洋大学 | Promote sow mammogenesis and improve the feed addictive of milk quality |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115606696A (en) * | 2022-09-08 | 2023-01-17 | 沈阳农业大学 | Feed additive for improving breeding capability and semen quality of male livestock |
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